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The amygdala differentially regulates defensive behaviors evoked by CO2.

Taugher RJ, Dlouhy BJ, Kreple CJ, Ghobbeh A, Conlon MM, Wang Y, Wemmie JA.

Behav Brain Res. 2019 Sep 16:112236. doi: 10.1016/j.bbr.2019.112236. [Epub ahead of print]


Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium.

Liu G, Thangavel R, Rysted J, Kim Y, Francis MB, Adams E, Lin Z, Taugher RJ, Wemmie JA, Usachev YM, Lee G.

J Neurosci Res. 2019 Nov;97(11):1393-1413. doi: 10.1002/jnr.24517. Epub 2019 Aug 26.


Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.

Gutman AL, Cosme CV, Noterman MF, Worth WR, Wemmie JA, LaLumiere RT.

Addict Biol. 2018 Nov 6. doi: 10.1111/adb.12690. [Epub ahead of print]


A novel role for acid-sensing ion channels in Pavlovian reward conditioning.

Ghobbeh A, Taugher RJ, Alam SM, Fan R, LaLumiere RT, Wemmie JA.

Genes Brain Behav. 2019 Sep;18(7):e12531. doi: 10.1111/gbb.12531. Epub 2018 Nov 28.


Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins.

Müller Ewald VA, De Corte BJ, Gupta SC, Lillis KV, Narayanan NS, Wemmie JA, LaLumiere RT.

Psychopharmacology (Berl). 2019 Jan;236(1):479-490. doi: 10.1007/s00213-018-4964-y. Epub 2018 Jul 12. Review.


Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.

Johnson CP, Christensen GE, Fiedorowicz JG, Mani M, Shaffer JJ Jr, Magnotta VA, Wemmie JA.

Bipolar Disord. 2018 Jun;20(4):381-390. doi: 10.1111/bdi.12581. Epub 2018 Jan 7.


Relationship altered between functional T1ρ and BOLD signals in bipolar disorder.

Shaffer JJ Jr, Johnson CP, Long JD, Fiedorowicz JG, Christensen GE, Wemmie JA, Magnotta VA.

Brain Behav. 2017 Sep 14;7(10):e00802. doi: 10.1002/brb3.802. eCollection 2017 Oct.


Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.

Shaffer JJ Jr, Johnson CP, Fiedorowicz JG, Christensen GE, Wemmie JA, Magnotta VA.

Brain Imaging Behav. 2018 Jun;12(3):837-847. doi: 10.1007/s11682-017-9741-8.


ASIC1A in neurons is critical for fear-related behaviors.

Taugher RJ, Lu Y, Fan R, Ghobbeh A, Kreple CJ, Faraci FM, Wemmie JA.

Genes Brain Behav. 2017 Nov;16(8):745-755. doi: 10.1111/gbb.12398. Epub 2017 Jul 21.


Transient acidosis while retrieving a fear-related memory enhances its lability.

Du J, Price MP, Taugher RJ, Grigsby D, Ash JJ, Stark AC, Hossain Saad MZ, Singh K, Mandal J, Wemmie JA, Welsh MJ.

Elife. 2017 Jun 26;6. pii: e22564. doi: 10.7554/eLife.22564.


Extinction of Cocaine Seeking Requires a Window of Infralimbic Pyramidal Neuron Activity after Unreinforced Lever Presses.

Gutman AL, Nett KE, Cosme CV, Worth WR, Gupta SC, Wemmie JA, LaLumiere RT.

J Neurosci. 2017 Jun 21;37(25):6075-6086. doi: 10.1523/JNEUROSCI.3821-16.2017. Epub 2017 May 24.


Peripheral inflammation during abnormal mood states in bipolar I disorder.

Fiedorowicz JG, Prossin AR, Johnson CP, Christensen GE, Magnotta VA, Wemmie JA.

J Affect Disord. 2015 Nov 15;187:172-8. doi: 10.1016/j.jad.2015.08.036. Epub 2015 Aug 21.


ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing.

Taugher RJ, Ghobbeh A, Sowers LP, Fan R, Wemmie JA.

Front Neurosci. 2015 Jul 21;9:239. doi: 10.3389/fnins.2015.00239. eCollection 2015.


Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation.

Dlouhy BJ, Gehlbach BK, Kreple CJ, Kawasaki H, Oya H, Buzza C, Granner MA, Welsh MJ, Howard MA, Wemmie JA, Richerson GB.

J Neurosci. 2015 Jul 15;35(28):10281-9. doi: 10.1523/JNEUROSCI.0888-15.2015.


Eccentricity mapping of the human visual cortex to evaluate temporal dynamics of functional T1ρ mapping.

Heo HY, Wemmie JA, Johnson CP, Thedens DR, Magnotta VA.

J Cereb Blood Flow Metab. 2015 Jul;35(7):1213-9. doi: 10.1038/jcbfm.2015.94. Epub 2015 May 13.


