Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 151

1.

DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.

Loniewska MM, Gupta A, Bhatia S, MacKay-Clackett I, Jia Z, Wells PG.

Redox Biol. 2019 Sep 18;28:101332. doi: 10.1016/j.redox.2019.101332. [Epub ahead of print]

2.
3.

Western Analysis of Breast Cancer 1 Protein (BRCA1).

Drake DM, Wells PG.

Methods Mol Biol. 2019;1965:351-374. doi: 10.1007/978-1-4939-9182-2_23.

PMID:
31069686
4.
5.

Measurement of the Oxidative DNA Lesion 8-Oxoguanine (8-oxoG) by ELISA or by High-Performance Liquid Chromatography (HPLC) with Electrochemical Detection.

Drake DM, Shapiro AM, Wells PG.

Methods Mol Biol. 2019;1965:313-328. doi: 10.1007/978-1-4939-9182-2_21.

PMID:
31069684
6.

Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders.

Bhatia S, Drake DM, Miller L, Wells PG.

Birth Defects Res. 2019 Jul 15;111(12):714-748. doi: 10.1002/bdr2.1509. Epub 2019 Apr 29. Review.

PMID:
31033255
7.

A new target for thalidomide.

Wells PG.

Nat Chem Biol. 2018 Oct;14(10):904-905. doi: 10.1038/s41589-018-0134-0. No abstract available.

PMID:
30224691
8.

Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer.

Dunne M, Dou YN, Drake DM, Spence T, Gontijo SML, Wells PG, Allen C.

J Control Release. 2018 Jul 28;282:35-45. doi: 10.1016/j.jconrel.2018.04.029. Epub 2018 Apr 16.

PMID:
29673642
9.

The Gulfwatch contaminants monitoring program in the Gulf of Maine: Are its data being used for ocean protection, with special reference to Nova Scotia, Canada?

Chamberlain SD, Wells PG, MacDonald BH.

Mar Pollut Bull. 2018 Feb;127:781-787. doi: 10.1016/j.marpolbul.2017.09.050. Epub 2017 Oct 3.

PMID:
28986110
10.

The iconic Torrey Canyon oil spill of 1967 - Marking its legacy.

Wells PG.

Mar Pollut Bull. 2017 Feb 15;115(1-2):1-2. doi: 10.1016/j.marpolbul.2016.12.013. Epub 2016 Dec 13.

PMID:
27979617
11.

Response to comments by White and colleagues.

Sweeting JN, Wells PG.

Reprod Toxicol. 2016 Dec;66:126-127. doi: 10.1016/j.reprotox.2016.08.013. Epub 2016 Aug 28. No abstract available.

PMID:
27581322
12.

Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine.

Wells PG, Bhatia S, Drake DM, Miller-Pinsler L.

Birth Defects Res C Embryo Today. 2016 Jun;108(2):108-30. doi: 10.1002/bdrc.21134. Review.

PMID:
27345013
13.

Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies.

Shapiro AM, Miller-Pinsler L, Wells PG.

Redox Biol. 2016 Apr;7:30-38. doi: 10.1016/j.redox.2015.11.005. Epub 2015 Nov 18.

14.

Methamphetamine oxidative stress, neurotoxicity, and functional deficits are modulated by nuclear factor-E2-related factor 2.

Ramkissoon A, Wells PG.

Free Radic Biol Med. 2015 Dec;89:358-68. doi: 10.1016/j.freeradbiomed.2015.07.157. Epub 2015 Sep 30.

PMID:
26427884
15.

New Zealand white rabbit progeny exposed in utero to methanol are resistant to skeletal anomalies reported for rodents, but exhibit a novel vertebral defect.

Sweeting JN, Wells PG.

Reprod Toxicol. 2015 Dec;58:104-10. doi: 10.1016/j.reprotox.2015.09.004. Epub 2015 Sep 21.

PMID:
26393277
16.

Embryonic catalase protects against ethanol embryopathies in acatalasemic mice and transgenic human catalase-expressing mice in embryo culture.

Miller-Pinsler L, Wells PG.

Toxicol Appl Pharmacol. 2015 Sep 15;287(3):232-9. doi: 10.1016/j.taap.2015.06.007. Epub 2015 Jun 11.

PMID:
26074427
17.

Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture.

Miller-Pinsler L, Sharma A, Wells PG.

Arch Toxicol. 2016 Mar;90(3):717-30. doi: 10.1007/s00204-015-1482-0. Epub 2015 Mar 1.

PMID:
25726414
18.

Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent.

Miller-Pinsler L, Wells PG.

