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Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression.

Kushner MH, Ory V, Graham GT, Sharif GM, Kietzman WB, Thevissen S, Yuan M, Schmidt MO, Wellstein A, Riegel AT.

EMBO Rep. 2020 Jan 7;21(1):e48741. doi: 10.15252/embr.201948741. Epub 2019 Dec 2.


Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer.

Kietzman WB, Graham GT, Ory V, Sharif GM, Kushner MH, Gallanis GT, Kallakury B, Wellstein A, Riegel AT.

Mol Cancer Ther. 2019 Dec;18(12):2220-2232. doi: 10.1158/1535-7163.MCT-19-0231. Epub 2019 Aug 26.


Depletion of the Transcriptional Coactivator Amplified in Breast Cancer 1 (AIB1) Uncovers Functionally Distinct Subpopulations in Triple-Negative Breast Cancer.

Saenz FR, Ory V, Schmidt MO, Kallakury BV, Mueller SC, Furth PA, Wellstein A, Riegel AT.

Neoplasia. 2019 Oct;21(10):963-973. doi: 10.1016/j.neo.2019.07.001. Epub 2019 Aug 19.


Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations.

Deslattes Mays A, Schmidt M, Graham G, Tseng E, Baybayan P, Sebra R, Sanda M, Mazarati JB, Riegel A, Wellstein A.

Genes (Basel). 2019 Mar 27;10(4). pii: E253. doi: 10.3390/genes10040253.


Reprint of: Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer.

Vietsch EE, Graham GT, McCutcheon JN, Javaid A, Giaccone G, Marshall JL, Wellstein A.

Cancer Genet. 2018 Dec;228-229:131-142. doi: 10.1016/j.cancergen.2018.11.001. Epub 2018 Nov 9.


Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism.

Tassi E, Garman KA, Schmidt MO, Ma X, Kabbara KW, Uren A, Tomita Y, Goetz R, Mohammadi M, Wilcox CS, Riegel AT, Carlstrom M, Wellstein A.

Sci Rep. 2018 Oct 29;8(1):15973. doi: 10.1038/s41598-018-34238-5.


High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Li L, Lai EY, Luo Z, Solis G, Mendonca M, Griendling KK, Wellstein A, Welch WJ, Wilcox CS.

Hypertension. 2018 Nov;72(5):1208-1216. doi: 10.1161/HYPERTENSIONAHA.118.11354.


Fenofibrate improves vascular endothelial function and contractility in diabetic mice.

Xu N, Wang Q, Jiang S, Wang Q, Hu W, Zhou S, Zhao L, Xie L, Chen J, Wellstein A, Lai EY.

Redox Biol. 2019 Jan;20:87-97. doi: 10.1016/j.redox.2018.09.024. Epub 2018 Oct 1.


Left Ventricular Dysfunction in Cancer Treatment: Is it Relevant?

Kenigsberg B, Wellstein A, Barac A.

JACC Heart Fail. 2018 Feb;6(2):87-95. doi: 10.1016/j.jchf.2017.08.024. Epub 2017 Dec 1. Review.


The PPARγ agonist efatutazone delays invasive progression and induces differentiation of ductal carcinoma in situ.

Ory V, Kietzman WB, Boeckelman J, Kallakury BV, Wellstein A, Furth PA, Riegel AT.

Breast Cancer Res Treat. 2018 May;169(1):47-57. doi: 10.1007/s10549-017-4649-y. Epub 2018 Jan 19.


NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion.

Wang C, Luo Z, Carter G, Wellstein A, Jose PA, Tomlinson J, Leiper J, Welch WJ, Wilcox CS, Wang D.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R399-R406. doi: 10.1152/ajpregu.00122.2017. Epub 2017 Nov 22.


Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).

Tassi E, Lai EY, Li L, Solis G, Chen Y, Kietzman WE, Ray PE, Riegel AT, Welch WJ, Wilcox CS, Wellstein A.

Hypertension. 2018 Jan;71(1):160-167. doi: 10.1161/HYPERTENSIONAHA.117.10268. Epub 2017 Nov 20.


Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer.

Vietsch EE, Graham GT, McCutcheon JN, Javaid A, Giaccone G, Marshall JL, Wellstein A.

Cancer Genet. 2017 Dec;218-219:39-50. doi: 10.1016/j.cancergen.2017.08.006. Epub 2017 Sep 14.


Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.

Shivapurkar N, Vietsch EE, Carney E, Isaacs C, Wellstein A.

Clin Transl Med. 2017 Oct 4;6(1):37. doi: 10.1186/s40169-017-0169-y.


Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses.

Giamanco NM, Jee YH, Wellstein A, Shriver CD, Summers TA, Baron J.

Cancer Biomark. 2017 Sep 7;20(3):299-307. doi: 10.3233/CBM-170145.


The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.

Schmidt MO, Garman KA, Lee YG, Zuo C, Beck PJ, Tan M, Aguilar-Pimentel JA, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de Angelis M; German Mouse Clinic Consortium, Tassi E, Riegel AT, Wellstein A.

