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Items: 1 to 50 of 278

1.

Self-assembly of DNA-peptide supermolecules: Coiled-coil peptide structures templated by D-DNA and L-DNA triplexes exhibit chirality-independent but orientation-dependent stabilizing cooperativity.

Lou C, Boesen JT, Christensen NJ, Sørensen KK, Thulstrup PW, Pedersen MN, Giralt E, Jensen KJ, Wengel J.

Chemistry. 2020 Feb 5. doi: 10.1002/chem.201905636. [Epub ahead of print]

PMID:
32022377
2.

Systemic Evaluation of Chimeric LNA/2'OMe Steric Blockers for Myotonic Dystrophy Type 1 Therapy.

Christou M, Wengel J, Sokratous K, Kyriacou K, Nikolaou G, Phylactou LA, Mastroyiannopoulos NP.

Nucleic Acid Ther. 2019 Dec 23. doi: 10.1089/nat.2019.0811. [Epub ahead of print]

PMID:
31873063
3.

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages.

Duschmalé J, Hansen HF, Duschmalé M, Koller E, Albaek N, Møller MR, Jensen K, Koch T, Wengel J, Bleicher K.

Nucleic Acids Res. 2020 Jan 10;48(1):63-74. doi: 10.1093/nar/gkz1099.

4.

Gapmer Antisense Oligonucleotides Containing 2',3'-Dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing.

Danielsen MB, Lou C, Lisowiec-Wachnicka J, Pasternak A, Jørgensen PT, Wengel J.

Chemistry. 2020 Jan 27;26(6):1368-1379. doi: 10.1002/chem.201904540. Epub 2020 Jan 20.

PMID:
31682037
5.

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers.

Abdelrahman A, Gouda AS, Jørgensen PT, Wengel J.

Nucleosides Nucleotides Nucleic Acids. 2019 Nov 1:1-15. doi: 10.1080/15257770.2019.1683188. [Epub ahead of print]

PMID:
31674270
6.

Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides.

Yadav Y, Sharma D, Kaushik K, Kumar V, Jha A, Prasad AK, Len C, Malhotra SV, Wengel J, Parmar VS.

Molecules. 2019 Oct 30;24(21). pii: E3922. doi: 10.3390/molecules24213922.

7.

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine.

Andersen VL, Vinther M, Kumar R, Ries A, Wengel J, Nielsen JS, Kjems J.

Theranostics. 2019 Apr 13;9(9):2662-2677. doi: 10.7150/thno.32060. eCollection 2019.

8.

Molecular determinants for agonist recognition and discrimination in P2X2 receptors.

Gasparri F, Wengel J, Grutter T, Pless SA.

J Gen Physiol. 2019 Jul 1;151(7):898-911. doi: 10.1085/jgp.201912347. Epub 2019 May 24.

9.

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation.

Moura J, Sørensen A, Leal EC, Svendsen R, Carvalho L, Willemoes RJ, Jørgensen PT, Jenssen H, Wengel J, Dalgaard LT, Carvalho E.

Sci Rep. 2019 Apr 9;9(1):5836. doi: 10.1038/s41598-019-42309-4.

10.

Oligonucleotide Binding to Non-B-DNA in MYC.

Umek T, Sollander K, Bergquist H, Wengel J, Lundin KE, Smith CIE, Zain R.

Molecules. 2019 Mar 12;24(5). pii: E1000. doi: 10.3390/molecules24051000.

11.

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study.

Xu Y, Gissberg O, Pabon-Martinez YV, Wengel J, Lundin KE, Smith CIE, Zain R, Nilsson L, Villa A.

PLoS One. 2019 Feb 12;14(2):e0211651. doi: 10.1371/journal.pone.0211651. eCollection 2019.

12.

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects.

Kotkowiak W, Wengel J, Scotton CJ, Pasternak A.

