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Items: 1 to 50 of 167

1.

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.

Sá JM, Kaslow SR, Moraes Barros RR, Brazeau NF, Parobek CM, Tao D, Salzman RE, Gibson TJ, Velmurugan S, Krause MA, Melendez-Muniz V, Kite WA, Han PK, Eastman RT, Kim A, Kessler EG, Abebe Y, James ER, Chakravarty S, Orr-Gonzalez S, Lambert LE, Engels T, Thomas ML, Fasinu PS, Serre D, Gwadz RW, Walker L, DeConti DK, Mu J, Bailey JA, Sim BKL, Hoffman SL, Fay MP, Dinglasan RR, Juliano JJ, Wellems TE.

Nat Commun. 2019 Sep 20;10(1):4300. doi: 10.1038/s41467-019-12256-9.

2.

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution.

Su XZ, Lane KD, Xia L, Sá JM, Wellems TE.

Clin Microbiol Rev. 2019 Jul 31;32(4). pii: e00019-19. doi: 10.1128/CMR.00019-19. Print 2019 Sep 18. Review.

PMID:
31366610
3.

Polyunsaturated fatty acids promote Plasmodium falciparum gametocytogenesis.

Tanaka TQ, Tokuoka SM, Nakatani D, Hamano F, Kawazu SI, Wellems TE, Kita K, Shimizu T, Tokumasu F.

Biol Open. 2019 Jul 16;8(7). pii: bio042259. doi: 10.1242/bio.042259.

4.

The PAGODAS protocol: pediatric assessment group of dengue and Aedes saliva protocol to investigate vector-borne determinants of Aedes-transmitted arboviral infections in Cambodia.

Manning JE, Oliveira F, Parker DM, Amaratunga C, Kong D, Man S, Sreng S, Lay S, Nang K, Kimsan S, Sokha L, Kamhawi S, Fay MP, Suon S, Ruhl P, Ackerman H, Huy R, Wellems TE, Valenzuela JG, Leang R.

Parasit Vectors. 2018 Dec 20;11(1):664. doi: 10.1186/s13071-018-3224-7.

5.

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Sá JM, Kaslow SR, Krause MA, Melendez-Muniz VA, Salzman RE, Kite WA, Zhang M, Moraes Barros RR, Mu J, Han PK, Mershon JP, Figan CE, Caleon RL, Rahman RS, Gibson TJ, Amaratunga C, Nishiguchi EP, Breglio KF, Engels TM, Velmurugan S, Ricklefs S, Straimer J, Gnädig NF, Deng B, Liu A, Diouf A, Miura K, Tullo GS, Eastman RT, Chakravarty S, James ER, Udenze K, Li S, Sturdevant DE, Gwadz RW, Porcella SF, Long CA, Fidock DA, Thomas ML, Fay MP, Sim BKL, Hoffman SL, Adams JH, Fairhurst RM, Su XZ, Wellems TE.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12513-12518. doi: 10.1073/pnas.1813386115. Epub 2018 Nov 19.

6.

Correction for Breglio et al., "Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro".

Breglio KF, Rahman RS, Sá JM, Hott A, Roberts DJ, Wellems TE.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e02070-18. doi: 10.1128/AAC.02070-18. Print 2018 Nov. No abstract available.

7.

Large-scale Artemisinin-Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa.

Deng C, Huang B, Wang Q, Wu W, Zheng S, Zhang H, Li D, Feng D, Li G, Xue L, Yang T, Tuo F, Mohadji F, Su XZ, Xu Q, Wu Z, Lin L, Zhou J, Yan H, Bacar A, Said Abdallah K, Kéké RA, Msa Mliva A, Mohamed M, Wang X, Huang S, Oithik F, Li XB, Lu F, Fay MP, Liu XH, Wellems TE, Song J.

Clin Infect Dis. 2018 Nov 13;67(11):1670-1676. doi: 10.1093/cid/ciy364.

8.

Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.

Lane KD, Mu J, Lu J, Windle ST, Liu A, Sun PD, Wellems TE.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6285-6290. doi: 10.1073/pnas.1804492115. Epub 2018 May 29.

9.

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.

Obaldia N 3rd, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M.

MBio. 2018 May 8;9(3). pii: e00625-18. doi: 10.1128/mBio.00625-18.

