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O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.

Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X.

Oncogene. 2019 Sep 9. doi: 10.1038/s41388-019-0975-3. [Epub ahead of print]


Reprogramming of Urine-Derived Renal Epithelial Cells into iPSCs Using srRNA and Consecutive Differentiation into Beating Cardiomyocytes.

Steinle H, Weber M, Behring A, Mau-Holzmann U, von Ohle C, Popov AF, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2019 Sep 6;17:907-921. doi: 10.1016/j.omtn.2019.07.016. Epub 2019 Jul 31.


The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.

Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, Viale A, Akkari L, Lowe SW, Ciriello G, Hendrickson RC, Wendel HG.

Cell. 2019 Aug 8;178(4):807-819.e21. doi: 10.1016/j.cell.2019.07.031.


Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA.

Steinle H, Weber M, Behring A, Mau-Holzmann U, Schlensak C, Wendel HP, Avci-Adali M.

Stem Cells Int. 2019 Jun 19;2019:7641767. doi: 10.1155/2019/7641767. eCollection 2019.


Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity.

Wang S, Mondal S, Zhao C, Berishaj M, Ghanakota P, Batlevi CL, Dogan A, Seshan VE, Abel R, Green MR, Younes A, Wendel HG.

JCI Insight. 2019 Jun 20;4(12). pii: 127566. doi: 10.1172/jci.insight.127566. eCollection 2019 Jun 20.


Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA.

Michel T, Golombek S, Steinle H, Hann L, Velic A, Macek B, Krajewski S, Schlensak C, Wendel HP, Avci-Adali M.

J Biol Eng. 2019 May 9;13:40. doi: 10.1186/s13036-019-0172-5. eCollection 2019.


In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants.

Cattaneo G, Bräuner C, Siekmeyer G, Ding A, Bauer S, Wohlschlögel M, Lang L, Hierlemann T, Akimov M, Schlensak C, Schüßler A, Wendel HP, Krajewski S.

J Mater Sci Mater Med. 2019 Jun 4;30(6):67. doi: 10.1007/s10856-019-6270-6.


Hemocompatibility of different burn wound dressings.

Denzinger M, Held M, Scheffler H, Haag H, Nussler AK, Wendel HP, Schlensak C, Daigeler A, Krajewski S.

Wound Repair Regen. 2019 Sep;27(5):470-476. doi: 10.1111/wrr.12739. Epub 2019 Jun 13.


c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma.

Singh K, Lin J, Zhong Y, Burčul A, Mohan P, Jiang M, Sun L, Yong-Gonzalez V, Viale A, Cross JR, Hendrickson RC, Rätsch G, Ouyang Z, Wendel HG.

J Exp Med. 2019 Jul 1;216(7):1509-1524. doi: 10.1084/jem.20181726. Epub 2019 May 29.


Generation of iPSCs from Jaw Periosteal Cells Using Self-Replicating RNA.

Umrath F, Steinle H, Weber M, Wendel HP, Reinert S, Alexander D, Avci-Adali M.

Int J Mol Sci. 2019 Apr 3;20(7). pii: E1648. doi: 10.3390/ijms20071648.


Exogenous Delivery of Link N mRNA into Chondrocytes and MSCs-The Potential Role in Increasing Anabolic Response.

Tendulkar G, Ehnert S, Sreekumar V, Chen T, Kaps HP, Golombek S, Wendel HP, Nüssler AK, Avci-Adali M.

Int J Mol Sci. 2019 Apr 6;20(7). pii: E1716. doi: 10.3390/ijms20071716.


GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.

Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7746. doi: 10.1126/scitranslmed.aau7746.


Hyaluronic acid/poly(ethylenimine) polyelectrolyte multilayer coatings for siRNA-mediated local gene silencing.

Koenig O, Neumann B, Schlensak C, Wendel HP, Nolte A.

PLoS One. 2019 Mar 19;14(3):e0212584. doi: 10.1371/journal.pone.0212584. eCollection 2019.