J Med Chem. 2019 Mar 14;62(5):2499-2507. doi: 10.1021/acs.jmedchem.8b01806. Epub 2019 Feb 22.

PMID:
30735377
13.

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis.

Garcia JP, Stein J, Cai Y, Riemers F, Wexselblatt E, Wengel J, Tryfonidou M, Yayon A, Howard KA, Creemers LB.

J Control Release. 2019 Jan 28;294:247-258. doi: 10.1016/j.jconrel.2018.12.030. Epub 2018 Dec 18.

14.

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells.

Ferino A, Miglietta G, Picco R, Vogel S, Wengel J, Xodo LE.

RNA Biol. 2018;15(10):1273-1285. doi: 10.1080/15476286.2018.1526536. Epub 2018 Oct 11.

15.

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions.

Ejlersen M, Lou C, Sanghvi YS, Tor Y, Wengel J.

Chem Commun (Camb). 2018 Jul 12;54(57):8003-8006. doi: 10.1039/c8cc01360h.

PMID:
29967912
16.

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides.

Lima JF, Carvalho J, Pinto-Ribeiro I, Almeida C, Wengel J, Cerqueira L, Figueiredo C, Oliveira C, Azevedo NF.

BMC Mol Biol. 2018 Jun 7;19(1):6. doi: 10.1186/s12867-018-0107-6.

17.

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury.

Moreno PMD, Ferreira AR, Salvador D, Rodrigues MT, Torrado M, Carvalho ED, Tedebark U, Sousa MM, Amaral IF, Wengel J, Pêgo AP.

Mol Ther Nucleic Acids. 2018 Jun 1;11:393-406. doi: 10.1016/j.omtn.2018.03.009. Epub 2018 Mar 20.

18.

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity.

Cai Y, Makarova AM, Wengel J, Howard KA.

J Gene Med. 2018 Jul;20(7-8):e3025. doi: 10.1002/jgm.3025. Epub 2018 Jun 25.

PMID:
29800498
19.

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA.

Ejlersen M, Christensen NJ, Sørensen KK, Jensen KJ, Wengel J, Lou C.

Bioconjug Chem. 2018 Apr 18;29(4):1025-1029. doi: 10.1021/acs.bioconjchem.8b00101. Epub 2018 Mar 13.

PMID:
29505242
20.

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative.

Kotkowiak W, Lisowiec-Wachnicka J, Grynda J, Kierzek R, Wengel J, Pasternak A.

Mol Ther Nucleic Acids. 2018 Mar 2;10:304-316. doi: 10.1016/j.omtn.2017.12.013. Epub 2017 Dec 30.

21.

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides.

Vejlegaard K, Wegeberg C, McKee V, Wengel J.

Org Biomol Chem. 2018 Feb 21;16(8):1312-1321. doi: 10.1039/c7ob02663c.

PMID:
29392247
22.

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications.

Kuhlmann M, Hamming JBR, Voldum A, Tsakiridou G, Larsen MT, Schmøkel JS, Sohn E, Bienk K, Schaffert D, Sørensen ES, Wengel J, Dupont DM, Howard KA.

Mol Ther Nucleic Acids. 2017 Dec 15;9:284-293. doi: 10.1016/j.omtn.2017.10.004. Epub 2017 Oct 7.

23.

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures.

Pabon-Martinez YV, Xu Y, Villa A, Lundin KE, Geny S, Nguyen CH, Pedersen EB, Jørgensen PT, Wengel J, Nilsson L, Smith CIE, Zain R.

Sci Rep. 2017 Sep 8;7(1):11043. doi: 10.1038/s41598-017-09147-8.

24.

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

Hvam ML, Cai Y, Dagnæs-Hansen F, Nielsen JS, Wengel J, Kjems J, Howard KA.

Mol Ther. 2017 Jul 5;25(7):1710-1717. doi: 10.1016/j.ymthe.2017.05.009. Epub 2017 Jun 20.

25.

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies.

