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Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial.

Vogel-Claussen J, Schönfeld CO, Kaireit TF, Voskrebenzev A, Czerner CP, Renne J, Tillmann HC, Berschneider K, Hiltl S, Bauersachs J, Welte T, Hohlfeld JM.

Am J Respir Crit Care Med. 2019 Jan 14. doi: 10.1164/rccm.201805-0995OC. [Epub ahead of print]


Low transmission risk of Pseudomonas aeruginosa in a bronchiectasis clinic based on the knowledge of bacterial population biology.

Cramer N, Sedlacek L, Tümmler B, Welte T.

Eur Respir J. 2019 Jan 11. pii: 1802191. doi: 10.1183/13993003.02191-2018. [Epub ahead of print] No abstract available.


Single- and multiple-dose pharmacokinetics and total removal of colistin in critically ill patients with acute kidney injury undergoing prolonged intermittent renal replacement therapy.

Schmidt JJ, Strunk AK, David S, Bode-Böger SM, Martens-Lobenhoffer J, Knitsch W, Scherneck S, Welte T, Kielstein JT.

J Antimicrob Chemother. 2019 Jan 8. doi: 10.1093/jac/dky511. [Epub ahead of print]


The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) ERS Clinical Research Collaboration.

Aliberti S, Polverino E, Chalmers JD, Altenburg J, Shteinberg M, Goeminne PC, Welte T, Shoemark A, Almagro M, Blasi F; EMBARC Clinical Research Collaboration.

Eur Respir J. 2018 Nov 29;52(5). pii: 1802074. doi: 10.1183/13993003.02074-2018. Print 2018 Nov. No abstract available.


The European Respiratory Society's 10 Principles for Lung Health.

Horváth I, Barry M, Brusselle G, Burghuber OC, Bush A, Robalo Cordeiro C, Gaga M, Gratziou C, Saraiva I, Stolz D, Troosters T, Welte T, Migliori GB, Joos G.

Eur Respir J. 2018 Nov 29;52(5). pii: 1801373. doi: 10.1183/13993003.01373-2018. Print 2018 Nov. No abstract available.


Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years.

Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller H, Gottlieb J, Eder M, Welte T, Hoeper MM, Scherag A, David S.

Crit Care. 2018 Nov 19;22(1):307. doi: 10.1186/s13054-018-2221-8.


Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues.

Aman K, Padroni G, Parkinson JA, Welte T, Burley GA.

Chemistry. 2018 Nov 8. doi: 10.1002/chem.201805338. [Epub ahead of print]


Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers.

Knaup H, Stahl K, Schmidt BMW, Idowu TO, Busch M, Wiesner O, Welte T, Haller H, Kielstein JT, Hoeper MM, David S.

Crit Care. 2018 Oct 30;22(1):285. doi: 10.1186/s13054-018-2220-9.


Comparison of quantitative regional perfusion-weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium-enhanced regional pulmonary perfusion MRI in COPD patients.

Kaireit TF, Voskrebenzev A, Gutberlet M, Freise J, Jobst B, Kauczor HU, Welte T, Wacker F, Vogel-Claussen J.

J Magn Reson Imaging. 2018 Oct 22. doi: 10.1002/jmri.26342. [Epub ahead of print]


ERS Clinical Research Collaborations: underpinning research excellence.

Brightling C, Genton C, Bill W, Welte T, Gaga M, Heuvelin E, Brusselle G.

Eur Respir J. 2018 Sep 15;52(3). pii: 1801534. doi: 10.1183/13993003.01534-2018. Print 2018 Sep. No abstract available.


The European Respiratory Society: ensuring excellence through education best practice.

Farr A, Gaga M, Welte T, Troosters T, Joos G, Robalo Cordeiro C, Burghuber OC, Brusselle G, Gratziou CG, Bush A, Saraiva I, Pannetier C, Stolz D.

Eur Respir J. 2018 Sep 15;52(3). pii: 1801248. doi: 10.1183/13993003.01248-2018. Print 2018 Sep. No abstract available.


[The 2017/2018 influenza season-business as usual? : A statement of medical societies].

