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Items: 32


A cancer-selective zinc ionophore inspired by the natural product naamidine A.

Vaden RM, Guillen KP, Salvant JM, Santiago CB, Gibbons JB, Pathi SS, Arunachalam S, Sigman MS, Looper RE, Welm BE.

ACS Chem Biol. 2018 Dec 20. doi: 10.1021/acschembio.8b00977. [Epub ahead of print]


Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15.

Madsen MJ, Knight S, Sweeney C, Factor R, Salama M, Stijleman IJ, Rajamanickam V, Welm BE, Arunachalam S, Jones B, Rachamadugu R, Rowe K, Cessna MH, Thomas A, Kushi LH, Caan BJ, Bernard PS, Camp NJ.

Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):644-652. doi: 10.1158/1055-9965.EPI-17-0887. Epub 2018 Apr 12.


Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer.

Vahrenkamp JM, Yang CH, Rodriguez AC, Almomen A, Berrett KC, Trujillo AN, Guillen KP, Welm BE, Jarboe EA, Janat-Amsbury MM, Gertz J.

Cell Rep. 2018 Mar 13;22(11):2995-3005. doi: 10.1016/j.celrep.2018.02.076.


Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential.

Drobysheva D, Smith BA, McDowell M, Guillen KP, Ekiz HA, Welm BE.

Breast Cancer Res. 2015 Oct 1;17(1):132. doi: 10.1186/s13058-015-0641-9.


Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

Gibbons JB, Salvant JM, Vaden RM, Kwon KH, Welm BE, Looper RE.

J Org Chem. 2015 Oct 16;80(20):10076-85. doi: 10.1021/acs.joc.5b01703. Epub 2015 Sep 24.


The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress.

Vaden RM, Gligorich KM, Jana R, Sigman MS, Welm BE.

Breast Cancer Res. 2014 Nov 26;16(6):472. doi: 10.1186/s13058-014-0472-0.


Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.

Basham KJ, Leonard CJ, Kieffer C, Shelton DN, McDowell ME, Bhonde VR, Looper RE, Welm BE.

Toxicol Sci. 2015 Jan;143(1):36-45. doi: 10.1093/toxsci/kfu203. Epub 2014 Sep 29.


Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

Basham KJ, Bhonde VR, Kieffer C, Mack JB, Hess M, Welm BE, Looper RE.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2473-6. doi: 10.1016/j.bmcl.2014.04.013. Epub 2014 Apr 13.


Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells.

Gligorich KM, Vaden RM, Shelton DN, Wang G, Matsen CB, Looper RE, Sigman MS, Welm BE.

Breast Cancer Res. 2013;15(4):R58.


Targeting the PyMT Oncogene to Diverse Mammary Cell Populations Enhances Tumor Heterogeneity and Generates Rare Breast Cancer Subtypes.

Smith BA, Shelton DN, Kieffer C, Milash B, Usary J, Perou CM, Bernard PS, Welm BE.

Genes Cancer. 2012 Sep;3(9-10):550-63. doi: 10.1177/1947601913475359.


Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine.

DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE.

Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60.


Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.

Basham KJ, Kieffer C, Shelton DN, Leonard CJ, Bhonde VR, Vankayalapati H, Milash B, Bearss DJ, Looper RE, Welm BE.

J Biol Chem. 2013 Jan 25;288(4):2261-70. doi: 10.1074/jbc.M112.411033. Epub 2012 Dec 3.


Transcription factor Oct1 is a somatic and cancer stem cell determinant.

Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin D.

PLoS Genet. 2012;8(11):e1003048. doi: 10.1371/journal.pgen.1003048. Epub 2012 Nov 8.


Synthesis of the reported structures for kealiinines B and C.

Gibbons JB, Gligorich KM, Welm BE, Looper RE.

Org Lett. 2012 Sep 21;14(18):4734-7. Epub 2012 Sep 11.


Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles.

Pathak TP, Osiak JG, Vaden RM, Welm BE, Sigman MS.

Tetrahedron. 2012 Jul 1;68(26):5203-5208.


On the shoulders of giants: a historical perspective of unique experimental methods in mammary gland research.

Smith BA, Welm AL, Welm BE.

Semin Cell Dev Biol. 2012 Jul;23(5):583-90. doi: 10.1016/j.semcdb.2012.03.005. Epub 2012 Mar 9. Review.


Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes.

DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, Ebbert MT, Factor R, Matsen C, Milash BA, Nelson E, Neumayer L, Randall RL, Stijleman IJ, Welm BE, Welm AL.

Nat Med. 2011 Oct 23;17(11):1514-20. doi: 10.1038/nm.2454.


A pharmacogenomic method for individualized prediction of drug sensitivity.

Cohen AL, Soldi R, Zhang H, Gustafson AM, Wilcox R, Welm BE, Chang JT, Johnson E, Spira A, Jeffrey SS, Bild AH.

Mol Syst Biol. 2011 Jul 19;7:513. doi: 10.1038/msb.2011.47.


Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

Pathak TP, Gligorich KM, Welm BE, Sigman MS.

J Am Chem Soc. 2010 Jun 16;132(23):7870-1. doi: 10.1021/ja103472a.


Use of stem cell markers in dissociated mammary populations.

Shelton DN, Fernandez-Gonzalez R, Illa-Bochaca I, Ortiz-de-Solorzano C, Barcellos-Hoff MH, Welm BE.

Methods Mol Biol. 2010;621:49-55. doi: 10.1007/978-1-60761-063-2_3.


Limiting-dilution transplantation assays in mammary stem cell studies.

Illa-Bochaca I, Fernandez-Gonzalez R, Shelton DN, Welm BE, Ortiz-de-Solorzano C, Barcellos-Hoff MH.

Methods Mol Biol. 2010;621:29-47. doi: 10.1007/978-1-60761-063-2_2.


In situ analysis of cell populations: long-term label-retaining cells.

Fernandez-Gonzalez R, Illa-Bochaca I, Shelton DN, Welm BE, Barcellos-Hoff MH, Ortiz-de-Solorzano C.

Methods Mol Biol. 2010;621:1-28. doi: 10.1007/978-1-60761-063-2_1.


Mapping mammary gland architecture using multi-scale in situ analysis.

Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH.

Integr Biol (Camb). 2009 Jan;1(1):80-9. doi: 10.1039/b816933k. Epub 2008 Dec 5.


Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.

Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z.

Dis Model Mech. 2008 Sep-Oct;1(2-3):155-67; discussion 165. doi: 10.1242/dmm.000596. Epub 2008 Sep 18.


Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z.

Cell Stem Cell. 2008 Jan 10;2(1):90-102. doi: 10.1016/j.stem.2007.10.002.


MET and MYC cooperate in mammary tumorigenesis.

Welm AL, Kim S, Welm BE, Bishop JM.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4324-9. Epub 2005 Feb 28.


Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice.

Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittmann M, Greenberg NM, Spencer DM.

Cancer Res. 2003 Dec 1;63(23):8256-63.


An inducible system for the study of FGF signalling in early amphibian development.

Pownall ME, Welm BE, Freeman KW, Spencer DM, Rosen JM, Isaacs HV.

Dev Biol. 2003 Apr 1;256(1):89-99.


Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.

Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM.

J Cell Biol. 2002 May 13;157(4):703-14. Epub 2002 May 13.


Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA.

Dev Biol. 2002 May 1;245(1):42-56.

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