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Realizing the "40 by 2022" Commitment from the United Nations High-Level Meeting on the Fight to End Tuberculosis: What Will It Take to Meet Rapid Diagnostic Testing Needs?

Piatek AS, Wells WA, Shen KC, Colvin CE.

Glob Health Sci Pract. 2019 Dec 23;7(4):551-563. doi: 10.9745/GHSP-D-19-00244. Print 2019 Dec 23.


Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells.

Lupien LE, Bloch K, Dehairs J, Traphagen NA, Feng WW, Dennis T, Davis WL, Swinnen JV, Wells WA, Smits NC, Kuemmerle NB, Miller TW, Kinlaw WB 3rd.

J Lipid Res. 2019 Dec 5. pii: jlr.RA119000327. doi: 10.1194/jlr.RA119000327. [Epub ahead of print]


Meet the patients where they are: A greater ambition for private provider engagement for TB.

Wells WA, Stallworthy G.

J Clin Tuberc Other Mycobact Dis. 2018 Dec 27;14:14-15. doi: 10.1016/j.jctube.2018.12.002. eCollection 2019 Feb. No abstract available.


Guidance for Studies Evaluating the Accuracy of Sputum-Based Tests to Diagnose Tuberculosis.

Schumacher SG, Wells WA, Nicol MP, Steingart KR, Theron G, Dorman SE, Pai M, Churchyard G, Scott L, Stevens W, Nabeta P, Alland D, Weyer K, Denkinger CM, Gilpin C.

J Infect Dis. 2019 Oct 8;220(Supplement_3):S99-S107. doi: 10.1093/infdis/jiz258.


Guidance for the Evaluation of Tuberculosis Diagnostics That Meet the World Health Organization (WHO) Target Product Profiles: An Introduction to WHO Process and Study Design Principles.

Denkinger CM, Schumacher SG, Gilpin C, Korobitsyn A, Wells WA, Pai M, Leeflang M, Steingart KR, Bulterys M, Schünemann H, Glaziou P, Weyer K.

J Infect Dis. 2019 Oct 8;220(Supplement_3):S91-S98. doi: 10.1093/infdis/jiz097.


Structured light imaging for breast-conserving surgery, part II: texture analysis and classification.

Streeter SS, Maloney BW, McClatchy DM, Jermyn M, Pogue BW, Rizzo EJ, Wells WA, Paulsen KD.

J Biomed Opt. 2019 Sep;24(9):1-12. doi: 10.1117/1.JBO.24.9.096003.


Structured light imaging for breast-conserving surgery, part I: optical scatter and color analysis.

Maloney BW, Streeter SS, McClatchy DM, Pogue BW, Rizzo EJ, Wells WA, Paulsen KD.

J Biomed Opt. 2019 Sep;24(9):1-8. doi: 10.1117/1.JBO.24.9.096002.


Avoiding false economies: paying for community tuberculosis outcomes.

Wells WA.

Public Health Action. 2019 Jun 21;9(2):49. doi: 10.5588/pha.19.0030. No abstract available.


A Randomized Prospective Trial of Supine MRI-Guided Versus Wire-Localized Lumpectomy for Breast Cancer.

Barth RJ Jr, Krishnaswamy V, Paulsen KD, Rooney TB, Wells WA, Angeles CV, Zuurbier RA, Rosenkranz K, Poplack S, Tosteson TD.

Ann Surg Oncol. 2019 Oct;26(10):3099-3108. doi: 10.1245/s10434-019-07531-4. Epub 2019 Jul 29.


Diagnostic and prognostic value of glucose transporters in melanocytic lesions.

Ruby KN, Liu CL, Li Z, Felty CC, Wells WA, Yan S.

Melanoma Res. 2019 Dec;29(6):603-611. doi: 10.1097/CMR.0000000000000626.


Scale and Ambition in the Engagement of Private Providers for Tuberculosis Care and Prevention.

Wells WA.

Glob Health Sci Pract. 2019 Mar 29;7(1):3-5. doi: 10.9745/GHSP-D-19-00074. Print 2019 Mar 22. No abstract available.


In Vivo and Ex Vivo Microscopy: A Business Plan to Justify the Introduction of Similar Emerging Technologies Into Pathology Practice.

Wells WA, Harhen MT, Thrall MJ, Shevchuk MM, Tearney GJ, Hariri LP.

Arch Pathol Lab Med. 2019 Mar;143(3):299-304. doi: 10.5858/arpa.2018-0375-RA. Epub 2018 Dec 10.