Quantitative T1ρ mapping links the cerebellum and lithium use in bipolar disorder.

Johnson CP, Follmer RL, Oguz I, Warren LA, Christensen GE, Fiedorowicz JG, Magnotta VA, Wemmie JA.

Mol Psychiatry. 2015 Feb;20(2):149. doi: 10.1038/mp.2015.10. No abstract available.


Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.

Johnson CP, Follmer RL, Oguz I, Warren LA, Christensen GE, Fiedorowicz JG, Magnotta VA, Wemmie JA.

Mol Psychiatry. 2015 Feb;20(2):201-6. doi: 10.1038/mp.2014.157. Epub 2015 Jan 6.


Rapid acquisition strategy for functional T1ρ mapping of the brain.

Johnson CP, Heo HY, Thedens DR, Wemmie JA, Magnotta VA.

Magn Reson Imaging. 2014 Nov;32(9):1067-77. doi: 10.1016/j.mri.2014.07.010. Epub 2014 Aug 2.


The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.

Taugher RJ, Lu Y, Wang Y, Kreple CJ, Ghobbeh A, Fan R, Sowers LP, Wemmie JA.

J Neurosci. 2014 Jul 30;34(31):10247-55. doi: 10.1523/JNEUROSCI.1680-14.2014.


Drug abuse and the simplest neurotransmitter.

Kreple CJ, Lu Y, LaLumiere RT, Wemmie JA.

ACS Chem Neurosci. 2014 Sep 17;5(9):746-8. doi: 10.1021/cn500154w. Epub 2014 Jul 23. Review.


Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.

Kreple CJ, Lu Y, Taugher RJ, Schwager-Gutman AL, Du J, Stump M, Wang Y, Ghobbeh A, Fan R, Cosme CV, Sowers LP, Welsh MJ, Radley JJ, LaLumiere RT, Wemmie JA.

Nat Neurosci. 2014 Aug;17(8):1083-91. doi: 10.1038/nn.3750. Epub 2014 Jun 22.


Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.

Du J, Reznikov LR, Price MP, Zha XM, Lu Y, Moninger TO, Wemmie JA, Welsh MJ.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8961-6. doi: 10.1073/pnas.1407018111. Epub 2014 Jun 2.


Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.

Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA.

FASEB J. 2014 Apr;28(4):1735-44. doi: 10.1096/fj.13-235648. Epub 2014 Jan 13.


Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.

Urbano FJ, Lino NG, González-Inchauspe CM, González LE, Colettis N, Vattino LG, Wunsch AM, Wemmie JA, Uchitel OD.

Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C396-406. doi: 10.1152/ajpcell.00301.2013. Epub 2013 Dec 11.


PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.

Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG.

PLoS One. 2013 Dec 3;8(12):e80737. doi: 10.1371/journal.pone.0080737. eCollection 2013.


Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

Price MP, Gong H, Parsons MG, Kundert JR, Reznikov LR, Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ.

Genes Brain Behav. 2014 Feb;13(2):179-94. doi: 10.1111/gbb.12108. Epub 2013 Dec 30.


Functional t1ρ imaging in panic disorder.

Magnotta VA, Johnson CP, Follmer R, Wemmie JA.

Biol Psychiatry. 2014 Jun 1;75(11):884-91. doi: 10.1016/j.biopsych.2013.09.008. Epub 2013 Oct 21.


The non-canonical Wnt ligand Wnt5a rescues morphological deficits in Prickle2-deficient hippocampal neurons.

Sowers LP, Mouw TJ, Ferguson PJ, Wemmie JA, Mohapatra DP, Bassuk AG.

Mol Psychiatry. 2013 Oct;18(10):1049. doi: 10.1038/mp.2013.119. No abstract available.


Acid-sensing ion channels in pain and disease.

Wemmie JA, Taugher RJ, Kreple CJ.

Nat Rev Neurosci. 2013 Jul;14(7):461-71. doi: 10.1038/nrn3529. Review.


Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction.

Sowers LP, Loo L, Wu Y, Campbell E, Ulrich JD, Wu S, Paemka L, Wassink T, Meyer K, Bing X, El-Shanti H, Usachev YM, Ueno N, Manak JR, Shepherd AJ, Ferguson PJ, Darbro BW, Richerson GB, Mohapatra DP, Wemmie JA, Bassuk AG.

Mol Psychiatry. 2013 Oct;18(10):1077-89. doi: 10.1038/mp.2013.71. Epub 2013 May 28. Erratum in: Mol Psychiatry. 2014 Jun;19(6):742. Manak, R J [corrected to Manak, J R].


Fear and panic in humans with bilateral amygdala damage.

Feinstein JS, Buzza C, Hurlemann R, Follmer RL, Dahdaleh NS, Coryell WH, Welsh MJ, Tranel D, Wemmie JA.