Arch Toxicol. 2016 Feb;90(2):415-25. doi: 10.1007/s00204-014-1397-1. Epub 2014 Oct 30.

PMID:
25354798
19.

Oxidative DNA damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice.

Miller-Pinsler L, Pinto DJ, Wells PG.

Free Radic Biol Med. 2015 Jan;78:23-9. doi: 10.1016/j.freeradbiomed.2014.09.026. Epub 2014 Oct 13.

PMID:
25311828
20.

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.

Chan N, Ali M, McCallum GP, Kumareswaran R, Koritzinsky M, Wouters BG, Wells PG, Gallinger S, Bristow RG.

Mol Cancer Res. 2014 Oct;12(10):1407-15. doi: 10.1158/1541-7786.MCR-14-0246. Epub 2014 Jul 16.

21.

Managing ocean information in the digital era--events in Canada open questions about the role of marine science libraries.

Wells PG.

Mar Pollut Bull. 2014 Jun 15;83(1):1-4. doi: 10.1016/j.marpolbul.2014.04.012. Epub 2014 Apr 24.

22.

A role for glutathione, independent of oxidative stress, in the developmental toxicity of methanol.

Siu MT, Shapiro AM, Wiley MJ, Wells PG.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):508-15. doi: 10.1016/j.taap.2013.09.020. Epub 2013 Oct 2.

PMID:
24095963
23.

Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits.

Ramkissoon A, Wells PG.

Free Radic Biol Med. 2013 Dec;65:620-631. doi: 10.1016/j.freeradbiomed.2013.07.043. Epub 2013 Aug 7.

PMID:
23932974
24.

Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice.

Miller L, Shapiro AM, Wells PG.

Toxicol Sci. 2013 Aug;134(2):400-11. doi: 10.1093/toxsci/kft122. Epub 2013 Jun 2.

PMID:
23733920
25.

Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice.

Jeng W, Loniewska MM, Wells PG.

ACS Chem Neurosci. 2013 Jul 17;4(7):1123-32. doi: 10.1021/cn400079y. Epub 2013 May 14.

26.

Expression of human oxoguanine glycosylase 1 or formamidopyrimidine glycosylase in human embryonic kidney 293 cells exacerbates methylmercury toxicity in vitro.

Ondovcik SL, Preston TJ, McCallum GP, Wells PG.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):41-8. doi: 10.1016/j.taap.2013.04.008. Epub 2013 Apr 19.

PMID:
23607987
27.

Sensitivity to methylmercury toxicity is enhanced in oxoguanine glycosylase 1 knockout murine embryonic fibroblasts and is dependent on cellular proliferation capacity.

Ondovcik SL, Tamblyn L, McPherson JP, Wells PG.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):23-30. doi: 10.1016/j.taap.2013.02.018. Epub 2013 Apr 6.

PMID:
23566953
28.

The free radical spin trapping agent phenylbutylnitrone reduces fetal brain DNA oxidation and postnatal cognitive deficits caused by in utero exposure to a non-structurally teratogenic dose of ethanol: a role for oxidative stress.

Miller L, Shapiro AM, Cheng J, Wells PG.

Free Radic Biol Med. 2013 Jul;60:223-32. doi: 10.1016/j.freeradbiomed.2013.02.015. Epub 2013 Feb 26. Erratum in: Free Radic Biol Med. 2013 Oct;63:368.

PMID:
23485582
29.

Canadian aquatic science and environmental legislation under threat.

Wells PG.

Mar Pollut Bull. 2013 Apr 15;69(1-2):1-2. doi: 10.1016/j.marpolbul.2013.01.035. Epub 2013 Mar 1. No abstract available.

30.

Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase.

Siu MT, Wiley MJ, Wells PG.

Reprod Toxicol. 2013 Apr;36:33-9. doi: 10.1016/j.reprotox.2012.11.006. Epub 2012 Dec 1.

PMID:
23207165
31.

Oxoguanine glycosylase 1 (OGG1) protects cells from DNA double-strand break damage following methylmercury (MeHg) exposure.

Ondovcik SL, Tamblyn L, McPherson JP, Wells PG.

Toxicol Sci. 2012 Jul;128(1):272-83. doi: 10.1093/toxsci/kfs138. Epub 2012 Apr 20.

PMID:
22523232
32.

Protective role of endogenous catalase in baseline and phenytoin-enhanced neurodevelopmental and behavioral deficits initiated in utero and in aged mice.

Abramov JP, Tran A, Shapiro AM, Wells PG.

