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Items: 1 to 50 of 421

1.

miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.

Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick MA, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ.

Nat Metab. 2019 Apr;1(4):460-474. doi: 10.1038/s42255-019-0052-9. Epub 2019 Apr 8.

PMID:
31535082
2.

Declining incidence of pyloric stenosis in New Zealand.

Yau A, Cha R, Jayaratnam S, Wilson T, Kukkady A, Evans SM, Wells JM.

ANZ J Surg. 2019 Aug 26. doi: 10.1111/ans.15377. [Epub ahead of print]

PMID:
31450263
3.

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on single-cell Transcriptome Analyses.

Lau ST, Li Z, Lai FP, Lui KN, Li P, Munera JO, Pan G, Mahe MM, Hui CC, Wells JM, Ngan ES.

Gastroenterology. 2019 Aug 20. pii: S0016-5085(19)41233-X. doi: 10.1053/j.gastro.2019.08.019. [Epub ahead of print]

PMID:
31442438
4.

Classification of Trauma-Associated Invasive Fungal Infections to Support Wound Treatment Decisions.

Ganesan A, Shaikh F, Bradley W, Blyth DM, Bennett D, Petfield JL, Carson ML, Wells JM, Tribble DR; Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group.

Emerg Infect Dis. 2019 Sep;25(9). doi: 10.3201/eid2509.190168.

5.

Recent advances in deriving human endodermal tissues from pluripotent stem cells.

Kechele DO, Wells JM.

Curr Opin Cell Biol. 2019 Aug 16;61:92-100. doi: 10.1016/j.ceb.2019.07.009. [Epub ahead of print] Review.

PMID:
31425933
6.

Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury.

Xing D, Wells JM, Giordano SS, Feng W, Gaggar A, Yan J, Hage FG, Li L, Chen YF, Oparil S.

J Appl Physiol (1985). 2019 Aug 1;127(2):444-456. doi: 10.1152/japplphysiol.00587.2018. Epub 2019 Jul 11.

PMID:
31295064
7.

Noncoding deletions reveal a gene that is critical for intestinal function.

Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, Tatarskyy P, Milgrom R, Schvimer M, Barshack I, Imai DM, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, van Bueren KL, Barnes RM, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Visel A, Lancet D, Anikster Y, Pennacchio LA.

Nature. 2019 Jul;571(7763):107-111. doi: 10.1038/s41586-019-1312-2. Epub 2019 Jun 19.

PMID:
31217582
8.

Critical design and validation considerations for the development of neonatal minimally invasive surgery simulators.

Nair D, Wells JM, Cook N, Moorhead A, Beasley SW.

J Pediatr Surg. 2019 Jun 7. pii: S0022-3468(19)30390-2. doi: 10.1016/j.jpedsurg.2019.05.022. [Epub ahead of print] Review.

PMID:
31213289
9.

A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.

Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM.

Dev Cell. 2019 Aug 5;50(3):367-380.e7. doi: 10.1016/j.devcel.2019.05.017. Epub 2019 Jun 6.

PMID:
31178402
10.

Organoids by design.

Takebe T, Wells JM.

Science. 2019 Jun 7;364(6444):956-959. doi: 10.1126/science.aaw7567. Review.

PMID:
31171692
11.

Draft Genome Sequence of Streptococcus suis S10, a Virulent Strain Used in Experimental Pig Infections.

Gaiser RA, Zomer AL, Wells JM, van Baarlen P.

Microbiol Resour Announc. 2019 Jun 6;8(23). pii: e00227-19. doi: 10.1128/MRA.00227-19.

12.

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.

Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T.

Cell Metab. 2019 Aug 6;30(2):374-384.e6. doi: 10.1016/j.cmet.2019.05.007. Epub 2019 May 30.

PMID:
31155493
13.

Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ.

Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Epub 2019 May 30. Review.

PMID:
31154041
14.

Selection of antimicrobial frog peptides and temporin-1DRa analogs for treatment of bacterial infections based on their cytotoxicity and differential activity against pathogens.

Gaiser RA, Ayerra Mangado J, Mechkarska M, Kaman WE, van Baarlen P, Conlon JM, Wells JM.

