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Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.

van Harten AM, Poell JB, Buijze M, Brink A, Wells SI, René Leemans C, Wolthuis RMF, Brakenhoff RH.

Oral Oncol. 2019 Nov;98:53-61. doi: 10.1016/j.oraloncology.2019.09.004. Epub 2019 Sep 18.


Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.

Toptan T, Brusadelli MG, Turpin B, Witte DP, Surrallés J, Velleuer E, Schramm M, Dietrich R, Brakenhoff RH, Moore PS, Chang Y, Wells SI.

PLoS One. 2018 Dec 27;13(12):e0209235. doi: 10.1371/journal.pone.0209235. eCollection 2018.


The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix.

Nicol AF, de Andrade CV, Gomes SC Jr, Brusadelli MG, Lodin HM, Wells SI, Nuovo GJ.

Ann Diagn Pathol. 2019 Feb;38:115-122. doi: 10.1016/j.anndiagpath.2018.12.001. Epub 2018 Dec 14.


Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.

Trisno SL, Philo KED, McCracken KW, Catá EM, Ruiz-Torres S, Rankin SA, Han L, Nasr T, Chaturvedi P, Rothenberg ME, Mandegar MA, Wells SI, Zorn AM, Wells JM.

Cell Stem Cell. 2018 Oct 4;23(4):501-515.e7. doi: 10.1016/j.stem.2018.08.008. Epub 2018 Sep 20.


New biomarkers of human papillomavirus infection in acute cervical intraepithelial neoplasia.

Nuovo GJ, de Andrade CV, Wells SI, Brusadelli M, Nicol AF.

Ann Diagn Pathol. 2018 Oct;36:21-27. doi: 10.1016/j.anndiagpath.2018.06.008. Epub 2018 Jun 22.


Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy.

Sertorio M, Perentesis JP, Vatner RE, Mascia AE, Zheng Y, Wells SI.

Int J Part Ther. 2018 Summer;5(1):40-48. doi: 10.14338/IJPT-18-00023.1. Epub 2018 Sep 21. Review.


Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.

Matrka MC, Cimperman KA, Haas SR, Guasch G, Ehrman LA, Waclaw RR, Komurov K, Lane A, Wikenheiser-Brokamp KA, Wells SI.

PLoS Genet. 2018 Mar 14;14(3):e1007227. doi: 10.1371/journal.pgen.1007227. eCollection 2018 Mar.


Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells.

Zhao X, Brusadelli MG, Sauter S, Butsch Kovacic M, Zhang W, Romick-Rosendale LE, Lambert PF, Setchell KDR, Wells SI.

Clin Cancer Res. 2018 Jun 1;24(11):2700-2709. doi: 10.1158/1078-0432.CCR-17-3686. Epub 2018 Mar 12.


Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know.

Khoury R, Sauter S, Butsch Kovacic M, Nelson AS, Myers KC, Mehta PA, Davies SM, Wells SI.

Viruses. 2018 Jan 20;10(1). pii: E47. doi: 10.3390/v10010047. Review.


Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.

Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27.


The nuclear DEK interactome supports multi-functionality.

Smith EA, Krumpelbeck EF, Jegga AG, Prell M, Matrka MM, Kappes F, Greis KD, Ali AM, Meetei AR, Wells SI.

Proteins. 2018 Jan;86(1):88-97. doi: 10.1002/prot.25411. Epub 2017 Nov 11.


Antibody response to human papillomavirus vaccination and natural exposure in individuals with Fanconi Anemia.

Mehta PA, Sauter S, Zhang X, Davies SM, Wells SI, Myers KC, Panicker G, Unger ER, Butsch Kovacic M.

Vaccine. 2017 Dec 4;35(48 Pt B):6712-6719. doi: 10.1016/j.vaccine.2017.10.015. Epub 2017 Oct 16.


Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis.

Matrka MC, Watanabe M, Muraleedharan R, Lambert PF, Lane AN, Romick-Rosendale LE, Wells SI.

PLoS One. 2017 May 30;12(5):e0177952. doi: 10.1371/journal.pone.0177952. eCollection 2017.


Impaired immune function in children and adults with Fanconi anemia.

