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Items: 13

1.

Oral drug suitability parameters.

Wenlock MC.

Medchemcomm. 2018 Feb 5;9(3):460-470. doi: 10.1039/c7md00586e. eCollection 2018 Mar 1.

2.

Designing safer oral drugs.

Wenlock MC.

Medchemcomm. 2017 Jan 20;8(3):571-577. doi: 10.1039/c6md00706f. eCollection 2017 Mar 1.

3.

Interpreting physicochemical experimental data sets.

Colclough N, Wenlock MC.

J Comput Aided Mol Des. 2015 Sep;29(9):779-94. doi: 10.1007/s10822-015-9850-7. Epub 2015 Jun 9.

PMID:
26054297
4.

How experimental errors influence drug metabolism and pharmacokinetic QSAR/QSPR models.

Wenlock MC, Carlsson LA.

J Chem Inf Model. 2015 Jan 26;55(1):125-34. doi: 10.1021/ci500535s. Epub 2014 Dec 24.

5.

In silico physicochemical parameter predictions.

Wenlock MC, Barton P.

Mol Pharm. 2013 Apr 1;10(4):1224-35. doi: 10.1021/mp300537k. Epub 2013 Jan 24.

PMID:
23305561
6.

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.

Luker T, Alcaraz L, Chohan KK, Blomberg N, Brown DS, Butlin RJ, Elebring T, Griffin AM, Guile S, St-Gallay S, Swahn BM, Swallow S, Waring MJ, Wenlock MC, Leeson PD.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5673-9. doi: 10.1016/j.bmcl.2011.07.074. Epub 2011 Jul 27.

PMID:
21852131
7.

A highly automated assay for determining the aqueous equilibrium solubility of drug discovery compounds.

Wenlock MC, Austin RP, Potter T, Barton P.

J Lab Autom. 2011 Aug;16(4):276-84. doi: 10.1016/j.jala.2010.10.002. Epub 2011 Mar 26.

PMID:
21764023
8.

Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.

Wenlock MC, Barton P, Luker T.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3550-6. doi: 10.1016/j.bmcl.2011.04.133. Epub 2011 May 5.

PMID:
21601448
9.

A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril.

Wenlock MC, Barton P, Austin RP.

J Pharm Biomed Anal. 2011 Jun 1;55(3):385-90. doi: 10.1016/j.jpba.2011.02.006. Epub 2011 Mar 2.

PMID:
21371844
10.

A method for measuring the lipophilicity of compounds in mixtures of 10.

Wenlock MC, Potter T, Barton P, Austin RP.

J Biomol Screen. 2011 Mar;16(3):348-55. doi: 10.1177/1087057110396372. Epub 2011 Feb 22.

PMID:
21343602
11.

The thermodynamics of the partitioning of ionizing molecules between aqueous buffers and phospholipid membranes.

Austin RP, Barton P, Davis AM, Fessey RE, Wenlock MC.

Pharm Res. 2005 Oct;22(10):1649-57. Epub 2005 Sep 22.

PMID:
16180122
12.

A comparison of physiochemical property profiles of development and marketed oral drugs.

Wenlock MC, Austin RP, Barton P, Davis AM, Leeson PD.

J Med Chem. 2003 Mar 27;46(7):1250-6.

PMID:
12646035
13.

The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

Austin RP, Barton P, Cockroft SL, Wenlock MC, Riley RJ.

Drug Metab Dispos. 2002 Dec;30(12):1497-503.

PMID:
12433825

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