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Items: 30


Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite.

Wein S, Ghezal S, Buré C, Maynadier M, Périgaud C, Vial HJ, Lefebvre-Tournier I, Wengelnik K, Cerdan R.

J Lipid Res. 2018 Aug;59(8):1461-1471. doi: 10.1194/jlr.M085589. Epub 2018 May 31.


Phosphoinositides and their functions in apicomplexan parasites.

Wengelnik K, Daher W, Lebrun M.

Int J Parasitol. 2018 Jun;48(7):493-504. doi: 10.1016/j.ijpara.2018.01.009. Epub 2018 Mar 26. Review.


Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A.

Cell. 2018 Apr 5;173(2):443-455.e12. doi: 10.1016/j.cell.2018.02.047. Epub 2018 Mar 22.


Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell.

Andreadaki M, Hanssen E, Deligianni E, Claudet C, Wengelnik K, Mollard V, McFadden GI, Abkarian M, Braun-Breton C, Siden-Kiamos I.

Sci Rep. 2018 Feb 23;8(1):3543. doi: 10.1038/s41598-018-21801-3.


Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O.

Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030.


High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.

Wein S, Taudon N, Maynadier M, Tran Van Ba C, Margout D, Bordat Y, Fraisse L, Wengelnik K, Cerdan R, Bressolle-Gomeni F, Vial HJ.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00352-17. doi: 10.1128/AAC.00352-17. Print 2017 Aug.


Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containing protein that binds to the phosphoinositide PI(3,5)P2.

Daher W, Morlon-Guyot J, Alayi TD, Tomavo S, Wengelnik K, Lebrun M.

Mol Biochem Parasitol. 2016 May;207(1):39-44. doi: 10.1016/j.molbiopara.2016.03.011. Epub 2016 Apr 7.


Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening.

Contet A, Pihan E, Lavigne M, Wengelnik K, Maheshwari S, Vial H, Douguet D, Cerdan R.

FEBS Lett. 2015 Apr 13;589(9):992-1000. doi: 10.1016/j.febslet.2015.03.003. Epub 2015 Mar 13.


Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii.

Daher W, Morlon-Guyot J, Sheiner L, Lentini G, Berry L, Tawk L, Dubremetz JF, Wengelnik K, Striepen B, Lebrun M.

Cell Microbiol. 2015 Apr;17(4):559-78. doi: 10.1111/cmi.12383. Epub 2014 Nov 22.


Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active.

Maheshwari S, Lavigne M, Contet A, Alberge B, Pihan E, Kocken C, Wengelnik K, Douguet D, Vial H, Cerdan R.

Biochem J. 2013 Feb 15;450(1):159-67. doi: 10.1042/BJ20121480.


Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium.

Raabe A, Berry L, Sollelis L, Cerdan R, Tawk L, Vial HJ, Billker O, Wengelnik K.

Exp Parasitol. 2011 Sep;129(1):75-80. doi: 10.1016/j.exppara.2011.05.023. Epub 2011 May 30.


Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation.

Raabe AC, Wengelnik K, Billker O, Vial HJ.

Cell Microbiol. 2011 Jul;13(7):955-66. doi: 10.1111/j.1462-5822.2011.01591.x. Epub 2011 Apr 26.


Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis.

Tawk L, Dubremetz JF, Montcourrier P, Chicanne G, Merezegue F, Richard V, Payrastre B, Meissner M, Vial HJ, Roy C, Wengelnik K, Lebrun M.

PLoS Pathog. 2011 Feb;7(2):e1001286. doi: 10.1371/journal.ppat.1001286. Epub 2011 Feb 17.


Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast.

Tawk L, Chicanne G, Dubremetz JF, Richard V, Payrastre B, Vial HJ, Roy C, Wengelnik K.

Eukaryot Cell. 2010 Oct;9(10):1519-30. doi: 10.1128/EC.00124-10. Epub 2010 Aug 13.


Glycerophospholipid acquisition in Plasmodium - a puzzling assembly of biosynthetic pathways.

Déchamps S, Shastri S, Wengelnik K, Vial HJ.

Int J Parasitol. 2010 Oct;40(12):1347-65. doi: 10.1016/j.ijpara.2010.05.008. Epub 2010 Jul 1. Review.


The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages.

Déchamps S, Wengelnik K, Berry-Sterkers L, Cerdan R, Vial HJ, Gannoun-Zaki L.

Mol Biochem Parasitol. 2010 Oct;173(2):69-80. doi: 10.1016/j.molbiopara.2010.05.006. Epub 2010 May 15.


Quantitative assessment of DNA replication to monitor microgametogenesis in Plasmodium berghei.

Raabe AC, Billker O, Vial HJ, Wengelnik K.

Mol Biochem Parasitol. 2009 Dec;168(2):172-6. doi: 10.1016/j.molbiopara.2009.08.004. Epub 2009 Aug 25.


Characterisation of the phosphatidylinositol synthase gene of Plasmodium species.

Wengelnik K, Vial HJ.

Res Microbiol. 2007 Jan-Feb;158(1):51-9. Epub 2006 Dec 19.


A class of potent antimalarials and their specific accumulation in infected erythrocytes.

Wengelnik K, Vidal V, Ancelin ML, Cathiard AM, Morgat JL, Kocken CH, Calas M, Herrera S, Thomas AW, Vial HJ.

Science. 2002 Feb 15;295(5558):1311-4.


Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme.

Martin D, Gannoun-Zaki L, Bonnefoy S, Eldin P, Wengelnik K, Vial H.

Mol Biochem Parasitol. 2000 Sep;110(1):93-105.


Structure-function analysis of malaria proteins by gene targeting--a response.

Wengelnik K, Spaccapelo R, Naitza S, Crisanti A.

Parasitol Today. 2000 Jun;16(6):224-5. No abstract available.


CTRP is essential for mosquito infection by malaria ookinetes.

Dessens JT, Beetsma AL, Dimopoulos G, Wengelnik K, Crisanti A, Kafatos FC, Sinden RE.

EMBO J. 1999 Nov 15;18(22):6221-7.


The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands.

Wengelnik K, Spaccapelo R, Naitza S, Robson KJ, Janse CJ, Bistoni F, Waters AP, Crisanti A.

EMBO J. 1999 Oct 1;18(19):5195-204.


The Xanthomonas Hrp type III system secretes proteins from plant and mammalian bacterial pathogens.

Rossier O, Wengelnik K, Hahn K, Bonas U.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9368-73.


Characterization of the fimA gene encoding bundle-forming fimbriae of the plant pathogen Xanthomonas campestris pv. vesicatoria.

Ojanen-Reuhs T, Kalkkinen N, Westerlund-Wikström B, van Doorn J, Haahtela K, Nurmiaho-Lassila EL, Wengelnik K, Bonas U, Korhonen TK.

J Bacteriol. 1997 Feb;179(4):1280-90.


HrpG, a key hrp regulatory protein of Xanthomonas campestris pv. vesicatoria is homologous to two-component response regulators.

Wengelnik K, Van den Ackerveken G, Bonas U.

Mol Plant Microbe Interact. 1996 Nov;9(8):704-12.


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