Chem Biol Drug Des. 2019 May 18. doi: 10.1111/cbdd.13569. [Epub ahead of print]

PMID:
31102497
15.

Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study.

Gulati S, Wells JM, Urdaneta GP, Balestrini K, Vital I, Tovar K, Barnes JW, Bhatt SP, Campos M, Krick S.

Int J Mol Sci. 2019 May 9;20(9). pii: E2292. doi: 10.3390/ijms20092292.

16.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.

Múnera JO, Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM.

Cell Stem Cell. 2019 May 2;24(5):829. doi: 10.1016/j.stem.2019.04.002. No abstract available.

17.

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-Induced Emphysema.

Abdul Roda M, Xu X, Abdalla TH, Sadik M, Szul T, Bratcher PE, Viera L, Solomon GM, Wells JM, McNicholas CM, Redegeld FA, Folkerts G, Blalock JE, Gaggar A.

Am J Respir Cell Mol Biol. 2019 Apr 8. doi: 10.1165/rcmb.2018-0216OC. [Epub ahead of print]

PMID:
30958968
18.

In vivo transcriptomes of Streptococcus suis reveal genes required for niche-specific adaptation and pathogenesis.

Arenas J, Bossers-de Vries R, Harders-Westerveen J, Buys H, Ruuls-van Stalle LMF, Stockhofe-Zurwieden N, Zaccaria E, Tommassen J, Wells JM, Smith HE, de Greeff A.

Virulence. 2019 Dec;10(1):334-351. doi: 10.1080/21505594.2019.1599669.

19.

Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales.

Wileman TM, Weinert LA, Howell KJ, Wang J, Peters SE, Williamson SM, Wells JM, Langford PR, Rycroft AN, Wren BW, Maskell DJ, Tucker AW.

J Clin Microbiol. 2019 Jun 25;57(7). pii: e01712-18. doi: 10.1128/JCM.01712-18. Print 2019 Jul.

20.

From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients.

Lee JSH, Darcy KM, Hu H, Casablanca Y, Conrads TP, Dalgard CL, Freymann JB, Hanlon SE, Huang GD, Kvecher L, Maxwell GL, Meng F, Moncur JT, Turner C, Wells JM, Wilkerson MD, Zhu K, Ramoni RB, Shriver CD.

Clin Pharmacol Ther. 2019 Jul;106(1):52-57. doi: 10.1002/cpt.1425. Epub 2019 Apr 29. No abstract available.

21.

Phenotype Detection Registry System (PheDRS) - Implementation of a Generalizable Single Institution Clinical Registry Architecture.

Osborne JD, Khare A, Dempsey DM, Wells JM, Wyatt M, Gordon G, Liang WH, Cimino J.

AMIA Annu Symp Proc. 2018 Dec 5;2018:847-856. eCollection 2018.

22.

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.

Castro-Bravo N, Margolles A, Wells JM, Ruas-Madiedo P.

Anaerobe. 2019 Apr;56:98-101. doi: 10.1016/j.anaerobe.2019.02.014. Epub 2019 Feb 20.

PMID:
30794874
23.

Arterial Vascular Pruning, Right Ventricular Size, and Clinical Outcomes in Chronic Obstructive Pulmonary Disease. A Longitudinal Observational Study.

Washko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt SP, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agustí A, San José Estépar R.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):454-461. doi: 10.1164/rccm.201811-2063OC.

PMID:
30758975
24.

Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe.

Ryan PM, Stolte EH, London LEE, Wells JM, Long SL, Joyce SA, Gahan CGM, Fitzgerald GF, Ross RP, Caplice NM, Stanton C.

BMC Microbiol. 2019 Feb 8;19(1):33. doi: 10.1186/s12866-019-1403-0.

25.

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.

Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, Woo J, Wells JM, Labaki WW, Doerschuk CM, Kanner RE, Han MK, Martinez C, Paulin LM, Martinez FJ, Wise RA, O'Neal WK, Barr RG, Hansel NN; SPIROMICS investigators.

