Wempe MF[au] - PubMed

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M.

Elife. 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344.

PMID:: 31120420

Free PMC Article

Similar articles

Select item 311117495.

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy.

Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L.

Clin Toxicol (Phila). 2019 May 21:1-5. doi: 10.1080/15563650.2019.1616093. [Epub ahead of print]

PMID:: 31111749

Similar articles

Select item 308736126.

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.

Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN.

J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11.

PMID:: 30873612

Similar articles

Select item 308288847.

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.

Tyagi A, Kumar S, Raina K, Wempe MF, Maroni PD, Agarwal R, Agarwal C.

Mol Carcinog. 2019 Jul;58(7):1105-1117. doi: 10.1002/mc.22995. Epub 2019 Mar 3.

PMID:: 30828884

Similar articles

Select item 307841738.

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V.

J Cell Mol Med. 2019 Apr;23(4):2711-2718. doi: 10.1111/jcmm.14176. Epub 2019 Feb 19.

PMID:: 30784173

Free PMC Article

Similar articles

Select item 306630599.

Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening.

Wempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR 2nd.

J Inherit Metab Dis. 2019 May;42(3):565-574. doi: 10.1002/jimd.12059. Epub 2019 Mar 11.

PMID:: 30663059

Similar articles

Select item 3060788910.

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.

Mizuno T, Gist KM, Gao Z, Wempe MF, Alten J, Cooper DS, Goldstein SL, Vinks AA.

Clin Pharmacokinet. 2019 Jun;58(6):793-803. doi: 10.1007/s40262-018-0729-3.

PMID:: 30607889

Similar articles

Select item 3044900611.

Carnosine protects cardiac myocytes against lipid peroxidation products.

Zhao J, Posa DK, Kumar V, Hoetker D, Kumar A, Ganesan S, Riggs DW, Bhatnagar A, Wempe MF, Baba SP.

Amino Acids. 2019 Jan;51(1):123-138. doi: 10.1007/s00726-018-2676-6. Epub 2018 Nov 17.

PMID:: 30449006

Similar articles

Select item 3004318712.

The genotypic spectrum of ALDH7A1 mutations resulting in pyridoxine dependent epilepsy: A common epileptic encephalopathy.

Coughlin CR 2nd, Swanson MA, Spector E, Meeks NJL, Kronquist KE, Aslamy M, Wempe MF, van Karnebeek CDM, Gospe SM Jr, Aziz VG, Tsai BP, Gao H, Nagy PL, Hyland K, van Dooren SJM, Salomons GS, Van Hove JLK.

J Inherit Metab Dis. 2019 Mar;42(2):353-361. doi: 10.1002/jimd.12045. Epub 2019 Feb 22.

PMID:: 30043187

Similar articles

Select item 2990631013.

A Randomized Pharmacokinetic and Pharmacodynamic Evaluation of Every 8-Hour and 12-Hour Dosing Strategies of Vancomycin and Cefepime in Neurocritically ill Patients.

Kassel LE, Van Matre ET, Foster CJ, Fish DN, Mueller SW, Sherman DS, Wempe MF, MacLaren R, Neumann RT, Kiser TH.

Pharmacotherapy. 2018 Sep;38(9):921-934. doi: 10.1002/phar.2156. Epub 2018 Jul 20.

PMID:: 29906310

Similar articles

Select item 2972701914.

Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells.

Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R.

Mol Carcinog. 2018 Sep;57(9):1166-1180. doi: 10.1002/mc.22833. Epub 2018 May 18.

PMID:: 29727019

Free PMC Article

Similar articles

Select item 2953392415.

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.

Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR.

J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.

PMID:: 29533924

Free PMC Article

Similar articles

Select item 2952900716.

Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery.

Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL.

Ther Drug Monit. 2018 Apr;40(2):186-194. doi: 10.1097/FTD.0000000000000496.

PMID:: 29529007

Free PMC Article

Similar articles

Select item 2932616417.

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).

Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J.

J Biol Chem. 2018 Feb 23;293(8):2877-2887. doi: 10.1074/jbc.RA117.001342. Epub 2018 Jan 11.

PMID:: 29326164

Free PMC Article

Similar articles

Select item 2920090218.

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells.

Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK.

Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607. doi: 10.4196/kjpp.2017.21.6.599. Epub 2017 Oct 30.

PMID:: 29200902

Free PMC Article

Similar articles

Select item 2887646519.

Procyanidin B2 3,3″-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK.

Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C.

Mol Carcinog. 2018 Jan;57(1):57-69. doi: 10.1002/mc.22731. Epub 2017 Sep 22.

PMID:: 28876465

Free PMC Article

Similar articles

Select item 2864150520.

In Utero Exposure to Di( n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty.

Okayama Y, Wakui S, Wempe MF, Sugiyama M, Motohashi M, Mutou T, Takahashi H, Kume E, Ikegami H.

Toxicol Pathol. 2017 Jun;45(4):526-535. doi: 10.1177/0192623317709091.

PMID:: 28641505

Similar articles

Select item 2864147321.

Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells.

Imbert V, Nebout M, Mary D, Endou H, Wempe MF, Supuran CT, Winum JY, Peyron JF.

Leuk Lymphoma. 2018 Feb;59(2):460-468. doi: 10.1080/10428194.2017.1339875. Epub 2017 Jun 22.

PMID:: 28641473

Similar articles

Select item 2855778822.

Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes.

McHenry AR, Wempe MF, Rice PJ.

Int J Pharm Compd. 2017 May-Jun;21(3):251-254.

PMID:: 28557788

Similar articles

Select item 2838237323.

Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells.

Dosier LBM, Premkumar VJ, Zhu H, Akosman I, Wempe MF, McMahon TJ.

Thromb Haemost. 2017 Jun 28;117(7):1402-1411. doi: 10.1160/TH16-05-0373. Epub 2017 Apr 6.

PMID:: 28382373

Free PMC Article

Similar articles

Select item 2833976024.

Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma.

Kume E, Mutou T, Kansaku N, Takahashi H, Wempe MF, Ikegami M, Kanai Y, Endou H, Wakui S.

Microscopy (Oxf). 2017 Jun 1;66(3):198-203. doi: 10.1093/jmicro/dfx008.

PMID:: 28339760

Similar articles

Select item 2819401825.

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice.

Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA.

Nat Commun. 2017 Feb 13;8:14181. doi: 10.1038/ncomms14181.

PMID:: 28194018

Free PMC Article

Similar articles

Select item 2817421126.

Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.

Schuetze KB, Stratton MS, Blakeslee WW, Wempe MF, Wagner FF, Holson EB, Kuo YM, Andrews AJ, Gilbert TM, Hooker JM, McKinsey TA.

J Pharmacol Exp Ther. 2017 Apr;361(1):140-150. doi: 10.1124/jpet.116.237701. Epub 2017 Feb 7.

PMID:: 28174211

Free PMC Article

Similar articles

Select item 2782576427.

Synthesis of novel Ral inhibitors: An in vitro and in vivo study.

Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12.

PMID:: 27825764

Free PMC Article

Similar articles

Select item 2779103628.

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. Epub 2016 Oct 10.

PMID:: 27791036

Free PMC Article

Similar articles

Select item 2738570329.

Stability of dronabinol capsules when stored frozen, refrigerated, or at room temperature.

Wempe MF, Oldland A, Stolpman N, Kiser TH.

Am J Health Syst Pharm. 2016 Jul 15;73(14):1088-92. doi: 10.2146/ajhp150501.

PMID:: 27385703

Similar articles

Select item 2730445430.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Jul 15;11(7):2066-7. doi: 10.1021/acschembio.6b00466. Epub 2016 Jun 15. No abstract available.

PMID:: 27304454

Similar articles

Select item 2730216531.

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J.

Cancer Res. 2016 Aug 1;76(15):4481-92. doi: 10.1158/0008-5472.CAN-15-3376. Epub 2016 Jun 14. Erratum in: Cancer Res. 2017 Jul 1;77(13):3721.

PMID:: 27302165

Free Article

Similar articles

Select item 2696160332.

In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats.

Motohashi M, Wempe MF, Mutou T, Okayama Y, Kansaku N, Takahashi H, Ikegami M, Asari M, Wakui S.

J Toxicol Sci. 2016 Apr;41(2):195-206. doi: 10.2131/jts.41.195.

PMID:: 26961603

Free Article

Similar articles

Select item 2691839733.

Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung.

Bao EL, Chystsiakova A, Brahmajothi MV, Sunday ME, Pavlisko EN, Wempe MF, Auten RL.

Pediatr Pulmonol. 2016 Oct;51(10):1048-1056. doi: 10.1002/ppul.23402. Epub 2016 Feb 26.

PMID:: 26918397

Free PMC Article

Similar articles

Select item 2689277734.

Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342).

Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL.

J Antimicrob Chemother. 2016 Jun;71(6):1609-18. doi: 10.1093/jac/dkw005. Epub 2016 Feb 17.

PMID:: 26892777

Free PMC Article

Similar articles

Select item 2674524135.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Apr 15;11(4):921-30. doi: 10.1021/acschembio.5b00725. Epub 2016 Jan 8. Erratum in: ACS Chem Biol. 2016 Jul 15;11(7):2066-7.

PMID:: 26745241

Similar articles

Select item 2670603136.

Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins.

Motohashi M, Wempe MF, Mutou T, Takahashi H, Kansaku N, Ikegami M, Inomata T, Asari M, Wakui S.

Reprod Toxicol. 2016 Jan;59:139-46. doi: 10.1016/j.reprotox.2015.12.001. Epub 2015 Dec 17.

PMID:: 26706031

Similar articles

Select item 2581675037.

Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle.

Lemon DD, Harrison BC, Horn TR, Stratton MS, Ferguson BS, Wempe MF, McKinsey TA.

FEBS Lett. 2015 Apr 28;589(10):1080-8. doi: 10.1016/j.febslet.2015.03.017. Epub 2015 Mar 25.

PMID:: 25816750

Free PMC Article

Similar articles

Select item 2564566038.

Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy.

Kiser TH, Fish DN, Aquilante CL, Rower JE, Wempe MF, MacLaren R, Teitelbaum I.

Crit Care. 2015 Feb 3;19:32. doi: 10.1186/s13054-015-0753-8.

PMID:: 25645660

Free PMC Article

Similar articles

Select item 2558152739.

Analyzing insulin samples by size-exclusion chromatography: a column degradation study.

Teska BM, Kumar A, Carpenter JF, Wempe MF.

J Pharm Sci. 2015 Apr;104(4):1555-60. doi: 10.1002/jps.24330. Epub 2015 Jan 7.

PMID:: 25581527

Free PMC Article

Similar articles

Select item 2555225740.

Procyanidin B2 3,3″-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways.

Kumar R, Deep G, Wempe MF, Agarwal R, Agarwal C.

Curr Cancer Drug Targets. 2015;15(1):14-26.

PMID:: 25552257

Free PMC Article

Similar articles

Select item 2554767941.

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J.

Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29.

PMID:: 25547679

Free PMC Article

Similar articles

Select item 2549223942.

Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.

Tilley C, Deep G, Agarwal C, Wempe MF, Biedermann D, Valentová K, Kren V, Agarwal R.

Mol Carcinog. 2016 Jan;55(1):3-14. doi: 10.1002/mc.22253. Epub 2014 Dec 9.

PMID:: 25492239

Free PMC Article

Similar articles

Select item 2548213043.

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia.

Rosilio C, Nebout M, Imbert V, Griessinger E, Neffati Z, Benadiba J, Hagenbeek T, Spits H, Reverso J, Ambrosetti D, Michiels JF, Bailly-Maitre B, Endou H, Wempe MF, Peyron JF.

Leukemia. 2015 Jun;29(6):1253-66. doi: 10.1038/leu.2014.338. Epub 2014 Dec 8.

PMID:: 25482130

Similar articles

Select item 2530853444.

Long-term storage of lyophilized liposomal formulations.

Payton NM, Wempe MF, Xu Y, Anchordoquy TJ.

J Pharm Sci. 2014 Dec;103(12):3869-3878. doi: 10.1002/jps.24171. Epub 2014 Oct 10.

PMID:: 25308534

Free PMC Article

Similar articles

Select item 2525217945.

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.

Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G.

Mol Carcinog. 2015 Nov;54(11):1417-29. doi: 10.1002/mc.22220. Epub 2014 Sep 22.

PMID:: 25252179

Free PMC Article

Similar articles

Select item 2521985146.

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14.