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Items: 1 to 50 of 209

1.

Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges.

Shibata-Germanos S, Goodman JR, Grieg A, Trivedi CA, Benson BC, Foti SC, Faro A, Castellan RFP, Correra RM, Barber M, Ruhrberg C, Weller RO, Lashley T, Iliff JJ, Hawkins TA, Rihel J.

Acta Neuropathol. 2019 Nov 6. doi: 10.1007/s00401-019-02091-z. [Epub ahead of print]

PMID:
31696318
2.

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain.

Aldea R, Weller RO, Wilcock DM, Carare RO, Richardson G.

Front Aging Neurosci. 2019 Jan 23;11:1. doi: 10.3389/fnagi.2019.00001. eCollection 2019.

3.

A control mechanism for intra-mural peri-arterial drainage via astrocytes: How neuronal activity could improve waste clearance from the brain.

Diem AK, Carare RO, Weller RO, Bressloff NW.

PLoS One. 2018 Oct 4;13(10):e0205276. doi: 10.1371/journal.pone.0205276. eCollection 2018.

4.

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways.

Albargothy NJ, Johnston DA, MacGregor-Sharp M, Weller RO, Verma A, Hawkes CA, Carare RO.

Acta Neuropathol. 2018 Jul;136(1):139-152. doi: 10.1007/s00401-018-1862-7. Epub 2018 May 12.

5.

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS.

Weller RO, Sharp MM, Christodoulides M, Carare RO, Møllgård K.

Acta Neuropathol. 2018 Mar;135(3):363-385. doi: 10.1007/s00401-018-1809-z. Epub 2018 Jan 24. Review.

PMID:
29368214
6.

The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain.

Dobson H, Sharp MM, Cumpsty R, Criswell TP, Wellman T, Finucane C, Sullivan JM, Weller RO, Verma A, Carare RO.

Clin Sci (Lond). 2017 Nov 13;131(22):2745-2752. doi: 10.1042/CS20171265. Print 2017 Nov 15.

PMID:
29021222
7.

The structure of the perivascular compartment in the old canine brain: a case study.

Criswell TP, Sharp MM, Dobson H, Finucane C, Weller RO, Verma A, Carare RO.

Clin Sci (Lond). 2017 Nov 13;131(22):2737-2744. doi: 10.1042/CS20171278. Print 2017 Nov 15.

PMID:
28982724
8.

The movers and shapers in immune privilege of the CNS.

Engelhardt B, Vajkoczy P, Weller RO.

Nat Immunol. 2017 Feb;18(2):123-131. doi: 10.1038/ni.3666. Epub 2017 Jan 16. Review.

PMID:
28092374
9.

Quantitative Assessment of Cerebral Basement Membranes Using Electron Microscopy.

Sharp MM, Page A, Morris A, Weller RO, Carare RO.

Methods Mol Biol. 2017;1559:367-375. doi: 10.1007/978-1-4939-6786-5_25.

PMID:
28063057
10.

Investigating the Lymphatic Drainage of the Brain: Essential Skills and Tools.

Albargothy NJ, Sharp MM, Gatherer M, Morris A, Weller RO, Hawkes C, Carare RO.

Methods Mol Biol. 2017;1559:343-365. doi: 10.1007/978-1-4939-6786-5_24.

PMID:
28063056
11.

Vascular, glial, and lymphatic immune gateways of the central nervous system.

Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO.

Acta Neuropathol. 2016 Sep;132(3):317-38. doi: 10.1007/s00401-016-1606-5. Epub 2016 Aug 13. Review.

12.

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases.

Bakker EN, Bacskai BJ, Arbel-Ornath M, Aldea R, Bedussi B, Morris AW, Weller RO, Carare RO.

Cell Mol Neurobiol. 2016 Mar;36(2):181-94. doi: 10.1007/s10571-015-0273-8. Epub 2016 Mar 18. Review.

13.

Vascular basement membranes as pathways for the passage of fluid into and out of the brain.

Morris AW, Sharp MM, Albargothy NJ, Fernandes R, Hawkes CA, Verma A, Weller RO, Carare RO.

Acta Neuropathol. 2016 May;131(5):725-36. doi: 10.1007/s00401-016-1555-z. Epub 2016 Mar 14.

14.

A Simulation Model of Periarterial Clearance of Amyloid-β from the Brain.

Diem AK, Tan M, Bressloff NW, Hawkes C, Morris AW, Weller RO, Carare RO.

Front Aging Neurosci. 2016 Feb 12;8:18. doi: 10.3389/fnagi.2016.00018. eCollection 2016.

15.

Peristalsis with Oscillating Flow Resistance: A Mechanism for Periarterial Clearance of Amyloid Beta from the Brain.

Sharp MK, Diem AK, Weller RO, Carare RO.

Ann Biomed Eng. 2016 May;44(5):1553-65. doi: 10.1007/s10439-015-1457-6. Epub 2015 Sep 23.

