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Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA.

Circulation. 2018 Nov 20;138(21):2367-2378. doi: 10.1161/CIRCULATIONAHA.118.033540.


Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster.

Rhoades SD, Nayak K, Zhang SL, Sehgal A, Weljie AM.

J Biol Rhythms. 2018 Apr;33(2):126-136. doi: 10.1177/0748730417753003. Epub 2018 Jan 21.


A Pilot Characterization of the Human Chronobiome.

Skarke C, Lahens NF, Rhoades SD, Campbell A, Bittinger K, Bailey A, Hoffmann C, Olson RS, Chen L, Yang G, Price TS, Moore JH, Bushman FD, Greene CS, Grant GR, Weljie AM, FitzGerald GA.

Sci Rep. 2017 Dec 7;7(1):17141. doi: 10.1038/s41598-017-17362-6.


Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver.

Sengupta A, Rhoades SD, Kim EJ, Nayak S, Grant GR, Meerlo P, Weljie AM.

Int J Biochem Cell Biol. 2017 Dec;93:129-135. doi: 10.1016/j.biocel.2017.08.014. Epub 2017 Aug 30.


Primary Metabolism and Medium-Chain Fatty Acid Alterations Precede Long-Chain Fatty Acid Changes Impacting Neutral Lipid Metabolism in Response to an Anticancer Lysophosphatidylcholine Analogue in Yeast.

Tambellini NP, Zaremberg V, Krishnaiah S, Turner RJ, Weljie AM.

J Proteome Res. 2017 Oct 6;16(10):3741-3752. doi: 10.1021/acs.jproteome.7b00430. Epub 2017 Sep 13.


Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.

Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE.

Mol Cell. 2017 Jul 20;67(2):252-265.e6. doi: 10.1016/j.molcel.2017.06.008. Epub 2017 Jul 6.


Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.

Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM.

Cell Metab. 2017 May 2;25(5):1206. doi: 10.1016/j.cmet.2017.04.023. No abstract available.


Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia.

Banoei MM, Vogel HJ, Weljie AM, Kumar A, Yende S, Angus DC, Winston BW; Canadian Critical Care Translational Biology Group (CCCTBG).

Crit Care. 2017 Apr 19;21(1):97. doi: 10.1186/s13054-017-1672-7.


Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.

Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM.

Cell Metab. 2017 Apr 4;25(4):961-974.e4. doi: 10.1016/j.cmet.2017.03.019. Erratum in: Cell Metab. 2017 May 2;25(5):1206.


Comprehensive Optimization of LC-MS Metabolomics Methods Using Design of Experiments (COLMeD).

Rhoades SD, Weljie AM.

Metabolomics. 2016 Dec;12(12). pii: 183. doi: 10.1007/s11306-016-1132-4. Epub 2016 Oct 24.


ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection.

Vysochan A, Sengupta A, Weljie AM, Alwine JC, Yu Y.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1528-E1535. doi: 10.1073/pnas.1614268114. Epub 2017 Feb 6.


Distinguishing Benign from Malignant Pancreatic and Periampullary Lesions Using Combined Use of ¹H-NMR Spectroscopy and Gas Chromatography-Mass Spectrometry.

McConnell YJ, Farshidfar F, Weljie AM, Kopciuk KA, Dixon E, Ball CG, Sutherland FR, Vogel HJ, Bathe OF.

Metabolites. 2017 Jan 13;7(1). pii: E3. doi: 10.3390/metabo7010003.


ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE.

Cell Rep. 2016 Oct 18;17(4):1037-1052. doi: 10.1016/j.celrep.2016.09.069.


Time is ripe: maturation of metabolomics in chronobiology.

Rhoades SD, Sengupta A, Weljie AM.

Curr Opin Biotechnol. 2017 Feb;43:70-76. doi: 10.1016/j.copbio.2016.09.007. Epub 2016 Oct 1. Review.


A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics.

Farshidfar F, Weljie AM, Kopciuk KA, Hilsden R, McGregor SE, Buie WD, MacLean A, Vogel HJ, Bathe OF.

Br J Cancer. 2016 Sep 27;115(7):848-57. doi: 10.1038/bjc.2016.243. Epub 2016 Aug 25.


A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C.

Sarfaraz MO, Myers RP, Coffin CS, Gao ZH, Shaheen AA, Crotty PM, Zhang P, Vogel HJ, Weljie AM.

Clin Transl Med. 2016 Dec;5(1):33. doi: 10.1186/s40169-016-0109-2. Epub 2016 Aug 18.


Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome.

