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Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery.

Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao W, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman PS, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N.

J Med Chem. 2019 Sep 19. doi: 10.1021/acs.jmedchem.9b01030. [Epub ahead of print]


Vitamin C and Thiamine for Sepsis and Septic Shock.

Mitchell AB, Ryan TE, Gillion AR, Wells LD, Muthiah MP.

Am J Med. 2019 Aug 27. pii: S0002-9343(19)30699-0. doi: 10.1016/j.amjmed.2019.07.054. [Epub ahead of print]


Effects of Temperature on Seed Germination of Plantago lanceolata and Management in Carya illinoinensis Production.

Grey TL, Eason KM, Wells L, Basinger NT.

Plants (Basel). 2019 Aug 28;8(9). pii: E308. doi: 10.3390/plants8090308.


Physeal fractures of the distal femur: does a lower threshold for surgery lead to better outcomes?

Adams AJ, Mahmoud MAH, Wells L, Flynn JM, Arkader A.

J Pediatr Orthop B. 2019 Aug 16. doi: 10.1097/BPB.0000000000000664. [Epub ahead of print]


Rate of conversion to an open procedure is reduced in patients undergoing robotic colorectal surgery: A single-institution experience.

Wells LE, Smith B, Honaker MD.

J Minim Access Surg. 2019 Jul 24. doi: 10.4103/jmas.JMAS_318_18. [Epub ahead of print]


Correlations Between LC-MS/MS-Detected Glycomics and NMR-Detected Metabolomics in Caenorhabditis elegans Development.

Sheikh MO, Tayyari F, Zhang S, Judge MT, Weatherly DB, Ponce FV, Wells L, Edison AS.

Front Mol Biosci. 2019 Jun 28;6:49. doi: 10.3389/fmolb.2019.00049. eCollection 2019.


Editorial overview: Carbohydrates: O-glycosylation.

Wells L, Feizi T.

Curr Opin Struct Biol. 2019 Jun;56:iii-v. doi: 10.1016/ Epub 2019 Jun 12. No abstract available.


Imaging chemotherapy induced acute cardiotoxicity with 18F-labelled lipophilic cations.

McCluskey S, Haslop A, Coello C, Gunn R, Tate E, Southworth R, Plisson C, Long NJ, Wells L.

J Nucl Med. 2019 May 30. pii: jnumed.119.226787. doi: 10.2967/jnumed.119.226787. [Epub ahead of print]


Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC.

Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29.


Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing.

Klaver E, Zhao P, May M, Flanagan-Steet H, Freeze HH, Gilmore R, Wells L, Contessa J, Steet R.

Dis Model Mech. 2019 Jun 5;12(6). pii: dmm039602. doi: 10.1242/dmm.039602.


Building a Culture of Intimate Partner Violence Prevention in Alberta, Canada Through the Promotion of Healthy Youth Relationships.

Exner-Cortens D, Wells L, Lee L, Spiric V.

Prev Sci. 2019 Apr 25. doi: 10.1007/s11121-019-01011-7. [Epub ahead of print]


A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction.

Brunckhorst O, Wells L, Teeling F, Muir G, Muneer A, Ahmed K.

Int Urol Nephrol. 2019 May;51(5):773-781. doi: 10.1007/s11255-019-02127-z. Epub 2019 Mar 22. Review.


Use of secukinumab in a pediatric patient leads to significant improvement in nail psoriasis and psoriatic arthritis.

Wells LE, Evans T, Hilton R, Wine Lee L, Ruth N.

Pediatr Dermatol. 2019 May;36(3):384-385. doi: 10.1111/pde.13767. Epub 2019 Feb 27.


Polycyclic N-oxides: high performing, low sensitivity energetic materials.

Snyder CJ, Wells LA, Chavez DE, Imler GH, Parrish DA.

Chem Commun (Camb). 2019 Feb 21;55(17):2461-2464. doi: 10.1039/c8cc09653h.


Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry.

Sheikh MO, Gas-Pascual E, Glushka JN, Bustamante JM, Wells L, West CM.

Glycobiology. 2019 Apr 1;29(4):280-284. doi: 10.1093/glycob/cwy111.


Delayed Diagnosis of Vulvar Crohn's Disease in a Patient with No Gastrointestinal Symptoms.

Wells LE, Cohen D.

Case Rep Dermatol. 2018 Nov 28;10(3):263-267. doi: 10.1159/000495000. eCollection 2018 Sep-Dec.


Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Miller J, Wells L, Nwulu U, Currow D, Johnson MJ, Skipworth RJE.

Am J Clin Nutr. 2018 Dec 1;108(6):1196-1208. doi: 10.1093/ajcn/nqy244.


CRISPR/Cas9 and glycomics tools for Toxoplasma glycobiology.

Gas-Pascual E, Ichikawa HT, Sheikh MO, Serji MI, Deng B, Mandalasi M, Bandini G, Samuelson J, Wells L, West CM.