Myers KC, Sauter S, Zhang X, Bleesing JJ, Davies SM, Wells SI, Mehta PA, Kumar A, Marmer D, Marsh R, Brown D, Butsch Kovacic M.

Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26599. Epub 2017 May 30.


DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma.

Smith EA, Kumar B, Komurov K, Smith SM, Brown NV, Zhao S, Kumar P, Teknos TN, Wells SI.

Oncotarget. 2017 Apr 4;8(14):23414-23426. doi: 10.18632/oncotarget.15582.


DEK is required for homologous recombination repair of DNA breaks.

Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI.

Sci Rep. 2017 Mar 20;7:44662. doi: 10.1038/srep44662.


PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.

Koncar RF, Chu Z, Romick-Rosendale LE, Wells SI, Chan TA, Qi X, Bahassi EM.

Oncotarget. 2017 Feb 28;8(9):15827-15837. doi: 10.18632/oncotarget.15015.


Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.

Chlon TM, Ruiz-Torres S, Maag L, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI.

Stem Cell Reports. 2016 Jan 12;6(1):44-54. doi: 10.1016/j.stemcr.2015.12.001.


Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.

Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert PF, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI.

Clin Cancer Res. 2016 Apr 15;22(8):2062-73. doi: 10.1158/1078-0432.CCR-15-2209. Epub 2015 Nov 24.


The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma.

Tuttle TR, Mierzwa ML, Wells SI, Fox SR, Ben-Jonathan N.

Cancer Lett. 2016 Jan 28;370(2):279-85. doi: 10.1016/j.canlet.2015.10.024. Epub 2015 Nov 10.


IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI.

Oncotarget. 2015 Dec 22;6(41):43395-407. doi: 10.18632/oncotarget.6028.


DEK over-expression promotes mitotic defects and micronucleus formation.

Matrka MC, Hennigan RF, Kappes F, DeLay ML, Lambert PF, Aronow BJ, Wells SI.

Cell Cycle. 2015;14(24):3939-53. doi: 10.1080/15384101.2015.1044177. Epub 2015 May 6.


Oral human papillomavirus is common in individuals with Fanconi anemia.

Sauter SL, Wells SI, Zhang X, Hoskins EE, Davies SM, Myers KC, Mueller R, Panicker G, Unger ER, Sivaprasad U, Brown DR, Mehta PA, Butsch Kovacic M.

Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):864-72. doi: 10.1158/1055-9965.EPI-15-0097-T. Epub 2015 Mar 25.


Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.

Lombardi AJ, Hoskins EE, Foglesong GD, Wikenheiser-Brokamp KA, Wiesmüller L, Hanenberg H, Andreassen PR, Jacobs AJ, Olson SB, Keeble WW, Hays LE, Wells SI.

Clin Cancer Res. 2015 Apr 15;21(8):1962-72. doi: 10.1158/1078-0432.CCR-14-2616. Epub 2015 Jan 21.


Human papillomavirus induced transformation in cervical and head and neck cancers.

Adams AK, Wise-Draper TM, Wells SI.

Cancers (Basel). 2014 Sep 15;6(3):1793-820. doi: 10.3390/cancers6031793. Review.


High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.

Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI.

J Virol. 2014 Oct;88(19):11315-26. doi: 10.1128/JVI.01533-14. Epub 2014 Jul 16.


The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.

Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SI.

Oncogene. 2015 Apr 30;34(18):2325-36. doi: 10.1038/onc.2014.173. Epub 2014 Jun 23.


DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.

Adams AK, Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI.

Oncogene. 2015 Feb 12;34(7):868-77. doi: 10.1038/onc.2014.15. Epub 2014 Mar 10.


Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner.

Kim KJ, Godarova A, Seedle K, Kim MH, Ince TA, Wells SI, Driscoll JJ, Godar S.

PLoS One. 2013 Dec 4;8(12):e80590. doi: 10.1371/journal.pone.0080590. eCollection 2013.


A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer.

Bahassi el M, Li YQ, Wise-Draper TM, Deng L, Wang J, Darnell CN, Wilson KM, Wells SI, Stambrook PJ, Rixe O.

Eur J Cancer. 2013 Jul;49(10):2345-55. doi: 10.1016/j.ejca.2013.03.005. Epub 2013 Apr 8.