Sengupta A, Krishnaiah SY, Rhoades S, Growe J, Slaff B, Venkataraman A, Olarerin-George AO, Van Dang C, Hogenesch JB, Weljie AM.

Metabolites. 2016 Jul 27;6(3). pii: E23. doi: 10.3390/metabo6030023.


Temporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment.

Hao D, Sarfaraz MO, Farshidfar F, Bebb DG, Lee CY, Card CM, David M, Weljie AM.

Metabolomics. 2016;12:58. doi: 10.1007/s11306-016-0961-5. Epub 2016 Feb 27.


A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.

Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z.

Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7.


A Pilot Study on the Utility of Serum Metabolomics in Neuroblastoma Patients and Xenograft Models.

Beaudry P, Campbell M, Dang NH, Wen J, Blote K, Weljie AM.

Pediatr Blood Cancer. 2016 Feb;63(2):214-20. doi: 10.1002/pbc.25784. Epub 2015 Oct 20.


MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.

Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.


Metabolomics reveals differences of metal toxicity in cultures of Pseudomonas pseudoalcaligenes KF707 grown on different carbon sources.

Booth SC, Weljie AM, Turner RJ.

Front Microbiol. 2015 Aug 17;6:827. doi: 10.3389/fmicb.2015.00827. eCollection 2015.


Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis.

Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal A.

J Biol Chem. 2015 Aug 14;290(33):20407-16. doi: 10.1074/jbc.M114.602276. Epub 2015 Jun 29.


Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis.

Mickiewicz B, Kelly JJ, Ludwig TE, Weljie AM, Wiley JP, Schmidt TA, Vogel HJ.

J Orthop Res. 2015 Nov;33(11):1631-8. doi: 10.1002/jor.22949. Epub 2015 Jun 12.


Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.

Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2569-74. doi: 10.1073/pnas.1417432112. Epub 2015 Feb 9.


Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production.

Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis JD.

Gut. 2016 Jan;65(1):63-72. doi: 10.1136/gutjnl-2014-308209. Epub 2014 Nov 26.


Evaluation of extraction protocols for simultaneous polar and non-polar yeast metabolite analysis using multivariate projection methods.

Tambellini NP, Zaremberg V, Turner RJ, Weljie AM.

Metabolites. 2013 Jul 23;3(3):592-605. doi: 10.3390/metabo3030592.


Computational tools for the secondary analysis of metabolomics experiments.

Booth SC, Weljie AM, Turner RJ.

Comput Struct Biotechnol J. 2013 Feb 6;4:e201301003. doi: 10.5936/csbj.201301003. eCollection 2013. Review.


Satiety hormone and metabolomic response to an intermittent high energy diet differs in rats consuming long-term diets high in protein or prebiotic fiber.

Reimer RA, Maurer AD, Eller LK, Hallam MC, Shaykhutdinov R, Vogel HJ, Weljie AM.

J Proteome Res. 2012 Aug 3;11(8):4065-74. doi: 10.1021/pr300487s. Epub 2012 Jul 23.


Serum metabolomic profile as a means to distinguish stage of colorectal cancer.

Farshidfar F, Weljie AM, Kopciuk K, Buie WD, Maclean A, Dixon E, Sutherland FR, Molckovsky A, Vogel HJ, Bathe OF.

Genome Med. 2012 May 14;4(5):42. doi: 10.1186/gm341.


An in vivo patient-derived model of endogenous IDH1-mutant glioma.

Luchman HA, Stechishin OD, Dang NH, Blough MD, Chesnelong C, Kelly JJ, Nguyen SA, Chan JA, Weljie AM, Cairncross JG, Weiss S.

Neuro Oncol. 2012 Feb;14(2):184-91. doi: 10.1093/neuonc/nor207. Epub 2011 Dec 13.


Environmental contaminant mixtures at ambient concentrations invoke a metabolic stress response in goldfish not predicted from exposure to individual compounds alone.

Jordan J, Zare A, Jackson LJ, Habibi HR, Weljie AM.

J Proteome Res. 2012 Feb 3;11(2):1133-43. doi: 10.1021/pr200840b. Epub 2011 Dec 29.


Metabolomics and its application to studying metal toxicity.

Booth SC, Workentine ML, Weljie AM, Turner RJ.

Metallomics. 2011 Nov;3(11):1142-52. doi: 10.1039/c1mt00070e. Epub 2011 Sep 16. Review.


Elevated physiological levels of folic acid can increase in vitro growth and invasiveness of prostate cancer cells.

Petersen LF, Brockton NT, Bakkar A, Liu S, Wen J, Weljie AM, Bismar TA.

BJU Int. 2012 Mar;109(5):788-95. doi: 10.1111/j.1464-410X.2011.10437.x. Epub 2011 Jul 19.


