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Items: 1 to 50 of 267

1.

Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD2 Receptors: 15-LO Role in Cytokine Secretion.

Magalhães KG, Luna-Gomes T, Mesquita-Santos F, Corrêa R, Assunção LS, Atella GC, Weller PF, Bandeira-Melo C, Bozza PT.

Front Immunol. 2019 Jan 25;9:3161. doi: 10.3389/fimmu.2018.03161. eCollection 2018.

2.

Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Schistosoma mansoni Infection.

Dias FF, Amaral KB, Malta KK, Silva TP, Rodrigues GSC, Rosa FM, Rodrigues GOL, Costa VV, Chiarini-Garcia H, Weller PF, Melo RCN.

Front Immunol. 2018 Dec 20;9:3019. doi: 10.3389/fimmu.2018.03019. eCollection 2018.

3.

Evaluation of clinical benefit from treatment with mepolizumab for patients with eosinophilic granulomatosis with polyangiitis.

Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME.

J Allergy Clin Immunol. 2019 Jun;143(6):2170-2177. doi: 10.1016/j.jaci.2018.11.041. Epub 2018 Dec 19.

PMID:
30578883
4.

Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors.

Amorim NRT, Luna-Gomes T, Gama-Almeida M, Souza-Almeida G, Canetti C, Diaz BL, Weller PF, Torres Bozza P, Maya-Monteiro CM, Bandeira-Melo C.

Front Immunol. 2018 Sep 20;9:2139. doi: 10.3389/fimmu.2018.02139. eCollection 2018.

5.

Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases.

Shamri R, Young KM, Weller PF.

Clin Exp Allergy. 2019 Feb;49(2):190-198. doi: 10.1111/cea.13292. Epub 2018 Nov 19.

PMID:
30295352
6.

Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death.

Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, Konno Y, Takeda M, Yamamoto Y, Hirokawa M, Fujieda S, Spencer LA, Weller PF.

Blood. 2018 Nov 15;132(20):2183-2187. doi: 10.1182/blood-2018-04-842260. Epub 2018 Aug 28.

PMID:
30154112
7.

Single-Cell Analyses of Human Eosinophils at High Resolution to Understand Compartmentalization and Vesicular Trafficking of Interferon-Gamma.

Carmo LAS, Bonjour K, Spencer LA, Weller PF, Melo RCN.

Front Immunol. 2018 Jul 9;9:1542. doi: 10.3389/fimmu.2018.01542. eCollection 2018.

8.

Contemporary understanding of the secretory granules in human eosinophils.

Melo RCN, Weller PF.

J Leukoc Biol. 2018 Jul;104(1):85-93. doi: 10.1002/JLB.3MR1217-476R. Epub 2018 May 11. Review.

PMID:
29749658
9.

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD).

Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD.

J Leukoc Biol. 2018 Jul;104(1):69-83. doi: 10.1002/JLB.5MR0118-028R. Epub 2018 Apr 19. Review.

PMID:
29672914
10.

Functions of tissue-resident eosinophils.

Weller PF, Spencer LA.

Nat Rev Immunol. 2017 Dec;17(12):746-760. doi: 10.1038/nri.2017.95. Epub 2017 Sep 11. Review.

11.

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.

Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ; EGPA Mepolizumab Study Team.

N Engl J Med. 2017 May 18;376(20):1921-1932. doi: 10.1056/NEJMoa1702079.

12.

Measuring Success in Global Health Training: Data From 14 Years of a Postdoctoral Fellowship in Infectious Diseases and Tropical Medicine.

Tucker JD, Hughes MA, Durvasula RV, Vinetz JM, McGovern VP, Schultz R, Dunavan CP, Wilson ME, Milner DA, LaRocque RC, Calderwood SB, Guerrant RL, Weller PF, Taylor TE.

Clin Infect Dis. 2017 Jun 15;64(12):1768-1772. doi: 10.1093/cid/cix242.

13.

EicosaCell: An Imaging-Based Assay to Identify Spatiotemporal Eicosanoid Synthesis.

Bandeira-Melo C, Paiva LA, Amorim NRT, Weller PF, Bozza PT.

Methods Mol Biol. 2017;1554:127-141. doi: 10.1007/978-1-4939-6759-9_6.

14.

LEUKOCYTE LIPID BODIES - STRUCTURE AND FUNCTION AS "EICOSASOMES".

Weller PF.

Trans Am Clin Climatol Assoc. 2016;127:328-340.

15.

Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4.

Wang HB, Akuthota P, Kanaoka Y, Weller PF.

Allergy. 2017 Jun;72(6):927-936. doi: 10.1111/all.13094. Epub 2017 Jan 11.

16.

Eosinophilia.

Kovalszki A, Weller PF.

Prim Care. 2016 Dec;43(4):607-617. doi: 10.1016/j.pop.2016.07.010. Epub 2016 Oct 14. Review.

17.

Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli.

Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC.

Front Cell Dev Biol. 2016 Oct 27;4:117. eCollection 2016.

18.

