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Items: 42

1.

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.

Badarau A, Rouha H, Malafa S, Battles MB, Walker L, Nielson N, Dolezilkova I, Teubenbacher A, Banerjee S, Maierhofer B, Weber S, Stulik L, Logan DT, Welin M, Mirkina I, Pleban C, Zauner G, Gross K, Jägerhofer M, Magyarics Z, Nagy E.

MAbs. 2016 Oct;8(7):1347-1360. Epub 2016 Jul 28.

2.

Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins.

Nilsson LM, Green LC, Muralidharan SV, Demir D, Welin M, Bhadury J, Logan DT, Walse B, Nilsson JA.

Cancer Res. 2016 Apr 15;76(8):2376-83. doi: 10.1158/0008-5472.CAN-15-2721. Epub 2016 Mar 3.

3.

De Novo Fragment Design for Drug Discovery and Chemical Biology.

Rodrigues T, Reker D, Welin M, Caldera M, Brunner C, Gabernet G, Schneider P, Walse B, Schneider G.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15079-83. doi: 10.1002/anie.201508055. Epub 2015 Oct 21.

PMID:
26486226
4.

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P.

PLoS One. 2015 Jun 29;10(6):e0131507. doi: 10.1371/journal.pone.0131507. eCollection 2015.

5.

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P.

Structure. 2014 May 6;22(5):744-55. doi: 10.1016/j.str.2014.01.013. Epub 2014 Apr 3.

6.

Substrate specificity and oligomerization of human GMP synthetase.

Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P.

J Mol Biol. 2013 Nov 15;425(22):4323-33. doi: 10.1016/j.jmb.2013.06.032. Epub 2013 Jun 28.

7.

In support of the European Union biosimilar framework.

Schneider CK, Borg JJ, Ehmann F, Ekman N, Heinonen E, Ho K, Hoefnagel MH, van der Plas RM, Ruiz S, van der Stappen AJ, Thorpe R, Tiitso K, Tsiftsoglou AS, Vleminckx C, Waxenecker G, Welin M, Weise M, Trouvin JH; Working Party on Similar Biological (Biosimilar) Medicinal Products (BMWP); Biologicals Working Party (BWP) of the Committee for Medicinal Products for Human Use (CHMP).

Nat Biotechnol. 2012 Aug;30(8):745-8; author reply 748-9. doi: 10.1038/nbt.2322. No abstract available.

PMID:
22871707
8.

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Egeblad L, Welin M, Flodin S, Gräslund S, Wang L, Balzarini J, Eriksson S, Nordlund P.

PLoS One. 2012;7(5):e37724. doi: 10.1371/journal.pone.0037724. Epub 2012 May 25.

9.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Trésaugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P.

FEBS J. 2010 Dec;277(23):4920-30. doi: 10.1111/j.1742-4658.2010.07897.x. Epub 2010 Nov 5.

10.

The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface.

Nyman T, Trésaugues L, Welin M, Lehtiö L, Flodin S, Persson C, Johansson I, Hammarström M, Nordlund P.

PLoS One. 2010 Sep 23;5(9):e12907. doi: 10.1371/journal.pone.0012907.

11.

Structural studies of tri-functional human GART.

Welin M, Grossmann JG, Flodin S, Nyman T, Stenmark P, Trésaugues L, Kotenyova T, Johansson I, Nordlund P, Lehtiö L.

Nucleic Acids Res. 2010 Nov;38(20):7308-19. doi: 10.1093/nar/gkq595. Epub 2010 Jul 14.

12.

Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism.

Welin M, Nordlund P.

Biochem Biophys Res Commun. 2010 May 21;396(1):157-63. doi: 10.1016/j.bbrc.2010.04.054. Review.

PMID:
20494131
13.

Structures of BIR domains from human NAIP and cIAP2.

