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Occurrence of T-cell and NK-cell subsets with less well-recognized phenotypes in peripheral blood submitted for routine flow cytometry analysis.

Hill AJ, Zhang C, Kusakabe M, Gowing K, Wang X, Brinkman RR, Weng AP, Craig JW.

Cytometry B Clin Cytom. 2020 Mar 28. doi: 10.1002/cyto.b.21876. [Epub ahead of print] No abstract available.


TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.

Ennishi D, Healy S, Bashashati A, Saberi S, Hother C, Mottok A, Chan FC, Chong L, Abraham L, Kridel R, Boyle M, Meissner B, Aoki T, Takata K, Woolcock BW, Viganò E, Gold M, Molday LL, Molday RS, Telenius A, Li MY, Wretham N, Dos Santos N, Wong M, Viller NN, Uger RA, Duns G, Baticados A, Madero A, Bristow BN, Farinha P, Slack GW, Ben-Neriah S, Lai D, Zhang AW, Salehi S, Shulha HP, Chiu DS, Mostafavi S, Gerrie AS, Huang DW, Rushton C, Villa D, Sehn LH, Savage KJ, Mungall AJ, Weng AP, Bally MB, Morin RD, Cohen Freue GV, Staudt LM, Connors JM, Marra MA, Shah SP, Gascoyne RD, Scott DW, Steidl C.

Nat Med. 2020 Feb 24. doi: 10.1038/s41591-020-0757-z. [Epub ahead of print]


Ultrasensitive Detection of NOTCH1 c.7544_7545delCT Mutations in Chronic Lymphocytic Leukemia by Droplet Digital PCR Reveals High Frequency of Subclonal Mutations and Predicts Clinical Outcome in Cases with Trisomy 12.

Hoofd C, Huang SJ, Gusscott S, Lam S, Wong R, Johnston A, Ben-Neriah S, Steidl C, Scott DW, Bruyere H, Gillan TL, Toze CL, Gerrie AS, Weng AP.

J Mol Diagn. 2020 Feb 6. pii: S1525-1578(20)30015-5. doi: 10.1016/j.jmoldx.2020.01.008. [Epub ahead of print]


Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier.

Carpio C, Bouabdallah R, Ysebaert L, Sancho JM, Salles G, Cordoba R, Pinto A, Gharibo M, Rasco D, Panizo C, Lopez-Martin JA, Santoro A, Salar A, Damian S, Martin A, Verhoef G, Van den Neste E, Wang M, Couto S, Carrancio S, Weng A, Wang X, Schmitz F, Wei X, Hege K, Trotter MWB, Risueño A, Buchholz TJ, Hagner PR, Gandhi AK, Pourdehnad M, Ribrag V.

Blood. 2020 Mar 26;135(13):996-1007. doi: 10.1182/blood.2019002395.


Size-adjusted muscle power and muscle metabolism in patients with cystic fibrosis are equal to healthy controls - a case control study.

Ruf K, Beer M, Köstler H, Weng AM, Neubauer H, Klein A, Platek K, Roth K, Beneke R, Hebestreit H.

BMC Pulm Med. 2019 Dec 30;19(1):269. doi: 10.1186/s12890-019-1039-8.


Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma.

Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Viganò E, Woolcock BW, Telenius A, Li MY, Healy S, Ghesquiere C, Kos D, Goodyear T, Veldman J, Zhang AW, Kim J, Saberi S, Ding J, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C.

Cancer Discov. 2020 Mar;10(3):406-421. doi: 10.1158/2159-8290.CD-19-0680. Epub 2019 Dec 19.


Twin Robotic X-Ray System for 3D Cone-Beam CT of the Wrist: An Evaluation of Image Quality and Radiation Dose.

Grunz JP, Gietzen CH, Kunz AS, Weng AM, Veyhl-Wichmann M, Ergün S, Bley TA, Schmitt R, Gassenmaier T.

AJR Am J Roentgenol. 2020 Feb;214(2):422-427. doi: 10.2214/AJR.19.21911. Epub 2019 Dec 4.


Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A.

PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019.


Single Cell Phenotypic Profiling of 27 DLBCL Cases Reveals Marked Intertumoral and Intratumoral Heterogeneity.

Nissen MD, Kusakabe M, Wang X, Simkin G, Gracias D, Tyshchenko K, Hill A, Meskas J, Hung S, Chavez EA, Ennishi D, Aoki T, Sarkozy C, Connors JM, Farinha P, Slack GW, Gascoyne RD, Brinkman RR, Scott DW, Steidl C, Weng AP.

