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A lipoprotein lipase --GPI-anchored high density lipoprotein binding protein 1 fusion lowers triglycerides in mice: implications for managing familial chylomicronemia syndrome.

Nimonkar AV, Weldon S, Godbout K, Panza D, Hanrahan S, Cubbon R, Xu F, Trauger JW, Gao J, Voznesensky A.

J Biol Chem. 2019 Oct 23. pii: jbc.RA119.011079. doi: 10.1074/jbc.RA119.011079. [Epub ahead of print]


Targeting Proteases in Cystic Fibrosis Lung Disease: Paradigms, Progress, and Potential.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC.

Am J Respir Crit Care Med. 2019 Oct 18. doi: 10.1164/rccm.201906-1190PP. [Epub ahead of print]


Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease.

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA.

Am J Respir Cell Mol Biol. 2019 Sep 9. doi: 10.1165/rcmb.2018-0359OC. [Epub ahead of print]


The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Ojo O, Weldon SM, Thompson T, Vargo EJ.

Int J Environ Res Public Health. 2019 May 16;16(10). pii: E1716. doi: 10.3390/ijerph16101716. Review.


Structure of lipoprotein lipase in complex with GPIHBP1.

Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10360-10365. doi: 10.1073/pnas.1820171116. Epub 2019 May 9.


In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.

Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. doi: 10.1073/pnas.1815354116. Epub 2019 Apr 26.


Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection.

Carlile SR, Shiels J, Kerrigan L, Delaney R, Megaw J, Gilmore BF, Weldon S, Dalton JP, Taggart CC.

Sci Rep. 2019 Apr 15;9(1):6071. doi: 10.1038/s41598-019-42537-8.


A Surgical Team Simulation to Improve Teamwork and Communication across Two Continents: ViSIOT Proof-of-Concept Study.

Weldon SM, Korkiakangas T, Calzada J, Korndorffer JR Jr, Kneebone RL.

J Surg Educ. 2019 Sep - Oct;76(5):1413-1424. doi: 10.1016/j.jsurg.2019.03.016. Epub 2019 Apr 4.


Inhibitors of Aldosterone Synthase.

Weldon SM, Brown NF.

Vitam Horm. 2019;109:211-239. doi: 10.1016/bs.vh.2018.10.002. Epub 2018 Dec 21. Review.


Targeting of cathepsin S reduces cystic fibrosis-like lung disease.

Small DM, Brown RR, Doherty DF, Abladey A, Zhou-Suckow Z, Delaney RJ, Kerrigan L, Dougan CM, Borensztajn KS, Holsinger L, Booth R, Scott CJ, López-Campos G, Elborn JS, Mall MA, Weldon S, Taggart CC.

Eur Respir J. 2019 Mar 28;53(3). pii: 1801523. doi: 10.1183/13993003.01523-2018. Print 2019 Mar.


Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.

Doherty DF, Nath S, Poon J, Foronjy RF, Ohlmeyer M, Dabo AJ, Salathe M, Birrell M, Belvisi M, Baumlin N, Kim MD, Weldon S, Taggart C, Geraghty P.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):51-62. doi: 10.1164/rccm.201808-1518OC.


Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field.

Ghita M, Dunne VL, McMahon SJ, Osman SO, Small DM, Weldon S, Taggart CC, McGarry CK, Hounsell AR, Graves EE, Prise KM, Hanna GG, Butterworth KT.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1231-1240. doi: 10.1016/j.ijrobp.2018.12.010. Epub 2018 Dec 12.


A new approach to multi-professional end of life care training using a sequential simulation (SqS Simulation™) design: A mixed methods study.

Weil A, Weldon SM, Kronfli M, Watkins B, Kneebone R, Bello F, Cox S.

Nurse Educ Today. 2018 Dec;71:26-33. doi: 10.1016/j.nedt.2018.08.022. Epub 2018 Sep 9.


Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.

Dey T, Kalita J, Weldon S, Taggart CC.

J Clin Med. 2018 Aug 28;7(9). pii: E244. doi: 10.3390/jcm7090244. Review.


Hybrid thoracoabdominal aortic aneurysm repair: is the future here?

Orozco-Sevilla V, Weldon SA, Coselli JS.

J Vis Surg. 2018 Mar 30;4:61. doi: 10.21037/jovs.2018.02.14. eCollection 2018. Review.


Immobilization of heavy metals in contaminated soil after mining activity by using biochar and other industrial by-products: the significant role of minerals on the biochar surfaces.

Dang VM, Joseph S, Van HT, Mai TLA, Duong TMH, Weldon S, Munroe P, Mitchell D, Taherymoosavi S.

Environ Technol. 2019 Oct;40(24):3200-3215. doi: 10.1080/09593330.2018.1468487. Epub 2018 May 8.


The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma.

Tanaka A, Allam VSRR, Simpson J, Tiberti N, Shiels J, To J, Lund M, Combes V, Weldon S, Taggart C, Dalton JP, Phipps S, Sukkar MB, Donnelly S.

J Allergy Clin Immunol. 2018 Jun;141(6):2316-2319. doi: 10.1016/j.jaci.2018.01.050. Epub 2018 Mar 6. No abstract available.


Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).

Chen Q, Pandi SPS, Kerrigan L, McElvaney NG, Greene CM, Elborn JS, Taggart CC, Weldon S.

J Cyst Fibros. 2018 Sep;17(5):616-623. doi: 10.1016/j.jcf.2018.01.010. Epub 2018 Mar 2.


Valve-sparing versus composite root replacement procedures in patients with Marfan syndrome.

Coselli JS, Weldon SA, Preventza O, de la Cruz KI, LeMaire SA.

