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Items: 37

1.

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths.

Wolock SL, Krishnan I, Tenen DE, Matkins V, Camacho V, Patel S, Agarwal P, Bhatia R, Tenen DG, Klein AM, Welner RS.

Cell Rep. 2019 Jul 9;28(2):302-311.e5. doi: 10.1016/j.celrep.2019.06.031.

2.

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG.

Nat Commun. 2018 Apr 24;9(1):1622. doi: 10.1038/s41467-018-03854-0.

3.

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP.

Nat Commun. 2018 Apr 23;9(1):1603. doi: 10.1038/s41467-018-03886-6.

4.

C/EBPγ is dispensable for steady-state and emergency granulopoiesis.

Kardosova M, Zjablovskaja P, Danek P, Angelisova P, de Figueiredo-Pontes LL, Welner RS, Brdicka T, Lee S, Tenen DG, Alberich-Jorda M.

Haematologica. 2018 Aug;103(8):e331-e335. doi: 10.3324/haematol.2017.173781. Epub 2018 Mar 22. No abstract available.

5.

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG.

J Biol Chem. 2017 Nov 17;292(46):18924-18936. doi: 10.1074/jbc.M117.811109. Epub 2017 Sep 12.

6.

Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment.

Camacho V, McClearn V, Patel S, Welner RS.

Int J Hematol. 2017 May;105(5):566-577. doi: 10.1007/s12185-017-2184-6. Epub 2017 Feb 7. Review.

PMID:
28176225
7.

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.

Sci Transl Med. 2016 Aug 3;8(350):350ra104. doi: 10.1126/scitranslmed.aad6066.

PMID:
27488898
8.

The second hit of DNA methylation.

Di Ruscio A, Welner RS, Tenen DG, Amabile G.

Mol Cell Oncol. 2015 Oct 29;3(3):e1093690. doi: 10.1080/23723556.2015.1093690. eCollection 2016 May.

9.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2016 Apr 14;7:e2185. doi: 10.1038/cddis.2016.59. No abstract available.

10.

Acetylation of C/EBPα inhibits its granulopoietic function.

Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG.

Nat Commun. 2016 Mar 23;7:10968. doi: 10.1038/ncomms10968.

11.

The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.

Park J, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG, Yan CT.

J Immunol. 2016 Jan 1;196(1):244-55. doi: 10.4049/jimmunol.1403099. Epub 2015 Nov 25.

12.

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Ye M, Zhang H, Yang H, Koche R, Staber PB, Cusan M, Levantini E, Welner RS, Bach CS, Zhang J, Krivtsov AV, Armstrong SA, Tenen DG.

Cell Stem Cell. 2015 Nov 5;17(5):611-23. doi: 10.1016/j.stem.2015.08.011. Epub 2015 Sep 24.

13.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G.

Cell Death Dis. 2015 Jul 9;6:e1806. doi: 10.1038/cddis.2015.179. Review. Erratum in: Cell Death Dis. 2016;7:e2185.

14.

Dissecting the role of aberrant DNA methylation in human leukaemia.

Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG.

Nat Commun. 2015 May 22;6:7091. doi: 10.1038/ncomms8091.

15.

Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells.

Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG.

Cancer Cell. 2015 May 11;27(5):671-81. doi: 10.1016/j.ccell.2015.04.004.

16.

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.

Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG.

Blood. 2014 Oct 9;124(15):2391-9. doi: 10.1182/blood-2014-01-550855. Epub 2014 Sep 3.

17.

9-1-1: HSCs respond to emergency calls.

Welner RS, Kincade PW.

Cell Stem Cell. 2014 Apr 3;14(4):415-6. doi: 10.1016/j.stem.2014.03.010.

18.

Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry.

Iida R, Welner RS, Zhao W, Alberola-lla J, Medina KL, Zhao ZJ, Kincade PW.

PLoS One. 2014 Apr 3;9(4):e93643. doi: 10.1371/journal.pone.0093643. eCollection 2014.

19.

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG.

Cancer Cell. 2013 Nov 11;24(5):575-88. doi: 10.1016/j.ccr.2013.09.018. Epub 2013 Oct 31. Erratum in: Cancer Cell. 2014 Feb 10;25(2):257. Diruscio, Annalisa [corrected to Di Ruscio, Annalisa].