J Invest Dermatol. 2018 Jan;138(1):179-188. doi: 10.1016/j.jid.2017.07.847. Epub 2017 Aug 31.


Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.

Suprynowicz FA, Kamonjoh CM, Krawczyk E, Agarwal S, Wellstein A, Agboke FA, Choudhury S, Liu X, Schlegel R.

PLoS One. 2017 Jul 10;12(7):e0180897. doi: 10.1371/journal.pone.0180897. eCollection 2017.


Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.

Li L, Lai EY, Luo Z, Solis G, Griendling KK, Taylor WR, Jose PA, Wellstein A, Welch WJ, Wilcox CS.

Kidney Int. 2017 Sep;92(3):625-633. doi: 10.1016/j.kint.2017.02.009. Epub 2017 Apr 7. Erratum in: Kidney Int. 2017 Dec;92(6):1558.


Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio).

Berens EB, Sharif GM, Wellstein A, Glasgow E.

J Vis Exp. 2016 Nov 3;(117). doi: 10.3791/55007.


Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion.

Berens EB, Sharif GM, Schmidt MO, Yan G, Shuptrine CW, Weiner LM, Glasgow E, Riegel AT, Wellstein A.

Oncogene. 2017 Feb 2;36(5):593-605. doi: 10.1038/onc.2016.234. Epub 2016 Jul 4.


Circulating biomarkers to monitor cancer progression and treatment.

Rapisuwon S, Vietsch EE, Wellstein A.

Comput Struct Biotechnol J. 2016 Jun 1;14:211-22. doi: 10.1016/j.csbj.2016.05.004. eCollection 2016. Review.


Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies.

Jee YH, Lebenthal Y, Chaemsaithong P, Yan G, Peran I, Wellstein A, Romero R, Baron J.

PLoS One. 2016 Apr 18;11(4):e0153325. doi: 10.1371/journal.pone.0153325. eCollection 2016.


Differential effects of superoxide and hydrogen peroxide on myogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles.

Li L, Lai EY, Wellstein A, Welch WJ, Wilcox CS.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1197-205. doi: 10.1152/ajprenal.00575.2015. Epub 2016 Apr 6.


Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer.

Tian X, Shivapurkar N, Wu Z, Hwang JJ, Pishvaian MJ, Weiner LM, Ley L, Zhou D, Zhi X, Wellstein A, Marshall JL, He AR.

Oncol Lett. 2016 Mar;11(3):1645-1650. Epub 2016 Jan 13.


Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer.

Jee YH, Sadowski SM, Celi FS, Xi L, Raffeld M, Sacks DB, Remaley AT, Wellstein A, Kebebew E, Baron J.

PLoS One. 2016 Feb 25;11(2):e0149383. doi: 10.1371/journal.pone.0149383. eCollection 2016.


A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting.

Berens EB, Holy JM, Riegel AT, Wellstein A.

J Vis Exp. 2015 Nov 20;(105). doi: 10.3791/53409.


Cell density regulates cancer metastasis via the Hippo pathway.

Sharif GM, Wellstein A.

Future Oncol. 2015;11(24):3253-60. doi: 10.2217/fon.15.268. Epub 2015 Nov 12. Review.


Circulating DNA and Micro-RNA in Patients with Pancreatic Cancer.

Vietsch EE, van Eijck CH, Wellstein A.

Pancreat Disord Ther. 2015 Jun;5(2). pii: 156.


Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma.

LaConti JJ, Laiakis EC, Mays AD, Peran I, Kim SE, Shay JW, Riegel AT, Fornace AJ Jr, Wellstein A.

BMC Genomics. 2015;16 Suppl 1:S1. doi: 10.1186/1471-2164-16-S1-S1. Epub 2015 Jan 15.


Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.

Sharif GM, Schmidt MO, Yi C, Hu Z, Haddad BR, Glasgow E, Riegel AT, Wellstein A.

Oncogene. 2015 Nov 26;34(48):5879-89. doi: 10.1038/onc.2015.44. Epub 2015 Mar 16.


Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease.

Wang C, Luo Z, Kohan D, Wellstein A, Jose PA, Welch WJ, Wilcox CS, Wang D.

Hypertension. 2015 May;65(5):1055-63. doi: 10.1161/HYPERTENSIONAHA.115.05244. Epub 2015 Mar 2.


Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.

Ray PE, Al-Attar A, Liu XH, Das JR, Tassi E, Wellstein A.

J AIDS Clin Res. 2014 Jun;5(6). pii: 309.


Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype.

Saenz FR, Ory V, AlOtaiby M, Rosenfield S, Furlong M, Cavalli LR, Johnson MD, Liu X, Schlegel R, Wellstein A, Riegel AT.

PLoS One. 2014 May 15;9(5):e97666. doi: 10.1371/journal.pone.0097666. eCollection 2014.


Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.

Zhang W, Nandakumar N, Shi Y, Manzano M, Smith A, Graham G, Gupta S, Vietsch EE, Laughlin SZ, Wadhwa M, Chetram M, Joshi M, Wang F, Kallakury B, Toretsky J, Wellstein A, Yi C.