The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.

Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI.

Mutat Res. 2013 Mar-Apr;743-744:78-88. doi: 10.1016/j.mrfmmm.2013.01.001. Epub 2013 Jan 17. Review.


Stacking the DEK: from chromatin topology to cancer stem cells.

Privette Vinnedge LM, Kappes F, Nassar N, Wells SI.

Cell Cycle. 2013 Jan 1;12(1):51-66. doi: 10.4161/cc.23121. Epub 2012 Dec 19. Review.


The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.

Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells SI.

PLoS One. 2012;7(10):e46985. doi: 10.1371/journal.pone.0046985. Epub 2012 Oct 10.


Future directions and treatment strategies for head and neck squamous cell carcinomas.

Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI.

Transl Res. 2012 Sep;160(3):167-77. doi: 10.1016/j.trsl.2012.02.002. Epub 2012 Feb 28.


The fanconi anemia pathway limits human papillomavirus replication.

Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI.

J Virol. 2012 Aug;86(15):8131-8. doi: 10.1128/JVI.00408-12. Epub 2012 May 23.


Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.

Morrison MA, Morreale RJ, Akunuru S, Kofron M, Zheng Y, Wells SI.

J Virol. 2011 Oct;85(20):10487-98. doi: 10.1128/JVI.05126-11. Epub 2011 Aug 10.


The human DEK oncogene regulates DNA damage response signaling and repair.

Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmüller L, Wells SI.

Nucleic Acids Res. 2011 Sep 1;39(17):7465-76. doi: 10.1093/nar/gkr454. Epub 2011 Jun 7.


Impaired immune function in children with Fanconi anaemia.

Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, Harris RE, Filipovich AH, Kovacic MB, Wells SI, Mehta PA.

Br J Haematol. 2011 Jul;154(2):234-40. doi: 10.1111/j.1365-2141.2011.08721.x. Epub 2011 May 4.


The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.

Privette Vinnedge LM, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE, Wells SI.

Oncogene. 2011 Jun 16;30(24):2741-52. doi: 10.1038/onc.2011.2. Epub 2011 Feb 14.


Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.

Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM.

Nature. 2011 Feb 3;470(7332):105-9. doi: 10.1038/nature09691. Epub 2010 Dec 12.


Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus.

Wald AI, Hoskins EE, Wells SI, Ferris RL, Khan SA.

Head Neck. 2011 Apr;33(4):504-12. doi: 10.1002/hed.21475.


Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.

Meyer SE, Peace BE, Bahassi el M, Kavanaugh GM, Wagh PK, Robbins SB, Yin M, Wells SI, Zinser GM, Stambrook PJ, Waltz SE.

Cancer Lett. 2010 Oct 28;296(2):186-93. doi: 10.1016/j.canlet.2010.04.011.


Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME.

J Immunol. 2010 Apr 1;184(7):4033-41. doi: 10.4049/jimmunol.0903069. Epub 2010 Mar 5.


Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.

Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S.

Cancer Res. 2009 Sep 1;69(17):7022-9. doi: 10.1158/0008-5472.CAN-09-0925. Epub 2009 Aug 25.


Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.

Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI.

Cancer Res. 2009 Mar 1;69(5):1792-9. doi: 10.1158/0008-5472.CAN-08-2304. Epub 2009 Feb 17.


HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.

Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S.

Cancer Res. 2008 Dec 1;68(23):9954-63. doi: 10.1158/0008-5472.CAN-08-0224.


DEK proto-oncogene expression interferes with the normal epithelial differentiation program.

Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI.

Am J Pathol. 2009 Jan;174(1):71-81. doi: 10.2353/ajpath.2009.080330. Epub 2008 Nov 26.


Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.

Hoskins EE, Morris TA, Higginbotham JM, Spardy N, Cha E, Kelly P, Williams DA, Wikenheiser-Brokamp KA, Duensing S, Wells SI.

Oncogene. 2009 Feb 5;28(5):674-85. doi: 10.1038/onc.2008.416. Epub 2008 Nov 17.


Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines.

Bourgo RJ, Braden WA, Wells SI, Knudsen ES.

Mol Carcinog. 2009 Jan;48(1):45-55. doi: 10.1002/mc.20456.

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