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Items: 1 to 50 of 81

1.

modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury.

Sauerbeck AD, Fanizzi C, Kim JH, Gangolli M, Bayly PV, Wellington CL, Brody DL, Kummer TT.

Sci Rep. 2018 May 16;8(1):7677. doi: 10.1038/s41598-018-25737-6.

2.

A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.

Silverman JM, Gibbs E, Peng X, Martens KM, Balducci C, Wang J, Yousefi M, Cowan CM, Lamour G, Louadi S, Ban Y, Robert J, Stukas S, Forloni G, Hsiung GR, Plotkin SS, Wellington CL, Cashman NR.

ACS Chem Neurosci. 2018 Jul 18;9(7):1591-1606. doi: 10.1021/acschemneuro.7b00469. Epub 2018 Apr 16.

PMID:
29614860
3.

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway.

Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engkvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, Wood MW, Kulic I, Wellington CL.

J Lipid Res. 2018 May;59(5):830-842. doi: 10.1194/jlr.M081851. Epub 2018 Mar 21.

PMID:
29563219
4.

Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice.

Cheng WH, Stukas S, Martens KM, Namjoshi DR, Button EB, Wilkinson A, Bashir A, Robert J, Cripton PA, Wellington CL.

Exp Neurol. 2018 Mar;301(Pt A):26-38. doi: 10.1016/j.expneurol.2017.12.007. Epub 2017 Dec 18.

PMID:
29269117
5.

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels.

Robert J, Button EB, Yuen B, Gilmour M, Kang K, Bahrabadi A, Stukas S, Zhao W, Kulic I, Wellington CL.

Elife. 2017 Oct 10;6. pii: e29595. doi: 10.7554/eLife.29595.

6.

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.

Robert J, Button EB, Stukas S, Boyce GK, Gibbs E, Cowan CM, Gilmour M, Cheng WH, Soo SK, Yuen B, Bahrabadi A, Kang K, Kulic I, Francis G, Cashman N, Wellington CL.

Mol Neurodegener. 2017 Aug 22;12(1):60. doi: 10.1186/s13024-017-0201-0.

7.

Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12.

Vonder Haar C, Martens KM, Riparip LK, Rosi S, Wellington CL, Winstanley CA.

J Neurotrauma. 2017 Oct 1;34(19):2790-2800. doi: 10.1089/neu.2016.4813. Epub 2017 May 24.

8.

Defining the biomechanical and biological threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration).

Namjoshi DR, Cheng WH, Bashir A, Wilkinson A, Stukas S, Martens KM, Whyte T, Abebe ZA, McInnes KA, Cripton PA, Wellington CL.

Exp Neurol. 2017 Jun;292:80-91. doi: 10.1016/j.expneurol.2017.03.003. Epub 2017 Mar 6.

9.

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.

Fan J, Zareyan S, Zhao W, Shimizu Y, Pfeifer TA, Tak JH, Isman MB, Van den Hoven B, Duggan ME, Wood MW, Wellington CL, Kulic I.

PLoS One. 2016 Sep 6;11(9):e0162384. doi: 10.1371/journal.pone.0162384. eCollection 2016.

10.

Relation between plasma and brain lipids.

Wellington CL, Frikke-Schmidt R.

Curr Opin Lipidol. 2016 Jun;27(3):225-32. doi: 10.1097/MOL.0000000000000291. Review.

PMID:
27149391
11.

Distinct roles for metalloproteinases during traumatic brain injury.

Zhang S, Kojic L, Tsang M, Grewal P, Liu J, Namjoshi D, Wellington CL, Tetzlaff W, Cynader MS, Jia W.

Neurochem Int. 2016 Jun;96:46-55. doi: 10.1016/j.neuint.2016.02.013. Epub 2016 Mar 3.

PMID:
26939762
12.

Chronic Exposure to Androgenic-Anabolic Steroids Exacerbates Axonal Injury and Microgliosis in the CHIMERA Mouse Model of Repetitive Concussion.

Namjoshi DR, Cheng WH, Carr M, Martens KM, Zareyan S, Wilkinson A, McInnes KA, Cripton PA, Wellington CL.

PLoS One. 2016 Jan 19;11(1):e0146540. doi: 10.1371/journal.pone.0146540. eCollection 2016.

13.

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice.