Kochanek M, Böll B, Shimabukuro-Vornhagen A, Welte T, Wieland U, Pletz M, Hallek M, Fätkenheuer G, Salzberger B.

Internist (Berl). 2018 Sep 14. doi: 10.1007/s00108-018-0501-7. [Epub ahead of print] German. No abstract available.


[Pneumological Assessment with Regard to Performance Demands - Concept: "Load to Capacity"].

Kroidl RF, Fröhlich MJ, Welte T.

Pneumologie. 2018 Nov;72(11):e2. doi: 10.1055/a-0721-0598. Epub 2018 Aug 30. German. No abstract available.


Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis.

Contarini M, Shoemark A, Rademacher J, Finch S, Gramegna A, Gaffuri M, Roncoroni L, Seia M, Ringshausen FC, Welte T, Blasi F, Aliberti S, Chalmers JD.

Multidiscip Respir Med. 2018 Aug 9;13(Suppl 1):26. doi: 10.1186/s40248-018-0143-6. eCollection 2018. Review.


Lobe-wise assessment of lung volume and density distribution in lung transplant patients and value for early detection of bronchiolitis obliterans syndrome.

Dettmer S, Suhling H, Klingenberg I, Otten O, Kaireit T, Fuge J, Kuhnigk JM, Gottlieb J, Haverich A, Welte T, Wacker F, Vogel-Claussen J, Shin HO.

Eur J Radiol. 2018 Sep;106:137-144. doi: 10.1016/j.ejrad.2018.07.016. Epub 2018 Jul 25.


[The lung in systemic diseases : Between holistic and individualized medicine-a challenge for internal medicine].

Welte T, Vogelmeier C, Hiddemann W, Märker-Hermann E.

Internist (Berl). 2018 Sep;59(9):873-875. doi: 10.1007/s00108-018-0481-7. German. No abstract available.


[Pneumological Assessment with Regard to Performance Demands - Concept: "Load to Capacity"].

Kroidl RF, Fröhlich MJ, Welte T.

Pneumologie. 2018 Nov;72(11):766-773. doi: 10.1055/a-0647-9650. Epub 2018 Aug 22. German. Erratum in: Pneumologie. 2018 Nov;72(11):e2.


Anti-IL-5 therapy in patients with severe eosinophilic asthma - clinical efficacy and possible criteria for treatment response.

Drick N, Seeliger B, Welte T, Fuge J, Suhling H.

BMC Pulm Med. 2018 Jul 18;18(1):119. doi: 10.1186/s12890-018-0689-2.


Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia.

Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, Kollef M, Li Bassi G, Luna CM, Martin-Loeches I, Paiva JA, Read RC, Rigau D, François Timsit J, Welte T, Wunderink R.

ERJ Open Res. 2018 Jun 26;4(2). pii: 00028-2018. doi: 10.1183/23120541.00028-2018. eCollection 2018 Apr.


Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials.

Schuetz P, Bolliger R, Merker M, Christ-Crain M, Stolz D, Tamm M, Luyt CE, Wolff M, Schroeder S, Nobre V, Reinhart K, Branche A, Damas P, Nijsten M, Deliberato RO, Verduri A, Beghé B, Cao B, Shehabi Y, Jensen JS, Beishuizen A, de Jong E, Briel M, Welte T, Mueller B.

Expert Rev Anti Infect Ther. 2018 Jul;16(7):555-564. doi: 10.1080/14787210.2018.1496331. Epub 2018 Jul 13. Review.


Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease.

Schumann DM, Leeming D, Papakonstantinou E, Blasi F, Kostikas K, Boersma W, Louis R, Milenkovic B, Aerts J, Sand JMB, Wouters EFM, Rohde G, Prat C, Torres A, Welte T, Tamm M, Karsdal M, Stolz D.

Chest. 2018 Oct;154(4):798-807. doi: 10.1016/j.chest.2018.06.028. Epub 2018 Jun 30.


The liver-first approach for combined lung and liver transplantation.

