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Items: 1 to 50 of 205

1.

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium.

Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE.

Metabolites. 2019 Jun 6;9(6). pii: E106. doi: 10.3390/metabo9060106.

2.

Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis.

Tang P, Low HB, Png CW, Torta F, Kumar JK, Lim HY, Zhou Y, Yang H, Angeli V, Shabbir A, Tai ES, Flavell RA, Dong C, Wenk MR, Yang DY, Zhang Y.

Hepatol Commun. 2019 Mar 1;3(6):748-762. doi: 10.1002/hep4.1324. eCollection 2019 Jun.

3.

Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence.

Chew WS, Torta F, Ji S, Choi H, Begum H, Sim X, Khoo CM, Khoo EYH, Ong WY, Van Dam RM, Wenk MR, Tai ES, Herr DR.

JCI Insight. 2019 Jun 4;5. pii: 126925. doi: 10.1172/jci.insight.126925.

4.

The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection.

Piccirillo AR, Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM, Wong BH, Foo JC, Cazenave-Gassiot A, Wenk MR, Delgoffe GM, Watkins SC, Silver DL, D'Cruz LM.

J Immunol. 2019 Jul 1;203(1):117-126. doi: 10.4049/jimmunol.1801585. Epub 2019 May 24.

PMID:
31127034
5.

Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes.

Maric S, Lind TK, Raida MR, Bengtsson E, Fredrikson GN, Rogers S, Moulin M, Haertlein M, Forsyth VT, Wenk MR, Pomorski TG, Arnebrant T, Lund R, Cárdenas M.

Sci Rep. 2019 May 20;9(1):7591. doi: 10.1038/s41598-019-43713-6.

6.

Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure.

Sieber-Ruckstuhl NS, Burla B, Spoerel S, Schmid F, Venzin C, Cazenave-Gassiot A, Bendt AK, Torta F, Wenk MR, Boretti FS.

Sci Rep. 2019 Apr 12;9(1):6015. doi: 10.1038/s41598-019-42190-1.

7.

Metabolism of 13C-Labeled Fatty Acids in Term Human Placental Explants by Liquid Chromatography-Mass Spectrometry.

Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY.

Endocrinology. 2019 Jun 1;160(6):1394-1408. doi: 10.1210/en.2018-01020.

PMID:
30920585
8.

Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?

Sharman MJ, Gyengesi E, Liang H, Chatterjee P, Karl T, Li QX, Wenk MR, Halliwell B, Martins RN, Münch G.

Neurobiol Dis. 2019 Apr;124:505-519. doi: 10.1016/j.nbd.2018.11.026. Epub 2019 Jan 2.

PMID:
30610916
9.

Analytical Considerations of Stable Isotope Labelling in Lipidomics.

Triebl A, Wenk MR.

Biomolecules. 2018 Nov 16;8(4). pii: E151. doi: 10.3390/biom8040151. Review.

10.

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.

Sci Data. 2018 Oct 23;5:180231. doi: 10.1038/sdata.2018.231.

11.

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity.

Lim YP, Go MK, Raida M, Inoue T, Wenk MR, Keasling JD, Chang MW, Yew WS.

ACS Omega. 2018 Sep 30;3(9):11050-11061. doi: 10.1021/acsomega.8b01620. Epub 2018 Sep 12.

12.

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.

Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.

PMID:
30269951
13.

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR.

J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163. Epub 2018 Aug 16.

14.

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.

Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S, Wenk MR, Cazenave-Gassiot A, Silver DL.

PLoS Biol. 2018 Aug 3;16(8):e2006443. doi: 10.1371/journal.pbio.2006443. eCollection 2018 Aug.

15.

Tear eicosanoids in healthy people and ocular surface disease.

Ambaw YA, Chao C, Ji S, Raida M, Torta F, Wenk MR, Tong L.

Sci Rep. 2018 Jul 26;8(1):11296. doi: 10.1038/s41598-018-29568-3.

16.

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL, Elpeleg O, Edvardson S.

Neurogenetics. 2018 Dec;19(4):227-235. doi: 10.1007/s10048-018-0556-6. Epub 2018 Jul 24.

PMID:
30043326
17.

Sphingolipidomics analysis of large clinical cohorts. Part 1: Technical notes and practical considerations.

Chew WS, Seow WL, Chong JR, Lai MKP, Torta F, Wenk MR, Herr DR.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):596-601. doi: 10.1016/j.bbrc.2018.04.076. Epub 2018 Apr 19. Review.

PMID:
29654754
18.

LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA.

JCI Insight. 2018 Mar 8;3(5). pii: 96151. doi: 10.1172/jci.insight.96151.

19.

Sphingolipid Analysis in Clinical Research.

Burla B, Muralidharan S, Wenk MR, Torta F.

Methods Mol Biol. 2018;1730:135-162. doi: 10.1007/978-1-4939-7592-1_11.

PMID:
29363072
20.

Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.).

Woodfield HK, Cazenave-Gassiot A, Haslam RP, Guschina IA, Wenk MR, Harwood JL.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):339-348. doi: 10.1016/j.bbalip.2017.12.010. Epub 2017 Dec 22.

21.

Sex Differences in 20-Hydroxyecdysone Hormone Levels Control Sexual Dimorphism in Bicyclus anynana Wing Patterns.

Bhardwaj S, Prudic KL, Bear A, Dasgupta M, Wasik BR, Tong X, Cheong WF, Wenk MR, Monteiro A.

Mol Biol Evol. 2018 Feb 1;35(2):465-472. doi: 10.1093/molbev/msx301.

22.

Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q, Wakelam MJO, Haemmerle G, Spener F, Köfeler HC, Thallinger GG.