PMID:
26399987
16.

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy.

Keable A, Fenna K, Yuen HM, Johnston DA, Smyth NR, Smith C, Al-Shahi Salman R, Samarasekera N, Nicoll JA, Attems J, Kalaria RN, Weller RO, Carare RO.

Biochim Biophys Acta. 2016 May;1862(5):1037-46. doi: 10.1016/j.bbadis.2015.08.024. Epub 2015 Aug 29.

17.

Quantification of molecular interactions between ApoE, amyloid-beta (Aβ) and laminin: Relevance to accumulation of Aβ in Alzheimer's disease.

Zekonyte J, Sakai K, Nicoll JA, Weller RO, Carare RO.

Biochim Biophys Acta. 2016 May;1862(5):1047-53. doi: 10.1016/j.bbadis.2015.08.025. Epub 2015 Aug 29.

18.

Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

Weller RO, Hawkes CA, Carare RO, Hardy J.

Acta Neuropathol. 2015 May;129(5):763-6. doi: 10.1007/s00401-015-1416-1. Epub 2015 Mar 27. No abstract available.

PMID:
25814152
19.

White matter changes in dementia: role of impaired drainage of interstitial fluid.

Weller RO, Hawkes CA, Kalaria RN, Werring DJ, Carare RO.

Brain Pathol. 2015 Jan;25(1):63-78. doi: 10.1111/bpa.12218. Review.

PMID:
25521178
20.

Amyloid and tau in the brain in sporadic Alzheimer's disease: defining the chicken and the egg.

Hawkes CA, Carare RO, Weller RO.

Acta Neuropathol. 2014 Apr;127(4):617-8. doi: 10.1007/s00401-014-1243-9. Epub 2014 Jan 23. No abstract available.

21.

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer's disease.

Carare RO, Teeling JL, Hawkes CA, Püntener U, Weller RO, Nicoll JA, Perry VH.

Acta Neuropathol Commun. 2013 Aug 9;1:48. doi: 10.1186/2051-5960-1-48.

22.

Afferent and efferent immunological pathways of the brain. Anatomy, function and failure.

Carare RO, Hawkes CA, Weller RO.

Brain Behav Immun. 2014 Feb;36:9-14. doi: 10.1016/j.bbi.2013.10.012. Epub 2013 Oct 18. Review.

PMID:
24145049
23.

Drainage of cells and soluble antigen from the CNS to regional lymph nodes.

Laman JD, Weller RO.

J Neuroimmune Pharmacol. 2013 Sep;8(4):840-56. doi: 10.1007/s11481-013-9470-8. Epub 2013 May 22. Review.

PMID:
23695293
24.

Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy.

Carare RO, Hawkes CA, Jeffrey M, Kalaria RN, Weller RO.

Neuropathol Appl Neurobiol. 2013 Oct;39(6):593-611. doi: 10.1111/nan.12042. Review.

PMID:
23489283
25.

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain.

Hawkes CA, Gatherer M, Sharp MM, Dorr A, Yuen HM, Kalaria R, Weller RO, Carare RO.

Aging Cell. 2013 Apr;12(2):224-36. doi: 10.1111/acel.12045. Epub 2013 Feb 18.

26.

Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele.

Hawkes CA, Sullivan PM, Hands S, Weller RO, Nicoll JA, Carare RO.

PLoS One. 2012;7(7):e41636. doi: 10.1371/journal.pone.0041636. Epub 2012 Jul 25.

27.

Editorial: route by which monocytes leave the brain is revealed.

Laman JD, Weller RO.

J Leukoc Biol. 2012 Jul;92(1):6-9. doi: 10.1189/jlb.0212110. No abstract available.

PMID:
22745459
28.

Infant subcortical cystic leucomalacia: a distinct pathological entity resulting from impaired fluid handling.

Squier W, Austin T, Anslow P, Weller RO.

Early Hum Dev. 2011 Jun;87(6):421-6. doi: 10.1016/j.earlhumdev.2011.03.003. Epub 2011 Apr 8.

PMID:
21482047
29.

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.

Hawkes CA, Härtig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO.

Acta Neuropathol. 2011 Apr;121(4):431-43. doi: 10.1007/s00401-011-0801-7. Epub 2011 Jan 23.

PMID:
21259015
30.

Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis.

Weller RO, Galea I, Carare RO, Minagar A.

Pathophysiology. 2010 Sep;17(4):295-306. doi: 10.1016/j.pathophys.2009.10.007. Epub 2009 Dec 1.

PMID:
19954936
31.

Cervical lymph nodes are found in direct relationship with the internal carotid artery: significance for the lymphatic drainage of the brain.

Clapham R, O'Sullivan E, Weller RO, Carare RO.

Clin Anat. 2010 Jan;23(1):43-7. doi: 10.1002/ca.20887.

PMID:
19918869
32.

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease.

Weller RO, Preston SD, Subash M, Carare RO.

