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Items: 1 to 50 of 51

1.

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Giambra V, Gusscott S, Gracias D, Song R, Lam SH, Panelli P, Tyshchenko K, Jenkins CE, Hoofd C, Lorzadeh A, Carles A, Hirst M, Eaves CJ, Weng AP.

Cell Stem Cell. 2018 Nov 1;23(5):714-726.e7. doi: 10.1016/j.stem.2018.08.018. Epub 2018 Sep 27.

PMID:
30269902
2.

RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes.

Jenkins CE, Gusscott S, Wong RJ, Shevchuk OO, Rana G, Giambra V, Tyshchenko K, Islam R, Hirst M, Weng AP.

Exp Hematol. 2018 Aug;64:84-96. doi: 10.1016/j.exphem.2018.04.008. Epub 2018 May 5.

PMID:
29733873
3.

Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2.

Weiswald LB, Hasan MR, Wong JCT, Pasiliao CC, Rahman M, Ren J, Yin Y, Gusscott S, Vacher S, Weng AP, Kennecke HF, Bièche I, Schaeffer DF, Yapp DT, Tai IT.

Mol Cancer Ther. 2017 Oct;16(10):2292-2303. doi: 10.1158/1535-7163.MCT-16-0666. Epub 2017 Jun 29.

4.

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.

Sasaki T, Rivera-Mulia JC, Vera D, Zimmerman J, Das S, Padget M, Nakamichi N, Chang BH, Tyner J, Druker BJ, Weng AP, Civin CI, Eaves CJ, Gilbert DM.

Exp Hematol. 2017 Jul;51:71-82.e3. doi: 10.1016/j.exphem.2017.04.004. Epub 2017 Apr 19.

5.

Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.

Yuan T, Yang Y, Chen J, Li W, Li W, Zhang Q, Mi Y, Goswami RS, You JQ, Lin D, Qian MD, Calin S, Liang Y, Miranda RN, Calin GA, Zhou X, Ma L, Zweidler-McKay PA, Liu B, Weng AP, Medeiros LJ, Zhang Y, You MJ.

Leukemia. 2017 Nov;31(11):2355-2364. doi: 10.1038/leu.2017.80. Epub 2017 Mar 10.

6.

Defining the clonality of peripheral T cell lymphomas using RNA-seq.

Brown SD, Hapgood G, Steidl C, Weng AP, Savage KJ, Holt RA.

Bioinformatics. 2017 Apr 15;33(8):1111-1115. doi: 10.1093/bioinformatics/btw810.

7.

IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias.

Gusscott S, Jenkins CE, Lam SH, Giambra V, Pollak M, Weng AP.

PLoS One. 2016 Aug 17;11(8):e0161158. doi: 10.1371/journal.pone.0161158. eCollection 2016.

8.

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM.

Cancer Cell. 2016 Jul 11;30(1):183. doi: 10.1016/j.ccell.2016.06.008. Epub 2016 Jul 11. No abstract available.

9.

Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing.

Parker JD, Shen Y, Pleasance E, Li Y, Schein JE, Zhao Y, Moore R, Wegrzyn-Woltosz J, Savage KJ, Weng AP, Gascoyne RD, Jones S, Marra M, Laskin J, Karsan A.

Cold Spring Harb Mol Case Stud. 2016 Mar;2(2):a000679. doi: 10.1101/mcs.a000679.

10.

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM.

Cancer Cell. 2016 Apr 11;29(4):574-586. doi: 10.1016/j.ccell.2016.03.008. Erratum in: Cancer Cell. 2016 Jul 11;30(1):183.

11.

Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?

Belmonte M, Hoofd C, Weng AP, Giambra V.

Curr Oncol. 2016 Feb;23(1):34-41. doi: 10.3747/co.23.2806. Epub 2016 Feb 18. Review.

12.

CD44 promotes chemoresistance in T-ALL by increased drug efflux.

Hoofd C, Wang X, Lam S, Jenkins C, Wood B, Giambra V, Weng AP.

Exp Hematol. 2016 Mar;44(3):166-71.e17. doi: 10.1016/j.exphem.2015.12.001. Epub 2015 Dec 18.

PMID:
26708679
13.

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling.

Giambra V, Jenkins CE, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, Weng AP.

