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Composite Resin Versus Amalgam for Dental Restorations: A Health Technology Assessment [Internet].

Khangura SD, Seal K, Esfandiari S, Quiñonez C, Mierzwinski-Urban M, Mulla SM, Laplante S, Tsoi B, Godfrey C, Weeks L, Helis E, Wells C, Pullman D, Basu N.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Mar.


Checkpoint inhibitors in patients with metastatic renal cell carcinoma: Results from the international metastatic renal cell carcinoma database consortium.

Yip SM, Wells C, Moreira R, Wong A, Srinivas S, Beuselinck B, Porta C, Sim HW, Ernst DS, Rini BI, Yuasa T, Basappa NS, Kanesvaran R, Wood LA, Canil C, Kapoor A, Fu SYF, Choueiri TK, Heng DYC.

Cancer. 2018 Oct 11. doi: 10.1002/cncr.31595. [Epub ahead of print]


Proton Beam Therapy for the Treatment of Cancer in Children and Adults: A Health Technology Assessment [Internet].

Kim J, Wells C, Khangura S, Alexander C, Mulla S, Farrah K, Paulden M, Tsoi B, DeJean D, Duthie K, Dufour BG.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Aug.


Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7951. doi: 10.1126/scisignal.aat7951.


PCSK-9 Inhibitors for Hyperlipidemia: A Review of the Comparative Clinical Effectiveness [Internet].

Banerjee S, Wells C, Grobelna A.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Jun 6.


Methods for High-Resolution Electrical Mapping in the Gastrointestinal Tract.

OGrady G, Angeli TR, Paskaranandavadivel N, Erickson JC, Wells C, Gharibans AA, Cheng LK, Du P.

IEEE Rev Biomed Eng. 2018 Aug 29. doi: 10.1109/RBME.2018.2867555. [Epub ahead of print]


Viscosupplementation for Knee Osteoarthritis: A Review of Clinical and Cost-Effectiveness and Guidelines [Internet].

Kaulback K, Jones S, Wells C, Felipe E.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Jun 22.


In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.

Wells CI, Kapadia NR, Couñago RM, Drewry DH.

Medchemcomm. 2017 Dec 8;9(1):44-66. doi: 10.1039/c7md00510e. eCollection 2018 Jan 1. Review.


European Pain Federation (EFIC) position paper on appropriate use of cannabis-based medicines and medical cannabis for chronic pain management.

Häuser W, Finn DP, Kalso E, Krcevski-Skvarc N, Kress HG, Morlion B, Perrot S, Schäfer M, Wells C, Brill S.

Eur J Pain. 2018 Oct;22(9):1547-1564. doi: 10.1002/ejp.1297. Epub 2018 Sep 4.


Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome.

Natoli R, Mason E, Jiao H, Chuah A, Patel H, Fernando N, Valter K, Wells CA, Provis J, Rutar M.

Front Immunol. 2018 Jul 18;9:1666. doi: 10.3389/fimmu.2018.01666. eCollection 2018.


Correction: Changes in scoring of Direct Observation of Procedural Skills (DOPS) forms and the impact on competence assessment.

Siau K, Dunckley P, Valori R, Feeney M, Hawkes ND, Anderson JT, Beales ILP, Wells C, Thomas-Gibson S, Johnson G; Joint Advisory Group on Gastrointestinal Endoscopy (JAG).

Endoscopy. 2018 Aug;50(8):C9. doi: 10.1055/a-0658-2732. Epub 2018 Jul 26. No abstract available.


Relationship between total body protein and cross-sectional skeletal muscle area in liver cirrhosis is influenced by overhydration.

Wells CI, McCall JL, Plank LD.

Liver Transpl. 2018 Jul 24. doi: 10.1002/lt.25314. [Epub ahead of print]


Correlation between RB1germline mutations and second primary malignancies in hereditary retinoblastoma patients treated with external beam radiotherapy.

Chaussade A, Millot G, Wells C, Brisse H, Laé M, Savignoni A, Desjardins L, Dendale R, Doz F, Aerts I, Jimenez I, Cassoux N, Stoppa Lyonnet D, Gauthier Villars M, Houdayer C.

Eur J Med Genet. 2018 Jul 18. pii: S1769-7212(18)30010-7. doi: 10.1016/j.ejmg.2018.07.017. [Epub ahead of print] Review.


A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home.

Verceles AC, Wells CL, Sorkin JD, Terrin ML, Beans J, Jenkins T, Goldberg AP.

J Crit Care. 2018 Oct;47:204-210. doi: 10.1016/j.jcrc.2018.07.006. Epub 2018 Jul 11.


Review of Russian language studies on radionuclide behaviour in agricultural animals: Transfer to animal tissues.

Fesenko S, Isamov N, Howard BJ, Sanzharova N, Wells C.

J Environ Radioact. 2018 Dec;192:233-249. doi: 10.1016/j.jenvrad.2018.06.012. Epub 2018 Jul 6. Review.


Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish.

Glazer L, Hawkey AB, Wells CN, Drastal M, Odamah KA, Behl M, Levin ED.