20.

C/EBPα is required for development of dendritic cell progenitors.

Welner RS, Bararia D, Amabile G, Czibere A, Benoukraf T, Bach C, Wansa KD, Ye M, Zhang H, Iino T, Hetherington CJ, Akashi K, Tenen DG.

Blood. 2013 May 16;121(20):4073-81. doi: 10.1182/blood-2012-10-463448. Epub 2013 Apr 1.

21.

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG.

Mol Cell. 2013 Mar 7;49(5):934-46. doi: 10.1016/j.molcel.2013.01.007. Epub 2013 Feb 8.

22.

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG.

Blood. 2013 Feb 21;121(8):1255-64. doi: 10.1182/blood-2012-06-434407. Epub 2012 Dec 4.

23.

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.

Shimazu T, Iida R, Zhang Q, Welner RS, Medina KL, Alberola-Lla J, Kincade PW.

Blood. 2012 May 24;119(21):4889-97. doi: 10.1182/blood-2011-10-388736. Epub 2012 Feb 27.

24.

Chronic exposure to a TLR ligand injures hematopoietic stem cells.

Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW.

J Immunol. 2011 May 1;186(9):5367-75. doi: 10.4049/jimmunol.1003438. Epub 2011 Mar 25.

25.

Functional diversity of stem and progenitor cells with B-lymphopoietic potential.

Ichii M, Shimazu T, Welner RS, Garrett KP, Zhang Q, Esplin BL, Kincade PW.

Immunol Rev. 2010 Sep;237(1):10-21. doi: 10.1111/j.1600-065X.2010.00933.x. Review.

26.

Asynchronous RAG-1 expression during B lymphopoiesis.

Welner RS, Esplin BL, Garrett KP, Pelayo R, Luche H, Fehling HJ, Kincade PW.

J Immunol. 2009 Dec 15;183(12):7768-77. doi: 10.4049/jimmunol.0902333.

27.

A possible contribution of retinoids to regulation of fetal B lymphopoiesis.

Chen X, Welner RS, Kincade PW.

Eur J Immunol. 2009 Sep;39(9):2515-24. doi: 10.1002/eji.200939374.

28.

A differentiation pathway for B1 cells in adult bone marrow.

Esplin BL, Welner RS, Zhang Q, Borghesi LA, Kincade PW.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5773-8. doi: 10.1073/pnas.0811632106. Epub 2009 Mar 23.

29.

Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.

Cochrane SW, Zhao Y, Welner RS, Sun XH.

Blood. 2009 Jan 29;113(5):1016-26. doi: 10.1182/blood-2008-06-164996. Epub 2008 Oct 16.

30.

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection.

Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ, Borghesi LA, Farrar MA, Kincade PW.

Blood. 2008 Nov 1;112(9):3753-61. doi: 10.1182/blood-2008-04-151506. Epub 2008 Jun 13.

31.

Evolving views on the genealogy of B cells.

Welner RS, Pelayo R, Kincade PW.

Nat Rev Immunol. 2008 Feb;8(2):95-106. doi: 10.1038/nri2234. Review.

PMID:
18204470
33.

Retinoids accelerate B lineage lymphoid differentiation.

Chen X, Esplin BL, Garrett KP, Welner RS, Webb CF, Kincade PW.

J Immunol. 2008 Jan 1;180(1):138-45.

34.

Stem cells on patrol.

Welner RS, Kincade PW.

Cell. 2007 Nov 30;131(5):842-4.

35.

Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors.

Welner RS, Pelayo R, Garrett KP, Chen X, Perry SS, Sun XH, Kee BL, Kincade PW.

Blood. 2007 Jun 1;109(11):4825-931. Epub 2007 Feb 22.

36.

Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential.

Perry SS, Welner RS, Kouro T, Kincade PW, Sun XH.

J Immunol. 2006 Sep 1;177(5):2880-7.

37.

Life before the pre-B cell receptor checkpoint: specification and commitment of primitive lymphoid progenitors in adult bone marrow.

Pelayo R, Welner RS, Nagai Y, Kincade PW.

Semin Immunol. 2006 Feb;18(1):2-11. Epub 2005 Nov 28. Review.

PMID:
16310376

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