Sci Signal. 2014 May 6;7(324):ra42. doi: 10.1126/scisignal.2005049.


SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

Kolukula VK, Sahu G, Wellstein A, Rodriguez OC, Preet A, Iacobazzi V, D'Orazi G, Albanese C, Palmieri F, Avantaggiati ML.

Oncotarget. 2014 Mar 15;5(5):1212-25.


Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex.

Garee JP, Chien CD, Li JV, Wellstein A, Riegel AT.

Mol Endocrinol. 2014 Jun;28(6):846-59. doi: 10.1210/me.2013-1379. Epub 2014 Mar 28.


Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs.

Shivapurkar N, Weiner LM, Marshall JL, Madhavan S, Deslattes Mays A, Juhl H, Wellstein A.

PLoS One. 2014 Jan 6;9(1):e84686. doi: 10.1371/journal.pone.0084686. eCollection 2014. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/86f9cc5c-58b7-4c07-8742-c3036c13e73a.


Utility of a human-mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing.

Shanmugam VK, Tassi E, Schmidt MO, McNish S, Baker S, Attinger C, Wang H, Shara N, Wellstein A.

Int Wound J. 2015 Dec;12(6):699-705. doi: 10.1111/iwj.12205. Epub 2013 Dec 23.


Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) study.

Shanmugam VK, McNish S, Duncan J, Root B, Tassi E, Wellstein A, Kallakury B, Attinger CE.

Int Wound J. 2015 Oct;12(5):537-44. doi: 10.1111/iwj.12156. Epub 2013 Sep 13.


The nuclear coactivator amplified in breast cancer 1 maintains tumor-initiating cells during development of ductal carcinoma in situ.

Ory V, Tassi E, Cavalli LR, Sharif GM, Saenz F, Baker T, Schmidt MO, Mueller SC, Furth PA, Wellstein A, Riegel AT.

Oncogene. 2014 Jun 5;33(23):3033-42. doi: 10.1038/onc.2013.263. Epub 2013 Jul 15.


Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells.

Li JV, Chien CD, Garee JP, Xu J, Wellstein A, Riegel AT.

Mol Endocrinol. 2013 Jul;27(7):1113-27. doi: 10.1210/me.2012-1353. Epub 2013 May 9.


ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers.

Wellstein A.

Front Oncol. 2012 Dec 19;2:192. doi: 10.3389/fonc.2012.00192. eCollection 2012.


Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy.

Rodriguez OC, Choudhury S, Kolukula V, Vietsch EE, Catania J, Preet A, Reynoso K, Bargonetti J, Wellstein A, Albanese C, Avantaggiati ML.

Cell Cycle. 2012 Dec 1;11(23):4436-46. doi: 10.4161/cc.22778. Epub 2012 Nov 14.


The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML.

Oncotarget. 2012 Oct;3(10):1220-35.


Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells.

Rosenfield SM, Bowden ET, Cohen-Missner S, Gibby KA, Ory V, Henke RT, Riegel AT, Wellstein A.

PLoS One. 2012;7(10):e47876. doi: 10.1371/journal.pone.0047876. Epub 2012 Oct 15.


Decrease in blood miR-296 predicts chemotherapy resistance and poor clinical outcome in patients receiving systemic chemotherapy for metastatic colon cancer.

Shivapurkar N, Mikhail S, Navarro R, Bai W, Marshall J, Hwang J, Pishvaian M, Wellstein A, He AR.

Int J Colorectal Dis. 2013 Jun;28(6):887. doi: 10.1007/s00384-012-1560-1. Epub 2012 Aug 15. No abstract available.


Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.

Lai EY, Luo Z, Onozato ML, Rudolph EH, Solis G, Jose PA, Wellstein A, Aslam S, Quinn MT, Griendling K, Le T, Li P, Palm F, Welch WJ, Wilcox CS.

Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F64-74. doi: 10.1152/ajprenal.00005.2012. Epub 2012 Apr 4.


Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing.

Al-Otaiby M, Tassi E, Schmidt MO, Chien CD, Baker T, Salas AG, Xu J, Furlong M, Schlegel R, Riegel AT, Wellstein A.

Am J Pathol. 2012 Apr;180(4):1474-84. doi: 10.1016/j.ajpath.2011.12.032. Epub 2012 Feb 14.


p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.

Lai EY, Solis G, Luo Z, Carlstrom M, Sandberg K, Holland S, Wellstein A, Welch WJ, Wilcox CS.

Hypertension. 2012 Feb;59(2):415-20. doi: 10.1161/HYPERTENSIONAHA.111.184291. Epub 2011 Dec 19.


Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing.

Tassi E, McDonnell K, Gibby KA, Tilan JU, Kim SE, Kodack DP, Schmidt MO, Sharif GM, Wilcox CS, Welch WJ, Gallicano GI, Johnson MD, Riegel AT, Wellstein A.

Am J Pathol. 2011 Nov;179(5):2220-32. doi: 10.1016/j.ajpath.2011.07.043. Epub 2011 Sep 21.

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