Nat Neurosci. 2013 Mar;16(3):270-2. doi: 10.1038/nn.3323. Epub 2013 Feb 3.


Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.

Holland PR, Akerman S, Andreou AP, Karsan N, Wemmie JA, Goadsby PJ.

Ann Neurol. 2012 Oct;72(4):559-63. doi: 10.1002/ana.23653.


Detecting activity-evoked pH changes in human brain.

Magnotta VA, Heo HY, Dlouhy BJ, Dahdaleh NS, Follmer RL, Thedens DR, Welsh MJ, Wemmie JA.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8270-3. doi: 10.1073/pnas.1205902109. Epub 2012 May 7.


Neurobiology of panic and pH chemosensation in the brain.

Wemmie JA.

Dialogues Clin Neurosci. 2011;13(4):475-83. Review.


Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice.

Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL.

Clin Sci (Lond). 2011 Nov;121(10):427-36. doi: 10.1042/CS20110153.


Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning.

Vralsted VC, Price MP, Du J, Schnizler M, Wunsch AM, Ziemann AE, Welsh MJ, Wemmie JA.

Genes Brain Behav. 2011 Jun;10(4):444-50. doi: 10.1111/j.1601-183X.2011.00683.x. Epub 2011 Mar 7.


Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice.

Erkonen GE, Hermann GM, Miller RL, Thedens DL, Nopoulos PC, Wemmie JA, Roghair RD.

Pediatr Res. 2011 May;69(5 Pt 1):406-12. doi: 10.1203/PDR.0b013e3182110c7d.


Amygdala volume correlates positively with fearfulness in normal healthy girls.

van der Plas EA, Boes AD, Wemmie JA, Tranel D, Nopoulos P.

Soc Cogn Affect Neurosci. 2010 Dec;5(4):424-31. doi: 10.1093/scan/nsq009. Epub 2010 Feb 11.


Histologic examination of the eye of acid-sensing ion channel 1a knockout mice.

Render JA, Howe KR, Wunsch AM, Guionaud S, Cox PJ, Wemmie JA.

Int J Physiol Pathophysiol Pharmacol. 2010 Mar 22;2(1):69-72.


ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.

Walder RY, Rasmussen LA, Rainier JD, Light AR, Wemmie JA, Sluka KA.

J Pain. 2010 Mar;11(3):210-8. doi: 10.1016/j.jpain.2009.07.004. Epub 2009 Dec 16.


The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA 3rd, Welsh MJ, Wemmie JA.

Cell. 2009 Nov 25;139(5):1012-21. doi: 10.1016/j.cell.2009.10.029.


Acid-sensing ion channels: A new target for pain and CNS diseases.

Sluka KA, Winter OC, Wemmie JA.

Curr Opin Drug Discov Devel. 2009 Sep;12(5):693-704. Review.


Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.

Recober A, Kuburas A, Zhang Z, Wemmie JA, Anderson MG, Russo AF.

J Neurosci. 2009 Jul 8;29(27):8798-804. doi: 10.1523/JNEUROSCI.1727-09.2009.


Stereotactic atlas-based depth electrode localization in the human amygdala.

Oya H, Kawasaki H, Dahdaleh NS, Wemmie JA, Howard MA 3rd.

Stereotact Funct Neurosurg. 2009;87(4):219-28. doi: 10.1159/000225975. Epub 2009 Jun 26.


Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior.

Coryell MW, Wunsch AM, Haenfler JM, Allen JE, Schnizler M, Ziemann AE, Cook MN, Dunning JP, Price MP, Rainier JD, Liu Z, Light AR, Langbehn DR, Wemmie JA.

J Neurosci. 2009 Apr 29;29(17):5381-8. doi: 10.1523/JNEUROSCI.0360-09.2009.


Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.

Zha XM, Wang R, Collier DM, Snyder PM, Wemmie JA, Welsh MJ.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3573-8. doi: 10.1073/pnas.0813402106. Epub 2009 Feb 13.


Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses.

Coryell MW, Wunsch AM, Haenfler JM, Allen JE, McBride JL, Davidson BL, Wemmie JA.

J Neurosci. 2008 Dec 17;28(51):13738-41. doi: 10.1523/JNEUROSCI.3907-08.2008.


The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction.

Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, Hell JW, Welsh MJ.

J Biol Chem. 2009 Jan 30;284(5):2697-705. doi: 10.1074/jbc.M805110200. Epub 2008 Nov 21.


Seizure termination by acidosis depends on ASIC1a.

Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard MA 3rd, Welsh MJ, Wemmie JA.

Nat Neurosci. 2008 Jul;11(7):816-22. doi: 10.1038/nn.2132. Epub 2008 Jun 8.


Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.

Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L.

Nat Med. 2007 Dec;13(12):1483-9. Epub 2007 Nov 11.


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