Emerging epigenetic-modulating therapies in lymphoma.

Sermer D, Pasqualucci L, Wendel HG, Melnick A, Younes A.

Nat Rev Clin Oncol. 2019 Aug;16(8):494-507. doi: 10.1038/s41571-019-0190-8. Review.


Hemostatic wound dressings: Predicting their effects by in vitro tests.

Wiegand C, Abel M, Hipler UC, Elsner P, Zieger M, Kurz J, Wendel HP, Stoppelkamp S.

J Biomater Appl. 2019 Apr;33(9):1285-1297. doi: 10.1177/0885328219831095. Epub 2019 Feb 21.


Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA.

Michel T, Link A, Abraham MK, Schlensak C, Peter K, Wendel HP, Wang X, Krajewski S.

J Vis Exp. 2019 Feb 1;(144). doi: 10.3791/58444.


Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis.

Sauter RJ, Sauter M, Obrich M, Emschermann FN, Nording H, Patzelt J, Wendel HP, Reil JC, Edlich F, Langer HF.

Thromb Haemost. 2019 Jan;119(1):179-182. doi: 10.1055/s-0038-1676349. Epub 2018 Dec 31.


Inflammatory potential of cotton-based surgically invasive devices: Implications for cardiac surgery.

Trunk S, Müllerbader P, Hennig U, Abel M, Koggel A, Stang K, Altreuter Y, Steger V, Schlensak C, Wendel HP, Stoppelkamp S.

J Biomed Mater Res B Appl Biomater. 2019 Aug;107(6):1877-1888. doi: 10.1002/jbm.b.34280. Epub 2018 Nov 22.


Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations.

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A.

JCI Insight. 2018 Nov 15;3(22). pii: 125568. doi: 10.1172/jci.insight.125568. No abstract available.


NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death.

Liu Y, Mondello P, Erazo T, Tannan NB, Asgari Z, de Stanchina E, Nanjangud G, Seshan VE, Wang S, Wendel HG, Younes A.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12034-12039. doi: 10.1073/pnas.1806928115. Epub 2018 Nov 7.


Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes.

Denzinger M, Link A, Kurz J, Krauss S, Thoma R, Schlensak C, Wendel HP, Krajewski S.

Nucleic Acid Ther. 2018 Dec;28(6):335-347. doi: 10.1089/nat.2018.0737. Epub 2018 Oct 30.


Epicardial adhesion prophylaxis in swine model with a bio-absorbable polymer membrane.

Lescan M, Al-Saidi A, Neumann B, Greiner TO, Walker T, Hierlemann H, Brochhausen C, Planck H, Wendel HP, Schlensak C, Lausberg H.

J Mater Sci Mater Med. 2018 Oct 22;29(11):157. doi: 10.1007/s10856-018-6173-y. No abstract available.


Improving the Angiogenic Potential of EPCs via Engineering with Synthetic Modified mRNAs.

Steinle H, Golombek S, Behring A, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2018 Dec 7;13:387-398. doi: 10.1016/j.omtn.2018.09.005. Epub 2018 Sep 13.


EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC.

Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein RA, Knauf JA, Rätsch G, Fagin JA.

Cancer Discov. 2019 Feb;9(2):264-281. doi: 10.1158/2159-8290.CD-18-0606. Epub 2018 Oct 10.


Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility.

Weber M, Steinle H, Golombek S, Hann L, Schlensak C, Wendel HP, Avci-Adali M.

Front Bioeng Biotechnol. 2018 Jul 16;6:99. doi: 10.3389/fbioe.2018.00099. eCollection 2018. Review.


Development, preclinical evaluation and validation of a novel quick vascular closure device for transluminal, cardiac and radiological arterial catheterization.

Linti C, Doser M, Planck H, Oberhoffner S, Mueller E, Renardy M, Biesinger J, Neumann B, Stang K, Greiner TO, Schlensak C, Krajewski S, Wendel HP.