Herman MD, Moche M, Flodin S, Welin M, Trésaugues L, Johansson I, Nilsson M, Nordlund P, Nyman T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1091-6. doi: 10.1107/S1744309109038597. Epub 2009 Oct 24.

14.

[Biosimilar products comparable to original preparations. The Medical Products Agency will not yet classify the agents as generics].

Welin M, Liliemark J.

Lakartidningen. 2009 Jun 3-9;106(23):1547-8. Swedish. No abstract available.

PMID:
19583011
15.

Quality-by-design for biotechnology-related pharmaceuticals.

Mandenius CF, Graumann K, Schultz TW, Premstaller A, Olsson IM, Petiot E, Clemens C, Welin M.

Biotechnol J. 2009 May;4(5):600-9. doi: 10.1002/biot.200800333.

PMID:
19418475
16.

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, Kotenyova T, Flores A, Nordlund P.

FEBS Lett. 2008 Oct 29;582(25-26):3590-4. doi: 10.1016/j.febslet.2008.09.028. Epub 2008 Sep 21.

17.

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P.

Proteins. 2008 Dec;73(4):1047-52. doi: 10.1002/prot.22198. No abstract available.

PMID:
18767156
18.

Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target.

Egeblad-Welin L, Welin M, Wang L, Eriksson S.

FEBS J. 2007 Dec;274(24):6403-14. Epub 2007 Nov 15.

19.

In situ proteolysis for protein crystallization and structure determination.

Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H.

Nat Methods. 2007 Dec;4(12):1019-21. Epub 2007 Nov 4.

20.

Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity.

Welin M, Wang L, Eriksson S, Eklund H.

J Mol Biol. 2007 Mar 9;366(5):1615-23. Epub 2006 Dec 8.

PMID:
17229440
21.

Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.

Welin M, Skovgaard T, Knecht W, Zhu C, Berenstein D, Munch-Petersen B, Piskur J, Eklund H.

FEBS J. 2005 Jul;272(14):3733-42.

22.

Structures of thymidine kinase 1 of human and mycoplasmic origin.

Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu C, Wang L, Eriksson S, Munch-Petersen B, Eklund H.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17970-5. Epub 2004 Dec 20.

23.

New vaccine production technologies and their impact on the use of animals.

Pastoret PP, Sitrin R, Merten OW, Vincent Falquet JC, Schwanig M, Welin M, Hegger I, Neeleman R, van der Velden T, Urital A, Rene S, Behr-Gross ME, Smith M, McArdle J, Prior S, Schmidt C, Krell T, Chevalier M, Klein H, Rosskopf-Streicher U, Jaekel C.

Dev Biol (Basel). 2002;111:219-20. No abstract available.

PMID:
12678245
24.

Statistical model of the interactions between Helicobacter pylori infection and gastric cancer development.

Welin M, Holmgren NM, Nilsson P, Enroth H.

Helicobacter. 2003 Feb;8(1):72-8.

PMID:
12603619
25.
26.

Low calcitonin gene-related, peptide-like immunoreactivity in cerebrospinal fluid from chronic pain patients.

Lindh C, Liu Z, Welin M, Ordeberg G, Nyberg F.

Neuropeptides. 1999 Dec;33(6):517-21.

PMID:
10657534
27.

Chronic subarachnoid midazolam (Dormicum) in the rat. Morphologic evidence of spinal cord neurotoxicity.

Svensson BA, Welin M, Gordh T Jr, Westman J.

Reg Anesth. 1995 Sep-Oct;20(5):426-34.

PMID:
8519721
28.

Cholecystokinin receptor binding in morphine analgesia: tolerance, withdrawal and abstinence.

Welin M, Harro J, Yukhananov R, Nyberg F, Oreland L.

Neuropeptides. 1994 Jun;26(6):379-83.

PMID:
7936125
29.

[rDNA technique in production of drugs. How endogenous are human proteins prepared with rDNA?].

Welin M.