10.

Infection of mosquitoes from in vitro cultivated Plasmodium knowlesi H strain.

Armistead JS, Moraes Barros RR, Gibson TJ, Kite WA, Mershon JP, Lambert LE, Orr-Gonzalez SE, Sá JM, Adams JH, Wellems TE.

Int J Parasitol. 2018 Jul;48(8):601-610. doi: 10.1016/j.ijpara.2018.02.004. Epub 2018 Apr 30.

11.

Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro.

Breglio KF, Rahman RS, Sá JM, Hott A, Roberts DJ, Wellems TE.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02256-17. doi: 10.1128/AAC.02256-17. Print 2018 May. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

12.

A set of microsatellite markers to differentiate Plasmodium falciparum progeny of four genetic crosses.

Figan CE, Sá JM, Mu J, Melendez-Muniz VA, Liu CH, Wellems TE.

Malar J. 2018 Feb 2;17(1):60. doi: 10.1186/s12936-018-2210-z.

13.

Comparison of two methods for transformation of Plasmodium knowlesi: Direct schizont electroporation and spontaneous plasmid uptake from plasmid-loaded red blood cells.

Moraes Barros RR, Gibson TJ, Kite WA, Sá JM, Wellems TE.

Mol Biochem Parasitol. 2017 Dec;218:16-22. doi: 10.1016/j.molbiopara.2017.10.001. Epub 2017 Oct 6.

14.

High-Sensitivity Assays for Plasmodium falciparum Infection by Immuno-Polymerase Chain Reaction Detection of PfIDEh and PfLDH Antigens.

Mu J, Andersen JF, Valenzuela JG, Wellems TE.

J Infect Dis. 2017 Sep 15;216(6):713-722. doi: 10.1093/infdis/jix369.

15.

Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity.

Kite WA, Melendez-Muniz VA, Moraes Barros RR, Wellems TE, Sá JM.

Malar J. 2016 Feb 17;15:94. doi: 10.1186/s12936-016-1148-2.

16.

Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria.

Shah SS, Rockett KA, Jallow M, Sisay-Joof F, Bojang KA, Pinder M, Jeffreys A, Craik R, Hubbart C, Wellems TE, Kwiatkowski DP; MalariaGEN Consortium.

Malar J. 2016 Jan 7;15:13. doi: 10.1186/s12936-015-1045-0.

17.

Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy.

Gadalla NB, Tavera G, Mu J, Kabyemela ER, Fried M, Duffy PE, Sá JM, Wellems TE.

Malar J. 2015 Mar 25;14:129. doi: 10.1186/s12936-015-0642-2.

18.

Imaging of the subsurface structures of "unroofed" Plasmodium falciparum-infected erythrocytes.

Hayakawa EH, Tokumasu F, Usukura J, Matsuoka H, Tsuboi T, Wellems TE.

Exp Parasitol. 2015 Jun;153:174-9. doi: 10.1016/j.exppara.2015.03.021. Epub 2015 Mar 28.

PMID:
25825251
19.

Development of a single nucleotide polymorphism barcode to genotype Plasmodium vivax infections.

Baniecki ML, Faust AL, Schaffner SF, Park DJ, Galinsky K, Daniels RF, Hamilton E, Ferreira MU, Karunaweera ND, Serre D, Zimmerman PA, Sá JM, Wellems TE, Musset L, Legrand E, Melnikov A, Neafsey DE, Volkman SK, Wirth DF, Sabeti PC.

PLoS Negl Trop Dis. 2015 Mar 17;9(3):e0003539. doi: 10.1371/journal.pntd.0003539. eCollection 2015 Mar.

20.

Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya.

Shah SS, Macharia A, Makale J, Uyoga S, Kivinen K, Craik R, Hubbart C, Wellems TE, Rockett KA, Kwiatkowski DP, Williams TN.

BMC Med Genet. 2014 Sep 9;15:93. doi: 10.1186/s12881-014-0093-6.

21.

Editing the Plasmodium vivax genome, using zinc-finger nucleases.

Moraes Barros RR, Straimer J, Sa JM, Salzman RE, Melendez-Muniz VA, Mu J, Fidock DA, Wellems TE.

J Infect Dis. 2015 Jan 1;211(1):125-9. doi: 10.1093/infdis/jiu423. Epub 2014 Jul 31.

