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Items: 1 to 50 of 54

1.

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa.

Ahmed CM, Dwyer BT, Romashko A, Van Adestine S, Park EH, Lou Z, Welty D, Josiah S, Savinainen A, Zhang B, Lewin AS.

Transl Vis Sci Technol. 2019 Dec 12;8(6):30. doi: 10.1167/tvst.8.6.30. eCollection 2019 Nov.

3.

Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs.

Chung JK, Spencer E, Hunt M, McCauley T, Welty D.

J Ocul Pharmacol Ther. 2018 Jan/Feb;34(1-2):224-232. doi: 10.1089/jop.2017.0106. Epub 2017 Dec 21.

5.

In vitro drug-drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymes.

Chen N, Cui D, Wang Q, Wen Z, Finkelman RD, Welty D.

Xenobiotica. 2018 Jun;48(6):637-646. doi: 10.1080/00498254.2017.1344911. Epub 2017 Jul 21.

PMID:
28730856
6.

Continuous infusion of the α7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study.

van Goethem NP, Prickaerts J, Welty D, Flood DG, Koenig G.

Behav Pharmacol. 2015 Jun;26(4):403-6. doi: 10.1097/FBP.0000000000000134.

PMID:
25794332
7.

Neuropharmacokinetics of two investigational compounds in rats: divergent temporal profiles in the brain and cerebrospinal fluid.

Tang C, Chen T, Kapadnis S, Hodgdon H, Tao Y, Chen X, Wen M, Costa D, Murphy D, Nolan S, Flood DG, Welty DF, Koenig G.

Biochem Pharmacol. 2014 Oct 15;91(4):543-51. doi: 10.1016/j.bcp.2014.07.023. Epub 2014 Aug 1.

PMID:
25091561
8.

A dynamic view to the modulation of phosphorylation and O-GlcNAcylation by inhibition of O-GlcNAcase.

Tang C, Welty DF.

Comput Biol Chem. 2013 Aug;45:9-16. doi: 10.1016/j.compbiolchem.2013.03.001. Epub 2013 Mar 23.

PMID:
23608187
9.

Pharmacokinetics of a sustained-release dexamethasone intravitreal implant in vitrectomized and nonvitrectomized eyes.

Chang-Lin JE, Burke JA, Peng Q, Lin T, Orilla WC, Ghosn CR, Zhang KM, Kuppermann BD, Robinson MR, Whitcup SM, Welty DF.

Invest Ophthalmol Vis Sci. 2011 Jun 28;52(7):4605-9. doi: 10.1167/iovs.10-6387.

PMID:
21421864
10.

Ocular pharmacokinetics of 0.45% ketorolac tromethamine.

Attar M, Schiffman R, Borbridge L, Farnes Q, Welty D.

Clin Ophthalmol. 2010 Dec 1;4:1403-8. doi: 10.2147/OPTH.S15146.

11.

Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC-MS/MS.

Ni J, Ouyang H, Seto C, Sakuma T, Ellis R, Rowe J, Acheampong A, Welty D, Szekely-Klepser G.

Bioanalysis. 2010 Mar;2(3):407-19. doi: 10.4155/bio.10.10.

PMID:
21083251
12.

Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant.

Chang-Lin JE, Attar M, Acheampong AA, Robinson MR, Whitcup SM, Kuppermann BD, Welty D.

Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):80-6. doi: 10.1167/iovs.10-5285.

PMID:
20702826
13.

Microdosing assessment to evaluate pharmacokinetics and drug metabolism in rats using liquid chromatography-tandem mass spectrometry.

Ni J, Ouyang H, Aiello M, Seto C, Borbridge L, Sakuma T, Ellis R, Welty D, Acheampong A.

Pharm Res. 2008 Jul;25(7):1572-82. doi: 10.1007/s11095-008-9555-x. Epub 2008 Feb 26.

PMID:
18299965
14.

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives.

Chaurasia CS, Müller M, Bashaw ED, Benfeldt E, Bolinder J, Bullock R, Bungay PM, DeLange EC, Derendorf H, Elmquist WF, Hammarlund-Udenaes M, Joukhadar C, Kellogg DL Jr, Lunte CE, Nordstrom CH, Rollema H, Sawchuk RJ, Cheung BW, Shah VP, Stahle L, Ungerstedt U, Welty DF, Yeo H.

Pharm Res. 2007 May;24(5):1014-25. Epub 2007 Mar 27.

PMID:
17458685
15.

AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives.

Chaurasia CS, Müller M, Bashaw ED, Benfeldt E, Bolinder J, Bullock R, Bungay PM, DeLange EC, Derendorf H, Elmquist WF, Hammarlund-Udenaes M, Joukhadar C, Kellogg DL Jr, Lunte CE, Nordstrom CH, Rollema H, Sawchuk RJ, Cheung BW, Shah VP, Stahle L, Ungerstedt U, Welty DF, Yeo H.

J Clin Pharmacol. 2007 May;47(5):589-603. No abstract available.

PMID:
17442685
16.

Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Long RD, Dorward DW, Gardner DJ, Lina G, Kreiswirth BN, DeLeo FR.

J Infect Dis. 2006 Dec 15;194(12):1761-70. Epub 2006 Nov 2.

PMID:
17109350
17.

Ocular pharmacokinetics of moxifloxacin after topical treatment of animals and humans.

Chang Lin JE, Welty D.

Surv Ophthalmol. 2006 Sep-Oct;51(5):530; author reply 530-1. No abstract available.