Robert J, Stukas S, Button E, Cheng WH, Lee M, Fan J, Wilkinson A, Kulic I, Wright SD, Wellington CL.

Biochim Biophys Acta. 2016 May;1862(5):1027-36. doi: 10.1016/j.bbadis.2015.10.005. Epub 2015 Oct 9.

14.

Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury.

Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL.

Mol Neurodegener. 2014 Dec 1;9:55. doi: 10.1186/1750-1326-9-55.

15.

Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus.

Stukas S, Robert J, Lee M, Kulic I, Carr M, Tourigny K, Fan J, Namjoshi D, Lemke K, DeValle N, Chan J, Wilson T, Wilkinson A, Chapanian R, Kizhakkedathu JN, Cirrito JR, Oda MN, Wellington CL.

J Am Heart Assoc. 2014 Nov 12;3(6):e001156. doi: 10.1161/JAHA.114.001156.

16.

LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice.

Stukas S, Freeman L, Lee M, Wilkinson A, Ossoli A, Vaisman B, Demosky S, Chan J, Hirsch-Reinshagen V, Remaley AT, Wellington CL.

J Lipid Res. 2014 Aug;55(8):1721-9. doi: 10.1194/jlr.M049940. Epub 2014 Jun 20.

17.

HDL and cholesterol handling in the brain.

Vitali C, Wellington CL, Calabresi L.

Cardiovasc Res. 2014 Aug 1;103(3):405-13. doi: 10.1093/cvr/cvu148. Epub 2014 Jun 6. Review.

PMID:
24907980
18.

High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease.

Stukas S, Robert J, Wellington CL.

Cell Metab. 2014 Apr 1;19(4):574-91. doi: 10.1016/j.cmet.2014.01.003. Epub 2014 Feb 6. Review.

19.

Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective.

Namjoshi DR, Good C, Cheng WH, Panenka W, Richards D, Cripton PA, Wellington CL.

Dis Model Mech. 2013 Nov;6(6):1325-38. doi: 10.1242/dmm.011320. Epub 2013 Sep 12. Review.

20.

Hormonal modulators of glial ABCA1 and apoE levels.

Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T, Wellington CL.

J Lipid Res. 2013 Nov;54(11):3139-50. doi: 10.1194/jlr.M042473. Epub 2013 Sep 2.

21.

ABCA1 influences neuroinflammation and neuronal death.

Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR.

Neurobiol Dis. 2013 Jun;54:445-55. doi: 10.1016/j.nbd.2013.01.018. Epub 2013 Jan 30.

PMID:
23376685
22.

The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.

Namjoshi DR, Martin G, Donkin J, Wilkinson A, Stukas S, Fan J, Carr M, Tabarestani S, Wuerth K, Hancock RE, Wellington CL.

PLoS One. 2013;8(1):e53529. doi: 10.1371/journal.pone.0053529. Epub 2013 Jan 17.

23.

LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function.

Hoekstra M, Korporaal SJ, van der Sluis RJ, Hirsch-Reinshagen V, Bochem AE, Wellington CL, Van Berkel TJ, Kuivenhoven JA, Van Eck M.

J Lipid Res. 2013 Feb;54(2):358-64. doi: 10.1194/jlr.M030080. Epub 2012 Nov 24.

24.

Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels.

Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL.

Curr Gerontol Geriatr Res. 2012;2012:179318. doi: 10.1155/2012/179318. Epub 2012 May 9.

25.

Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.

Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR.

Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7.

26.

The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1.

Stukas S, May S, Wilkinson A, Chan J, Donkin J, Wellington CL.

Biochim Biophys Acta. 2012 Mar;1821(3):536-46. doi: 10.1016/j.bbalip.2011.08.014. Epub 2011 Aug 26.

PMID:
21889608
27.

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia.

Fan J, Stukas S, Wong C, Chan J, May S, DeValle N, Hirsch-Reinshagen V, Wilkinson A, Oda MN, Wellington CL.

J Lipid Res. 2011 Sep;52(9):1605-16. doi: 10.1194/jlr.M014365. Epub 2011 Jun 26.

28.

ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype.

Vila-Rodriguez F, Honer WG, Innis SM, Wellington CL, Beasley CL.

J Psychiatry Neurosci. 2011 Jan;36(1):47-55. doi: 10.1503/jpn.090116.

29.

ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.

Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, Chan J, Fan J, Collins J, Wellington CL.