J Biol Chem. 2019 Jan 25;294(4):1104-1125. doi: 10.1074/jbc.RA118.006072. Epub 2018 Nov 21.


Obesity and recovery of muscle strength after anterior cruciate ligament reconstruction in pediatric patients.

Lee RJ, Margalit A, Nduaguba A, Gunderson MA, Wells L.

J Orthop Surg (Hong Kong). 2018 May-Aug;26(3):2309499018806631. doi: 10.1177/2309499018806631.


Parental education differentially predicts young adults' frequency and quantity of alcohol use in a longitudinal Swedish sample.

Wells L, Östberg V.

SSM Popul Health. 2018 Sep 5;6:91-97. doi: 10.1016/j.ssmph.2018.09.001. eCollection 2018 Dec.


Association of the Graft Size and Arthrofibrosis in Young Patients After Primary Anterior Cruciate Ligament Reconstruction.

Su AW, Storey EP, Lin SC, Forst B, Lawrence JT, Ganley TJ, Wells L.

J Am Acad Orthop Surg. 2018 Dec 1;26(23):e483-e489. doi: 10.5435/JAAOS-D-17-00177.


The effects of haloperidol on microglial morphology and translocator protein levels: An in vivo study in rats using an automated cell evaluation pipeline.

Bloomfield PS, Bonsall D, Wells L, Dormann D, Howes O, De Paola V.

J Psychopharmacol. 2018 Nov;32(11):1264-1272. doi: 10.1177/0269881118788830. Epub 2018 Aug 21.


Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach.

Papageorgiou M, Wells L, Williams C, White KLM, De Santis B, Liu Y, Debegnach F, Miano B, Moretti G, Greetham S, Brera C, Atkin SL, Hardie LJ, Sathyapalan T.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Oct;35(10):2032-2044. doi: 10.1080/19440049.2018.1508890. Epub 2018 Aug 17.


Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.

Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR.

Immunity. 2018 Aug 21;49(2):301-311.e5. doi: 10.1016/j.immuni.2018.07.005. Epub 2018 Jul 31.


Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases.

Yu SH, Zhao P, Prabhakar PK, Sun T, Beedle A, Boons GJ, Moremen KW, Wells L, Steet R.

J Biol Chem. 2018 Sep 14;293(37):14534-14544. doi: 10.1074/jbc.RA118.003014. Epub 2018 Jul 26.


Orbital infantile haemangioma: radiological features and treatment - case series and literature review.

Albanese G, Mohandas P, Wells L, Ravenscroft J, Srinivasan J, Thomas S, Taylor T, Tambe K.

Orbit. 2019 Feb;38(1):67-71. doi: 10.1080/01676830.2018.1501397. Epub 2018 Jul 24. Review.


Validated Pediatric Functional Outcomes of All-epiphyseal ACL Reconstructions: Does Reinjury Affect Outcomes?

Ranade SC, Refakis CA, Cruz AI Jr, Leddy KL, Wells L, Lawrence JT, Ganley TJ.

J Pediatr Orthop. 2018 Jun 20. doi: 10.1097/BPO.0000000000001217. [Epub ahead of print]


Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology consensus guidelines.

Solman L, Glover M, Beattie PE, Buckley H, Clark S, Gach JE, Giardini A, Helbling I, Hewitt RJ, Laguda B, Langan SM, Martinez AE, Murphy R, Proudfoot L, Ravenscroft J, Shahidullah H, Shaw L, Syed SB, Wells L, Flohr C.

Br J Dermatol. 2018 Sep;179(3):582-589. doi: 10.1111/bjd.16779.


O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling.

Selvan N, George S, Serajee FJ, Shaw M, Hobson L, Kalscheuer V, Prasad N, Levy SE, Taylor J, Aftimos S, Schwartz CE, Huq AM, Gecz J, Wells L.

J Biol Chem. 2018 Jul 6;293(27):10810-10824. doi: 10.1074/jbc.RA118.002583. Epub 2018 May 16.


How Much Will My Child's Operation Cost? Availability of Consumer Prices From US Hospitals for a Common Pediatric Orthopaedic Surgical Procedure.

Racimo AR, Talathi NS, Zelenski NA, Wells L, Shah AS.

J Pediatr Orthop. 2018 Aug;38(7):e411-e416. doi: 10.1097/BPO.0000000000001194.


Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G.

PLoS Comput Biol. 2018 Apr 20;14(4):e1006093. doi: 10.1371/journal.pcbi.1006093. eCollection 2018 Apr.


Assessment of Urinary Deoxynivalenol Biomarkers in UK Children and Adolescents.

Papageorgiou M, Wells L, Williams C, White K, De Santis B, Liu Y, Debegnach F, Miano B, Moretti G, Greetham S, Brera C, Atkin SL, Hardie LJ, Sathyapalan T.

Toxins (Basel). 2018 Jan 23;10(2). pii: E50. doi: 10.3390/toxins10020050.


Rash on extensor surfaces of a child.

Wells L, Mahil S.