22.

Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids.

Tokumasu F, Crivat G, Ackerman H, Hwang J, Wellems TE.

Biol Open. 2014 May 29;3(6):529-41. doi: 10.1242/bio.20147732.

23.

Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro.

Furuya T, Sá JM, Chitnis CE, Wellems TE, Stedman TT.

Parasitol Int. 2014 Apr;63(2):278-84. doi: 10.1016/j.parint.2013.11.011. Epub 2013 Dec 1.

24.

Malaria biology and disease pathogenesis: insights for new treatments.

Miller LH, Ackerman HC, Su XZ, Wellems TE.

Nat Med. 2013 Feb;19(2):156-67. doi: 10.1038/nm.3073. Epub 2013 Feb 6. Review.

25.

Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats.

Hayton K, Dumoulin P, Henschen B, Liu A, Papakrivos J, Wellems TE.

Mol Biochem Parasitol. 2013 Feb;187(2):103-10. doi: 10.1016/j.molbiopara.2012.12.005. Epub 2013 Jan 7.

26.

Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria.

Kone A, Mu J, Maiga H, Beavogui AH, Yattara O, Sagara I, Tekete MM, Traore OB, Dara A, Dama S, Diallo N, Kodio A, Traoré A, Björkman A, Gil JP, Doumbo OK, Wellems TE, Djimde AA.

J Infect Dis. 2013 Feb 1;207(3):520-7. doi: 10.1093/infdis/jis691. Epub 2012 Nov 16.

27.

Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.

Fairhurst RM, Nayyar GML, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM.

Am J Trop Med Hyg. 2012 Aug;87(2):231-241. doi: 10.4269/ajtmh.2012.12-0025. Review.

28.

Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.

Papakrivos J, Sá JM, Wellems TE.

PLoS One. 2012;7(6):e39569. doi: 10.1371/journal.pone.0039569. Epub 2012 Jun 19.

29.

A high-throughput method to detect Plasmodium falciparum clones in limiting dilution microplates.

Lyko B, Hammershaimb EA, Nguitragool W, Wellems TE, Desai SA.

Malar J. 2012 Apr 24;11:124. doi: 10.1186/1475-2875-11-124.

30.

A novel cytofluorometric assay for the detection and quantification of glucose-6-phosphate dehydrogenase deficiency.

Shah SS, Diakite SA, Traore K, Diakite M, Kwiatkowski DP, Rockett KA, Wellems TE, Fairhurst RM.

Sci Rep. 2012;2:299. doi: 10.1038/srep00299. Epub 2012 Mar 5.

31.

An evolving picture of the interactions between malaria parasites and their host erythrocytes.

Wellems TE, Fairhurst RM.

Cell Res. 2012 Mar;22(3):453-6. doi: 10.1038/cr.2012.14. Epub 2012 Jan 24. No abstract available.

32.

First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium.

Musselwhite LW, Maciag K, Lankowski A, Gretes MC, Wellems TE, Tavera G, Goulding RE, Guillen E.

Am J Trop Med Hyg. 2012 Jan;86(1):65-74. doi: 10.4269/ajtmh.2012.11-0608.

33.

Malaria drug resistance: new observations and developments.

Sá JM, Chong JL, Wellems TE.

Essays Biochem. 2011;51:137-60. doi: 10.1042/bse0510137. Review.

34.

The threat of artemisinin-resistant malaria.

Dondorp AM, Fairhurst RM, Slutsker L, Macarthur JR, Breman JG, Guerin PJ, Wellems TE, Ringwald P, Newman RD, Plowe CV.

N Engl J Med. 2011 Sep 22;365(12):1073-5. doi: 10.1056/NEJMp1108322. No abstract available.

35.

Tetracysteine-based fluorescent tags to study protein localization and trafficking in Plasmodium falciparum-infected erythrocytes.

Crivat G, Tokumasu F, Sa JM, Hwang J, Wellems TE.

PLoS One. 2011;6(8):e22975. doi: 10.1371/journal.pone.0022975. Epub 2011 Aug 10.

36.

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ.

Science. 2011 Aug 5;333(6043):724-9. doi: 10.1126/science.1205216.

37.