Cytometry A. 2019 Oct 22. doi: 10.1002/cyto.a.23919. [Epub ahead of print]


Five-Month Follow-up Shows No Improvement in Dermatological Complications in Children With Type 1 Diabetes Using Continuous Glucose Monitoring Systems and Insulin Pumps.

Weng AT, Zachariae C, Christensen KB, Svensson J, Berg AK.

J Diabetes Sci Technol. 2019 Oct 16:1932296819882425. doi: 10.1177/1932296819882425. [Epub ahead of print]


Insulin-like growth factor (IGF) signaling in T-cell acute lymphoblastic leukemia.

Gusscott S, Tamiro F, Giambra V, Weng AP.

Adv Biol Regul. 2019 Dec;74:100652. doi: 10.1016/j.jbior.2019.100652. Epub 2019 Sep 15.


3D cone-beam CT of the ankle using a novel twin robotic X-ray system: Assessment of image quality and radiation dose.

Grunz JP, Kunz AS, Gietzen CH, Weng AM, Veyhl-Wichmann M, Ergün S, Schmitt R, Bley TA, Gassenmaier T.

Eur J Radiol. 2019 Oct;119:108659. doi: 10.1016/j.ejrad.2019.108659. Epub 2019 Sep 7.


Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

Zhang AW, O'Flanagan C, Chavez EA, Lim JLP, Ceglia N, McPherson A, Wiens M, Walters P, Chan T, Hewitson B, Lai D, Mottok A, Sarkozy C, Chong L, Aoki T, Wang X, Weng AP, McAlpine JN, Aparicio S, Steidl C, Campbell KR, Shah SP.

Nat Methods. 2019 Oct;16(10):1007-1015. doi: 10.1038/s41592-019-0529-1. Epub 2019 Sep 9.


T1- and ECV-mapping in clinical routine at 3 T: differences between MOLLI, ShMOLLI and SASHA.

Heidenreich JF, Weng AM, Donhauser J, Greiser A, Chow K, Nordbeck P, Bley TA, Köstler H.

BMC Med Imaging. 2019 Aug 1;19(1):59. doi: 10.1186/s12880-019-0362-0.


Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, Holt RA, Steidl C, Karsan A, Humphries RK, Eaves CJ, Hirst M, Weng AP.

Nat Commun. 2019 Jul 2;10(1):2913. doi: 10.1038/s41467-019-10510-8.


Tin-filtered 100 kV ultra-low-dose CT of the paranasal sinus: Initial clinical results.

Petritsch B, Kosmala A, Weng AM, Bley TA.

PLoS One. 2019 May 6;14(5):e0216295. doi: 10.1371/journal.pone.0216295. eCollection 2019.


Spin echo based cardiac diffusion imaging at 7T: An ex vivo study of the porcine heart at 7T and 3T.

Lohr D, Terekhov M, Weng AM, Schroeder A, Walles H, Schreiber LM.

PLoS One. 2019 Mar 25;14(3):e0213994. doi: 10.1371/journal.pone.0213994. eCollection 2019.


Structure-Activity Relationship of Transfection-Modulating Saponins - A Pursuit for the Optimal Gene Trafficker.

Sama S, Jerz G, Thakur M, Melzig MF, Weng A.

Planta Med. 2019 Apr;85(6):513-518. doi: 10.1055/a-0863-4795. Epub 2019 Mar 1.


A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.

Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL.

J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29.


Radiation dose of coronary CT angiography with a third-generation dual-source CT in a "real-world" patient population.

Kosmala A, Petritsch B, Weng AM, Bley TA, Gassenmaier T.

Eur Radiol. 2019 Aug;29(8):4341-4348. doi: 10.1007/s00330-018-5856-6. Epub 2018 Nov 30.


A new type 1 ribosome-inactivating protein from the seeds of Gypsophila elegans M.Bieb.

Kokorin A, Weise C, Sama S, Weng A.

Phytochemistry. 2019 Jan;157:121-127. doi: 10.1016/j.phytochem.2018.10.024. Epub 2018 Nov 3.


UTE-SENCEFUL: first results for 3D high-resolution lung ventilation imaging.

Mendes Pereira L, Wech T, Weng AM, Kestler C, Veldhoen S, Bley TA, Köstler H.

Magn Reson Med. 2019 Apr;81(4):2464-2473. doi: 10.1002/mrm.27576. Epub 2018 Nov 4.


Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging.

Christa M, Weng AM, Geier B, Wörmann C, Scheffler A, Lehmann L, Oberberger J, Kraus BJ, Hahner S, Störk S, Klink T, Bauer WR, Hammer F, Köstler H.

Eur Heart J Cardiovasc Imaging. 2019 Mar 1;20(3):263-270. doi: 10.1093/ehjci/jey134.


Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Giambra V, Gusscott S, Gracias D, Song R, Lam SH, Panelli P, Tyshchenko K, Jenkins CE, Hoofd C, Lorzadeh A, Carles A, Hirst M, Eaves CJ, Weng AP.

Cell Stem Cell. 2018 Nov 1;23(5):714-726.e7. doi: 10.1016/j.stem.2018.08.018. Epub 2018 Sep 27.


Synthesis and bioactivity studies of sex pheromone analogs of the diamond back moth, Plutella xylostella.

Wang AJ, Zhang KX, Gao YL, Weng AZ, Wang LY, Zhang YH, Zhang Z, She DM, Ning J, Mei XD.

Pest Manag Sci. 2019 Apr;75(4):1045-1055. doi: 10.1002/ps.5214. Epub 2018 Nov 19.


Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes.

Sama S, Jerz G, Schmieder P, Joseph JF, Melzig MF, Weng A.

J Biotechnol. 2018 Oct 20;284:131-139. doi: 10.1016/j.jbiotec.2018.07.037. Epub 2018 Jul 30.


Grade of retraction and tendon thickness correlates with MR-spectroscopically measured amount of fatty degeneration in full thickness supraspinatus tears.

Gilbert F, Meffert RH, Schmalzl J, Weng AM, Köstler H, Eden L.

BMC Musculoskelet Disord. 2018 Jun 21;19(1):197. doi: 10.1186/s12891-018-2096-5.


Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes.

Weng AM, Wilimsky S, Bender G, Hahner S, Köstler H, Ritter CO.

J Magn Reson Imaging. 2018 Dec;48(6):1595-1601. doi: 10.1002/jmri.26191. Epub 2018 Jun 13.


Dual-energy CT of the bone marrow in multiple myeloma: diagnostic accuracy for quantitative differentiation of infiltration patterns.

Kosmala A, Weng AM, Krauss B, Knop S, Bley TA, Petritsch B.

Eur Radiol. 2018 Dec;28(12):5083-5090. doi: 10.1007/s00330-018-5537-5. Epub 2018 Jun 7.


RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes.

Jenkins CE, Gusscott S, Wong RJ, Shevchuk OO, Rana G, Giambra V, Tyshchenko K, Islam R, Hirst M, Weng AP.

Exp Hematol. 2018 Aug;64:84-96. doi: 10.1016/j.exphem.2018.04.008. Epub 2018 May 5.


Quantitative MRI comparison of multifidus muscle degeneration in thoracolumbar fractures treated with open and minimally invasive approach.

Gilbert F, Heintel TM, Jakubietz MG, Köstler H, Sebald C, Meffert RH, Weng AM.

BMC Musculoskelet Disord. 2018 Mar 7;19(1):75. doi: 10.1186/s12891-018-2001-2.


Stable and efficient retrospective 4D-MRI using non-uniformly distributed quasi-random numbers.

Breuer K, Meyer CB, Breuer FA, Richter A, Exner F, Weng AM, Ströhle S, Polat B, Jakob PM, Sauer OA, Flentje M, Weick S.

Phys Med Biol. 2018 Mar 22;63(7):075002. doi: 10.1088/1361-6560/aab342.


Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma.

Sama S, Woith E, Walther W, Jerz G, Chen W, Hart S, Melzig MF, Weng A.

J Control Release. 2018 Apr 10;275:208-216. doi: 10.1016/j.jconrel.2018.02.031. Epub 2018 Feb 23.


Supraspinatus muscle elasticity measured with real time shear wave ultrasound elastography correlates with MRI spectroscopic measured amount of fatty degeneration.

Gilbert F, Klein D, Weng AM, Köstler H, Schmitz B, Schmalzl J, Böhm D.

BMC Musculoskelet Disord. 2017 Dec 28;18(1):549. doi: 10.1186/s12891-017-1911-8.


A novel adenine-releasing assay for ribosome-inactivating proteins.

Weng A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:300-304. doi: 10.1016/j.jchromb.2017.11.038. Epub 2017 Nov 28.


Quantification of fat fraction in lumbar vertebrae: correlation with age and implications for bone marrow dosimetry in molecular radiotherapy.

Salas-Ramirez M, Tran-Gia J, Kesenheimer C, Weng AM, Kosmala A, Heidemeier A, Köstler H, Lassmann M.

Phys Med Biol. 2018 Jan 16;63(2):025029. doi: 10.1088/1361-6560/aa9a28.


Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery.

Sama S, Jerz G, Schmieder P, Woith E, Melzig MF, Weng A.