Nat Methods. 2017 Dec;14(12):1171-1174. doi: 10.1038/nmeth.4470. Epub 2017 Oct 23.

23.

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.

Vu TM, Ishizu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S, Toh SES, Suda T, Silver DL, Wenk MR, Nguyen LN.

Nature. 2017 Oct 26;550(7677):524-528. doi: 10.1038/nature24053. Epub 2017 Oct 18.

PMID:
29045386
24.

Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease.

Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S.

J Alzheimers Dis. 2017;60(4):1429-1442. doi: 10.3233/JAD-170093.

PMID:
29036814
25.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

26.

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.

Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.

27.

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2147-2155. doi: 10.1161/ATVBAHA.117.309574. Epub 2017 Sep 7.

PMID:
28882873
28.

Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells.

Wang D, Du S, Cazenave-Gassiot A, Ge J, Lee JS, Wenk MR, Yao SQ.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5829-5833. doi: 10.1002/anie.201702509. Epub 2017 Apr 21.

PMID:
28429463
29.

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.

Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR.

PLoS One. 2017 Apr 19;12(4):e0175886. doi: 10.1371/journal.pone.0175886. eCollection 2017.

30.

Hypoxia enhances antibody-dependent dengue virus infection.

Gan ES, Cheong WF, Chan KR, Ong EZ, Chai X, Tan HC, Ghosh S, Wenk MR, Ooi EE.

EMBO J. 2017 May 15;36(10):1348-1363. doi: 10.15252/embj.201695642. Epub 2017 Mar 20.

31.

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.

32.

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Ahmed MY, Al-Khayat A, Al-Murshedi F, Al-Futaisi A, Chioza BA, Pedro Fernandez-Murray J, Self JE, Salter CG, Harlalka GV, Rawlins LE, Al-Zuhaibi S, Al-Azri F, Al-Rashdi F, Cazenave-Gassiot A, Wenk MR, Al-Salmi F, Patton MA, Silver DL, Baple EL, McMaster CR, Crosby AH.

Brain. 2017 Mar 1;140(3):547-554. doi: 10.1093/brain/aww318.

33.

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

Laursen T, Borch J, Knudsen C, Bavishi K, Torta F, Martens HJ, Silvestro D, Hatzakis NS, Wenk MR, Dafforn TR, Olsen CE, Motawia MS, Hamberger B, Møller BL, Bassard JE.

Science. 2016 Nov 18;354(6314):890-893.

PMID:
27856908
34.

Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline.

Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY.

Neuroscience. 2017 Jan 6;340:91-100. doi: 10.1016/j.neuroscience.2016.10.037. Epub 2016 Oct 24.

PMID:
27789386
35.
36.

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.

Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS.

Elife. 2016 Aug 16;5. pii: e19042. doi: 10.7554/eLife.19042.

37.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2016 Jul;22(7):629. doi: 10.1016/j.molmed.2016.05.008. Epub 2016 Jun 6. No abstract available.

PMID:
27282088
38.

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC.

Sci Rep. 2016 May 10;6:25650. doi: 10.1038/srep25650.

39.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14. doi: 10.1074/jbc.M116.721340. Epub 2016 Mar 22.

40.

Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.

Yang Y, Torta F, Arai K, Wenk MR, Herr DR, Wong PT, Lai MK.

Neurochem Int. 2016 Mar;94:90-7. doi: 10.1016/j.neuint.2016.02.012. Epub 2016 Feb 24.

PMID:
26921668
41.

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.

Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN.

J Alzheimers Dis. 2016;50(3):887-94. doi: 10.3233/JAD-150948.

42.

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR.

Sci Rep. 2016 Jan 8;6:19139. doi: 10.1038/srep19139.

43.

Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.

Hebbar S, Sahoo I, Matysik A, Argudo Garcia I, Osborne KA, Papan C, Torta F, Narayanaswamy P, Fun XH, Wenk MR, Shevchenko A, Schwudke D, Kraut R.

Sci Rep. 2015 Dec 7;5:15926. doi: 10.1038/srep15926.

44.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2015 Dec;21(12):736-748. doi: 10.1016/j.molmed.2015.10.001. Epub 2015 Nov 17. Review. Erratum in: Trends Mol Med. 2016 Jul;22(7):629.

PMID:
26596867
45.

Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs.

Monteiro A, Tong X, Bear A, Liew SF, Bhardwaj S, Wasik BR, Dinwiddie A, Bastianelli C, Cheong WF, Wenk MR, Cao H, Prudic KL.

PLoS Genet. 2015 Sep 25;11(9):e1005529. doi: 10.1371/journal.pgen.1005529. eCollection 2015.

46.

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.

Kanehara K, Yu CY, Cho Y, Cheong WF, Torta F, Shui G, Wenk MR, Nakamura Y.

PLoS Genet. 2015 Sep 24;11(9):e1005511. doi: 10.1371/journal.pgen.1005511. eCollection 2015 Sep.

47.

The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C.

J Cell Biol. 2015 Sep 14;210(6):951-60.

48.

INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.

Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P.

Science. 2015 Jul 24;349(6246):428-32. doi: 10.1126/science.aab1370.

49.

Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ.

Sleep. 2015 Nov 1;38(11):1683-91. doi: 10.5665/sleep.5142.

50.

Phosphatidic acid is a major phospholipid class in reproductive organs of Arabidopsis thaliana.

Yunus IS, Cazenave-Gassiot A, Liu YC, Lin YC, Wenk MR, Nakamura Y.

Plant Signal Behav. 2015;10(8):e1049790. doi: 10.1080/15592324.2015.1049790.

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