PMID:
16950254
18.

Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection.

Graham MR, Virtaneva K, Porcella SF, Gardner DJ, Long RD, Welty DM, Barry WT, Johnson CA, Parkins LD, Wright FA, Musser JM.

Am J Pathol. 2006 Sep;169(3):927-42.

19.

Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response.

Sumby P, Barbian KD, Gardner DJ, Whitney AR, Welty DM, Long RD, Bailey JR, Parnell MJ, Hoe NP, Adams GG, Deleo FR, Musser JM.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1679-84. Epub 2005 Jan 24.

20.

Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits.

Dong JQ, Babusis DM, Welty DF, Acheampong AA, Tang-Liu D, Whitcup SM.

J Ocul Pharmacol Ther. 2004 Aug;20(4):285-92.

PMID:
15321023
21.

Internalization of OspA in rsCD14 complex and aggregated forms.

Welty DM, Snyder DS.

Mol Microbiol. 2003 Nov;50(3):835-43.

22.
23.

Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024).

Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME.

J Pharmacol Exp Ther. 2003 May;305(2):772-85. Epub 2003 Jan 24.

PMID:
12606640
24.

Formulation effects on ocular absorption of brimonidine in rabbit eyes.

Acheampong AA, Small D, Baumgarten V, Welty D, Tang-Liu D.

J Ocul Pharmacol Ther. 2002 Aug;18(4):325-37. Erratum in: J Ocul Pharmacol Ther. 2003 Feb;19(1):91..

PMID:
12222763
25.

The pharmacology of bimatoprost (Lumigan).

Woodward DF, Krauss AH, Chen J, Lai RK, Spada CS, Burk RM, Andrews SW, Shi L, Liang Y, Kedzie KM, Chen R, Gil DW, Kharlamb A, Archeampong A, Ling J, Madhu C, Ni J, Rix P, Usansky J, Usansky H, Weber A, Welty D, Yang W, Tang-Liu DD, Garst ME, Brar B, Wheeler LA, Kaplan LJ.

Surv Ophthalmol. 2001 May;45 Suppl 4:S337-45. Review. Erratum in: Surv Ophthalmol 2002 May-Jun;47(3):295.

PMID:
11434936
26.

A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells.

George KM, Pascopella L, Welty DM, Small PL.

Infect Immun. 2000 Feb;68(2):877-83.

27.
28.

The neuroprotective effect of the novel AMPA receptor antagonist PD152247 (PNQX) in temporary focal ischemia in the rat.

Schielke GP, Kupina NC, Boxer PA, Bigge CF, Welty DF, Iadecola C.

Stroke. 1999 Jul;30(7):1472-7.

PMID:
10390325
29.

Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.

George KM, Chatterjee D, Gunawardana G, Welty D, Hayman J, Lee R, Small PL.

Science. 1999 Feb 5;283(5403):854-7.

31.

A summary of mechanistic hypotheses of gabapentin pharmacology.

Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P, Singh L.

Epilepsy Res. 1998 Feb;29(3):233-49. Review.

PMID:
9551785
32.
33.
34.

Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms.

Welty DJ, Jones JM, Nakai H.

J Mol Biol. 1997 Sep 12;272(1):31-41.

PMID:
9299335
35.

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF.

Neuron. 1996 Mar;16(3):675-86.

38.

Potential treatment of amyotrophic lateral sclerosis with gabapentin: a hypothesis.

Welty DF, Schielke GP, Rothstein JD.

Ann Pharmacother. 1995 Nov;29(11):1164-7.

PMID:
8573965
39.

Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA.

Goldlust A, Su TZ, Welty DF, Taylor CP, Oxender DL.

Epilepsy Res. 1995 Sep;22(1):1-11.

PMID:
8565962
40.

Hepatic and adrenal toxicity of a novel lipid regulator in beagle dogs.

Wolfgang GH, Robertson DG, Welty DF, Metz AL.

Fundam Appl Toxicol. 1995 Jul;26(2):272-81.

PMID:
7589916
41.
42.

The temporal effect of food on tacrine bioavailability.

Welty DF, Siedlik PH, Posvar EL, Selen A, Sedman AJ.

J Clin Pharmacol. 1994 Oct;34(10):985-8.

PMID:
7836549
43.

Acid and base resistance in Escherichia coli and Shigella flexneri: role of rpoS and growth pH.

Small P, Blankenhorn D, Welty D, Zinser E, Slonczewski JL.

J Bacteriol. 1994 Mar;176(6):1729-37.

44.

Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate.

Welty DF, Schielke GP, Vartanian MG, Taylor CP.

Epilepsy Res. 1993 Dec;16(3):175-81.

PMID:
8119268
45.

Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells.

Morgan D, Welty D, Glick A, Greenhalgh D, Hennings H, Yuspa SH.

Cancer Res. 1992 Jun 1;52(11):3145-56.

46.

Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion.

Hennings H, Robinson VA, Yuspa SH, Welty DJ, Greenhalgh DG.

Cancer Commun. 1991 Sep;3(9):277-81.

PMID:
1911043
47.
48.
49.

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

Greenhalgh DA, Welty DJ, Player A, Yuspa SH.

Proc Natl Acad Sci U S A. 1990 Jan;87(2):643-7.

50.

LC determination of the diastereomers of 1-(beta-D-glucopyranosyl)phenobarbital in human urine.

Soine WH, Soine PJ, England TM, Welty DF, Wood JH.

J Pharm Biomed Anal. 1990;8(4):365-72.

PMID:
2100211

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