Hartono YD, Pabon-Martinez YV, Uyar A, Wengel J, Lundin KE, Zain R, Smith CIE, Nilsson L, Villa A.

ACS Omega. 2017 May 31;2(5):2165-2177. doi: 10.1021/acsomega.7b00347. Epub 2017 May 17.

26.

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers.

Vejlegaard K, Paul S, Kosbar T, Wengel J, Caruthers MH.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3173-3176. doi: 10.1016/j.bmcl.2017.05.023. Epub 2017 May 17.

PMID:
28552336
27.

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.

Kumar R, Ries A, Wengel J.

Molecules. 2017 May 21;22(5). pii: E852. doi: 10.3390/molecules22050852.

28.

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex.

Lou C, Christensen NJ, Martos-Maldonado MC, Midtgaard SR, Ejlersen M, Thulstrup PW, Sørensen KK, Jensen KJ, Wengel J.

Chemistry. 2017 Jul 12;23(39):9297-9305. doi: 10.1002/chem.201700971. Epub 2017 May 10.

PMID:
28383784
29.

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.

Schmøkel J, Voldum A, Tsakiridou G, Kuhlmann M, Cameron J, Sørensen ES, Wengel J, Howard KA.

Nanotechnology. 2017 May 19;28(20):204004. doi: 10.1088/1361-6528/aa6a9b. Epub 2017 Mar 31.

PMID:
28362634
30.

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.

Zaghloul EM, Gissberg O, Moreno PMD, Siggens L, Hällbrink M, Jørgensen AS, Ekwall K, Zain R, Wengel J, Lundin KE, Smith CIE.

Nucleic Acids Res. 2017 May 19;45(9):5153-5169. doi: 10.1093/nar/gkx111.

31.

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA.

Lou C, Samuelsen SV, Christensen NJ, Vester B, Wengel J.

Bioconjug Chem. 2017 Apr 19;28(4):1214-1220. doi: 10.1021/acs.bioconjchem.7b00061. Epub 2017 Apr 5.

PMID:
28332825
32.

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.

Cai Y, López-Ruiz E, Wengel J, Creemers LB, Howard KA.

J Control Release. 2017 May 10;253:153-159. doi: 10.1016/j.jconrel.2017.03.004. Epub 2017 Mar 6.

PMID:
28274742
33.

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes.

Ejlersen M, Langkjær N, Wengel J.

Org Biomol Chem. 2017 Mar 1;15(9):2073-2085. doi: 10.1039/c6ob02773c.

PMID:
28210721
34.

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.

Aaldering LJ, Poongavanam V, Langkjaer N, Murugan NA, Jørgensen PT, Wengel J, Veedu RN.

Chembiochem. 2017 Apr 18;18(8):755-763. doi: 10.1002/cbic.201600654. Epub 2017 Mar 15.

35.

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers.

Ries A, Kumar R, Lou C, Kosbar T, Vengut-Climent E, Jørgensen PT, Morales JC, Wengel J.

J Org Chem. 2016 Nov 18;81(22):10845-10856. Epub 2016 Oct 25.

PMID:
27736097
36.

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic.

Lou C, Martos-Maldonado MC, Madsen CS, Thomsen RP, Midtgaard SR, Christensen NJ, Kjems J, Thulstrup PW, Wengel J, Jensen KJ.

Nat Commun. 2016 Jul 28;7:12294. doi: 10.1038/ncomms12294.

37.

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.

Bienk K, Hvam ML, Pakula MM, Dagnæs-Hansen F, Wengel J, Malle BM, Kragh-Hansen U, Cameron J, Bukrinski JT, Howard KA.

J Control Release. 2016 Jun 28;232:143-51. doi: 10.1016/j.jconrel.2016.04.013. Epub 2016 Apr 12.

PMID:
27084489
38.

Application of locked nucleic acid-based probes in fluorescence in situ hybridization.

