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EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC.

Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein R, Knauf JA, Rätsch G, Fagin JA.

Cancer Discov. 2018 Oct 10. pii: CD-18-0606. doi: 10.1158/2159-8290.CD-18-0606. [Epub ahead of print]


Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility.

Weber M, Steinle H, Golombek S, Hann L, Schlensak C, Wendel HP, Avci-Adali M.

Front Bioeng Biotechnol. 2018 Jul 16;6:99. doi: 10.3389/fbioe.2018.00099. eCollection 2018. Review.


Development, preclinical evaluation and validation of a novel quick vascular closure device for transluminal, cardiac and radiological arterial catheterization.

Linti C, Doser M, Planck H, Oberhoffner S, Mueller E, Renardy M, Biesinger J, Neumann B, Stang K, Greiner TO, Schlensak C, Krajewski S, Wendel HP.

J Mater Sci Mater Med. 2018 Jun 11;29(6):83. doi: 10.1007/s10856-018-6092-y.


Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.

Santomasso BD, Park JH, Salloum D, Riviere I, Flynn J, Mead E, Halton E, Wang X, Senechal B, Purdon T, Cross JR, Liu H, Vachha B, Chen X, DeAngelis LM, Li D, Bernal Y, Gonen M, Wendel HG, Sadelain M, Brentjens RJ.

Cancer Discov. 2018 Aug;8(8):958-971. doi: 10.1158/2159-8290.CD-17-1319. Epub 2018 Jun 7.


De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells.

Lescan M, Perl RM, Golombek S, Pilz M, Hann L, Yasmin M, Behring A, Keller T, Nolte A, Gruhn F, Kochba E, Levin Y, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2018 Jun 1;11:475-484. doi: 10.1016/j.omtn.2018.03.013. Epub 2018 Mar 30.


Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin.

Golombek S, Pilz M, Steinle H, Kochba E, Levin Y, Lunter D, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392. doi: 10.1016/j.omtn.2018.03.005. Epub 2018 Mar 14.


Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells.

Steinle H, Ionescu TM, Schenk S, Golombek S, Kunnakattu SJ, Özbek MT, Schlensak C, Wendel HP, Avci-Adali M.

Int J Mol Sci. 2018 Apr 27;19(5). pii: E1313. doi: 10.3390/ijms19051313.


QCM-D surpassing clinical standard for the dose administration of new oral anticoagulant in the patient of coagulation disorders.

Hussain M, Wendel HP, Schmidt K, Langer E, Körber MK, Faul O, Northoff H, von Heymann C, Gehring FK.

Biosens Bioelectron. 2018 May 1;104:15-20. doi: 10.1016/j.bios.2017.12.043. Epub 2017 Dec 27.


Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections.

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S.

Drug Des Devel Ther. 2017 Sep 18;11:2753-2762. doi: 10.2147/DDDT.S138510. eCollection 2017.


Nanoliposomes for Safe and Efficient Therapeutic mRNA Delivery: A Step Toward Nanotheranostics in Inflammatory and Cardiovascular Diseases as well as Cancer.

Abraham MK, Peter K, Michel T, Wendel HP, Krajewski S, Wang X.

Nanotheranostics. 2017 Apr 5;1(2):154-165. doi: 10.7150/ntno.19449. eCollection 2017.


Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures.

Reinbold J, Uhde AK, Müller I, Weindl T, Geis-Gerstorfer J, Schlensak C, Wendel HP, Krajewski S.

Molecules. 2017 Sep 19;22(9). pii: E1570. doi: 10.3390/molecules22091570.


Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.

Michel T, Luft D, Abraham MK, Reinhardt S, Salinas Medina ML, Kurz J, Schaller M, Avci-Adali M, Schlensak C, Peter K, Wendel HP, Wang X, Krajewski S.

Mol Ther Nucleic Acids. 2017 Sep 15;8:459-468. doi: 10.1016/j.omtn.2017.07.013. Epub 2017 Jul 25.


Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A, Lewis JS, Weber WA, Wendel HG, Reiner T.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7441-E7449. doi: 10.1073/pnas.1705013114. Epub 2017 Aug 21.


Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane.

Lukas K, Stadtherr K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C, Lehle K.

Materials (Basel). 2017 Mar 24;10(4). pii: E335. doi: 10.3390/ma10040335.


Evaluation of platelet adhesion and activation on polymers: Round-robin study to assess inter-center variability.

Braune S, Sperling C, Maitz MF, Steinseifer U, Clauser J, Hiebl B, Krajewski S, Wendel HP, Jung F.

Colloids Surf B Biointerfaces. 2017 Oct 1;158:416-422. doi: 10.1016/j.colsurfb.2017.06.053. Epub 2017 Jul 3.


Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.

Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaak9969. doi: 10.1126/scitranslmed.aak9969.


Low-thrombogenic fibrin-heparin coating promotes in vitro endothelialization.

Kaplan O, Hierlemann T, Krajewski S, Kurz J, Nevoralová M, Houska M, Riedel T, Riedelová Z, Zárubová J, Wendel HP, Brynda E.

J Biomed Mater Res A. 2017 Nov;105(11):2995-3005. doi: 10.1002/jbm.a.36152. Epub 2017 Aug 7.


Rapid Complexation of Aptamers by Their Specific Antidotes.

Stoll H, Steinle H, Wilhelm N, Hann L, Kunnakattu SJ, Narita M, Schlensak C, Wendel HP, Avci-Adali M.

Molecules. 2017 Jun 8;22(6). pii: E954. doi: 10.3390/molecules22060954.


Catheter-based tricuspid valve replacement: first experimental data of a newly designed bileaflet stent graft prosthesis.

Lausberg HF, Gryszkiewicz R, Kuetting M, Baumgaertner M, Centola M, Wendel HP, Nowak-Machen M, Schibilsky D, Kruger T, Schlensak C.

Eur J Cardiothorac Surg. 2017 Jul 1;52(1):189-196. doi: 10.1093/ejcts/ezx084.


Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations.

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A.

JCI Insight. 2017 Mar 23;2(6):e90196. doi: 10.1172/jci.insight.90196.


An Atelocollagen Coating for Efficient Local Gene Silencing by Using Small Interfering RNA.

Koenig O, Nothdurft D, Perle N, Neumann B, Behring A, Degenkolbe I, Walker T, Schlensak C, Wendel HP, Nolte A.

Mol Ther Nucleic Acids. 2017 Mar 17;6:290-301. doi: 10.1016/j.omtn.2017.01.006. Epub 2017 Feb 9.


RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept.

Koenig O, Zengerle D, Perle N, Hossfeld S, Neumann B, Behring A, Avci-Adali M, Walker T, Schlensak C, Wendel HP, Nolte A.

Pharmaceuticals (Basel). 2017 Feb 10;10(1). pii: E23. doi: 10.3390/ph10010023.


The age of stored erythrocytes influences methaemoglobin formation when circulated in a heart-lung machine model.

Krampen L, Krajewski S, Roth H, Handgretinger R, Schlensak C, Bruchelt G, Wendel HP.

Blood Transfus. 2018 Jul;16(4):343-347. doi: 10.2450/2017.0185-16. Epub 2017 Jan 25. No abstract available.


Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges.

Steinle H, Behring A, Schlensak C, Wendel HP, Avci-Adali M.

Stem Cells. 2017 Jan;35(1):68-79. doi: 10.1002/stem.2402. Epub 2016 Jun 20. Review.


Generation of Large-Scale DNA Hydrogels with Excellent Blood and Cell Compatibility.

Stoll H, Steinle H, Stang K, Kunnakattu S, Scheideler L, Neumann B, Kurz J, Degenkolbe I, Perle N, Schlensak C, Wendel HP, Avci-Adali M.

Macromol Biosci. 2017 Apr;17(4). doi: 10.1002/mabi.201600252. Epub 2016 Oct 19.


CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM.

Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12.


Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.

Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, Jiang M, Mottok A, Denis-Lagache N, Ciriello G, Tam W, Teruya-Feldstein J, de Stanchina E, Chan WC, Malek SN, Ennishi D, Brentjens RJ, Gascoyne RD, Cogné M, Tarte K, Wendel HG.

Cell. 2016 Oct 6;167(2):405-418.e13. doi: 10.1016/j.cell.2016.08.032. Epub 2016 Sep 29.


Hemostyptic property of chitosan: Opportunities and pitfalls.

Denzinger M, Hinkel H, Kurz J, Hierlemann T, Schlensak C, Wendel HP, Krajewski S.

Biomed Mater Eng. 2016 Sep 28;27(4):353-364.


Development and in vitro characterization of poly(lactide-co-glycolide) microspheres loaded with an antibacterial natural drug for the treatment of long-term bacterial infections.

Reinbold J, Hierlemann T, Hinkel H, Müller I, Maier ME, Weindl T, Schlensak C, Wendel HP, Krajewski S.

Drug Des Devel Ther. 2016 Sep 7;10:2823-2832. eCollection 2016.


RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints.

Zhong Y, Karaletsos T, Drewe P, Sreedharan VT, Kuo D, Singh K, Wendel HG, Rätsch G.

Bioinformatics. 2017 Jan 1;33(1):139-141. doi: 10.1093/bioinformatics/btw585. Epub 2016 Sep 14.


More than 70 years of pyrogen detection: Current state and future perspectives.

Fennrich S, Hennig U, Toliashvili L, Schlensak C, Wendel HP, Stoppelkamp S.

Altern Lab Anim. 2016 Jul;44(3):239-53. Review.


Surface biofunctionalization of β-TCP blocks using aptamer 74 for bone tissue engineering.

Ardjomandi N, Huth J, Stamov DR, Henrich A, Klein C, Wendel HP, Reinert S, Alexander D.

Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:267-275. doi: 10.1016/j.msec.2016.05.002. Epub 2016 May 13.


Speeding up pyrogenicity testing: Identification of suitable cell components and readout parameters for an accelerated monocyte activation test (MAT).

Stoppelkamp S, Würschum N, Stang K, Löder J, Avci-Adali M, Toliashvili L, Schlensak C, Wendel HP, Fennrich S.

Drug Test Anal. 2017 Feb;9(2):260-273. doi: 10.1002/dta.1973. Epub 2016 Apr 28.


Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR.

J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available.


Hypercoagulant Abdominal Swabs in Cardiac Surgery: Potential Problems and Background.

Krajewski S, Hierlemann T, Neumann B, Nathan T, Abel M, Koggel A, Schlensak C, Wendel HP.

Thorac Cardiovasc Surg. 2016 Oct;64(7):589-595. Epub 2016 Jan 14.


Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves.

Brubert J, Krajewski S, Wendel HP, Nair S, Stasiak J, Moggridge GD.

J Mater Sci Mater Med. 2016 Feb;27(2):32. doi: 10.1007/s10856-015-5628-7. Epub 2015 Dec 24.


Technical-Induced Hemolysis in Patients with Respiratory Failure Supported with Veno-Venous ECMO - Prevalence and Risk Factors.

Lehle K, Philipp A, Zeman F, Lunz D, Lubnow M, Wendel HP, Göbölös L, Schmid C, Müller T.

PLoS One. 2015 Nov 25;10(11):e0143527. doi: 10.1371/journal.pone.0143527. eCollection 2015.


In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications.

Abraham MK, Nolte A, Reus R, Behring A, Zengerle D, Avci-Adali M, Hohmann JD, Peter K, Schlensak C, Wendel HP, Krajewski S.

PLoS One. 2015 Sep 18;10(9):e0138375. doi: 10.1371/journal.pone.0138375. eCollection 2015.


The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG.

Nat Med. 2015 Oct;21(10):1199-208. doi: 10.1038/nm.3943. Epub 2015 Sep 14.


Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.

Stoppelkamp S, Veseli K, Stang K, Schlensak C, Wendel HP, Walker T.