Blood. 2015 Jun 18;125(25):3917-27. doi: 10.1182/blood-2014-10-609370. Epub 2015 May 1.

14.

Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, Karsan A, Weng AP, Humphries RK, Heuser M.

PLoS One. 2014 Nov 17;9(11):e112671. doi: 10.1371/journal.pone.0112671. eCollection 2014.

15.

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ, Humphries RK.

Blood. 2014 Dec 4;124(24):3608-12. doi: 10.1182/blood-2014-04-564666. Epub 2014 Oct 22.

16.

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia.

Bentley VL, Veinotte CJ, Corkery DP, Pinder JB, LeBlanc MA, Bedard K, Weng AP, Berman JN, Dellaire G.

Haematologica. 2015 Jan;100(1):70-6. doi: 10.3324/haematol.2014.110742. Epub 2014 Oct 3.

17.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, Kim ND, Look T, Mitsiades CS, Weng AP, Brown JR, Benes CH, Marto JA, Young RA, Gray NS.

Nature. 2014 Jul 31;511(7511):616-20. doi: 10.1038/nature13393. Epub 2014 Jun 22.

18.

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.

J Clin Invest. 2014 Feb;124(2):644-55. doi: 10.1172/JCI65093. Epub 2014 Jan 9.

19.

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.

Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT.

Cancer Discov. 2013 May;3(5):564-77. doi: 10.1158/2159-8290.CD-12-0504. Epub 2013 Mar 7.

20.

Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts.

Yost AJ, Shevchuk OO, Gooch R, Gusscott S, You MJ, Ince TA, Aster JC, Weng AP.

Leukemia. 2013 Jun;27(6):1437-40. doi: 10.1038/leu.2012.337. Epub 2012 Nov 21. No abstract available.

21.

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP.

Nat Med. 2012 Nov;18(11):1693-8. doi: 10.1038/nm.2960. Epub 2012 Oct 21.

22.

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

Jenkins CR, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, Weng AP.

Exp Hematol. 2012 Sep;40(9):715-723.e6. doi: 10.1016/j.exphem.2012.05.003. Epub 2012 May 18.

PMID:
22613471
23.

B cells with high side scatter parameter by flow cytometry correlate with inferior survival in diffuse large B-cell lymphoma.

Bashashati A, Johnson NA, Khodabakhshi AH, Whiteside MD, Zare H, Scott DW, Lo K, Gottardo R, Brinkman FS, Connors JM, Slack GW, Gascoyne RD, Weng AP, Brinkman RR.

Am J Clin Pathol. 2012 May;137(5):805-14. doi: 10.1309/AJCPGR8BG4JDVOWR.

24.

Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.

Gusscott S, Kuchenbauer F, Humphries RK, Weng AP.

Leuk Res. 2012 Jul;36(7):905-11. doi: 10.1016/j.leukres.2012.02.013. Epub 2012 Mar 17.

PMID:
22424712
25.

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

Kridel R, Meissner B, Rogic S, Boyle M, Telenius A, Woolcock B, Gunawardana J, Jenkins C, Cochrane C, Ben-Neriah S, Tan K, Morin RD, Opat S, Sehn LH, Connors JM, Marra MA, Weng AP, Steidl C, Gascoyne RD.

Blood. 2012 Mar 1;119(9):1963-71. doi: 10.1182/blood-2011-11-391474. Epub 2011 Dec 30.

26.

Automated analysis of multidimensional flow cytometry data improves diagnostic accuracy between mantle cell lymphoma and small lymphocytic lymphoma.

Zare H, Bashashati A, Kridel R, Aghaeepour N, Haffari G, Connors JM, Gascoyne RD, Gupta A, Brinkman RR, Weng AP.

Am J Clin Pathol. 2012 Jan;137(1):75-85. doi: 10.1309/AJCPMMLQ67YOMGEW.

27.

CD80 (B7.1) is expressed on both malignant B cells and nonmalignant stromal cells in non-Hodgkin lymphoma.

Dakappagari N, Ho SN, Gascoyne RD, Ranuio J, Weng AP, Tangri S.

Cytometry B Clin Cytom. 2012 Mar;82(2):112-9. doi: 10.1002/cyto.b.20631. Epub 2011 Nov 10.

28.