Vesicular trafficking of immune mediators in human eosinophils revealed by immunoelectron microscopy.

Melo RC, Weller PF.

Exp Cell Res. 2016 Oct 1;347(2):385-90. doi: 10.1016/j.yexcr.2016.08.016. Epub 2016 Aug 22. Review.

19.

Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation.

Ueki S, Tokunaga T, Fujieda S, Honda K, Hirokawa M, Spencer LA, Weller PF.

Curr Allergy Asthma Rep. 2016 Jul;16(8):54. doi: 10.1007/s11882-016-0634-5. Review.

20.

CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils.

Carmo LA, Bonjour K, Ueki S, Neves JS, Liu L, Spencer LA, Dvorak AM, Weller PF, Melo RC.

J Leukoc Biol. 2016 Aug;100(2):391-401. doi: 10.1189/jlb.3A1015-480R. Epub 2016 Mar 10.

PMID:
26965633
21.

Lipid droplets in leukocytes: Organelles linked to inflammatory responses.

Melo RC, Weller PF.

Exp Cell Res. 2016 Jan 15;340(2):193-7. doi: 10.1016/j.yexcr.2015.10.028. Epub 2015 Oct 29. Review.

22.

Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response.

Muniz VS, Baptista-Dos-Reis R, Benjamim CF, Mata-Santos HA, Pyrrho AS, Strauch MA, Melo PA, Vicentino AR, Silva-Paiva J, Bandeira-Melo C, Weller PF, Figueiredo RT, Neves JS.

PLoS One. 2015 Oct 8;10(10):e0139805. doi: 10.1371/journal.pone.0139805. eCollection 2015.

23.

Expression and subcellular localization of the Qa-SNARE syntaxin17 in human eosinophils.

Carmo LAS, Dias FF, Malta KK, Amaral KB, Shamri R, Weller PF, Melo RCN.

Exp Cell Res. 2015 Oct 1;337(2):129-135. doi: 10.1016/j.yexcr.2015.07.003. Epub 2015 Aug 6.

24.

Spectrum of Eosinophilic End-Organ Manifestations.

Akuthota P, Weller PF.

Immunol Allergy Clin North Am. 2015 Aug;35(3):403-11. doi: 10.1016/j.iac.2015.04.002. Epub 2015 Jun 17. Review.

25.

The transcription factor XBP1 is selectively required for eosinophil differentiation.

Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH.

Nat Immunol. 2015 Aug;16(8):829-37. doi: 10.1038/ni.3225. Epub 2015 Jul 6.

26.

Eosinophil extracellular trap cell death-derived DNA traps: Their presence in secretions and functional attributes.

Ueki S, Konno Y, Takeda M, Moritoki Y, Hirokawa M, Matsuwaki Y, Honda K, Ohta N, Yamamoto S, Takagi Y, Wada A, Weller PF.

J Allergy Clin Immunol. 2016 Jan;137(1):258-267. doi: 10.1016/j.jaci.2015.04.041. Epub 2015 Jun 9.

27.

Eosinophil secretion of granule-derived cytokines.

Spencer LA, Bonjour K, Melo RC, Weller PF.

Front Immunol. 2014 Oct 27;5:496. doi: 10.3389/fimmu.2014.00496. eCollection 2014. Review.

28.

Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes.

Melo RC, Morgan E, Monahan-Earley R, Dvorak AM, Weller PF.

Nat Protoc. 2014 Oct;9(10):2382-94. doi: 10.1038/nprot.2014.163. Epub 2014 Sep 11.

29.

Unraveling the complexity of lipid body organelles in human eosinophils.

Melo RC, Weller PF.

J Leukoc Biol. 2014 Nov;96(5):703-12. doi: 10.1189/jlb.3RU0214-110R. Epub 2014 Sep 10. Review.

30.

Eosinophil purification from peripheral blood.

Akuthota P, Capron K, Weller PF.

Methods Mol Biol. 2014;1178:13-20. doi: 10.1007/978-1-4939-1016-8_2.

31.

Eosinophilia in mast cell disease.

Kovalszki A, Weller PF.

Immunol Allergy Clin North Am. 2014 May;34(2):357-64. doi: 10.1016/j.iac.2014.01.013. Epub 2014 Mar 13. Review.

32.

Human Eosinophil Leukocytes Express Protein Disulfide Isomerase in Secretory Granules and Vesicles: Ultrastructural Studies.

Dias FF, Amaral KB, Carmo LA, Shamri R, Dvorak AM, Weller PF, Melo RC.

J Histochem Cytochem. 2014 Jun;62(6):450-459. Epub 2014 Mar 26.

33.

PI3K, ERK, p38 MAPK and integrins regulate CCR3-mediated secretion of mouse and human eosinophil-associated RNases.

Shamri R, Young KM, Weller PF.

Allergy. 2013 Jul;68(7):880-9. doi: 10.1111/all.12163. Epub 2013 Jun 6.

34.

The consequences of not having eosinophils.

Gleich GJ, Klion AD, Lee JJ, Weller PF.