Alzheimers Res Ther. 2009 Oct 12;1(2):6. doi: 10.1186/alzrt6.

33.

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy.

Weller RO, Boche D, Nicoll JA.

Acta Neuropathol. 2009 Jul;118(1):87-102. doi: 10.1007/s00401-009-0498-z. Epub 2009 Feb 22. Review.

PMID:
19234858
34.

Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review.

Keage HA, Carare RO, Friedland RP, Ince PG, Love S, Nicoll JA, Wharton SB, Weller RO, Brayne C.

BMC Neurol. 2009 Jan 13;9:3. doi: 10.1186/1471-2377-9-3. Review.

35.

Lymphatic drainage of the brain and the pathophysiology of neurological disease.

Weller RO, Djuanda E, Yow HY, Carare RO.

Acta Neuropathol. 2009 Jan;117(1):1-14. doi: 10.1007/s00401-008-0457-0. Epub 2008 Nov 11. Review.

PMID:
19002474
36.

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA.

Brain. 2008 Dec;131(Pt 12):3299-310. doi: 10.1093/brain/awn261. Epub 2008 Oct 25.

PMID:
18953056
37.

Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

Weller RO, Subash M, Preston SD, Mazanti I, Carare RO.

Brain Pathol. 2008 Apr;18(2):253-66. doi: 10.1111/j.1750-3639.2008.00133.x. Review.

PMID:
18363936
38.

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology.

Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH, Weller RO.

Neuropathol Appl Neurobiol. 2008 Apr;34(2):131-44. doi: 10.1111/j.1365-2990.2007.00926.x. Epub 2008 Jan 16.

PMID:
18208483
39.

The phagocytic capacity of neurones.

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJ, Revesz T, King RH, Berninghausen O, Fisher EM, Schiavo G, Martin JE.

Eur J Neurosci. 2007 May;25(10):2947-55.

PMID:
17561810
40.

An unusual familial oculopharyngeal syndrome.

Cooper SA, Hill ME, Weller RO, Hammans SR.

Eur J Neurol. 2006 May;13(5):549-50. No abstract available.

PMID:
16722985
41.

Immunotherapy for Alzheimer's disease and other dementias.

Boche D, Nicoll JA, Weller RO.

Clin Neuropharmacol. 2006 Jan-Feb;29(1):22-7.

PMID:
16518131
42.

Immunotherapy for Alzheimer's disease and other dementias.

Boche D, Nicoll JA, Weller RO.

Curr Opin Neurol. 2005 Dec;18(6):720-5. Review.

PMID:
16280685
43.

Cerebral amyloid angiopathy: both viper and maggot in the brain.

Weller RO, Nicoll JA.

Ann Neurol. 2005 Sep;58(3):348-50. No abstract available.

PMID:
16130089
44.

Mechanisms to explain the reverse perivascular transport of solutes out of the brain.

Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO.

J Theor Biol. 2006 Feb 21;238(4):962-74. Epub 2005 Aug 22.

PMID:
16112683
45.

Microscopic morphology and histology of the human meninges.

Weller RO.

Morphologie. 2005 Mar;89(284):22-34. Review.

PMID:
15943078
46.

Cerebrovascular disease and the pathophysiology of Alzheimer's disease. Implications for therapy.

Weller RO, Cohen NR, Nicoll JA.

Panminerva Med. 2004 Dec;46(4):239-51. Review.

PMID:
15876980
47.

Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease.

Li R, Johnson AB, Salomons G, Goldman JE, Naidu S, Quinlan R, Cree B, Ruyle SZ, Banwell B, D'Hooghe M, Siebert JR, Rolf CM, Cox H, Reddy A, Gutiérrez-Solana LG, Collins A, Weller RO, Messing A, van der Knaap MS, Brenner M.

Ann Neurol. 2005 Mar;57(3):310-26.

PMID:
15732097
48.

Giant tumefactive perivascular spaces.

Salzman KL, Osborn AG, House P, Jinkins JR, Ditchfield A, Cooper JA, Weller RO.

AJNR Am J Neuroradiol. 2005 Feb;26(2):298-305.

49.

Genetic and expression profiles of cerebellar liponeurocytomas.

Horstmann S, Perry A, Reifenberger G, Giangaspero F, Huang H, Hara A, Masuoka J, Rainov NG, Bergmann M, Heppner FL, Brandner S, Chimelli L, Montagna N, Jackson T, Davis DG, Markesbery WR, Ellison DW, Weller RO, Taddei GL, Conti R, Del Bigio MR, González-Cámpora R, Radhakrishnan VV, Söylemezoglu F, Uro-Coste E, Qian J, Kleihues P, Ohgaki H.

Brain Pathol. 2004 Jul;14(3):281-9.

PMID:
15446583
50.

Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis.

Sun D, Newman TA, Perry VH, Weller RO.

Neuropathol Appl Neurobiol. 2004 Aug;30(4):374-84.

PMID:
15305983

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