Salman J, Grannas G, Ius F, Sommer W, Siemeni T, Avsar M, Kuehn C, Boethig D, Fleissner F, Bobylev D, Gottlieb J, Klempnauer J, Welte T, Haverich A, Tudorache I, Warnecke G, Lehner F.

Eur J Cardiothorac Surg. 2018 Dec 1;54(6):1122-1127. doi: 10.1093/ejcts/ezy217.


Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach.

Kahnert K, Alter P, Welte T, Huber RM, Behr J, Biertz F, Watz H, Bals R, Vogelmeier CF, Jörres RA.

Respir Res. 2018 Jun 4;19(1):110. doi: 10.1186/s12931-018-0815-y.


The burden of sinus disease in cystic fibrosis lung transplant recipients.

Morlacchi LC, Greer M, Tudorache I, Blasi F, Welte T, Haverich A, Mainz JG, Gottlieb J.

Transpl Infect Dis. 2018 Oct;20(5):e12924. doi: 10.1111/tid.12924. Epub 2018 Jun 28.


Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy.

Eickhoff L, Golpon H, Zardo P, Suhling H, Welte T, Jonigk D, Gottlieb J, Fuehner T.

Pneumologie. 2018 Aug;72(8):559-567. doi: 10.1055/a-0583-0265. Epub 2018 May 22.


The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.

Janciauskiene S, Wrenger S, Immenschuh S, Olejnicka B, Greulich T, Welte T, Chorostowska-Wynimko J.

Front Pharmacol. 2018 Apr 17;9:341. doi: 10.3389/fphar.2018.00341. eCollection 2018. Review.


Preemptive treatment of early donor-specific antibodies with IgA- and IgM-enriched intravenous human immunoglobulins in lung transplantation.

Ius F, Verboom M, Sommer W, Poyanmehr R, Knoefel AK, Salman J, Kuehn C, Avsar M, Siemeni T, Erdfelder C, Hallensleben M, Boethig D, Schwerk N, Mueller C, Welte T, Falk C, Haverich A, Tudorache I, Warnecke G.

Am J Transplant. 2018 Sep;18(9):2295-2304. doi: 10.1111/ajt.14912. Epub 2018 Jun 3.


Déjà-vu-How Not to Make the Same Mistake Twice.

Welte T.

Dtsch Arztebl Int. 2018 Apr 6;115(14):233-234. doi: 10.3238/arztebl.2018.0233. No abstract available.


Quantitation of Perfused Lung Volume Using Hybrid SPECT/CT Allows Refining the Assessment of Lung Perfusion and Estimating Disease Extent in Chronic Thromboembolic Pulmonary Hypertension.

Derlin T, Kelting C, Hueper K, Weiberg D, Meyer K, Olsson KM, Thackeray JT, Welte T, Bengel FM, Hoeper MM.

Clin Nucl Med. 2018 Jun;43(6):e170-e177. doi: 10.1097/RLU.0000000000002085.


Effect of antifibrotics on short-term outcome after bilateral lung transplantation: a multicentre analysis.

Lambers C, Boehm PM, Lee S, Ius F, Jaksch P, Klepetko W, Tudorache I, Ristl R, Welte T, Gottlieb J.

Eur Respir J. 2018 Jun 21;51(6). pii: 1800503. doi: 10.1183/13993003.00503-2018. Print 2018 Jun. No abstract available.


Left ventricular volume and wall stress are linked to lung function impairment in COPD.

Alter P, Jörres RA, Watz H, Welte T, Gläser S, Schulz H, Bals R, Karch A, Wouters EFM, Vestbo J, Young D, Vogelmeier CF.

Int J Cardiol. 2018 Jun 15;261:172-178. doi: 10.1016/j.ijcard.2018.02.074.


Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).

Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martin-Loeches I, Almirall J, Artigas A, Ignacio Ayestarán J, Nuding S, Ferrer R, Sirgo Rodríguez G, Shankar-Hari M, Álvarez-Lerma F, Riessen R, Sirvent JM, Kluge S, Zacharowski K, Bonastre Mora J, Lapp H, Wöbker G, Achtzehn U, Brealey D, Kempa A, Sánchez García M, Brederlau J, Kochanek M, Reschreiter HP, Wise MP, Belohradsky BH, Bobenhausen I, Dälken B, Dubovy P, Langohr P, Mayer M, Schüttrumpf J, Wartenberg-Demand A, Wippermann U, Wolf D, Torres A.

