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Items: 38

1.

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.

Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW.

Cell. 2018 Oct 4;175(2):502-513.e13. doi: 10.1016/j.cell.2018.08.040. Epub 2018 Sep 20.

PMID:
30245009
2.

Metabolic Signaling to the Nucleus in Cancer.

Campbell SL, Wellen KE.

Mol Cell. 2018 Aug 2;71(3):398-408. doi: 10.1016/j.molcel.2018.07.015. Review.

PMID:
30075141
3.

Metabolite regulates differentiation.

Trefely S, Wellen KE.

Science. 2018 May 11;360(6389):603-604. doi: 10.1126/science.aat6663. No abstract available.

PMID:
29748271
4.

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.

Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S, Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, Freedman BD, Wellen KE.

Genes Dev. 2018 Apr 1;32(7-8):497-511. doi: 10.1101/gad.311027.117. Epub 2018 Apr 19.

5.

Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice.

Bloomer SA, Wellen KE, Henderson GC.

Lipids Health Dis. 2017 Dec 13;16(1):243. doi: 10.1186/s12944-017-0639-7.

6.

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.

Sivanand S, Viney I, Wellen KE.

Trends Biochem Sci. 2018 Jan;43(1):61-74. doi: 10.1016/j.tibs.2017.11.004. Epub 2017 Nov 23. Review.

PMID:
29174173
7.

Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.

Sodi VL, Bacigalupa ZA, Ferrer CM, Lee JV, Gocal WA, Mukhopadhyay D, Wellen KE, Ivan M, Reginato MJ.

Oncogene. 2018 Feb 15;37(7):924-934. doi: 10.1038/onc.2017.395. Epub 2017 Oct 23.

8.

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.

Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE.

Mol Cell. 2017 Jul 20;67(2):252-265.e6. doi: 10.1016/j.molcel.2017.06.008. Epub 2017 Jul 6.

9.

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.

McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP.

Nat Genet. 2017 Mar;49(3):367-376. doi: 10.1038/ng.3753. Epub 2017 Jan 16.

10.

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels.

Carrer A, Parris JL, Trefely S, Henry RA, Montgomery DC, Torres A, Viola JM, Kuo YM, Blair IA, Meier JL, Andrews AJ, Snyder NW, Wellen KE.

J Biol Chem. 2017 Feb 24;292(8):3312-3322. doi: 10.1074/jbc.M116.750620. Epub 2017 Jan 11.

11.

Metabolic control of epigenetics in cancer.

Kinnaird A, Zhao S, Wellen KE, Michelakis ED.

Nat Rev Cancer. 2016 Nov;16(11):694-707. doi: 10.1038/nrc.2016.82. Epub 2016 Sep 16. Review.

PMID:
27634449
12.

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE.

Cell Rep. 2016 Oct 18;17(4):1037-1052. doi: 10.1016/j.celrep.2016.09.069.

13.

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

Shah S, Carriveau WJ, Li J, Campbell SL, Kopinski PK, Lim HW, Daurio N, Trefely S, Won KJ, Wallace DC, Koumenis C, Mancuso A, Wellen KE.

Oncotarget. 2016 Jul 12;7(28):43713-43730. doi: 10.18632/oncotarget.9666.

14.

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage.

Liu L, Shah S, Fan J, Park JO, Wellen KE, Rabinowitz JD.

Nat Chem Biol. 2016 May;12(5):345-52. doi: 10.1038/nchembio.2047. Epub 2016 Mar 21.

15.

Immunometabolism: Metabolism fine-tunes macrophage activation.

Torres A, Makowski L, Wellen KE.

Elife. 2016 Feb 19;5. pii: e14354. doi: 10.7554/eLife.14354.

16.

Metabolic control of methylation and acetylation.

Su X, Wellen KE, Rabinowitz JD.

Curr Opin Chem Biol. 2016 Feb;30:52-60. doi: 10.1016/j.cbpa.2015.10.030. Epub 2015 Nov 28. Review.

17.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

18.

Dysregulated metabolism contributes to oncogenesis.

Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team.