In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice.

Wells WA, Thrall M, Sorokina A, Fine J, Krishnamurthy S, Haroon A, Rao B, Shevchuk MM, Wolfsen HC, Tearney GJ, Hariri LP.

Arch Pathol Lab Med. 2019 Mar;143(3):288-298. doi: 10.5858/arpa.2018-0298-RA. Epub 2018 Dec 10. Review.


How tuberculosis programs can navigate the world of social health insurance.

Wells WA, Stallworthy G, Balsara Z.

Int J Tuberc Lung Dis. 2019 Jan 1;23(1):26-37. doi: 10.5588/ijtld.18.0289. Epub 2018 Nov 13. Review.


Ductal Carcinoma in Situ Biomarkers in a Precision Medicine Era: Current and Future Molecular-Based Testing.

Shee K, Muller KE, Marotti J, Miller TW, Wells WA, Tsongalis GJ.

Am J Pathol. 2019 May;189(5):956-965. doi: 10.1016/j.ajpath.2018.08.020. Epub 2018 Oct 29. Review.


Review of methods for intraoperative margin detection for breast conserving surgery.

Maloney BW, McClatchy DM, Pogue BW, Paulsen KD, Wells WA, Barth RJ.

J Biomed Opt. 2018 Oct;23(10):1-19. doi: 10.1117/1.JBO.23.10.100901. Review.


Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue.

McClatchy DM, Rizzo EJ, Wells WA, Black CC, Paulsen KD, Kanick SC, Pogue BW.

J Biomed Opt. 2018 Sep;24(7):1-11. doi: 10.1117/1.JBO.24.7.071605.


Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology.

McClatchy DM 3rd, Zuurbier RA, Wells WA, Paulsen KD, Pogue BW.

Breast Cancer Res Treat. 2018 Dec;172(3):587-595. doi: 10.1007/s10549-018-4951-3. Epub 2018 Sep 17.


Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study.

Zignol M, Cabibbe AM, Dean AS, Glaziou P, Alikhanova N, Ama C, Andres S, Barbova A, Borbe-Reyes A, Chin DP, Cirillo DM, Colvin C, Dadu A, Dreyer A, Driesen M, Gilpin C, Hasan R, Hasan Z, Hoffner S, Hussain A, Ismail N, Kamal SMM, Khanzada FM, Kimerling M, Kohl TA, Mansjö M, Miotto P, Mukadi YD, Mvusi L, Niemann S, Omar SV, Rigouts L, Schito M, Sela I, Seyfaddinova M, Skenders G, Skrahina A, Tahseen S, Wells WA, Zhurilo A, Weyer K, Floyd K, Raviglione MC.

Lancet Infect Dis. 2018 Jun;18(6):675-683. doi: 10.1016/S1473-3099(18)30073-2. Epub 2018 Mar 21. Erratum in: Lancet Infect Dis. 2018 Mar 27;:.


Calibration and analysis of a multimodal micro-CT and structured light imaging system for the evaluation of excised breast tissue.

McClatchy DM, Rizzo EJ, Meganck J, Kempner J, Vicory J, Wells WA, Paulsen KD, Pogue BW.

Phys Med Biol. 2017 Nov 10;62(23):8983-9000. doi: 10.1088/1361-6560/aa94b6.


Onions and prevalence surveys: how to analyze and quantify tuberculosis case-finding gaps.

Wells WA.

Int J Tuberc Lung Dis. 2017 Nov 1;21(11):1101-1113. doi: 10.5588/ijtld.17.0271.


A Patient-Specific 3D-Printed Form Accurately Transfers Supine MRI-Derived Tumor Localization Information to Guide Breast-Conserving Surgery.

Barth RJ Jr, Krishnaswamy V, Paulsen KD, Rooney TB, Wells WA, Rizzo E, Angeles CV, Marotti JD, Zuurbier RA, Black CC.

Ann Surg Oncol. 2017 Oct;24(10):2950-2956. doi: 10.1245/s10434-017-5979-z. Epub 2017 Aug 1.


Triple-Negative Breast Cancer: Next-Generation Sequencing for Target Identification.

Marotti JD, de Abreu FB, Wells WA, Tsongalis GJ.

Am J Pathol. 2017 Oct;187(10):2133-2138. doi: 10.1016/j.ajpath.2017.05.018. Epub 2017 Jul 20. Review.


Reviewing the Evidence to Guide Clinical Care: Proliferative Breast Lesions in Breast Reduction Specimens.