J Mater Sci Mater Med. 2018 Jun 11;29(6):83. doi: 10.1007/s10856-018-6092-y.


Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.

Santomasso BD, Park JH, Salloum D, Riviere I, Flynn J, Mead E, Halton E, Wang X, Senechal B, Purdon T, Cross JR, Liu H, Vachha B, Chen X, DeAngelis LM, Li D, Bernal Y, Gonen M, Wendel HG, Sadelain M, Brentjens RJ.

Cancer Discov. 2018 Aug;8(8):958-971. doi: 10.1158/2159-8290.CD-17-1319. Epub 2018 Jun 7.


De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells.

Lescan M, Perl RM, Golombek S, Pilz M, Hann L, Yasmin M, Behring A, Keller T, Nolte A, Gruhn F, Kochba E, Levin Y, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2018 Jun 1;11:475-484. doi: 10.1016/j.omtn.2018.03.013. Epub 2018 Mar 30.


Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin.

Golombek S, Pilz M, Steinle H, Kochba E, Levin Y, Lunter D, Schlensak C, Wendel HP, Avci-Adali M.

Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392. doi: 10.1016/j.omtn.2018.03.005. Epub 2018 Mar 14.


Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells.

Steinle H, Ionescu TM, Schenk S, Golombek S, Kunnakattu SJ, Özbek MT, Schlensak C, Wendel HP, Avci-Adali M.

Int J Mol Sci. 2018 Apr 27;19(5). pii: E1313. doi: 10.3390/ijms19051313.


QCM-D surpassing clinical standard for the dose administration of new oral anticoagulant in the patient of coagulation disorders.

Hussain M, Wendel HP, Schmidt K, Langer E, Körber MK, Faul O, Northoff H, von Heymann C, Gehring FK.

Biosens Bioelectron. 2018 May 1;104:15-20. doi: 10.1016/j.bios.2017.12.043. Epub 2017 Dec 27.


Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections.

Reinbold J, Hierlemann T, Urich L, Uhde AK, Müller I, Weindl T, Vogel U, Schlensak C, Wendel HP, Krajewski S.

Drug Des Devel Ther. 2017 Sep 18;11:2753-2762. doi: 10.2147/DDDT.S138510. eCollection 2017.


Nanoliposomes for Safe and Efficient Therapeutic mRNA Delivery: A Step Toward Nanotheranostics in Inflammatory and Cardiovascular Diseases as well as Cancer.

Abraham MK, Peter K, Michel T, Wendel HP, Krajewski S, Wang X.

Nanotheranostics. 2017 Apr 5;1(2):154-165. doi: 10.7150/ntno.19449. eCollection 2017.


Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures.

Reinbold J, Uhde AK, Müller I, Weindl T, Geis-Gerstorfer J, Schlensak C, Wendel HP, Krajewski S.

Molecules. 2017 Sep 19;22(9). pii: E1570. doi: 10.3390/molecules22091570.


Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.

Michel T, Luft D, Abraham MK, Reinhardt S, Salinas Medina ML, Kurz J, Schaller M, Avci-Adali M, Schlensak C, Peter K, Wendel HP, Wang X, Krajewski S.

Mol Ther Nucleic Acids. 2017 Sep 15;8:459-468. doi: 10.1016/j.omtn.2017.07.013. Epub 2017 Jul 25.


Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A, Lewis JS, Weber WA, Wendel HG, Reiner T.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7441-E7449. doi: 10.1073/pnas.1705013114. Epub 2017 Aug 21.


Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane.

Lukas K, Stadtherr K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C, Lehle K.

Materials (Basel). 2017 Mar 24;10(4). pii: E335. doi: 10.3390/ma10040335.


Evaluation of platelet adhesion and activation on polymers: Round-robin study to assess inter-center variability.

Braune S, Sperling C, Maitz MF, Steinseifer U, Clauser J, Hiebl B, Krajewski S, Wendel HP, Jung F.

