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Items: 1 to 50 of 364

1.

Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.

Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA.

J Am Chem Soc. 2018 Nov 19. doi: 10.1021/jacs.8b08402. [Epub ahead of print]

PMID:
30398859
2.

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.

Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20.

3.

The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.

Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA.

ACS Chem Biol. 2018 Sep 21;13(9):2398-2405. doi: 10.1021/acschembio.8b00508. Epub 2018 Aug 14.

PMID:
30080377
4.

Early Response to Anti-Vascular Endothelial Growth Factor and Two-Year Outcomes Among Eyes With Diabetic Macular Edema in Protocol T.

Bressler NM, Beaulieu WT, Maguire MG, Glassman AR, Blinder KJ, Bressler SB, Gonzalez VH, Jampol LM, Melia M, Sun JK, Wells JA 3rd; Diabetic Retinopathy Clinical Research Network.

Am J Ophthalmol. 2018 Nov;195:93-100. doi: 10.1016/j.ajo.2018.07.030. Epub 2018 Aug 2.

PMID:
30077569
5.

Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI.

Harrison IF, Siow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA.

Elife. 2018 Jul 31;7. pii: e34028. doi: 10.7554/eLife.34028.

6.

Comparison of Clinical and Echocardiographic Outcomes After Surgical Redo Mitral Valve Replacement and Transcatheter Mitral Valve-in-Valve Therapy.

Kamioka N, Babaliaros V, Morse MA, Frisoli T, Lerakis S, Iturbe JM, Binongo J, Corrigan F, Yousef A, Gleason P, Wells JA 4th, Caughron H, Dong A, Rodriguez E, Leshnower B, O'Neill W, Paone G, Eng M, Guyton R, Block PC, Greenbaum A.

JACC Cardiovasc Interv. 2018 Jun 25;11(12):1131-1138. doi: 10.1016/j.jcin.2018.03.011.

PMID:
29929633
7.

CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S.

Neuropharmacology. 2018 Aug;138:381-392. doi: 10.1016/j.neuropharm.2018.06.007. Epub 2018 Jun 9.

8.

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.

Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS.

Elife. 2018 Jun 7;7. pii: e36307. doi: 10.7554/eLife.36307.

9.

A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow.

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A, Gourine AV.

J Cereb Blood Flow Metab. 2018 Jun 4:271678X18780602. doi: 10.1177/0271678X18780602. [Epub ahead of print]

PMID:
29862863
10.

A Phase 1, Open-Label, Dose-Escalation Trial to Investigate Safety and Tolerability of Single Intravitreous Injections of ICON-1 Targeting Tissue Factor in Wet AMD.

Wells JA, Gonzales CR, Berger BB, Gonzalez VH, Sippy BD, Burian G.

Ophthalmic Surg Lasers Imaging Retina. 2018 May 1;49(5):336-345. doi: 10.3928/23258160-20180501-07.

PMID:
29772044
11.

Night shift preparation, performance, and perception: are there differences between emergency medicine nurses, residents, and faculty?

Richards JR, Stayton TL, Wells JA, Parikh AK, Laurin EG.

Clin Exp Emerg Med. 2018 Apr 30. doi: 10.15441/ceem.17.270. [Epub ahead of print]

12.

Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.

Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR.

Mol Pharm. 2018 May 7;15(5):2054-2059. doi: 10.1021/acs.molpharmaceut.8b00242. Epub 2018 Mar 23.

PMID:
29569925
13.

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.

Jampol LM, Glassman AR, Liu D, Aiello LP, Bressler NM, Duh EJ, Quaggin S, Wells JA, Wykoff CC; Diabetic Retinopathy Clinical Research Network.

Ophthalmology. 2018 Jul;125(7):1054-1063. doi: 10.1016/j.ophtha.2018.01.019. Epub 2018 Mar 7.

PMID:
29525602
14.

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2836-2841. doi: 10.1073/pnas.1721899115. Epub 2018 Feb 23.

15.

Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema With Vision Impairment: A Secondary Analysis of a Randomized Clinical Trial.

Bressler NM, Beaulieu WT, Glassman AR, Blinder KJ, Bressler SB, Jampol LM, Melia M, Wells JA 3rd; Diabetic Retinopathy Clinical Research Network.