BMJ. 2018 Jan 11;360:j5547. doi: 10.1136/bmj.j5547. No abstract available.


Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus.

Narayan N, Owen DR, Mandhair H, Smyth E, Carlucci F, Saleem A, Gunn RN, Rabiner EA, Wells L, Dakin SG, Sabokbar A, Taylor PC.

J Nucl Med. 2018 Jul;59(7):1125-1132. doi: 10.2967/jnumed.117.202200. Epub 2018 Jan 4.


Distinct roles of N- and O-glycans in cellulase activity and stability.

Amore A, Knott BC, Supekar NT, Shajahan A, Azadi P, Zhao P, Wells L, Linger JG, Hobdey SE, Vander Wall TA, Shollenberger T, Yarbrough JM, Tan Z, Crowley MF, Himmel ME, Decker SR, Beckham GT, Taylor LE 2nd.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13667-13672. doi: 10.1073/pnas.1714249114. Epub 2017 Dec 11.


Identification and characterization of the Streptococcus pneumoniae type 3 capsule-specific glycoside hydrolase of Paenibacillus species 32352.

Middleton DR, Zhang X, Wantuch PL, Ozdilek A, Liu X, LoPilato R, Gangasani N, Bridger R, Wells L, Linhardt RJ, Avci FY.

Glycobiology. 2018 Feb 1;28(2):90-99. doi: 10.1093/glycob/cwx097.


Control of Pecan Weevil With Microbial Biopesticides.

Shapiro-Ilan DI, Cottrell TE, Bock C, Mai K, Boykin D, Wells L, Hudson WG, Mizell RF 3rd.

Environ Entomol. 2017 Dec 8;46(6):1299-1304. doi: 10.1093/ee/nvx144.


The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages.

Narayan N, Mandhair H, Smyth E, Dakin SG, Kiriakidis S, Wells L, Owen D, Sabokbar A, Taylor P.

PLoS One. 2017 Oct 2;12(10):e0185767. doi: 10.1371/journal.pone.0185767. eCollection 2017.


Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

Rahman K, Mandalasi M, Zhao P, Sheikh MO, Taujale R, Kim HW, van der Wel H, Matta K, Kannan N, Glushka JN, Wells L, West CM.

J Biol Chem. 2017 Nov 10;292(45):18644-18659. doi: 10.1074/jbc.M117.809301. Epub 2017 Sep 19.


O-GlcNAc transferase regulates transcriptional activity of human Oct4.

Constable S, Lim JM, Vaidyanathan K, Wells L.

Glycobiology. 2017 Oct 1;27(10):927-937. doi: 10.1093/glycob/cwx055.


Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [18 F]-FDOPA PET study.

Bonsall DR, Kokkinou M, Veronese M, Coello C, Wells LA, Howes OD.

J Neurochem. 2017 Dec;143(5):551-560. doi: 10.1111/jnc.14223. Epub 2017 Oct 26.


Other Classes of Eukaryotic Glycans.

Haltiwanger RS, Wells L, Freeze HH, Stanley P.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 13.


Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer Using a Bifunctional CMP-Neu5Ac Derivative.

Capicciotti CJ, Zong C, Sheikh MO, Sun T, Wells L, Boons GJ.

J Am Chem Soc. 2017 Sep 27;139(38):13342-13348. doi: 10.1021/jacs.7b05358. Epub 2017 Sep 15.


Recent advancements in understanding mammalian O-mannosylation.

Sheikh MO, Halmo SM, Wells L.

Glycobiology. 2017 Sep 1;27(9):806-819. doi: 10.1093/glycob/cwx062. Review.


Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting.

Aarnio-Peterson M, Zhao P, Yu SH, Christian C, Flanagan-Steet H, Wells L, Steet R.

J Biol Chem. 2017 Sep 8;292(36):15094-15104. doi: 10.1074/jbc.M117.790139. Epub 2017 Jul 19.


Whoa man! Unexpected protein O-mannosylation pathways in mammals.

Sheikh MO, Wells L.

J Biol Chem. 2017 Jul 7;292(27):11599-11600. doi: 10.1074/jbc.H117.794487. Review.


Deoxynivalenol Biomarkers in the Urine of UK Vegetarians.

Wells L, Hardie L, Williams C, White K, Liu Y, De Santis B, Debegnach F, Moretti G, Greetham S, Brera C, Papageorgiou M, Thatcher NJ, Rigby A, Atkin SL, Sathyapalan T.

Toxins (Basel). 2017 Jun 22;9(7). pii: E196. doi: 10.3390/toxins9070196.


Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion.

Tse LV, Klinc KA, Madigan VJ, Castellanos Rivera RM, Wells LF, Havlik LP, Smith JK, Agbandje-McKenna M, Asokan A.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4812-E4821. doi: 10.1073/pnas.1704766114. Epub 2017 May 30.


Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.

Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LA, Taylor PC, Amor S, Antel JP, Matthews PM, Moore CS.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690. doi: 10.1177/0271678X17710182. Epub 2017 May 22.

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