Intensive Care Med. 2018 Apr;44(4):438-448. doi: 10.1007/s00134-018-5143-7. Epub 2018 Apr 9.


Detection of chronic lung allograft dysfunction using ventilation-weighted Fourier decomposition MRI.

Voskrebenzev A, Greer M, Gutberlet M, Schönfeld C, Renne J, Hinrichs J, Kaireit T, Welte T, Wacker F, Gottlieb J, Vogel-Claussen J.

Am J Transplant. 2018 Aug;18(8):2050-2060. doi: 10.1111/ajt.14759. Epub 2018 May 26.


Burden of pneumococcal community-acquired pneumonia in adults across Europe: A literature review.

Torres A, Cillóniz C, Blasi F, Chalmers JD, Gaillat J, Dartois N, Schmitt HJ, Welte T.

Respir Med. 2018 Apr;137:6-13. doi: 10.1016/j.rmed.2018.02.007. Epub 2018 Feb 19. Review.


Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling.

Alter P, Watz H, Kahnert K, Pfeifer M, Randerath WJ, Andreas S, Waschki B, Kleibrink BE, Welte T, Bals R, Schulz H, Biertz F, Young D, Vogelmeier CF, Jörres RA.

Respir Med. 2018 Apr;137:14-22. doi: 10.1016/j.rmed.2018.02.011. Epub 2018 Feb 19.


IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

Egli A, Mandal J, Schumann DM, Roth M, Thomas B, Lorne Tyrrell D, Blasi F, Kostikas K, Boersma W, Milenkovic B, Lacoma A, Rentsch K, Rohde GGU, Louis R, Aerts JG, Welte T, Torres A, Tamm M, Stolz D.

BMC Pulm Med. 2018 Mar 21;18(1):51. doi: 10.1186/s12890-018-0616-6.


Colonization-induced protection against invasive pneumococcal disease in mice is independent of CD103 driven adaptive immune responses.

Dommaschk A, Lang LF, Maus R, Stolper J, Welte T, Maus UA.

Eur J Immunol. 2018 Jun;48(6):965-974. doi: 10.1002/eji.201747236. Epub 2018 Apr 11.


[Guideline for the Diagnosis and Treatment of COPD Patients - Issued by the German Respiratory Society and the German Atemwegsliga in Cooperation with the Austrian Society of Pneumology].

Vogelmeier C, Buhl R, Burghuber O, Criée CP, Ewig S, Godnic-Cvar J, Hartl S, Herth F, Kardos P, Kenn K, Nowak D, Rabe KF, Studnicka M, Watz H, Welte T, Windisch W, Worth H; unter Mitwirkung der folgenden wissenschaftlichen Fachgesellschaften: Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. ; Deutsche Gesellschaft für Rehabilitationswissenschaften e.V.

Pneumologie. 2018 Apr;72(4):253-308. doi: 10.1055/s-0043-125031. Epub 2018 Mar 9. German.


New era for European Respiratory Society clinical practice guidelines: joining efficiency and high methodological standards.

Miravitlles M, Tonia T, Rigau D, Roche N, Genton C, Vaccaro V, Welte T, Gaga M, Brusselle G.

Eur Respir J. 2018 Mar 8;51(3). pii: 1800221. doi: 10.1183/13993003.00221-2018. Print 2018 Mar. No abstract available.


Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients.

Scheuch G, Canisius S, Nocker K, Hofmann T, Naumann R, Pleschka S, Ludwig S, Welte T, Planz O.

Emerg Microbes Infect. 2018 Mar 7;7(1):21. doi: 10.1038/s41426-018-0023-3.


Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial.

Hohlfeld JM, Vogel-Claussen J, Biller H, Berliner D, Berschneider K, Tillmann HC, Hiltl S, Bauersachs J, Welte T.