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

Medyouf H, Gusscott S, Wang H, Tseng JC, Wai C, Nemirovsky O, Trumpp A, Pflumio F, Carboni J, Gottardis M, Pollak M, Kung AL, Aster JC, Holzenberger M, Weng AP.

J Exp Med. 2011 Aug 29;208(9):1809-22. doi: 10.1084/jem.20110121. Epub 2011 Aug 1.

29.

Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.

Habibi D, Ogloff N, Jalili RB, Yost A, Weng AP, Ghahary A, Ong CJ.

Invest New Drugs. 2012 Aug;30(4):1361-70. doi: 10.1007/s10637-011-9700-y. Epub 2011 Jun 17.

PMID:
21678129
30.

Comprehensive microRNA expression profiling of the hematopoietic hierarchy.

Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei CJ, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15443-8. doi: 10.1073/pnas.1009320107. Epub 2010 Aug 11.

31.

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP.

Blood. 2010 Feb 11;115(6):1175-84. doi: 10.1182/blood-2009-04-214718. Epub 2009 Dec 11.

32.

Per-channel basis normalization methods for flow cytometry data.

Hahne F, Khodabakhshi AH, Bashashati A, Wong CJ, Gascoyne RD, Weng AP, Seyfert-Margolis V, Bourcier K, Asare A, Lumley T, Gentleman R, Brinkman RR.

Cytometry A. 2010 Feb;77(2):121-31. doi: 10.1002/cyto.a.20823.

33.

Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival.

Johnson NA, Boyle M, Bashashati A, Leach S, Brooks-Wilson A, Sehn LH, Chhanabhai M, Brinkman RR, Connors JM, Weng AP, Gascoyne RD.

Blood. 2009 Apr 16;113(16):3773-80. doi: 10.1182/blood-2008-09-177469. Epub 2008 Nov 24.

34.

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.

Chan SM, Weng AP, Tibshirani R, Aster JC, Utz PJ.

Blood. 2007 Jul 1;110(1):278-86. Epub 2007 Mar 15.

35.

Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma.

Rodig SJ, Savage KJ, LaCasce AS, Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, Kutok JL.

Am J Surg Pathol. 2007 Jan;31(1):106-12.

PMID:
17197926
36.

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. Epub 2006 Nov 17. Erratum in: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4240.

37.

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC.

Genes Dev. 2006 Aug 1;20(15):2096-109. Epub 2006 Jul 17. Erratum in: Genes Dev. 2007 Mar 1;21(5):625.

38.

Notch signaling in T-cell acute lymphoblastic leukemia.

Weng AP, Lau A.

Future Oncol. 2005 Aug;1(4):511-9. Review.

PMID:
16556027
39.

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.

Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC.

Mol Cell Biol. 2004 Nov;24(21):9265-73.

40.

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.

Science. 2004 Oct 8;306(5694):269-71.

41.

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L, Allman D, Aster JC, Pear WS.

Blood. 2004 Sep 15;104(6):1696-702. Epub 2004 Jun 8.

42.

Hodgkin disease associated with T-cell non-Hodgkin lymphomas: case reports and review of the literature.

Brown JR, Weng AP, Freedman AS.

Am J Clin Pathol. 2004 May;121(5):701-8.

PMID:
15151210
43.

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

44.

Multiple niches for Notch in cancer: context is everything.

Weng AP, Aster JC.

Curr Opin Genet Dev. 2004 Feb;14(1):48-54. Review.

PMID:
15108805
45.
46.

Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas.

Dorfman DM, van den Elzen P, Weng AP, Shahsafaei A, Glimcher LH.

Am J Clin Pathol. 2003 Dec;120(6):866-73.

PMID:
14671975
47.

CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall Th1- Th2+ immunophenotype.

Weng AP, Shahsafaei A, Dorfman DM.

Am J Clin Pathol. 2003 Mar;119(3):424-30.

PMID:
12645345
48.

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.

Nam Y, Weng AP, Aster JC, Blacklow SC.

J Biol Chem. 2003 Jun 6;278(23):21232-9. Epub 2003 Mar 18.

49.

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.

Mol Cell Biol. 2003 Jan;23(2):655-64.

50.

Expression of geminin as a marker of cell proliferation in normal tissues and malignancies.

Wohlschlegel JA, Kutok JL, Weng AP, Dutta A.

Am J Pathol. 2002 Jul;161(1):267-73.

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