JAMA Ophthalmol. 2018 Mar 1;136(3):257-269. doi: 10.1001/jamaophthalmol.2017.6565.

PMID:
29392288
16.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

17.

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.

Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA.

Elife. 2018 Jan 23;7. pii: e31098. doi: 10.7554/eLife.31098.

18.

Human antibody-based chemically induced dimerizers for cell therapeutic applications.

Hill ZB, Martinko AJ, Nguyen DP, Wells JA.

Nat Chem Biol. 2018 Feb;14(2):112-117. doi: 10.1038/nchembio.2529. Epub 2017 Dec 4.

PMID:
29200207
19.

In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis.

Colgan N, Ganeshan B, Harrison IF, Ismail O, Holmes HE, Wells JA, Powell NM, O'Callaghan JM, O'Neill MJ, Murray TK, Ahmed Z, Collins EC, Johnson RA, Groves A, Lythgoe MF.

Front Neurosci. 2017 Nov 6;11:599. doi: 10.3389/fnins.2017.00599. eCollection 2017.

20.

Engineering peptide ligase specificity by proteomic identification of ligation sites.

Weeks AM, Wells JA.

Nat Chem Biol. 2018 Jan;14(1):50-57. doi: 10.1038/nchembio.2521. Epub 2017 Nov 20.

21.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.

Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE.

Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28.

PMID:
28970360
22.

A Split-Abl Kinase for Direct Activation in Cells.

Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA.

Cell Chem Biol. 2017 Oct 19;24(10):1250-1258.e4. doi: 10.1016/j.chembiol.2017.08.007. Epub 2017 Sep 14.

23.

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo.

Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8174-E8183. doi: 10.1073/pnas.1705064114. Epub 2017 Sep 11.

24.

Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.

O'Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O'Neill MJ, Murray TK, Collins EC, Shmueli K, Lythgoe MF.

Neuroimage. 2017 Oct 1;159:334-345. doi: 10.1016/j.neuroimage.2017.08.003. Epub 2017 Aug 4.

25.

Ring opening polymerisation of lactide with uranium(iv) and cerium(iv) phosphinoaryloxide complexes.

Sinclair F, Hlina JA, Wells JAL, Shaver MP, Arnold PL.

Dalton Trans. 2017 Aug 22;46(33):10786-10790. doi: 10.1039/c7dt02167d.

PMID:
28765851
26.

Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.

Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP.

Cell Syst. 2017 Jun 28;4(6):636-644.e9. doi: 10.1016/j.cels.2017.05.001. Epub 2017 May 31.

27.

Caspases and their substrates.

Julien O, Wells JA.

Cell Death Differ. 2017 Aug;24(8):1380-1389. doi: 10.1038/cdd.2017.44. Epub 2017 May 12. Review.

28.

Change in Diabetic Retinopathy Through 2 Years: Secondary Analysis of a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab.

Bressler SB, Liu D, Glassman AR, Blodi BA, Castellarin AA, Jampol LM, Kaufman PL, Melia M, Singh H, Wells JA; Diabetic Retinopathy Clinical Research Network.

JAMA Ophthalmol. 2017 Jun 1;135(6):558-568. doi: 10.1001/jamaophthalmol.2017.0821.

29.

Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy.

Holmes HE, Powell NM, Ma D, Ismail O, Harrison IF, Wells JA, Colgan N, O'Callaghan JM, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, O'Neill MJ, Collins EC, Fisher EM, Ourselin S, Lythgoe MF.

Front Neuroinform. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020. eCollection 2017.

30.

Reply.

Wells JA, Glassman AR, Bressler NM, Ayala AR, Jampol LM.

Ophthalmology. 2017 Apr;124(4):e38-e39. doi: 10.1016/j.ophtha.2016.08.032. No abstract available.

PMID:
28335949
31.

Degree of Vascular Encasement in Sphenoid Wing Meningiomas Predicts Postoperative Ischemic Complications.

McCracken DJ, Higginbotham RA, Boulter JH, Liu Y, Wells JA, Halani SH, Saindane AM, Oyesiku NM, Barrow DL, Olson JJ.

Neurosurgery. 2017 Jun 1;80(6):957-966. doi: 10.1093/neuros/nyw134.

