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Items: 1 to 50 of 98

1.

Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients.

Beyer JT, Lind SE, Fisher S, Trujillo TC, Wempe MF, Kiser TH.

J Thromb Thrombolysis. 2019 Sep 26. doi: 10.1007/s11239-019-01961-3. [Epub ahead of print]

PMID:
31559512
2.

Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization.

Boakye AA, Zhang D, Guo L, Zheng Y, Hoetker D, Zhao J, Posa DK, Ng CK, Zheng H, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Conklin DJ, Baba SP.

Front Physiol. 2019 Jul 2;10:751. doi: 10.3389/fphys.2019.00751. eCollection 2019.

3.

Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer.

Dhar D, Raina K, Kant R, Wempe MF, Serkova NJ, Agarwal C, Agarwal R.

Carcinogenesis. 2019 Jun 13. pii: bgz114. doi: 10.1093/carcin/bgz114. [Epub ahead of print]

PMID:
31194859
4.

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M.

Elife. 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344.

5.

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy.

Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L.

Clin Toxicol (Phila). 2019 May 21:1-5. doi: 10.1080/15563650.2019.1616093. [Epub ahead of print]

PMID:
31111749
6.

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.

Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN.

J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11.

PMID:
30873612
7.

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.

Tyagi A, Kumar S, Raina K, Wempe MF, Maroni PD, Agarwal R, Agarwal C.

Mol Carcinog. 2019 Jul;58(7):1105-1117. doi: 10.1002/mc.22995. Epub 2019 Mar 3.

PMID:
30828884
8.

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V.

J Cell Mol Med. 2019 Apr;23(4):2711-2718. doi: 10.1111/jcmm.14176. Epub 2019 Feb 19.

9.

Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening.

Wempe MF, Kumar A, Kumar V, Choi YJ, Swanson MA, Friederich MW, Hyland K, Yue WW, Van Hove JLK, Coughlin CR 2nd.

J Inherit Metab Dis. 2019 May;42(3):565-574. doi: 10.1002/jimd.12059. Epub 2019 Mar 11.

PMID:
30663059
10.

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery.

Mizuno T, Gist KM, Gao Z, Wempe MF, Alten J, Cooper DS, Goldstein SL, Vinks AA.

Clin Pharmacokinet. 2019 Jun;58(6):793-803. doi: 10.1007/s40262-018-0729-3.

PMID:
30607889
11.

Carnosine protects cardiac myocytes against lipid peroxidation products.

Zhao J, Posa DK, Kumar V, Hoetker D, Kumar A, Ganesan S, Riggs DW, Bhatnagar A, Wempe MF, Baba SP.

Amino Acids. 2019 Jan;51(1):123-138. doi: 10.1007/s00726-018-2676-6. Epub 2018 Nov 17.

PMID:
30449006
12.

The genotypic spectrum of ALDH7A1 mutations resulting in pyridoxine dependent epilepsy: A common epileptic encephalopathy.

Coughlin CR 2nd, Swanson MA, Spector E, Meeks NJL, Kronquist KE, Aslamy M, Wempe MF, van Karnebeek CDM, Gospe SM Jr, Aziz VG, Tsai BP, Gao H, Nagy PL, Hyland K, van Dooren SJM, Salomons GS, Van Hove JLK.

J Inherit Metab Dis. 2019 Mar;42(2):353-361. doi: 10.1002/jimd.12045. Epub 2019 Feb 22.

PMID:
30043187
13.

A Randomized Pharmacokinetic and Pharmacodynamic Evaluation of Every 8-Hour and 12-Hour Dosing Strategies of Vancomycin and Cefepime in Neurocritically ill Patients.

Kassel LE, Van Matre ET, Foster CJ, Fish DN, Mueller SW, Sherman DS, Wempe MF, MacLaren R, Neumann RT, Kiser TH.

Pharmacotherapy. 2018 Sep;38(9):921-934. doi: 10.1002/phar.2156. Epub 2018 Jul 20.

PMID:
29906310
14.

Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells.

Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R.

Mol Carcinog. 2018 Sep;57(9):1166-1180. doi: 10.1002/mc.22833. Epub 2018 May 18.