Semin Cancer Biol. 2015 Dec;35 Suppl:S129-S150. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8. Review.

19.

Molecular biology: Salvaging the genome.

Sivanand S, Wellen KE.

Nature. 2015 Aug 6;524(7563):40-1. doi: 10.1038/nature14638. Epub 2015 Jul 22. No abstract available.

PMID:
26200344
20.

ATM couples replication stress and metabolic reprogramming during cellular senescence.

Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R.

Cell Rep. 2015 May 12;11(6):893-901. doi: 10.1016/j.celrep.2015.04.014. Epub 2015 Apr 30.

21.

A cancerous web: signaling, metabolism, and the epigenome.

Lee JV, Shah S, Carrer A, Wellen KE.

Mol Cell Oncol. 2014 Oct 30;2(2):e965620. doi: 10.4161/23723548.2014.965620. eCollection 2015 Apr-Jun.

22.

Metabolism and epigenetics: a link cancer cells exploit.

Carrer A, Wellen KE.

Curr Opin Biotechnol. 2015 Aug;34:23-9. doi: 10.1016/j.copbio.2014.11.012. Epub 2014 Nov 29. Review.

23.

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.

Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE.

Cell Metab. 2014 Aug 5;20(2):306-319. doi: 10.1016/j.cmet.2014.06.004. Epub 2014 Jul 3.

24.

DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation.

LondoƱo Gentile T, Lu C, Lodato PM, Tse S, Olejniczak SH, Witze ES, Thompson CB, Wellen KE.

Mol Cell Biol. 2013 Oct;33(19):3864-78. doi: 10.1128/MCB.01495-12. Epub 2013 Jul 29.

25.

Interplay between epigenetics & cancer metabolism.

Gupta V, Gopinath P, Iqbal MA, Mazurek S, Wellen KE, Bamezai RN.

Curr Pharm Des. 2014;20(11):1706-14.

PMID:
23888952
26.

Obesity, cancer, and acetyl-CoA metabolism.

Lee JV, Shah SA, Wellen KE.

Drug Discov Today Dis Mech. 2013 Jun;10(1-2):e55-e61.

27.

Pyruvate kinase M2: regulatory circuits and potential for therapeutic intervention.

Gupta V, Wellen KE, Mazurek S, Bamezai RN.

Curr Pharm Des. 2014;20(15):2595-606. Review.

PMID:
23859618
28.

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.

Jiang P, Du W, Mancuso A, Wellen KE, Yang X.

Nature. 2013 Jan 31;493(7434):689-93. doi: 10.1038/nature11776. Epub 2013 Jan 13.

29.

A two-way street: reciprocal regulation of metabolism and signalling.

Wellen KE, Thompson CB.

Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):270-6. doi: 10.1038/nrm3305. Review.

PMID:
22395772
30.

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.

Daye D, Wellen KE.

Semin Cell Dev Biol. 2012 Jun;23(4):362-9. doi: 10.1016/j.semcdb.2012.02.002. Epub 2012 Feb 11. Review.

PMID:
22349059
31.

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB.

Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860.

32.

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.

Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB.

Genes Dev. 2010 Dec 15;24(24):2784-99. doi: 10.1101/gad.1985910. Epub 2010 Nov 24.

33.

Cellular metabolic stress: considering how cells respond to nutrient excess.

Wellen KE, Thompson CB.

Mol Cell. 2010 Oct 22;40(2):323-32. doi: 10.1016/j.molcel.2010.10.004. Review.

34.

ATP-citrate lyase links cellular metabolism to histone acetylation.

Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB.

Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097.

35.

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS.

Cell. 2007 May 4;129(3):537-48.

36.

Inflammation, stress, and diabetes.

Wellen KE, Hotamisligil GS.

J Clin Invest. 2005 May;115(5):1111-9. Review.

37.

Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.

Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS.

Endocrinology. 2004 May;145(5):2214-20. Epub 2004 Feb 5.

PMID:
14764635
38.

Obesity-induced inflammatory changes in adipose tissue.

Wellen KE, Hotamisligil GS.

J Clin Invest. 2003 Dec;112(12):1785-8.

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