Ann Am Thorac Soc. 2018 Jun;15(6):710-717. doi: 10.1513/AnnalsATS.201708-687OC.

26.

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity.

Sovran B, Hugenholtz F, Elderman M, Van Beek AA, Graversen K, Huijskes M, Boekschoten MV, Savelkoul HFJ, De Vos P, Dekker J, Wells JM.

Sci Rep. 2019 Feb 5;9(1):1437. doi: 10.1038/s41598-018-35228-3.

27.

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection.

Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins JA, Sundaram N, Wroblewski LE, Peek RM Jr, Wang J, Helmrath M, Wells JM, Zavros Y.

PLoS Pathog. 2019 Jan 31;15(1):e1007468. doi: 10.1371/journal.ppat.1007468. eCollection 2019 Jan.

28.

Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy.

Wells JM, Arenberg DA, Barjaktarevic I, Bhatt SP, Bowler RP, Christenson SA, Couper DJ, Dransfield MT, Han MK, Hoffman EA, Kaner RJ, Kim V, Kleerup E, Martinez FJ, Moore WC, O'Beirne SL, Paine R 3rd, Putcha N, Raman SM, Barr RG, Rennard SI, Woodruff PG, Curtis JL.

Ann Am Thorac Soc. 2019 Apr;16(4):439-446. doi: 10.1513/AnnalsATS.201807-441OC.

PMID:
30653926
29.

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.

Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Abdul Roda M, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE.

Cell. 2019 Jan 10;176(1-2):113-126.e15. doi: 10.1016/j.cell.2018.12.002.

PMID:
30633902
30.

Generation of human antral and fundic gastric organoids from pluripotent stem cells.

Broda TR, McCracken KW, Wells JM.

Nat Protoc. 2019 Jan;14(1):28-50. doi: 10.1038/s41596-018-0080-z.

PMID:
30470820
31.

Inflammation and endothelial activation in early adulthood are associated with future emphysema: the CARDIA Lung Study.

Wells JM, Colangelo LA, Sivarajan L, Thyagarajan B, Dransfield MT, Iribarren C, Reyfman PA, Jacobs DR, Washko GR, Kalhan R.

Eur Respir J. 2019 Jan 17;53(1). pii: 1801532. doi: 10.1183/13993003.01532-2018. Print 2019 Jan. No abstract available.

PMID:
30464011
32.

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation.

Koper JEB, Loonen LMP, Wells JM, Troise AD, Capuano E, Fogliano V.

Mol Nutr Food Res. 2019 Feb;63(3):e1800722. doi: 10.1002/mnfr.201800722. Epub 2018 Nov 28.

33.

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A, Investigators TSAC.

JCI Insight. 2018 Nov 15;3(22). pii: 123614. doi: 10.1172/jci.insight.123614.

34.

Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.

Aggarwal S, Ahmad I, Lam A, Carlisle MA, Li C, Wells JM, Raju SV, Athar M, Rowe SM, Dransfield MT, Matalon S.

JCI Insight. 2018 Nov 2;3(21). pii: 120694. doi: 10.1172/jci.insight.120694.

35.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.

36.

Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway.

Meijerink M, Rösch C, Taverne N, Venema K, Gruppen H, Schols HA, Wells JM.

Front Immunol. 2018 Oct 12;9:1972. doi: 10.3389/fimmu.2018.01972. eCollection 2018.

37.

Interactions of Surface Exopolysaccharides From Bifidobacterium and Lactobacillus Within the Intestinal Environment.

Castro-Bravo N, Wells JM, Margolles A, Ruas-Madiedo P.

Front Microbiol. 2018 Oct 11;9:2426. doi: 10.3389/fmicb.2018.02426. eCollection 2018. Review.

38.

Logical MS/MS scans: a new set of operations for tandem mass spectrometry.

Snyder DT, Szalwinski LJ, Wells JM, Cooks RG.

Analyst. 2018 Nov 5;143(22):5438-5452. doi: 10.1039/c8an01661e.

PMID:
30311922
39.

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.