Differences in metabolism between the biofilm and planktonic response to metal stress.

Booth SC, Workentine ML, Wen J, Shaykhutdinov R, Vogel HJ, Ceri H, Turner RJ, Weljie AM.

J Proteome Res. 2011 Jul 1;10(7):3190-9. doi: 10.1021/pr2002353. Epub 2011 May 31.


(1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system.

Weljie AM, Bondareva A, Zang P, Jirik FR.

J Biomol NMR. 2011 Apr;49(3-4):185-93. doi: 10.1007/s10858-011-9486-4. Epub 2011 Mar 4.


Metabolomic response to exercise training in lean and diet-induced obese mice.

Duggan GE, Hittel DS, Sensen CW, Weljie AM, Vogel HJ, Shearer J.

J Appl Physiol (1985). 2011 May;110(5):1311-8. doi: 10.1152/japplphysiol.00701.2010. Epub 2011 Jan 26.


Feasibility of identifying pancreatic cancer based on serum metabolomics.

Bathe OF, Shaykhutdinov R, Kopciuk K, Weljie AM, McKay A, Sutherland FR, Dixon E, Dunse N, Sotiropoulos D, Vogel HJ.

Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):140-7. doi: 10.1158/1055-9965.EPI-10-0712. Epub 2010 Nov 23.


Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect.

Weljie AM, Jirik FR.

Int J Biochem Cell Biol. 2011 Jul;43(7):981-9. doi: 10.1016/j.biocel.2010.08.009. Epub 2010 Aug 24. Review.


A global metabolic shift is linked to Salmonella multicellular development.

White AP, Weljie AM, Apel D, Zhang P, Shaykhutdinov R, Vogel HJ, Surette MG.

PLoS One. 2010 Jul 27;5(7):e11814. doi: 10.1371/journal.pone.0011814.


Phenotypic and metabolic profiling of colony morphology variants evolved from Pseudomonas fluorescens biofilms.

Workentine ML, Harrison JJ, Weljie AM, Tran VA, Stenroos PU, Tremaroli V, Vogel HJ, Ceri H, Turner RJ.

Environ Microbiol. 2010 Jun;12(6):1565-77. doi: 10.1111/j.1462-2920.2010.02185.x. Epub 2010 Mar 3.


Quality assessment of ginseng by (1)H NMR metabolite fingerprinting and profiling analysis.

Lee EJ, Shaykhutdinov R, Weljie AM, Vogel HJ, Facchini PJ, Park SU, Kim YK, Yang TJ.

J Agric Food Chem. 2009 Aug 26;57(16):7513-22. doi: 10.1021/jf901675y.


Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis.

Weljie AM, Newton J, Jirik FR, Vogel HJ.

Anal Chem. 2008 Dec 1;80(23):8956-65. doi: 10.1021/ac8012362.


Metabolic footprinting study of white spruce somatic embryogenesis using NMR spectroscopy.

Dowlatabadi R, Weljie AM, Thorpe TA, Yeung EC, Vogel HJ.

Plant Physiol Biochem. 2009 May;47(5):343-50. doi: 10.1016/j.plaphy.2008.12.023. Epub 2009 Jan 10.


Metabolomic investigation of the bacterial response to a metal challenge.

Tremaroli V, Workentine ML, Weljie AM, Vogel HJ, Ceri H, Viti C, Tatti E, Zhang P, Hynes AP, Turner RJ, Zannoni D.

Appl Environ Microbiol. 2009 Feb;75(3):719-28. doi: 10.1128/AEM.01771-08. Epub 2008 Dec 1.


Quantitative 1H nuclear magnetic resonance metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy.

Hagel JM, Weljie AM, Vogel HJ, Facchini PJ.

Plant Physiol. 2008 Aug;147(4):1805-21. doi: 10.1104/pp.108.120493. Epub 2008 Jun 11.


Acute dextro-amphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3 and 18.8 T.

McGrath BM, McKay R, Dave S, Seres P, Weljie AM, Slupsky CM, Hanstock CC, Greenshaw AJ, Silverstone PH.

Neurosci Res. 2008 Aug;61(4):351-9. doi: 10.1016/j.neures.2008.04.001. Epub 2008 Apr 18.


Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles.

Slupsky CM, Rankin KN, Wagner J, Fu H, Chang D, Weljie AM, Saude EJ, Lix B, Adamko DJ, Shah S, Greiner R, Sykes BD, Marrie TJ.

Anal Chem. 2007 Sep 15;79(18):6995-7004. Epub 2007 Aug 17.


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