PMID:
28327941
32.

Outcomes After Paravalvular Leak Closure: Transcatheter Versus Surgical Approaches.

Wells JA 4th, Condado JF, Kamioka N, Dong A, Ritter A, Lerakis S, Clements S, Stewart J, Leshnower B, Guyton R, Forcillo J, Patel A, Thourani VH, Block PC, Babaliaros V.

JACC Cardiovasc Interv. 2017 Mar 13;10(5):500-507. doi: 10.1016/j.jcin.2016.11.043.

33.

Reply.

Wells JA, Glassman AR, Jampol LM, Ayala A, Bressler NM.

Ophthalmology. 2017 Mar;124(3):e26-e27. doi: 10.1016/j.ophtha.2016.07.001. No abstract available.

PMID:
28219510
34.

Redox-based reagents for chemoselective methionine bioconjugation.

Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ.

Science. 2017 Feb 10;355(6325):597-602. doi: 10.1126/science.aal3316.

35.

Volumetric Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI.

Christie IN, Wells JA, Kasparov S, Gourine AV, Lythgoe MF.

Sci Rep. 2017 Feb 8;7:41583. doi: 10.1038/srep41583.

36.

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.

Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA.

J Am Chem Soc. 2017 Feb 22;139(7):2541-2544. doi: 10.1021/jacs.6b10792. Epub 2017 Feb 13.

37.

Uranium rhodium bonding in heterometallic complexes.

Hlina JA, Wells JAL, Pankhurst JR, Love JB, Arnold PL.

Dalton Trans. 2017 May 2;46(17):5540-5545. doi: 10.1039/c6dt04570g.

38.

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.

Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK.

Mol Cell Proteomics. 2017 Apr;16(4):512-523. doi: 10.1074/mcp.M116.063818. Epub 2017 Jan 25.

39.

Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli.

Wells JA, Shibata S, Fujikawa A, Takahashi M, Saga T, Aoki I.

Sci Rep. 2017 Jan 12;7:38325. doi: 10.1038/srep38325.

40.

Reply.

Wells JA, Glassman AR, Ayala AR, Jampol LM.

Ophthalmology. 2017 Jan;124(1):e5-e6. doi: 10.1016/j.ophtha.2016.04.032. No abstract available.

PMID:
27993277
41.

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.

Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR.

J Med Chem. 2016 Dec 22;59(24):11161-11170. doi: 10.1021/acs.jmedchem.6b01470. Epub 2016 Dec 12.

42.

Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface.

Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J.

Oncotarget. 2016 Dec 27;7(52):86948-86971. doi: 10.18632/oncotarget.13566.

43.

Dinuclear uranium complexation and manipulation using robust tetraaryloxides.

Wells JA, Seymour ML, Suvova M, Arnold PL.

Dalton Trans. 2016 Oct 12;45(40):16026-16032.

PMID:
27727351
44.

Anti-Vascular Endothelial Growth Factor Comparative Effectiveness Trial for Diabetic Macular Edema: Additional Efficacy Post Hoc Analyses of a Randomized Clinical Trial.

Jampol LM, Glassman AR, Bressler NM, Wells JA, Ayala AR; Diabetic Retinopathy Clinical Research Network.

JAMA Ophthalmol. 2016 Dec 1;134(12). doi: 10.1001/jamaophthalmol.2016.3698.

45.

Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.

Hill ZB, Pollock SB, Zhuang M, Wells JA.

J Am Chem Soc. 2016 Oct 12;138(40):13123-13126. Epub 2016 Sep 28.

46.

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92. doi: 10.1073/pnas.1610099113. Epub 2016 Aug 1.

47.

MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.

Wells JA, Thomas DL, Saga T, Kershaw J, Aoki I.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2076-2083. doi: 10.1177/0271678X16660985. Epub 2016 Jan 1.

48.

A reactivity-based probe of the intracellular labile ferrous iron pool.

Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR.

Nat Chem Biol. 2016 Sep;12(9):680-5. doi: 10.1038/nchembio.2116. Epub 2016 Jul 4.

49.

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.

Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA.

Cell Death Differ. 2016 Oct;23(10):1717-26. doi: 10.1038/cdd.2016.62. Epub 2016 Jul 1.

50.

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA.

Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009.

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