Trisno SL, Philo KED, McCracken KW, Catá EM, Ruiz-Torres S, Rankin SA, Han L, Nasr T, Chaturvedi P, Rothenberg ME, Mandegar MA, Wells SI, Zorn AM, Wells JM.

Cell Stem Cell. 2018 Oct 4;23(4):501-515.e7. doi: 10.1016/j.stem.2018.08.008. Epub 2018 Sep 20.

PMID:
30244869
40.

Human stomach-on-a-chip with luminal flow and peristaltic-like motility.

Lee KK, McCauley HA, Broda TR, Kofron MJ, Wells JM, Hong CI.

Lab Chip. 2018 Oct 9;18(20):3079-3085. doi: 10.1039/c8lc00910d.

PMID:
30238091
41.

Life-Space mobility and clinical outcomes in COPD.

Iyer AS, Wells JM, Bhatt SP, Kirkpatrick DP, Sawyer P, Brown CJ, Allman RM, Bakitas MA, Dransfield MT.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 4;13:2731-2738. doi: 10.2147/COPD.S170887. eCollection 2018.

42.

Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction and Radiographic Bronchiectasis in Current and Former Smokers: A Cross-Sectional Study.

Teerapuncharoen K, Wells JM, Raju SV, Raraigh KS, Atalar Aksit M, Cutting GR, Rasmussen L, Nath PH, Bhatt SP, Solomon GM, Dransfield MT, Rowe SM.

Ann Am Thorac Soc. 2019 Jan;16(1):150-153. doi: 10.1513/AnnalsATS.201805-325RL. No abstract available.

PMID:
30230364
43.

Mechanically induced development and maturation of human intestinal organoids in vivo.

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM.

Nat Biomed Eng. 2018 Jun;2(6):429-442. doi: 10.1038/s41551-018-0243-9. Epub 2018 Jun 4.

44.

Deriving functional human enteroendocrine cells from pluripotent stem cells.

Sinagoga KL, McCauley HA, Múnera JO, Reynolds NA, Enriquez JR, Watson C, Yang HC, Helmrath MA, Wells JM.

Development. 2018 Oct 1;145(19). pii: dev165795. doi: 10.1242/dev.165795.

45.

The use of a standardized order set reduces systemic corticosteroid dose and length of stay for individuals hospitalized with acute exacerbations of COPD: a cohort study.

Gulati S, Zouk AN, Kalehoff JP, Wren CS, Davison PN, Kirkpatrick DP, Bhatt SP, Dransfield MT, Wells JM.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 27;13:2271-2278. doi: 10.2147/COPD.S165665. eCollection 2018.

46.

COPD ground zero: small airways rather than alveoli as the initial site of injury.

Russell DW, Wells JM.

Lancet Respir Med. 2018 Aug;6(8):568-569. doi: 10.1016/S2213-2600(18)30290-X. Epub 2018 Jul 4. No abstract available.

PMID:
30072103
47.

An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment.

Júnior NGO, Cardoso MH, Cândido ES, van den Broek D, de Lange N, Velikova N, Kleijn JM, Wells JM, Rezende TMB, Franco OL, de Vries R.

Sci Rep. 2018 Jul 24;8(1):11127. doi: 10.1038/s41598-018-29444-0.

48.

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort.

Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine R 3rd, Ortega VE, Peters SP, Krishnan JA, Bowler RP, Couper DJ, Woodruff PG, Martinez FJ, Martinez CH, Han MK.

Respir Med. 2018 Jul;140:87-93. doi: 10.1016/j.rmed.2018.06.005. Epub 2018 Jun 5.

49.

Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.

Larson-Casey JL, Gu L, Jackson PL, Briles DE, Hale JY, Blalock JE, Wells JM, Deshane JS, Wang Y, Davis D, Antony VB, Massicano AVF, Lapi SE, Carter AB.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1288-1301. doi: 10.1164/rccm.201712-2388OC.

PMID:
29897791
50.

Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort.

Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Vegas Sanchez-Ferrero G, Putman RK, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators.

Radiology. 2018 Aug;288(2):600-609. doi: 10.1148/radiol.2018172688. Epub 2018 Jun 5.

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