PLoS One. 2015 Aug 11;10(8):e0135527. doi: 10.1371/journal.pone.0135527. eCollection 2015.


Hemocompatibility of Axial Versus Centrifugal Pump Technology in Mechanical Circulatory Support Devices.

Schibilsky D, Lenglinger M, Avci-Adali M, Haller C, Walker T, Wendel HP, Schlensak C.

Artif Organs. 2015 Aug;39(8):723-8. doi: 10.1111/aor.12544.


Quantitative Assessment of Iron-Labeled Stem-Cell Adhesion at the Vessel Wall in a Vascular Flow Model: Correlation of T2*-Weighted Imaging at 3 T and Histology.

Grözinger G, Schick F, Eibofner F, Wiesinger B, Schenk M, Grosse U, Wendel HP, Elser S, Nikolaou K, Schmehl J.

J Vasc Interv Radiol. 2015 Nov;26(11):1728-34.e1-3. doi: 10.1016/j.jvir.2015.06.018. Epub 2015 Jul 29.


Blood compatibility of magnesium and its alloys.

Feyerabend F, Wendel HP, Mihailova B, Heidrich S, Agha NA, Bismayer U, Willumeit-Römer R.

Acta Biomater. 2015 Oct;25:384-94. doi: 10.1016/j.actbio.2015.07.029. Epub 2015 Jul 22.


Microfluidic chip system for the selection and enrichment of cell binding aptamers.

Stoll H, Kiessling H, Stelzle M, Wendel HP, Schütte J, Hagmeyer B, Avci-Adali M.

Biomicrofluidics. 2015 Jun 15;9(3):034111. doi: 10.1063/1.4922544. eCollection 2015 May.


In Vitro Evaluation of a Novel mRNA-Based Therapeutic Strategy for the Treatment of Patients Suffering from Alpha-1-Antitrypsin Deficiency.

Michel T, Kankura A, Salinas Medina ML, Kurz J, Behring A, Avci-Adali M, Nolte A, Schlensak C, Wendel HP, Krajewski S.

Nucleic Acid Ther. 2015 Oct;25(5):235-44. doi: 10.1089/nat.2015.0537. Epub 2015 Jun 30.


First In Vivo Results of a Novel Pediatric Oxygenator with an Integrated Pulsatile Pump.

Stang K, Borchardt R, Neumann B, Kurz J, Stoppelkamp S, Greiner TO, Fahrner C, Schenk M, Schlensak C, Schubert M, Lausberg H, Herold S, Schlanstein PC, Steinseifer U, Arens J, Wendel HP.

ASAIO J. 2015 Sep-Oct;61(5):574-82. doi: 10.1097/MAT.0000000000000256.


Intrajugular balloon catheter reduces air embolism in vitro and in vivo.

Eckle VS, Neumann B, Greiner TO, Wendel HP, Grasshoff C.

Br J Anaesth. 2015 Jun;114(6):973-8. doi: 10.1093/bja/aev040. Epub 2015 Apr 1.


Simple clotting test to detect procoagulant abdominal swabs.

Krajewski S, Nathan T, Neumann B, Hoffmann S, Abel M, Koggel A, Schlensak C, Wendel HP.

J Mater Sci Mater Med. 2015 Feb;26(2):106. doi: 10.1007/s10856-015-5430-6. Epub 2015 Feb 11.


Generation and characterization of a single-chain anti-EphA2 antibody.

Goldgur Y, Susi P, Karelehto E, Sanmark H, Lamminmäki U, Oricchio E, Wendel HG, Nikolov DB, Himanen JP.

Growth Factors. 2014 Dec;32(6):214-22. doi: 10.3109/08977194.2014.983225. Epub 2014 Nov 19.


One-staged aptamer-based isolation and application of endothelial progenitor cells in a porcine myocardial infarction model.

Haller C, Sobolewska B, Schibilsky D, Avci-Adali M, Schlensak C, Wendel HP, Walker T.

Nucleic Acid Ther. 2015 Feb;25(1):20-6. doi: 10.1089/nat.2014.0499. Epub 2014 Dec 10.


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