J Biol Chem. 2010 Oct 29;285(44):34144-54. doi: 10.1074/jbc.M110.108100. Epub 2010 Aug 25.

30.

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.

Takechi R, Galloway S, Pallebage-Gamarallage MM, Wellington CL, Johnsen RD, Dhaliwal SS, Mamo JC.

Br J Nutr. 2010 Mar;103(5):652-62. doi: 10.1017/S0007114509992194. Epub 2009 Oct 28.

PMID:
19860996
31.

Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.

Karasinska JM, Rinninger F, Lütjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR.

J Neurosci. 2009 Mar 18;29(11):3579-89. doi: 10.1523/JNEUROSCI.4741-08.2009.

32.

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1.

Parkinson PF, Kannangara TS, Eadie BD, Burgess BL, Wellington CL, Christie BR.

Lipids Health Dis. 2009 Feb 24;8:5. doi: 10.1186/1476-511X-8-5.

33.

Why lipids are important for Alzheimer disease?

Hirsch-Reinshagen V, Burgess BL, Wellington CL.

Mol Cell Biochem. 2009 Jun;326(1-2):121-9. doi: 10.1007/s11010-008-0012-2. Epub 2008 Dec 31.

PMID:
19116777
34.

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.

Hirsch-Reinshagen V, Donkin J, Stukas S, Chan J, Wilkinson A, Fan J, Parks JS, Kuivenhoven JA, Lütjohann D, Pritchard H, Wellington CL.

J Lipid Res. 2009 May;50(5):885-93. doi: 10.1194/jlr.M800584-JLR200. Epub 2008 Dec 8.

35.

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.

Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL.

J Lipid Res. 2008 Jun;49(6):1254-67. doi: 10.1194/jlr.M700481-JLR200. Epub 2008 Feb 26.

36.

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM.

J Clin Invest. 2008 Feb;118(2):671-82. doi: 10.1172/JCI33622.

37.

Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease.

Hirsch-Reinshagen V, Wellington CL.

Curr Opin Lipidol. 2007 Jun;18(3):325-32. Review.

PMID:
17495608
38.

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.

Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL.

J Lipid Res. 2007 May;48(5):1022-34. Epub 2007 Feb 10.

39.

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.

Hirsch-Reinshagen V, Chan JY, Wilkinson A, Tanaka T, Fan J, Ou G, Maia LF, Singaraja RR, Hayden MR, Wellington CL.

J Lipid Res. 2007 Apr;48(4):914-23. Epub 2007 Jan 18.

40.

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.

Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL.

Neurobiol Dis. 2006 Oct;24(1):114-27. Epub 2006 Aug 8.

PMID:
16899370
41.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.

Cell. 2006 Jun 16;125(6):1179-91.

42.

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

Abildayeva K, Jansen PJ, Hirsch-Reinshagen V, Bloks VW, Bakker AH, Ramaekers FC, de Vente J, Groen AK, Wellington CL, Kuipers F, Mulder M.

J Biol Chem. 2006 May 5;281(18):12799-808. Epub 2006 Mar 8.

43.

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.

Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, Ross CA, Ha HC, Li XJ, Snyder SH, Sawa A.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3405-9. Epub 2006 Feb 21.

44.

Wild-type huntingtin protects neurons from excitotoxicity.

Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR.

J Neurochem. 2006 Feb;96(4):1121-9. Epub 2006 Jan 17.

45.

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL.

J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5.

46.

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.

Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL.

J Biol Chem. 2004 Sep 24;279(39):41197-207. Epub 2004 Jul 21.

47.

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism.

Wellington CL.

Clin Genet. 2004 Jul;66(1):1-16. Review.

PMID:
15200500
48.

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease.

Zeron MM, Fernandes HB, Krebs C, Shehadeh J, Wellington CL, Leavitt BR, Baimbridge KG, Hayden MR, Raymond LA.

Mol Cell Neurosci. 2004 Mar;25(3):469-79.

PMID:
15033175
49.

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.

Selva DM, Hirsch-Reinshagen V, Burgess B, Zhou S, Chan J, McIsaac S, Hayden MR, Hammond GL, Vogl AW, Wellington CL.

J Lipid Res. 2004 Jun;45(6):1040-50. Epub 2004 Mar 16.

50.

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM.

J Biol Chem. 2004 May 7;279(19):20211-20. Epub 2004 Feb 23.

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