Toxicol Sci. 2018 Oct 1;165(2):487-498. doi: 10.1093/toxsci/kfy173.


Pan-tuberculosis regimens: re-framing the argument.

Gupta R, Wells CD.

Lancet Respir Med. 2018 Jul;6(7):e28. doi: 10.1016/S2213-2600(18)30189-9. No abstract available.


Characterizing the Patterns of HIV Disclosure to Clients Among South African Female Sex Workers in Port Elizabeth.

Wells C, Schwartz S, Phaswana-Mafuya N, Lambert A, Kose Z, Mcingana M, Hausler H, Rao A, Yah C, Ketende S, Baral S.

AIDS Behav. 2018 Jul 2. doi: 10.1007/s10461-018-2199-x. [Epub ahead of print]


Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial.

Bharucha KN, Brunner HI, Calvo Penadés I, Nikishina I, Rubio-Pérez N, Oliveira S, Kobusinska K, Schmeling H, Sztajnbok F, Weller-Heinemann F, Zholobova E, Zulian F, Allen R, Chaitow J, Frane J, Wells C, Ruperto N, De Benedetti F; Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group.

J Rheumatol. 2018 Aug;45(8):1173-1179. doi: 10.3899/jrheum.170326. Epub 2018 Jul 1.


Building reliable supply chains for noncommunicable disease commodities: lessons learned from HIV and evidence needs.

Pastakia SD, Tran DN, Manji I, Wells C, Kinderknecht K, Ferris R.

AIDS. 2018 Jul 1;32 Suppl 1:S55-S61. doi: 10.1097/QAD.0000000000001878.


New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265.


New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.

Byrne DP, Li Y, Ngamlert P, Ramakrishnan K, Eyers CE, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2435-2455. doi: 10.1042/BCJ20180266.


Extended Kd distributions for freshwater environment.

Boyer P, Wells C, Howard B.

J Environ Radioact. 2018 Dec;192:128-142. doi: 10.1016/j.jenvrad.2018.06.006. Epub 2018 Jun 18.


A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naïve Patients With Advanced NSCLC.

Lisberg A, Cummings A, Goldman JW, Bornazyan K, Reese N, Wang T, Coluzzi P, Ledezma B, Mendenhall M, Hunt J, Wolf B, Jones B, Madrigal J, Horton J, Spiegel M, Carroll J, Gukasyan J, Williams T, Sauer L, Wells C, Hardy A, Linares P, Lim C, Ma L, Adame C, Garon EB.

J Thorac Oncol. 2018 Aug;13(8):1138-1145. doi: 10.1016/j.jtho.2018.03.035. Epub 2018 Jun 1.


Trends in Avoidable Hospitalizations for Diabetes: Experience of a Large Clinically Integrated Health Care System.

Yaqoob M, Wang J, Sweeney AT, Wells C, Rego V, Jaber BL.

J Healthc Qual. 2018 Jun 4. doi: 10.1097/JHQ.0000000000000145. [Epub ahead of print]


Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.

Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ.

Front Cell Infect Microbiol. 2018 May 17;8:160. doi: 10.3389/fcimb.2018.00160. eCollection 2018.


Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages.

Butcher SK, O'Carroll CE, Wells CA, Carmody RJ.

Front Immunol. 2018 May 14;9:933. doi: 10.3389/fimmu.2018.00933. eCollection 2018.


The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons.

Ovchinnikov DA, Korn O, Virshup I, Wells CA, Wolvetang EJ.

Stem Cell Reports. 2018 Jul 10;11(1):32-42. doi: 10.1016/j.stemcr.2018.05.004. Epub 2018 May 31.


Recessive Spondylocarpotarsal Synostosis Syndrome Due to Compound Heterozygosity for Variants in MYH3.

Cameron-Christie SR, Wells CF, Simon M, Wessels M, Tang CZN, Wei W, Takei R, Aarts-Tesselaar C, Sandaradura S, Sillence DO, Cordier MP, Veenstra-Knol HE, Cassina M, Ludkig K, Trevisson E, Bahlo M, Markie DM, Jenkins ZA, Robertson SP.

Am J Hum Genet. 2018 Jun 7;102(6):1115-1125. doi: 10.1016/j.ajhg.2018.04.008. Epub 2018 May 24.


Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.

Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe KE, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE 3rd, Kumar V, Malhotra SV, Weigel NL, Gestwicki JE, Trepel JB, Neckers LM.

Cancer Res. 2018 Jul 15;78(14):4022-4035. doi: 10.1158/0008-5472.CAN-17-3728. Epub 2018 May 15.


Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.

Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM.

SLAS Discov. 2018 Sep;23(8):850-861. doi: 10.1177/2472555218773045. Epub 2018 May 9.


Vancomycin Versus Vancomycin Plus Rifampin for the Treatment of Acute Pulmonary Exacerbations of Cystic Fibrosis.

Fusco NM, Meaney CJ, Wells C, Frederick CA, Prescott WA Jr.

J Pediatr Pharmacol Ther. 2018 Mar-Apr;23(2):125-131. doi: 10.5863/1551-6776-23.2.125.


Challenges in ileus research.

Chapman SJ, Wells CI.