Allergy. 2013 Jul;68(7):829-35. doi: 10.1111/all.12169. Epub 2013 Jun 6. Review.

35.

The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.

Melo RC, Paganoti GF, Dvorak AM, Weller PF.

PLoS One. 2013;8(3):e59578. doi: 10.1371/journal.pone.0059578. Epub 2013 Mar 26.

36.

Human eosinophils express functional CCR7.

Akuthota P, Ueki S, Estanislau J, Weller PF.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):758-64. doi: 10.1165/rcmb.2012-0499OC.

37.

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans.

Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF.

Blood. 2013 Mar 14;121(11):2074-83. doi: 10.1182/blood-2012-05-432088. Epub 2013 Jan 9.

38.

ICON: Eosinophil Disorders.

Valent P, Klion AD, Rosenwasser LJ, Arock M, Bochner BS, Butterfield JH, Gotlib J, Haferlach T, Hellmann A, Horny HP, Leiferman KM, Metzgeroth G, Matsumoto K, Reiter A, Roufosse F, Rothenberg ME, Simon HU, Sotlar K, Vandenberghe P, Weller PF, Gleich GJ.

World Allergy Organ J. 2012 Dec;5(12):174-81. doi: 10.1097/WOX.0b013e31827f4192. No abstract available.

39.

Eosinophilic pneumonias.

Akuthota P, Weller PF.

Clin Microbiol Rev. 2012 Oct;25(4):649-60. doi: 10.1128/CMR.00025-12. Review.

40.

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

Bochner BS, Book W, Busse WW, Butterfield J, Furuta GT, Gleich GJ, Klion AD, Lee JJ, Leiferman KM, Minnicozzi M, Moqbel R, Rothenberg ME, Schwartz LB, Simon HU, Wechsler ME, Weller PF.

J Allergy Clin Immunol. 2012 Sep;130(3):587-96. doi: 10.1016/j.jaci.2012.07.024.

41.

Novel targeted therapies for eosinophilic disorders.

Wechsler ME, Fulkerson PC, Bochner BS, Gauvreau GM, Gleich GJ, Henkel T, Kolbeck R, Mathur SK, Ortega H, Patel J, Prussin C, Renzi P, Rothenberg ME, Roufosse F, Simon D, Simon HU, Wardlaw A, Weller PF, Klion AD.

J Allergy Clin Immunol. 2012 Sep;130(3):563-71. doi: 10.1016/j.jaci.2012.07.027. Review.

42.

Isolation of human eosinophils.

Akuthota P, Shamri R, Weller PF.

Curr Protoc Immunol. 2012 Aug;Chapter 7:Unit 7.31. doi: 10.1002/0471142735.im0731s98.

43.

Eosinophil crystalloid granules: structure, function, and beyond.

Muniz VS, Weller PF, Neves JS.

J Leukoc Biol. 2012 Aug;92(2):281-8. doi: 10.1189/jlb.0212067. Epub 2012 Jun 6. Review.

44.

Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.

Valent P, Gleich GJ, Reiter A, Roufosse F, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Sotlar K, Butterfield JH, Cerny-Reiterer S, Mayerhofer M, Vandenberghe P, Haferlach T, Bochner BS, Gotlib J, Horny HP, Simon HU, Klion AD.

Expert Rev Hematol. 2012 Apr;5(2):157-76. doi: 10.1586/ehm.11.81. Review.

45.

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes.

Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Haferlach T, Simon HU, Reiter A, Gleich GJ.

J Allergy Clin Immunol. 2012 Sep;130(3):607-612.e9. doi: 10.1016/j.jaci.2012.02.019. Epub 2012 Mar 28.

46.

Eosinophils and disease pathogenesis.

Akuthota P, Weller PF.

Semin Hematol. 2012 Apr;49(2):113-9. doi: 10.1053/j.seminhematol.2012.01.005. Review.

47.

CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules.

Shamri R, Melo RC, Young KM, Bivas-Benita M, Xenakis JJ, Spencer LA, Weller PF.

FASEB J. 2012 May;26(5):2084-93. doi: 10.1096/fj.11-200246. Epub 2012 Jan 31.

48.

Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.

Luna-Gomes T, Magalhães KG, Mesquita-Santos FP, Bakker-Abreu I, Samico RF, Molinaro R, Calheiros AS, Diaz BL, Bozza PT, Weller PF, Bandeira-Melo C.

J Immunol. 2011 Dec 15;187(12):6518-26. doi: 10.4049/jimmunol.1101806. Epub 2011 Nov 18.

49.

MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains.

Akuthota P, Melo RC, Spencer LA, Weller PF.

Am J Respir Cell Mol Biol. 2012 Feb;46(2):188-95. doi: 10.1165/rcmb.2010-0335OC. Epub 2011 Sep 1.

50.

Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.

Melo RC, D'Avila H, Wan HC, Bozza PT, Dvorak AM, Weller PF.

J Histochem Cytochem. 2011 May;59(5):540-56. doi: 10.1369/0022155411404073. Epub 2011 Mar 23. Review.

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