Lancet Respir Med. 2018 May;6(5):368-378. doi: 10.1016/S2213-2600(18)30054-7. Epub 2018 Feb 21.


The revised GOLD 2017 COPD categorization in relation to comorbidities.

Kahnert K, Alter P, Young D, Lucke T, Heinrich J, Huber RM, Behr J, Wacker M, Biertz F, Watz H, Bals R, Welte T, Wirtz H, Herth F, Vestbo J, Wouters EF, Vogelmeier CF, Jörres RA.

Respir Med. 2018 Jan;134:79-85. doi: 10.1016/j.rmed.2017.12.003. Epub 2017 Dec 5.


Microbiologic Outcome of Interventions Against Mycobacterium avium Complex Pulmonary Disease: A Systematic Review.

Diel R, Nienhaus A, Ringshausen FC, Richter E, Welte T, Rabe KF, Loddenkemper R.

Chest. 2018 Apr;153(4):888-921. doi: 10.1016/j.chest.2018.01.024. Epub 2018 Feb 2.


Computed tomography in adult patients with primary ciliary dyskinesia: Typical imaging findings.

Dettmer S, Ringshausen F, Vogel-Claussen J, Fuge J, Faschkami A, Shin HO, Schwerk N, Welte T, Wacker F, Rademacher J.

PLoS One. 2018 Feb 6;13(2):e0191457. doi: 10.1371/journal.pone.0191457. eCollection 2018.


Oxygen Consumption (V'O2) and physical Strainas measured by the occupational activity of cleaning personnel.

Fröhlich MJ, Kroidl RF, Welte T.

J Occup Med Toxicol. 2018 Jan 19;13:4. doi: 10.1186/s12995-018-0185-x. eCollection 2018.


Self-reported non-adherence to immunosuppressive medication in adult lung transplant recipients-A single-center cross-sectional study.

Drick N, Seeliger B, Fuge J, Tudorache I, Greer M, Welte T, Haverich A, Gottlieb J.

Clin Transplant. 2018 Apr;32(4):e13214. doi: 10.1111/ctr.13214. Epub 2018 Feb 23.


Infection transmission among lung transplant couples.

Rademacher J, Fuge J, Welte T, Gottlieb J, Suhling H.

Transpl Infect Dis. 2018 Apr;20(2):e12853. doi: 10.1111/tid.12853. Epub 2018 Feb 22.


[Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017 - S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology].

Dalhoff K, Abele-Horn M, Andreas S, Deja M, Ewig S, Gastmeier P, Gatermann S, Gerlach H, Grabein B, Heußel CP, Höffken G, Kolditz M, Kramme E, Kühl H, Lange C, Mayer K, Nachtigall I, Panning M, Pletz M, Rath PM, Rohde G, Rosseau S, Schaaf B, Schreiter D, Schütte H, Seifert H, Spies C, Welte T; Unter Mitwirkung der folgenden Wissenschaftlichen Fachgesellschaften und Institutionen: Deutsche Gesellschaft für Chirurgie; Deutsche Gesellschaft für Innere Medizin e. V; Deutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin; Deutsche Sepsis-Gesellschaft e. V; und Robert Koch-Institut.

Pneumologie. 2018 Jan;72(1):15-63. doi: 10.1055/s-0043-121734. Epub 2018 Jan 16. German.


Treating C3 glomerulopathy with eculizumab.

Welte T, Arnold F, Kappes J, Seidl M, Häffner K, Bergmann C, Walz G, Neumann-Haefelin E.

BMC Nephrol. 2018 Jan 12;19(1):7. doi: 10.1186/s12882-017-0802-4.


Functional lung MRI for regional monitoring of patients with cystic fibrosis.

Kaireit TF, Sorrentino SA, Renne J, Schoenfeld C, Voskrebenzev A, Gutberlet M, Schulz A, Jakob PM, Hansen G, Wacker F, Welte T, Tümmler B, Vogel-Claussen J.

PLoS One. 2017 Dec 7;12(12):e0187483. doi: 10.1371/journal.pone.0187483. eCollection 2017.

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