Colloids Surf B Biointerfaces. 2017 Oct 1;158:416-422. doi: 10.1016/j.colsurfb.2017.06.053. Epub 2017 Jul 3.


Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.

Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaak9969. doi: 10.1126/scitranslmed.aak9969.


Low-thrombogenic fibrin-heparin coating promotes in vitro endothelialization.

Kaplan O, Hierlemann T, Krajewski S, Kurz J, Nevoralová M, Houska M, Riedel T, Riedelová Z, Zárubová J, Wendel HP, Brynda E.

J Biomed Mater Res A. 2017 Nov;105(11):2995-3005. doi: 10.1002/jbm.a.36152. Epub 2017 Aug 7.


Rapid Complexation of Aptamers by Their Specific Antidotes.

Stoll H, Steinle H, Wilhelm N, Hann L, Kunnakattu SJ, Narita M, Schlensak C, Wendel HP, Avci-Adali M.

Molecules. 2017 Jun 8;22(6). pii: E954. doi: 10.3390/molecules22060954.


Catheter-based tricuspid valve replacement: first experimental data of a newly designed bileaflet stent graft prosthesis.

Lausberg HF, Gryszkiewicz R, Kuetting M, Baumgaertner M, Centola M, Wendel HP, Nowak-Machen M, Schibilsky D, Kruger T, Schlensak C.

Eur J Cardiothorac Surg. 2017 Jul 1;52(1):189-196. doi: 10.1093/ejcts/ezx084.


Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations.

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A.

JCI Insight. 2017 Mar 23;2(6):e90196. doi: 10.1172/jci.insight.90196. Erratum in: JCI Insight. 2018 Nov 15;3(22):.


An Atelocollagen Coating for Efficient Local Gene Silencing by Using Small Interfering RNA.

Koenig O, Nothdurft D, Perle N, Neumann B, Behring A, Degenkolbe I, Walker T, Schlensak C, Wendel HP, Nolte A.

Mol Ther Nucleic Acids. 2017 Mar 17;6:290-301. doi: 10.1016/j.omtn.2017.01.006. Epub 2017 Feb 9.


RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept.

Koenig O, Zengerle D, Perle N, Hossfeld S, Neumann B, Behring A, Avci-Adali M, Walker T, Schlensak C, Wendel HP, Nolte A.

Pharmaceuticals (Basel). 2017 Feb 10;10(1). pii: E23. doi: 10.3390/ph10010023.


The age of stored erythrocytes influences methaemoglobin formation when circulated in a heart-lung machine model.

Krampen L, Krajewski S, Roth H, Handgretinger R, Schlensak C, Bruchelt G, Wendel HP.

Blood Transfus. 2018 Jul;16(4):343-347. doi: 10.2450/2017.0185-16. Epub 2017 Jan 25. No abstract available.


Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges.

Steinle H, Behring A, Schlensak C, Wendel HP, Avci-Adali M.

Stem Cells. 2017 Jan;35(1):68-79. doi: 10.1002/stem.2402. Epub 2016 Jun 20. Review.


Generation of Large-Scale DNA Hydrogels with Excellent Blood and Cell Compatibility.

Stoll H, Steinle H, Stang K, Kunnakattu S, Scheideler L, Neumann B, Kurz J, Degenkolbe I, Perle N, Schlensak C, Wendel HP, Avci-Adali M.

Macromol Biosci. 2017 Apr;17(4). doi: 10.1002/mabi.201600252. Epub 2016 Oct 19.


CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM.

Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12.


Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.

Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, Jiang M, Mottok A, Denis-Lagache N, Ciriello G, Tam W, Teruya-Feldstein J, de Stanchina E, Chan WC, Malek SN, Ennishi D, Brentjens RJ, Gascoyne RD, Cogné M, Tarte K, Wendel HG.

Cell. 2016 Oct 6;167(2):405-418.e13. doi: 10.1016/j.cell.2016.08.032. Epub 2016 Sep 29.

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