An evaluation of concurrent G6PD (A-) deficiency and sickle cell trait in Malian populations of children with severe or uncomplicated P. falciparum malaria.

Guindo A, Traore K, Diakite S, Wellems TE, Doumbo OK, Diallo DA.

Am J Hematol. 2011 Sep;86(9):795-6. doi: 10.1002/ajh.22093. Epub 2011 Jul 22. No abstract available.

38.

High recombination rates and hotspots in a Plasmodium falciparum genetic cross.

Jiang H, Li N, Gopalan V, Zilversmit MM, Varma S, Nagarajan V, Li J, Mu J, Hayton K, Henschen B, Yi M, Stephens R, McVean G, Awadalla P, Wellems TE, Su XZ.

Genome Biol. 2011;12(4):R33. doi: 10.1186/gb-2011-12-4-r33. Epub 2011 Apr 4.

39.

High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria.

Wélé M, Djimdé AA, Guindo A, Beavogui AH, Traoré IZ, Sadou A, Blaise D, Diallo DA, Wellems TE, Doumbo OK.

Acta Trop. 2011 Jul;119(1):11-3. doi: 10.1016/j.actatropica.2011.01.002. Epub 2011 Feb 12.

40.

Optimism, persistence, and our collective crystal ball.

Wellems TE.

Am J Trop Med Hyg. 2010 Jul;83(1):1-6. doi: 10.4269/ajtmh.2010.10-0107. No abstract available.

41.

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.

Mu J, Myers RA, Jiang H, Liu S, Ricklefs S, Waisberg M, Chotivanich K, Wilairatana P, Krudsood S, White NJ, Udomsangpetch R, Cui L, Ho M, Ou F, Li H, Song J, Li G, Wang X, Seila S, Sokunthea S, Socheat D, Sturdevant DE, Porcella SF, Fairhurst RM, Wellems TE, Awadalla P, Su XZ.

Nat Genet. 2010 Mar;42(3):268-71. doi: 10.1038/ng.528. Epub 2010 Jan 31.

42.

Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine.

Sá JM, Twu O, Hayton K, Reyes S, Fay MP, Ringwald P, Wellems TE.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18883-9. doi: 10.1073/pnas.0911317106. Epub 2009 Nov 2.

43.

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.

Nat Chem Biol. 2009 Oct;5(10):765-71. doi: 10.1038/nchembio.215. Epub 2009 Sep 6.

44.

The impact of malaria parasitism: from corpuscles to communities.

Wellems TE, Hayton K, Fairhurst RM.

J Clin Invest. 2009 Sep;119(9):2496-505. doi: 10.1172/JCI38307. Review.

45.

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.

Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA.

Mol Biochem Parasitol. 2009 Jun;165(2):122-31. doi: 10.1016/j.molbiopara.2009.01.011. Epub 2009 Jan 30.

46.

Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion.

Hayton K, Gaur D, Liu A, Takahashi J, Henschen B, Singh S, Lambert L, Furuya T, Bouttenot R, Doll M, Nawaz F, Mu J, Jiang L, Miller LH, Wellems TE.

Cell Host Microbe. 2008 Jul 17;4(1):40-51. doi: 10.1016/j.chom.2008.06.001.

47.

Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin.

Cholera R, Brittain NJ, Gillrie MR, Lopera-Mesa TM, Diakité SA, Arie T, Krause MA, Guindo A, Tubman A, Fujioka H, Diallo DA, Doumbo OK, Ho M, Wellems TE, Fairhurst RM.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):991-6. doi: 10.1073/pnas.0711401105. Epub 2008 Jan 11.

48.

Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.

Dzikowski R, Li F, Amulic B, Eisberg A, Frank M, Patel S, Wellems TE, Deitsch KW.

EMBO Rep. 2007 Oct;8(10):959-65. Epub 2007 Aug 31.

49.

Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.

Su X, Hayton K, Wellems TE.

Nat Rev Genet. 2007 Jul;8(7):497-506. Review.

PMID:
17572690
50.

[In vitro cultivation of fields isolates of Plasmodium falciparum in Mali].

Djimde AA, Kirkman L, Kassambara L, Diallo M, Plowe CV, Wellems TE, Doumbo OK.

Bull Soc Pathol Exot. 2007 Feb;100(1):3-5. French.

PMID:
17402683

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