Akintayo RM, Rosenkranz KM, Wells WA, Ridgway EB.

Ann Plast Surg. 2017 Oct;79(4):410-414. doi: 10.1097/SAP.0000000000001102. Review.


Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis.

Gomez GB, Dowdy DW, Bastos ML, Zwerling A, Sweeney S, Foster N, Trajman A, Islam MA, Kapiga S, Sinanovic E, Knight GM, White RG, Wells WA, Cobelens FG, Vassall A.

BMC Infect Dis. 2016 Dec 1;16(1):726.


Mandatory tuberculosis case notification in high tuberculosis-incidence countries: policy and practice.

Uplekar M, Atre S, Wells WA, Weil D, Lopez R, Migliori GB, Raviglione M.

Eur Respir J. 2016 Dec;48(6):1571-1581. doi: 10.1183/13993003.00956-2016. Epub 2016 Oct 20. Review.


Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging.

McClatchy DM 3rd, Rizzo EJ, Wells WA, Cheney PP, Hwang JC, Paulsen KD, Pogue BW, Kanick SC.

Optica. 2016 Jun 20;3(6):613-621. Epub 2016 Jun 9.


Somatic gene mutation analysis of triple negative breast cancers.

Dillon JL, Mockus SM, Ananda G, Spotlow V, Wells WA, Tsongalis GJ, Marotti JD.

Breast. 2016 Oct;29:202-7. doi: 10.1016/j.breast.2016.06.018. Epub 2016 Jul 7.


Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project.

Zignol M, Dean AS, Alikhanova N, Andres S, Cabibbe AM, Cirillo DM, Dadu A, Dreyer A, Driesen M, Gilpin C, Hasan R, Hasan Z, Hoffner S, Husain A, Hussain A, Ismail N, Kamal M, Mansjö M, Mvusi L, Niemann S, Omar SV, Qadeer E, Rigouts L, Ruesch-Gerdes S, Schito M, Seyfaddinova M, Skrahina A, Tahseen S, Wells WA, Mukadi YD, Kimerling M, Floyd K, Weyer K, Raviglione MC.

Lancet Infect Dis. 2016 Oct;16(10):1185-1192. doi: 10.1016/S1473-3099(16)30190-6. Epub 2016 Jul 7.


Diagnostic and Prognostic Value of ProEx C and GLUT1 in Melanocytic Lesions.

Yan S, Coffing BN, Li Z, Xie H, Brennick JB, Beg HA, Froehlich HM, Wells WA.

Anticancer Res. 2016 Jun;36(6):2871-80.


Effective quality management practices in routine clinical next-generation sequencing.

de Abreu FB, Peterson JD, Amos CI, Wells WA, Tsongalis GJ.

Clin Chem Lab Med. 2016 May;54(5):761-71. doi: 10.1515/cclm-2015-1190.


Shortened first-line TB treatment in Brazil: potential cost savings for patients and health services.

Trajman A, Bastos ML, Belo M, Calaça J, Gaspar J, Dos Santos AM, Dos Santos CM, Brito RT, Wells WA, Cobelens FG, Vassall A, Gomez GB.

BMC Health Serv Res. 2016 Jan 22;16:27. doi: 10.1186/s12913-016-1269-x.


The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa.

Knight GM, Gomez GB, Dodd PJ, Dowdy D, Zwerling A, Wells WA, Cobelens F, Vassall A, White RG.

PLoS One. 2015 Dec 30;10(12):e0145796. doi: 10.1371/journal.pone.0145796. eCollection 2015.


Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas.

Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, Freemantle SJ, Dmitrovsky E.

BMC Cancer. 2015 Nov 10;15:886. doi: 10.1186/s12885-015-1883-8.


Achieving Systemic and Scalable Private Sector Engagement in Tuberculosis Care and Prevention in Asia.

Wells WA, Uplekar M, Pai M.

PLoS Med. 2015 Jun 23;12(6):e1001842. doi: 10.1371/journal.pmed.1001842. eCollection 2015 Jun. No abstract available.


A Pilot Study of Ultrasound-Guided Cryoablation of Invasive Ductal Carcinomas up to 15 mm With MRI Follow-Up and Subsequent Surgical Resection.

Poplack SP, Levine GM, Henry L, Wells WA, Heinemann FS, Hanna CM, Deneen DR, Tosteson TD, Barth RJ Jr.

AJR Am J Roentgenol. 2015 May;204(5):1100-8. doi: 10.2214/AJR.13.12325.


Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical assessment during breast conserving surgery.

