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Items: 31

1.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, Huber KVM, Rogers CM, Wells CI, Fedorov O, Rumpel K, Zoephel A, Mayer M, Wunberg T, Böse D, Zahn S, Arnhof H, Berger H, Reiser C, Hörmann A, Krammer T, Corcokovic M, Sharps B, Winkler S, Häring D, Cockcroft XL, Fuchs JE, Müllauer B, Weiss-Puxbaum A, Gerstberger T, Boehmelt G, Vakoc CR, Arrowsmith CH, Pearson M, McConnell DB.

Nat Chem Biol. 2019 Jul 8. doi: 10.1038/s41589-019-0310-x. [Epub ahead of print]

PMID:
31285596
2.

Australasian Students' Surgical Association: development, progress and future directions.

Wells CI, Fitzpatrick SE, Chan E, Ridley W, Hanney RM.

ANZ J Surg. 2019 Jun;89(6):629-630. doi: 10.1111/ans.15178. No abstract available.

PMID:
31179632
3.

A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction.

Drewry DH, Wells CI, Zuercher WJ, Willson TM.

SLAS Discov. 2019 Jun;24(5):505-514. doi: 10.1177/2472555219838210. Epub 2019 Apr 29.

PMID:
31034310
4.

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.

Asquith CRM, Naegeli KM, East MP, Laitinen T, Havener TM, Wells CI, Johnson GL, Drewry DH, Zuercher WJ, Morris DC.

J Med Chem. 2019 May 9;62(9):4772-4778. doi: 10.1021/acs.jmedchem.9b00350. Epub 2019 Apr 19.

PMID:
30973735
5.

Prevalence of diabetes in liver cirrhosis: A systematic review and meta-analysis.

Lee WG, Wells CI, McCall JL, Murphy R, Plank LD.

Diabetes Metab Res Rev. 2019 Mar 22:e3157. doi: 10.1002/dmrr.3157. [Epub ahead of print] Review.

PMID:
30901133
6.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ.

J Med Chem. 2019 Mar 14;62(5):2830-2836. doi: 10.1021/acs.jmedchem.8b01213. Epub 2019 Feb 26.

7.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.

8.

Colonic Electromechanical Abnormalities Underlying Post-operative Ileus: A Systematic and Critical Review.

Wells CI, O'Grady G, Bissett IP.

J Neurogastroenterol Motil. 2019 Jan 31;25(1):36-47. doi: 10.5056/jnm18030. Review.

9.

Electrical Stimulation and Recovery of Gastrointestinal Function Following Surgery: A Systematic Review.

Penfold JA, Wells CI, Du P, Bissett IP, O'Grady G.

Neuromodulation. 2018 Nov 19. doi: 10.1111/ner.12878. [Epub ahead of print] Review.

PMID:
30451336
10.

Methods for High-Resolution Electrical Mapping in the Gastrointestinal Tract.

O'Grady G, Angeli TR, Paskaranandavadivel N, Erickson JC, Wells CI, Gharibans AA, Cheng LK, Du P.

IEEE Rev Biomed Eng. 2019;12:287-302. doi: 10.1109/RBME.2018.2867555. Epub 2018 Aug 29. Review.

PMID:
30176605
11.

In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.

Wells CI, Kapadia NR, Couñago RM, Drewry DH.

Medchemcomm. 2017 Dec 8;9(1):44-66. doi: 10.1039/c7md00510e. eCollection 2018 Jan 1. Review.

12.

Relationship Between Total Body Protein and Cross-Sectional Skeletal Muscle Area in Liver Cirrhosis Is Influenced by Overhydration.

Wells CI, McCall JL, Plank LD.

Liver Transpl. 2019 Jan;25(1):45-55. doi: 10.1002/lt.25314.

PMID:
30040184
13.

Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.

Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM.

SLAS Discov. 2018 Sep;23(8):850-861. doi: 10.1177/2472555218773045. Epub 2018 May 9.

PMID:
29742358
14.

Challenges in ileus research.

Chapman SJ, Wells CI.

Colorectal Dis. 2018 Jul;20(7):639. doi: 10.1111/codi.14239. Epub 2018 May 16. No abstract available.

PMID:
29700969
15.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

16.

Hyperactive cyclic motor activity in the distal colon after colonic surgery as defined by high-resolution colonic manometry.