Int J Pharm. 2017 Dec 20;534(1-2):195-205. doi: 10.1016/j.ijpharm.2017.10.016. Epub 2017 Oct 17.


Multiple Myeloma and Dual-Energy CT: Diagnostic Accuracy of Virtual Noncalcium Technique for Detection of Bone Marrow Infiltration of the Spine and Pelvis.

Kosmala A, Weng AM, Heidemeier A, Krauss B, Knop S, Bley TA, Petritsch B.

Radiology. 2018 Jan;286(1):205-213. doi: 10.1148/radiol.2017170281. Epub 2017 Aug 11.


Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.

Bhargava C, Dürkop H, Zhao X, Weng A, Melzig MF, Fuchs H.

Mol Oncol. 2017 Nov;11(11):1527-1543. doi: 10.1002/1878-0261.12115. Epub 2017 Sep 15.


Impact of advanced modeled iterative reconstruction on interreader agreement in coronary artery measurements.

Gassenmaier T, Distelmaier I, Weng AM, Bley TA, Klink T.

Eur J Radiol. 2017 Sep;94:201-208. doi: 10.1016/j.ejrad.2017.06.029. Epub 2017 Jul 1.


A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.

Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL.

J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2.


Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2.

Weiswald LB, Hasan MR, Wong JCT, Pasiliao CC, Rahman M, Ren J, Yin Y, Gusscott S, Vacher S, Weng AP, Kennecke HF, Bièche I, Schaeffer DF, Yapp DT, Tai IT.

Mol Cancer Ther. 2017 Oct;16(10):2292-2303. doi: 10.1158/1535-7163.MCT-16-0666. Epub 2017 Jun 29.


Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.

Fuchs H, Niesler N, Trautner A, Sama S, Jerz G, Panjideh H, Weng A.

Biomedicines. 2017 Mar 29;5(2). pii: E14. doi: 10.3390/biomedicines5020014. Review.


Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.

Gilabert-Oriol R, Furness SGB, Stringer BW, Weng A, Fuchs H, Day BW, Kourakis A, Boyd AW, Hare DL, Thakur M, Johns TG, Wookey PJ.

Cancer Immunol Immunother. 2017 Sep;66(9):1217-1228. doi: 10.1007/s00262-017-2013-z. Epub 2017 May 13.


Diagnosis of Pulmonary Artery Embolism: Comparison of Single-Source CT and 3rd Generation Dual-Source CT using a Dual-Energy Protocol Regarding Image Quality and Radiation Dose.

Petritsch B, Kosmala A, Gassenmaier T, Weng AM, Veldhoen S, Kunz AS, Bley TA.

Rofo. 2017 Jun;189(6):527-536. doi: 10.1055/s-0043-103089. Epub 2017 Apr 26.


Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.

Sasaki T, Rivera-Mulia JC, Vera D, Zimmerman J, Das S, Padget M, Nakamichi N, Chang BH, Tyner J, Druker BJ, Weng AP, Civin CI, Eaves CJ, Gilbert DM.

Exp Hematol. 2017 Jul;51:71-82.e3. doi: 10.1016/j.exphem.2017.04.004. Epub 2017 Apr 19.


Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.

Manunta MDI, Tagalakis AD, Attwood M, Aldossary AM, Barnes JL, Munye MM, Weng A, McAnulty RJ, Hart SL.

Sci Rep. 2017 Apr 6;7(1):700. doi: 10.1038/s41598-017-00662-2.


Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.

Yuan T, Yang Y, Chen J, Li W, Li W, Zhang Q, Mi Y, Goswami RS, You JQ, Lin D, Qian MD, Calin S, Liang Y, Miranda RN, Calin GA, Zhou X, Ma L, Zweidler-McKay PA, Liu B, Weng AP, Medeiros LJ, Zhang Y, You MJ.

Leukemia. 2017 Nov;31(11):2355-2364. doi: 10.1038/leu.2017.80. Epub 2017 Mar 10.


Flavonol Glycosides and Cytotoxic Steroidal Saponins from Furcraea tuberosa (Agavaceae).

Tapondjou LA, Jenett-Siems K, Siems K, Weng A, Melzig MF.

Nat Prod Commun. 2017 Mar;12(3):347-350.


Vertebral Compression Fractures: Third-Generation Dual-Energy CT for Detection of Bone Marrow Edema at Visual and Quantitative Analyses.

Petritsch B, Kosmala A, Weng AM, Krauss B, Heidemeier A, Wagner R, Heintel TM, Gassenmaier T, Bley TA.

Radiology. 2017 Jul;284(1):161-168. doi: 10.1148/radiol.2017162165. Epub 2017 Feb 27.


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