Lakartidningen. 1994 Mar 23;91(12):1188-91. Swedish. No abstract available.

PMID:
8189847
30.

A rapid fluorometric enzyme immunoassay for the determination of neonatal TSH from blood spots.

Tuuminen T, Rakkolainen AE, Welin MG, Weber TH, Nylander PL, Käpyaho KI.

Clin Chim Acta. 1991 Oct 31;202(3):167-77.

PMID:
1814645
31.

3-p-hydroxyphenylpropionic acid--a sensitive fluorogenic substrate for automated fluorometric enzyme immunoassays.

Tuuminen T, Palomäki P, Rakkolainen A, Welin MG, Weber T, Käpyaho K.

J Immunoassay. 1991;12(1):29-46.

PMID:
2040711
32.

Rapid determination of C-reactive protein by enzyme immunoassay using two monoclonal antibodies.

Käpyaho K, Welin MG, Tanner P, Kärkkäinen T, Weber T.

Scand J Clin Lab Invest. 1989 Jun;49(4):389-93.

PMID:
2662385
33.

Monoclonal antibodies to the 27-34K insulin-like growth factor binding protein.

Rutanen EM, Kärkkäinen T, Lundqvist C, Pekonen F, Ritvos O, Tanner P, Welin M, Weber T.

Biochem Biophys Res Commun. 1988 Apr 15;152(1):208-15.

PMID:
2451912
34.

Peripheral blood lymphocyte subsets in radiologists exposed to ionizing radiation.

Forslund T, Welin MG, Laasonen L, Weber TH, Edgren J.

Acta Radiol Oncol. 1985 Sep-Oct;24(5):415-7.

PMID:
3002140
35.

Lymphocyte subpopulations and reactivity during and after infectious mononucleosis.

Lumio J, Welin MG, Hirvonen P, Weber T.

Med Biol. 1983;61(4):208-13.

PMID:
6317995
36.

In vitro production of leucocyte migration inhibitory factor by lymphocytes in exudative pleural effusions.

Pettersson T, Welin MG, Weber TH.

J Clin Lab Immunol. 1982 Jun;8(2):107-11.

PMID:
7050387
37.

Leucocyte migration inhibition assay from clotted plasma droplets.

Welin MG, Mäkinen T, Weber TH.

J Clin Lab Immunol. 1982 May;8(1):65-8.

PMID:
6808136
38.

Further decrease in thyroidal uptake and disappearance of endemic goitre in children after 30 years of iodine prophylaxis in the east of Finland.

Lamberg BA, Haikonen M, Mäkelä M, Jukkara A, Axelson E, Welin MG.

Acta Endocrinol (Copenh). 1981 Oct;98(2):205-9.

PMID:
7293651
39.

Increase in thyroxine-binding globulin (TBG) in lysinuric protein intolerance.

Lamberg BA, Perheentupa J, Rajantie J, Simell O, Saarinen P, Ebeling P, Welin MG.

Acta Endocrinol (Copenh). 1981 May;97(1):67-73.

PMID:
6784426
40.

Marathon run: effects on blood cortisol -- ACTH, iodothyronines -- TSH and vasopressin.

Dessypris A, Wägar G, Fyhrquist F, Mäkinen T, Welin MG, Lamberg BA.

Acta Endocrinol (Copenh). 1980 Oct;95(2):151-7.

PMID:
6254304
41.

Leucocyte migration inhibition factor (LIF) and antithrombin III (AT III).

Weber TH, Mäkinen T, Welin MG.

J Clin Lab Immunol. 1980 Jul;4(1):47-8.

PMID:
7007650
42.

Thyroid hormones and TSH, prolactin and LH responses to repeated TRH and LRH injections in depressed patients.

Linnoila M, Lamberg BA, Rosberg G, Karonen SL, Welin MG.

Acta Psychiatr Scand. 1979 May;59(5):536-44.

PMID:
111472

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