McClatchy DM 3rd, Krishnaswamy V, Kanick SC, Elliott JT, Wells WA, Barth RJ Jr, Paulsen KD, Pogue BW.

J Biomed Opt. 2015 Apr;20(4):040504. doi: 10.1117/1.JBO.20.4.040504.


Breast MRI-detected cystic apocrine metaplasia: imaging features with microvessel analysis and histologic correlation.

diFlorio-Alexander RM, Marotti JD, Bond JS, Schwab MC, Memoli VA, Wells WA, Poplack SP.

AJR Am J Roentgenol. 2015 Jan;204(1):211-8. doi: 10.2214/AJR.14.12869.


Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma.

Muller KE, Tafe LJ, de Abreu FB, Peterson JD, Wells WA, Barth RJ, Marotti JD.

Hum Pathol. 2015 Feb;46(2):327-33. doi: 10.1016/j.humpath.2014.10.014. Epub 2014 Nov 4.


Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.

MacKenzie TA, Schwartz GN, Calderone HM, Graveel CR, Winn ME, Hostetter G, Wells WA, Sempere LF.

Am J Pathol. 2014 Dec;184(12):3217-25. doi: 10.1016/j.ajpath.2014.08.020. Epub 2014 Nov 6.


Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach.

Samkoe KS, Tichauer KM, Gunn JR, Wells WA, Hasan T, Pogue BW.

Cancer Res. 2014 Dec 15;74(24):7465-74. doi: 10.1158/0008-5472.CAN-14-0141. Epub 2014 Oct 24.


Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment.

Jiang S, Pogue BW, Kaufman PA, Gui J, Jermyn M, Frazee TE, Poplack SP, DiFlorio-Alexander R, Wells WA, Paulsen KD.

Clin Cancer Res. 2014 Dec 1;20(23):6006-15. doi: 10.1158/1078-0432.CCR-14-1415. Epub 2014 Oct 7.


Real-time electrical impedance variations in women with and without breast cancer.

Halter RJ, Hartov A, Poplack SP, diFlorio-Alexander R, Wells WA, Rosenkranz KM, Barth RJ, Kaufman PA, Paulsen KD.

IEEE Trans Med Imaging. 2015 Jan;34(1):38-48. doi: 10.1109/TMI.2014.2342719. Epub 2014 Jul 24.


Structured light scatteroscopy.

Krishnaswamy V, Elliott JT, McClatchy DM 3rd, Barth RJ Jr, Wells WA, Pogue BW, Paulsen KD.

J Biomed Opt. 2014;19(7):070504. doi: 10.1117/1.JBO.19.7.070504.


Patient costs during tuberculosis treatment in Bangladesh and Tanzania: the potential of shorter regimens.

Gospodarevskaya E, Tulloch O, Bunga C, Ferdous S, Jonas A, Islam S, Rahman M, Hussain MA, Haque MN, Egwaga S, Gardiner E, PrayGod G, Islam MA, Mann GH, Wells WA, Squire SB.

Int J Tuberc Lung Dis. 2014 Jul;18(7):810-7. doi: 10.5588/ijtld.13.0391.


Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations.

Liu X, Mody K, de Abreu FB, Pipas JM, Peterson JD, Gallagher TL, Suriawinata AA, Ripple GH, Hourdequin KC, Smith KD, Barth RJ Jr, Colacchio TA, Tsapakos MJ, Zaki BI, Gardner TB, Gordon SR, Amos CI, Wells WA, Tsongalis GJ.

Clin Chem. 2014 Jul;60(7):1004-11. doi: 10.1373/clinchem.2014.225565. Epub 2014 May 12.


Personalized therapy for breast cancer.

De Abreu FB, Schwartz GN, Wells WA, Tsongalis GJ.

Clin Genet. 2014 Jul;86(1):62-7. doi: 10.1111/cge.12381. Epub 2014 Apr 9. Review.


Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations.

Tsongalis GJ, Peterson JD, de Abreu FB, Tunkey CD, Gallagher TL, Strausbaugh LD, Wells WA, Amos CI.

Clin Chem Lab Med. 2014 May;52(5):707-14. doi: 10.1515/cclm-2013-0883.


The emerging role of the molecular diagnostics laboratory in breast cancer personalized medicine.

De Abreu FB, Wells WA, Tsongalis GJ.

Am J Pathol. 2013 Oct;183(4):1075-1083. doi: 10.1016/j.ajpath.2013.07.002. Epub 2013 Aug 3. Review.

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