Reprod Toxicol. 2012 Jun;33(3):361-73. doi: 10.1016/j.reprotox.2012.01.010. Epub 2012 Feb 8.

PMID:
22342499
33.

Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.

Lee CJ, Shibata N, Wiley MJ, Wells PG.

Toxicol Sci. 2011 Jul;122(1):157-69. doi: 10.1093/toxsci/kfr086. Epub 2011 Apr 19.

PMID:
21505091
34.

Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.

Lee CJ, Gonçalves LL, Wells PG.

Toxicol Sci. 2011 Jul;122(1):146-56. doi: 10.1093/toxsci/kfr084. Epub 2011 Apr 19.

PMID:
21505090
35.
36.

Embryonic catalase protects against endogenous and phenytoin-enhanced DNA oxidation and embryopathies in acatalasemic and human catalase-expressing mice.

Abramov JP, Wells PG.

FASEB J. 2011 Jul;25(7):2188-200. doi: 10.1096/fj.11-182444. Epub 2011 Apr 8.

PMID:
21478259
37.

Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase.

Miller L, Wells PG.

Toxicol Appl Pharmacol. 2011 Apr 1;252(1):55-61. doi: 10.1016/j.taap.2011.01.019. Epub 2011 Feb 3.

PMID:
21295602
38.
39.

Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity.

Ramkissoon A, Wells PG.

Toxicol Sci. 2011 Mar;120(1):154-62. doi: 10.1093/toxsci/kfq377. Epub 2010 Dec 16.

PMID:
21163909
40.

Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates.

McCallum GP, Siu M, Ondovcik SL, Sweeting JN, Wells PG.

Mol Carcinog. 2011 Mar;50(3):163-72. doi: 10.1002/mc.20701. Epub 2010 Nov 23.

PMID:
21104990
41.

Reduced DNA oxidation in aged prostaglandin H synthase-1 knockout mice.

Jeng W, Ramkissoon A, Wells PG.

Free Radic Biol Med. 2011 Feb 15;50(4):550-6. doi: 10.1016/j.freeradbiomed.2010.11.016. Epub 2010 Nov 18.

PMID:
21094252
42.

Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites.

Ramkissoon A, Wells PG.

Free Radic Biol Med. 2011 Jan 15;50(2):295-304. doi: 10.1016/j.freeradbiomed.2010.11.010. Epub 2010 Nov 13.

PMID:
21078384
43.

Species- and strain-dependent teratogenicity of methanol in rabbits and mice.

Sweeting JN, Siu M, Wiley MJ, Wells PG.

Reprod Toxicol. 2011 Jan;31(1):50-8. doi: 10.1016/j.reprotox.2010.09.014. Epub 2010 Oct 16.

PMID:
20955785
44.

Methanol exposure does not produce oxidatively damaged DNA in lung, liver or kidney of adult mice, rabbits or primates.

McCallum GP, Siu M, Sweeting JN, Wells PG.

Toxicol Appl Pharmacol. 2011 Jan 15;250(2):147-53. doi: 10.1016/j.taap.2010.10.004. Epub 2010 Oct 13.

PMID:
20950637
45.

Cockayne syndrome B protects against methamphetamine-enhanced oxidative DNA damage in murine fetal brain and postnatal neurodevelopmental deficits.

McCallum GP, Wong AW, Wells PG.

Antioxid Redox Signal. 2011 Mar 1;14(5):747-56. doi: 10.1089/ars.2009.2946. Epub 2011 Jan 5.

46.

Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.

Wells PG, McCallum GP, Lam KC, Henderson JT, Ondovcik SL.

Birth Defects Res C Embryo Today. 2010 Jun;90(2):103-9. doi: 10.1002/bdrc.20177. Review.

PMID:
20544694
47.

Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primates.

Sweeting JN, Siu M, McCallum GP, Miller L, Wells PG.

Toxicol Appl Pharmacol. 2010 Aug 15;247(1):28-35. doi: 10.1016/j.taap.2010.05.009. Epub 2010 May 25.

PMID:
20510256
48.
49.

Receptor- and reactive intermediate-mediated mechanisms of teratogenesis.

Wells PG, Lee CJ, McCallum GP, Perstin J, Harper PA.

Handb Exp Pharmacol. 2010;(196):131-62. doi: 10.1007/978-3-642-00663-0_6. Review.

PMID:
20020262
50.

Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs.

Preston TJ, Henderson JT, McCallum GP, Wells PG.

Mol Cancer Ther. 2009 Jul;8(7):2015-26. doi: 10.1158/1535-7163.MCT-08-0929. Epub 2009 Jun 30.

Supplemental Content

Loading ...
Support Center