Colorectal Dis. 2018 Jul;20(7):639. doi: 10.1111/codi.14239. Epub 2018 May 16. No abstract available.


Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.


Hyperactive cyclic motor activity in the distal colon after colonic surgery as defined by high-resolution colonic manometry.

Vather R, O'Grady G, Lin AY, Du P, Wells CI, Rowbotham D, Arkwright J, Cheng LK, Dinning PG, Bissett IP.

Br J Surg. 2018 Jun;105(7):907-917. doi: 10.1002/bjs.10808. Epub 2018 Apr 14.


Reporting of complications after laparoscopic cholecystectomy: a systematic review.

Alexander HC, Bartlett AS, Wells CI, Hannam JA, Moore MR, Poole GH, Merry AF.

HPB (Oxford). 2018 Sep;20(9):786-794. doi: 10.1016/j.hpb.2018.03.004. Epub 2018 Apr 9. Review.


Re: Letter to the editor of public health in response to 'Access to treatment with controlled medicines rationale and recommendations for neutral, respectful, and precise language'.

Scholten W, Simon O, Maremmani I, Wells C, Kelly JF, Hämmig R, Radbruch L.

Public Health. 2018 Jul;160:157-158. doi: 10.1016/j.puhe.2018.02.001. Epub 2018 Apr 7. No abstract available.


Ciprofloxacin and Rifampin Dual Antibiotic-Loaded Biopolymer Chitosan Sponge for Bacterial Inhibition.

Wells CM, Beenken KE, Smeltzer MS, Courtney HS, Jennings JA, Haggard WO.

Mil Med. 2018 Mar 1;183(suppl_1):433-444. doi: 10.1093/milmed/usx150.


Association Between Circular Stapler Diameter and Stricture Rates Following Gastrointestinal Anastomosis: Systematic Review and Meta-analysis.

Allen W, Wells CI, Greenslade M, Bissett IP, O'Grady G.

World J Surg. 2018 Oct;42(10):3097-3105. doi: 10.1007/s00268-018-4606-x. Review.


Changes in scoring of Direct Observation of Procedural Skills (DOPS) forms and the impact on competence assessment.

Siau K, Dunckley P, Valori R, Feeney M, Hawkes ND, Anderson JT, Beales ILP, Wells C, Thomas-Gibson S, Johnson G; Joint Advisory Group on Gastrointestinal Endoscopy (JAG).

Endoscopy. 2018 Aug;50(8):770-778. doi: 10.1055/a-0576-6667. Epub 2018 Apr 3.


Reply to Jacob and Colebunders.

Ellenberg SS, Keusch GT, Babiker AG, Edwards KM, Lewis RJ, Lundgren JD, Wells CD, Wabwire-Mangen F, McAdam KPWJ.

Clin Infect Dis. 2018 Aug 31;67(6):985-986. doi: 10.1093/cid/ciy250. No abstract available.


The authors reply.

Wells CL, Forrester J, Vogel J, Rector R, Tabatabai A, Herr D.

Crit Care Med. 2018 Apr;46(4):e346. doi: 10.1097/CCM.0000000000002982. No abstract available.


Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis.

de Jong E, Hancock DG, Wells C, Richmond P, Simmer K, Burgner D, Strunk T, Currie AJ.

Immunol Cell Biol. 2018 Sep;96(8):792-804. doi: 10.1111/imcb.12037. Epub 2018 Apr 23.


PAK4 pathway as a potential therapeutic target in pancreatic cancer.

Thillai K, Sarker D, Wells C.

Future Oncol. 2018 Mar;14(7):579-582. doi: 10.2217/fon-2017-0458. Epub 2018 Mar 6. Review. No abstract available.


Perinatal outcomes associated with abnormal cardiac remodeling in women with treated chronic hypertension.

Ambia AM, Morgan JL, Wells CE, Roberts SW, Sanghavi M, Nelson DB, Cunningham FG.

Am J Obstet Gynecol. 2018 May;218(5):519.e1-519.e7. doi: 10.1016/j.ajog.2018.02.015. Epub 2018 Mar 2.


Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

Baillie JK, Bretherick A, Haley CS, Clohisey S, Gray A, Neyton LPA, Barrett J, Stahl EA, Tenesa A, Andersson R, Brown JB, Faulkner GJ, Lizio M, Schaefer U, Daub C, Itoh M, Kondo N, Lassmann T, Kawai J; IIBDGC Consortium, Mole D, Bajic VB, Heutink P, Rehli M, Kawaji H, Sandelin A, Suzuki H, Satsangi J, Wells CA, Hacohen N, Freeman TC, Hayashizaki Y, Carninci P, Forrest ARR, Hume DA.

PLoS Comput Biol. 2018 Mar 1;14(3):e1005934. doi: 10.1371/journal.pcbi.1005934. eCollection 2018 Mar.


The N54-αs Mutant Has Decreased Affinity for βγ and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation.

Cleator JH, Wells CA, Dingus J, Kurtz DT, Hildebrandt JD.

J Pharmacol Exp Ther. 2018 May;365(2):219-225. doi: 10.1124/jpet.117.245779. Epub 2018 Feb 28.


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