15.

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.

Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR.

J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.

16.

Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery.

Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL.

Ther Drug Monit. 2018 Apr;40(2):186-194. doi: 10.1097/FTD.0000000000000496.

17.

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).

Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J.

J Biol Chem. 2018 Feb 23;293(8):2877-2887. doi: 10.1074/jbc.RA117.001342. Epub 2018 Jan 11.

18.

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells.

Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK.

Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607. doi: 10.4196/kjpp.2017.21.6.599. Epub 2017 Oct 30.

19.

Procyanidin B2 3,3″-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK.

Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C.

Mol Carcinog. 2018 Jan;57(1):57-69. doi: 10.1002/mc.22731. Epub 2017 Sep 22.

20.

In Utero Exposure to Di( n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty.

Okayama Y, Wakui S, Wempe MF, Sugiyama M, Motohashi M, Mutou T, Takahashi H, Kume E, Ikegami H.

Toxicol Pathol. 2017 Jun;45(4):526-535. doi: 10.1177/0192623317709091.

PMID:
28641505
21.

Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells.

Imbert V, Nebout M, Mary D, Endou H, Wempe MF, Supuran CT, Winum JY, Peyron JF.

Leuk Lymphoma. 2018 Feb;59(2):460-468. doi: 10.1080/10428194.2017.1339875. Epub 2017 Jun 22.

PMID:
28641473
22.

Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes.

McHenry AR, Wempe MF, Rice PJ.

Int J Pharm Compd. 2017 May-Jun;21(3):251-254.

PMID:
28557788
23.

Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells.

Dosier LBM, Premkumar VJ, Zhu H, Akosman I, Wempe MF, McMahon TJ.

Thromb Haemost. 2017 Jun 28;117(7):1402-1411. doi: 10.1160/TH16-05-0373. Epub 2017 Apr 6.

24.

Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma.

Kume E, Mutou T, Kansaku N, Takahashi H, Wempe MF, Ikegami M, Kanai Y, Endou H, Wakui S.

Microscopy (Oxf). 2017 Jun 1;66(3):198-203. doi: 10.1093/jmicro/dfx008.

PMID:
28339760
25.

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice.

Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA.

Nat Commun. 2017 Feb 13;8:14181. doi: 10.1038/ncomms14181.

26.

Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.

Schuetze KB, Stratton MS, Blakeslee WW, Wempe MF, Wagner FF, Holson EB, Kuo YM, Andrews AJ, Gilbert TM, Hooker JM, McKinsey TA.

J Pharmacol Exp Ther. 2017 Apr;361(1):140-150. doi: 10.1124/jpet.116.237701. Epub 2017 Feb 7.

27.

Synthesis of novel Ral inhibitors: An in vitro and in vivo study.

Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12.

28.

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. Epub 2016 Oct 10.

29.

Stability of dronabinol capsules when stored frozen, refrigerated, or at room temperature.

Wempe MF, Oldland A, Stolpman N, Kiser TH.

Am J Health Syst Pharm. 2016 Jul 15;73(14):1088-92. doi: 10.2146/ajhp150501.

PMID:
27385703
30.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Jul 15;11(7):2066-7. doi: 10.1021/acschembio.6b00466. Epub 2016 Jun 15. No abstract available.

PMID:
27304454
31.

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J.

Cancer Res. 2016 Aug 1;76(15):4481-92. doi: 10.1158/0008-5472.CAN-15-3376. Epub 2016 Jun 14. Erratum in: Cancer Res. 2017 Jul 1;77(13):3721.

32.

In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats.

Motohashi M, Wempe MF, Mutou T, Okayama Y, Kansaku N, Takahashi H, Ikegami M, Asari M, Wakui S.

J Toxicol Sci. 2016 Apr;41(2):195-206. doi: 10.2131/jts.41.195.

33.

Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung.

Bao EL, Chystsiakova A, Brahmajothi MV, Sunday ME, Pavlisko EN, Wempe MF, Auten RL.

Pediatr Pulmonol. 2016 Oct;51(10):1048-1056. doi: 10.1002/ppul.23402. Epub 2016 Feb 26.

34.

Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342).

Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL.

J Antimicrob Chemother. 2016 Jun;71(6):1609-18. doi: 10.1093/jac/dkw005. Epub 2016 Feb 17.

35.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Apr 15;11(4):921-30. doi: 10.1021/acschembio.5b00725. Epub 2016 Jan 8. Erratum in: ACS Chem Biol. 2016 Jul 15;11(7):2066-7.

PMID:
26745241
36.

Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins.

Motohashi M, Wempe MF, Mutou T, Takahashi H, Kansaku N, Ikegami M, Inomata T, Asari M, Wakui S.

Reprod Toxicol. 2016 Jan;59:139-46. doi: 10.1016/j.reprotox.2015.12.001. Epub 2015 Dec 17.

PMID:
26706031
37.

Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle.

Lemon DD, Harrison BC, Horn TR, Stratton MS, Ferguson BS, Wempe MF, McKinsey TA.

FEBS Lett. 2015 Apr 28;589(10):1080-8. doi: 10.1016/j.febslet.2015.03.017. Epub 2015 Mar 25.

38.

Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy.

Kiser TH, Fish DN, Aquilante CL, Rower JE, Wempe MF, MacLaren R, Teitelbaum I.

Crit Care. 2015 Feb 3;19:32. doi: 10.1186/s13054-015-0753-8.

39.

Analyzing insulin samples by size-exclusion chromatography: a column degradation study.

Teska BM, Kumar A, Carpenter JF, Wempe MF.

J Pharm Sci. 2015 Apr;104(4):1555-60. doi: 10.1002/jps.24330. Epub 2015 Jan 7.

40.
41.

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J.

Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29.

42.

Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.

Tilley C, Deep G, Agarwal C, Wempe MF, Biedermann D, Valentová K, Kren V, Agarwal R.

Mol Carcinog. 2016 Jan;55(1):3-14. doi: 10.1002/mc.22253. Epub 2014 Dec 9.

43.

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia.

Rosilio C, Nebout M, Imbert V, Griessinger E, Neffati Z, Benadiba J, Hagenbeek T, Spits H, Reverso J, Ambrosetti D, Michiels JF, Bailly-Maitre B, Endou H, Wempe MF, Peyron JF.

Leukemia. 2015 Jun;29(6):1253-66. doi: 10.1038/leu.2014.338. Epub 2014 Dec 8.

PMID:
25482130
44.

Long-term storage of lyophilized liposomal formulations.

Payton NM, Wempe MF, Xu Y, Anchordoquy TJ.

J Pharm Sci. 2014 Dec;103(12):3869-3878. doi: 10.1002/jps.24171. Epub 2014 Oct 10.

45.

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.

Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G.

Mol Carcinog. 2015 Nov;54(11):1417-29. doi: 10.1002/mc.22220. Epub 2014 Sep 22.

46.

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14.

47.

Hyperoxia inhibits nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1.

Brahmajothi MV, Tinch BT, Wempe MF, Endou H, Auten RL.

Antioxid Redox Signal. 2014 Nov 1;21(13):1823-36. doi: 10.1089/ars.2013.5664. Epub 2014 Sep 22.

48.

Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate.

Wakui S, Motohashi M, Satoh T, Shirai M, Mutou T, Takahashi H, Wempe MF, Endou H, Inomata T, Asari M.

J Toxicol Pathol. 2013 Dec;26(4):439-46. doi: 10.1293/tox.2013-0031. Epub 2013 Dec 26.

49.

Weight-based versus set dosing of vancomycin for coronary artery bypass grafting or aortic valve surgery.

Hafermann MJ, Kiser TH, Lyda C, Fish DN, Barber GR, Wempe MF, Cleveland JC Jr.

J Thorac Cardiovasc Surg. 2014 Jun;147(6):1925-30. doi: 10.1016/j.jtcvs.2013.12.037. Epub 2014 Jan 15.

50.

JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells.

Yun DW, Lee SA, Park MG, Kim JS, Yu SK, Park MR, Kim SG, Oh JS, Kim CS, Kim HJ, Kim JS, Chun HS, Kanai Y, Endou H, Wempe MF, Kim DK.

J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 4.

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