Fontenete S, Carvalho D, Guimarães N, Madureira P, Figueiredo C, Wengel J, Azevedo NF.

Appl Microbiol Biotechnol. 2016 Jul;100(13):5897-906. doi: 10.1007/s00253-016-7429-4. Epub 2016 Mar 12.

PMID:
26969040
39.

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs.

Gissberg O, Zaghloul EM, Lundin KE, Nguyen CH, Landras-Guetta C, Wengel J, Zain R, Smith CI.

Nucleic Acid Ther. 2016 Jun;26(3):183-9. doi: 10.1089/nat.2015.0592. Epub 2016 Feb 9.

PMID:
26859550
40.

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes.

Geny S, Moreno PM, Krzywkowski T, Gissberg O, Andersen NK, Isse AJ, El-Madani AM, Lou C, Pabon YV, Anderson BA, Zaghloul EM, Zain R, Hrdlicka PJ, Jørgensen PT, Nilsson M, Lundin KE, Pedersen EB, Wengel J, Smith CI.

Nucleic Acids Res. 2016 Mar 18;44(5):2007-19. doi: 10.1093/nar/gkw021. Epub 2016 Feb 8.

41.

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model.

Fontenete S, Leite M, Cappoen D, Santos R, Ginneken CV, Figueiredo C, Wengel J, Cos P, Azevedo NF.

PLoS One. 2016 Feb 5;11(2):e0148353. doi: 10.1371/journal.pone.0148353. eCollection 2016.

42.

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori.

Santos RS, Dakwar GR, Xiong R, Forier K, Remaut K, Stremersch S, Guimarães N, Fontenete S, Wengel J, Leite M, Figueiredo C, De Smedt SC, Braeckmans K, Azevedo NF.

Mol Ther Nucleic Acids. 2015 Dec 8;4:e269. doi: 10.1038/mtna.2015.46.

43.

Watson-Crick hydrogen bonding of unlocked nucleic acids.

Langkjær N, Wengel J, Pasternak A.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5064-6. doi: 10.1016/j.bmcl.2015.10.024. Epub 2015 Oct 20.

PMID:
26497284
44.

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer.

Opazo F, Eiden L, Hansen L, Rohrbach F, Wengel J, Kjems J, Mayer G.

Mol Ther Nucleic Acids. 2015 Sep 1;4:e251. doi: 10.1038/mtna.2015.25.

45.

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition.

Edwards SL, Poongavanam V, Kanwar JR, Roy K, Hillman KM, Prasad N, Leth-Larsen R, Petersen M, Marušič M, Plavec J, Wengel J, Veedu RN.

Chem Commun (Camb). 2015 Jun 11;51(46):9499-502. doi: 10.1039/c5cc02756j. Epub 2015 May 13.

PMID:
25968110
46.

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes.

Fontenete S, Leite M, Guimarães N, Madureira P, Ferreira RM, Figueiredo C, Wengel J, Azevedo NF.

PLoS One. 2015 Apr 27;10(4):e0125494. doi: 10.1371/journal.pone.0125494. eCollection 2015.

47.

Erratum to: mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

Fontenete S, Barros J, Madureira P, Figueiredo C, Wengel J, Azevedo NF.

Appl Microbiol Biotechnol. 2015 May;99(9):4117. doi: 10.1007/s00253-015-6568-3. No abstract available.

PMID:
25846338
49.

Selection of LNA-containing DNA aptamers against recombinant human CD73.

Elle IC, Karlsen KK, Terp MG, Larsen N, Nielsen R, Derbyshire N, Mandrup S, Ditzel HJ, Wengel J.

Mol Biosyst. 2015 May;11(5):1260-70. doi: 10.1039/c5mb00045a.

PMID:
25720604
50.

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance.

Lou C, Vester B, Wengel J.

Chem Commun (Camb). 2015 Mar 7;51(19):4024-7. doi: 10.1039/c5cc00322a.

PMID:
25659978

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