Vather R, O'Grady G, Lin AY, Du P, Wells CI, Rowbotham D, Arkwright J, Cheng LK, Dinning PG, Bissett IP.

Br J Surg. 2018 Jun;105(7):907-917. doi: 10.1002/bjs.10808. Epub 2018 Apr 14.

PMID:
29656582
17.

Reporting of complications after laparoscopic cholecystectomy: a systematic review.

Alexander HC, Bartlett AS, Wells CI, Hannam JA, Moore MR, Poole GH, Merry AF.

HPB (Oxford). 2018 Sep;20(9):786-794. doi: 10.1016/j.hpb.2018.03.004. Epub 2018 Apr 9. Review.

PMID:
29650299
18.

Association Between Circular Stapler Diameter and Stricture Rates Following Gastrointestinal Anastomosis: Systematic Review and Meta-analysis.

Allen W, Wells CI, Greenslade M, Bissett IP, O'Grady G.

World J Surg. 2018 Oct;42(10):3097-3105. doi: 10.1007/s00268-018-4606-x. Review.

PMID:
29633101
19.

Research opportunities for medical students: time flies when you're having fun.

Wells CI, Al-Busaidi IS.

N Z Med J. 2018 Jan 19;131(1468):92-93. No abstract available.

PMID:
29346362
20.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.

Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB.

Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22.

21.

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.

Asquith CRM, Laitinen T, Bennett JM, Godoi PH, East MP, Tizzard GJ, Graves LM, Johnson GL, Dornsife RE, Wells CI, Elkins JM, Willson TM, Zuercher WJ.

ChemMedChem. 2018 Jan 8;13(1):48-66. doi: 10.1002/cmdc.201700663. Epub 2017 Nov 27.

22.
23.

Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms.

Wells CI, O'Grady G, Bissett IP.

World J Gastroenterol. 2017 Aug 14;23(30):5634-5644. doi: 10.3748/wjg.v23.i30.5634.

24.

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.

Couñago RM, Allerston CK, Savitsky P, Azevedo H, Godoi PH, Wells CI, Mascarello A, de Souza Gama FH, Massirer KB, Zuercher WJ, Guimarães CRW, Gileadi O.

Sci Rep. 2017 Aug 8;7(1):7501. doi: 10.1038/s41598-017-07755-y.

25.

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.

PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.

26.

Impact of atrial fibrillation on long-term survival following oesophagectomy: a 21-year observational study.

Wells CI, Robertson JP, Campbell S, Al-Herz F, Rhind B, Young M.

ANZ J Surg. 2018 Apr;88(4):E268-E272. doi: 10.1111/ans.14054. Epub 2017 Jun 7.

PMID:
28593749
27.

Response to Re: Trends in publication of general surgical research in New Zealand, 1996-2015.

Wells CI, Robertson JP, O'Grady G, Bissett IP.

ANZ J Surg. 2017 Apr;87(4):317. doi: 10.1111/ans.13923. No abstract available.

PMID:
28371033
28.

Trends in publication of general surgical research in New Zealand, 1996-2015.

Wells CI, Robertson JP, O'Grady G, Bissett IP.

ANZ J Surg. 2017 Jan;87(1-2):76-79. doi: 10.1111/ans.13821. Epub 2016 Nov 1. Review.

PMID:
27804200
29.

Effect of Diversion Ileostomy on the Occurrence and Consequences of Chemotherapy-Induced Diarrhea.

Robertson JP, Wells CI, Vather R, Bissett IP.

Dis Colon Rectum. 2016 Mar;59(3):194-200. doi: 10.1097/DCR.0000000000000531.

PMID:
26855393
30.

Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.

Billin AN, Bantscheff M, Drewes G, Ghidelli-Disse S, Holt JA, Kramer HF, McDougal AJ, Smalley TL, Wells CI, Zuercher WJ, Henke BR.

ACS Chem Biol. 2016 Feb 19;11(2):518-29. doi: 10.1021/acschembio.5b00772. Epub 2016 Jan 7.

PMID:
26696218
31.

Anterior resection syndrome--a risk factor analysis.

Wells CI, Vather R, Chu MJ, Robertson JP, Bissett IP.

J Gastrointest Surg. 2015 Feb;19(2):350-9. doi: 10.1007/s11605-014-2679-x. Epub 2014 Oct 18.

PMID:
25326125

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