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Items: 19


Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury.

Welsbie DS, Ziogas NK, Xu L, Kim BJ, Ge Y, Patel AK, Ryu J, Lehar M, Alexandris AS, Stewart N, Zack DJ, Koliatsos VE.

Mol Neurodegener. 2019 Nov 27;14(1):44. doi: 10.1186/s13024-019-0345-1.


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Foo VHX, Htoon HM, Welsbie DS, Perera SA.

Cochrane Database Syst Rev. 2019 Apr 19;4:CD011875. doi: 10.1002/14651858.CD011875.pub2.


Thyroid hormone signaling specifies cone subtypes in human retinal organoids.

Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ Jr.

Science. 2018 Oct 12;362(6411). pii: eaau6348. doi: 10.1126/science.aau6348.


Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.

Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS.

Exp Eye Res. 2018 Jun;171:54-61. doi: 10.1016/j.exer.2018.03.007. Epub 2018 Mar 8.


Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells.

Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ.

Stem Cells Transl Med. 2017 Nov;6(11):1972-1986. doi: 10.1002/sctm.17-0059. Epub 2017 Oct 10.


Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ.

Neuron. 2017 Jun 21;94(6):1142-1154.e6. doi: 10.1016/j.neuron.2017.06.008.


Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells.

Langouet-Astrie CJ, Yang Z, Polisetti SM, Welsbie DS, Hauswirth WW, Zack DJ, Merbs SL, Enke RA.

Exp Eye Res. 2016 Oct;151:61-7. doi: 10.1016/j.exer.2016.07.019. Epub 2016 Jul 30.


Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.

Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6927-36. doi: 10.1073/pnas.1512683112. Epub 2015 Nov 30.


Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma.

Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC.

PLoS One. 2015 Oct 27;10(10):e0141137. doi: 10.1371/journal.pone.0141137. eCollection 2015.


Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4.


More than just optic disc swelling.

Channa R, Welsbie DS, Patel VR.

JAMA Ophthalmol. 2013 Nov;131(11):1477-8. doi: 10.1001/jamaophthalmol.2013.7013. No abstract available.


Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.

Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34. doi: 10.1073/pnas.1217091110. Epub 2013 Aug 19.


Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50. doi: 10.1073/pnas.1211284110. Epub 2013 Feb 19.


Melanopsin signalling in mammalian iris and retina.

Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW.

Nature. 2011 Nov 2;479(7371):67-73. doi: 10.1038/nature10567.


Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer.

Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL.

Cancer Res. 2009 Feb 1;69(3):958-66. doi: 10.1158/0008-5472.CAN-08-2216. Epub 2009 Jan 27.


Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.

Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL.

Nat Med. 2006 Jan;12(1):122-7. Epub 2005 Dec 11.


Molecular determinants of resistance to antiandrogen therapy.

Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL.

Nat Med. 2004 Jan;10(1):33-9. Epub 2003 Dec 21.


Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein.

Watson AD, Subbanagounder G, Welsbie DS, Faull KF, Navab M, Jung ME, Fogelman AM, Berliner JA.

J Biol Chem. 1999 Aug 27;274(35):24787-98.

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