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Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery.

Benner NL, McClellan RL, Turlington CR, Haabeth OAW, Waymouth RM, Wender PA.

J Am Chem Soc. 2019 May 29;141(21):8416-8421. doi: 10.1021/jacs.9b03154. Epub 2019 May 17.


Clinical correlates of HIV-1 DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years.

Bitnun A, Ransy DG, Brophy J, Kakkar F, Hawkes M, Samson L, Annabi B, Pagliuzza A, Morand JA, Sauve L, Chomont N, Lavoie S, Kim J, Sandstrom P, Wender P, Lee T, Singer J, Read SE, Soudeyns H; EPIC Research Group.

Clin Infect Dis. 2019 Mar 28. pii: ciz251. doi: 10.1093/cid/ciz251. [Epub ahead of print]


Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection.

Huiting ED, Gittens K, Justement JS, Shi V, Blazkova J, Benko E, Kovacs C, Wender PA, Moir S, Sneller MC, Fauci AS, Chun TW.

J Infect Dis. 2019 Jun 19;220(2):270-274. doi: 10.1093/infdis/jiz100.


Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity.

Haabeth OAW, Blake TR, McKinlay CJ, Tveita AA, Sallets A, Waymouth RM, Wender PA, Levy R.

Cancer Res. 2019 Apr 1;79(7):1624-1634. doi: 10.1158/0008-5472.CAN-18-2867. Epub 2019 Jan 28.


A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations.

Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ.

Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3928-3933. doi: 10.1002/anie.201814366. Epub 2019 Feb 14.


Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters.

Fernandes-Cunha GM, McKinlay CJ, Vargas JR, Jessen HJ, Waymouth RM, Wender PA.

ACS Cent Sci. 2018 Oct 24;4(10):1394-1402. doi: 10.1021/acscentsci.8b00470. Epub 2018 Sep 26.


A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.

Antonoplis A, Zang X, Huttner MA, Chong KKL, Lee YB, Co JY, Amieva MR, Kline KA, Wender PA, Cegelski L.

J Am Chem Soc. 2018 Nov 28;140(47):16140-16151. doi: 10.1021/jacs.8b08711. Epub 2018 Nov 14.


mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice.

Haabeth OAW, Blake TR, McKinlay CJ, Waymouth RM, Wender PA, Levy R.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9153-E9161. doi: 10.1073/pnas.1810002115. Epub 2018 Sep 10.


Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters.

McKinlay CJ, Benner NL, Haabeth OA, Waymouth RM, Wender PA.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5859-E5866. doi: 10.1073/pnas.1805358115. Epub 2018 Jun 11.


Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.

Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA.

Virology. 2018 Jul;520:83-93. doi: 10.1016/j.virol.2018.05.006. Epub 2018 May 26.


Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).

Benner NL, Near KE, Bachmann MH, Contag CH, Waymouth RM, Wender PA.

Biomacromolecules. 2018 Jul 9;19(7):2812-2824. doi: 10.1021/acs.biomac.8b00401. Epub 2018 May 11.


REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment.

Yang H, Staveness D, Ryckbosch SM, Axtman AD, Loy BA, Barnes AB, Pande VS, Schaefer J, Wender PA, Cegelski L.

ACS Cent Sci. 2018 Jan 24;4(1):89-96. doi: 10.1021/acscentsci.7b00475. Epub 2018 Jan 2.


Gilbert Stork (1921-2017).

Wender PA.

Nature. 2017 Nov 30;551(7682):566. doi: 10.1038/d41586-017-07527-8. No abstract available.


Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models.

Liu B, Ramsundar B, Kawthekar P, Shi J, Gomes J, Luu Nguyen Q, Ho S, Sloane J, Wender P, Pande V.

ACS Cent Sci. 2017 Oct 25;3(10):1103-1113. doi: 10.1021/acscentsci.7b00303. Epub 2017 Sep 5.


Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions.

Wender PA, Ebner C, Fennell BD, Inagaki F, Schröder B.

Org Lett. 2017 Nov 3;19(21):5810-5813. doi: 10.1021/acs.orglett.7b02765.


Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.

Wender PA, Hardman CT, Ho S, Jeffreys MS, Maclaren JK, Quiroz RV, Ryckbosch SM, Shimizu AJ, Sloane JL, Stevens MC.

Science. 2017 Oct 13;358(6360):218-223. doi: 10.1126/science.aan7969.


In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.

Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA.

PLoS Pathog. 2017 Sep 21;13(9):e1006575. doi: 10.1371/journal.ppat.1006575. eCollection 2017 Sep.


Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.

Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB.

Sci Rep. 2017 Aug 7;7(1):7456. doi: 10.1038/s41598-017-07814-4.


Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.

Ryckbosch SM, Wender PA, Pande VS.

Nat Commun. 2017 Feb 23;8(1):6. doi: 10.1038/s41467-016-0015-8.


Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals.

McKinlay CJ, Vargas JR, Blake TR, Hardy JW, Kanada M, Contag CH, Wender PA, Waymouth RM.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E448-E456. doi: 10.1073/pnas.1614193114. Epub 2017 Jan 9.


Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery.

Benner NL, Zang X, Buehler DC, Kickhoefer VA, Rome ME, Rome LH, Wender PA.

ACS Nano. 2017 Jan 24;11(1):872-881. doi: 10.1021/acsnano.6b07440. Epub 2017 Jan 3.


Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.

Abdelnabi R, Staveness D, Near KE, Wender PA, Delang L, Neyts J, Leyssen P.

Biochem Pharmacol. 2016 Nov 15;120:15-21. doi: 10.1016/j.bcp.2016.09.020. Epub 2016 Sep 21.


Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.

Gift TE, Reimherr FW, Marchant BK, Steans TA, Wender PH.

J Nerv Ment Dis. 2016 May;204(5):355-63. doi: 10.1097/NMD.0000000000000470.


Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.

McKinlay CJ, Waymouth RM, Wender PA.

J Am Chem Soc. 2016 Mar 16;138(10):3510-7. doi: 10.1021/jacs.5b13452. Epub 2016 Mar 7.


Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.

Staveness D, Abdelnabi R, Near KE, Nakagawa Y, Neyts J, Delang L, Leyssen P, Wender PA.

J Nat Prod. 2016 Apr 22;79(4):680-4. doi: 10.1021/acs.jnatprod.5b01017. Epub 2016 Feb 22.


Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.

Staveness D, Abdelnabi R, Schrier AJ, Loy BA, Verma VA, DeChristopher BA, Near KE, Neyts J, Delang L, Leyssen P, Wender PA.

J Nat Prod. 2016 Apr 22;79(4):675-9. doi: 10.1021/acs.jnatprod.5b01016. Epub 2016 Feb 22.


Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.

Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ.

Nat Commun. 2016 Feb 4;7:10622. doi: 10.1038/ncomms10622.


Psychometric properties of the Self-Report Wender-Reimherr Adult Attention Deficit Disorder Scale.

Marchant BK, Reimherr FW, Wender PH, Gift TE.

Ann Clin Psychiatry. 2015 Nov;27(4):267-77; quiz 278-82.


Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System.

Hsu HT, Trantow BM, Waymouth RM, Wender PA.

Bioconjug Chem. 2016 Feb 17;27(2):376-82. doi: 10.1021/acs.bioconjchem.5b00469. Epub 2015 Sep 25.


Art, architecture, and the molecular frontier.

Wender PA.

Acc Chem Res. 2015 Aug 18;48(8):2169-70. doi: 10.1021/acs.accounts.5b00332. No abstract available.


Studies on the regio- and diastereo-selective epoxidation of daphnanes and tiglianes.

Boudreault PL, Mattler JK, Wender PA.

Tetrahedron Lett. 2015 Jun;56(23):3423-3427.


Types of adult attention-deficit hyperactivity disorder (ADHD): baseline characteristics, initial response, and long-term response to treatment with methylphenidate.

Reimherr FW, Marchant BK, Gift TE, Steans TA, Wender PH.

Atten Defic Hyperact Disord. 2015 Jun;7(2):115-28. doi: 10.1007/s12402-015-0176-z. Epub 2015 May 19.


Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions.

Wender PA, Jeffreys MS, Raub AG.

J Am Chem Soc. 2015 Jul 22;137(28):9088-93. doi: 10.1021/jacs.5b04091. Epub 2015 May 29.


Function through synthesis-informed design.

Wender PA, Quiroz RV, Stevens MC.

Acc Chem Res. 2015 Mar 17;48(3):752-60. doi: 10.1021/acs.accounts.5b00004. Epub 2015 Mar 5.


Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy.

Loy BA, Lesser AB, Staveness D, Billingsley KL, Cegelski L, Wender PA.

J Am Chem Soc. 2015 Mar 18;137(10):3678-85. doi: 10.1021/jacs.5b00886. Epub 2015 Mar 4.


Guanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA.

Wender PA, Huttner MA, Staveness D, Vargas JR, Xu AF.

Mol Pharm. 2015 Mar 2;12(3):742-50. doi: 10.1021/mp500581r. Epub 2015 Jan 27.


Revising the diagnostic criteria for Attention-Deficit Hyperactivity Disorder (ADHD): an adulthood perspective.

Reimherr FW, Marchant BK, Gift TE, Steans TA, Wender PH.

Atten Defic Hyperact Disord. 2015 Jun;7(2):113-4. doi: 10.1007/s12402-014-0159-5. Epub 2014 Nov 26. No abstract available.


Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.

Wender PA, Staveness D.

Org Lett. 2014 Oct 3;16(19):5140-3. doi: 10.1021/ol502492b. Epub 2014 Sep 19.


Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.

Wender PA, Nakagawa Y, Near KE, Staveness D.

Org Lett. 2014 Oct 3;16(19):5136-9. doi: 10.1021/ol502491f. Epub 2014 Sep 19.


Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.

Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH.

ACS Nano. 2014 Aug 26;8(8):7723-32. doi: 10.1021/nn5002694. Epub 2014 Jul 31.


Propargyltrimethylsilanes as allene equivalents in transition metal-catalyzed [5 + 2] cycloadditions.

Wender PA, Inagaki F, Pfaffenbach M, Stevens MC.

Org Lett. 2014 Jun 6;16(11):2923-5. doi: 10.1021/ol501114q. Epub 2014 May 12.


Cell-penetrating, guanidinium-rich molecular transporters for overcoming efflux-mediated multidrug resistance.

Vargas JR, Stanzl EG, Teng NN, Wender PA.

Mol Pharm. 2014 Aug 4;11(8):2553-65. doi: 10.1021/mp500161z. Epub 2014 May 9. Review.


Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents.

Wender PA, Fournogerakis DN, Jeffreys MS, Quiroz RV, Inagaki F, Pfaffenbach M.

Nat Chem. 2014 May;6(5):448-52. doi: 10.1038/nchem.1917. Epub 2014 Apr 13.


Toward the ideal synthesis and molecular function through synthesis-informed design.

Wender PA.

Nat Prod Rep. 2014 Apr;31(4):433-40. doi: 10.1039/c4np00013g. Epub 2014 Mar 3. Review.


Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.

Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11698-703. doi: 10.1073/pnas.1302634110. Epub 2013 Jun 28.

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