Ann Cardiothorac Surg. 2017 Nov;6(6):692-696. doi: 10.21037/acs.2017.11.02. Review. No abstract available.


Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):979-984. doi: 10.1016/j.bmcl.2017.12.015. Epub 2017 Dec 8.


Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease.

Bragonzi A, Horati H, Kerrigan L, Lorè NI, Scholte BJ, Weldon S.

J Cyst Fibros. 2018 Mar;17(2S):S40-S45. doi: 10.1016/j.jcf.2017.10.004. Epub 2017 Oct 27. Review.


Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells.

Brunssen C, Hofmann A, Peitzsch M, Frenzel A, Ziegler CG, Brown NF, Weldon SM, Eisenhofer G, Willenberg HS, Bornstein SR, Morawietz H.

Horm Metab Res. 2017 Sep;49(9):701-706. doi: 10.1055/s-0043-113829. Epub 2017 Jul 31.


Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.


Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.

Dunne V, Ghita M, Small DM, Coffey CBM, Weldon S, Taggart CC, Osman SO, McGarry CK, Prise KM, Hanna GG, Butterworth KT.

Radiother Oncol. 2017 Sep;124(3):475-481. doi: 10.1016/j.radonc.2017.06.025. Epub 2017 Jul 8.


Activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens.

Payne JE, Dubois AV, Ingram RJ, Weldon S, Taggart CC, Elborn JS, Tunney MM.

Int J Antimicrob Agents. 2017 Sep;50(3):427-435. doi: 10.1016/j.ijantimicag.2017.04.014. Epub 2017 Jun 27.


The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice.

Hofmann A, Brunssen C, Peitzsch M, Balyura M, Mittag J, Frenzel A, Jannasch A, Brown NF, Weldon SM, Gueneva-Boucheva KK, Eisenhofer G, Bornstein SR, Morawietz H.

Horm Metab Res. 2017 Jun;49(6):466-471. doi: 10.1055/s-0043-101821. Epub 2017 Apr 20.


Extent II Thoracoabdominal Aortic Aneurysm Repair: How I Do It.

Coselli JS, de la Cruz KI, Preventza O, LeMaire SA, Weldon SA.

Semin Thorac Cardiovasc Surg. 2016 Summer;28(2):221-237. doi: 10.1053/j.semtcvs.2016.07.005. Epub 2016 Jul 17.


Microanalysis of video from the operating room: an underused approach to patient safety research.

Bezemer J, Cope A, Korkiakangas T, Kress G, Murtagh G, Weldon SM, Kneebone R.

BMJ Qual Saf. 2017 Jul;26(7):583-587. doi: 10.1136/bmjqs-2016-005816. Epub 2016 Dec 9. No abstract available.


The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease.

Small DM, Doherty DF, Dougan CM, Weldon S, Taggart CC.

Biol Chem. 2017 Apr 1;398(4):425-440. doi: 10.1515/hsz-2016-0262. Review.


Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes.

Hofmann A, Peitzsch M, Brunssen C, Mittag J, Jannasch A, Frenzel A, Brown N, Weldon SM, Eisenhofer G, Bornstein SR, Morawietz H.

Horm Metab Res. 2017 Jan;49(1):43-49. doi: 10.1055/s-0042-116157. Epub 2016 Nov 3.


Small-molecule WNK inhibition regulates cardiovascular and renal function.

Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L.

Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5.


Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase.

Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1198-F1210. doi: 10.1152/ajprenal.00062.2016. Epub 2016 Sep 28.


Sequential simulation (SqS) of clinical pathways: a tool for public and patient engagement in point-of-care diagnostics.

Huddy JR, Weldon SM, Ralhan S, Painter T, Hanna GB, Kneebone R, Bello F.

BMJ Open. 2016 Sep 13;6(9):e011043. doi: 10.1136/bmjopen-2016-011043.


Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.

Hofmann A, Brunssen C, Peitzsch M, Martin M, Mittag J, Jannasch A, Engelmann F, Brown NF, Weldon SM, Huber J, Streicher R, Deussen A, Eisenhofer G, Bornstein SR, Morawietz H.

Endocrinology. 2016 Oct;157(10):3844-3855. Epub 2016 Aug 15.


Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates.

Weldon SM, Cerny MA, Gueneva-Boucheva K, Cogan D, Guo X, Moss N, Parmentier JH, Richman JR, Reinhart GA, Brown NF.

J Pharmacol Exp Ther. 2016 Oct;359(1):142-50. doi: 10.1124/jpet.116.236463. Epub 2016 Aug 1.


Sequential simulation of a patient journey.

Weldon SM, Ralhan S, Paice L, Kneebone R, Bello F.

Clin Teach. 2017 Apr;14(2):90-94. doi: 10.1111/tct.12549. Epub 2016 Jun 21.


Engaging patients and clinicians through simulation: rebalancing the dynamics of care.

Kneebone R, Weldon SM, Bello F.

Adv Simul (Lond). 2016 Jun 15;1:19. doi: 10.1186/s41077-016-0019-9. eCollection 2016.


Quantification and Comparison of Anti-Fibrotic Therapies by Polarized SRM and SHG-Based Morphometry in Rat UUO Model.

Qian HS, Weldon SM, Matera D, Lee C, Yang H, Fryer RM, Fogo AB, Reinhart GA.

PLoS One. 2016 Jun 3;11(6):e0156734. doi: 10.1371/journal.pone.0156734. eCollection 2016.


Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.

Zhu Y, Blum M, Hoff U, Wesser T, Fechner M, Westphal C, Gürgen D, Catar RA, Philippe A, Wu K, Bubalo G, Rothe M, Weldon SM, Dragun D, Schunck WH.

PLoS One. 2016 Jan 4;11(1):e0145645. doi: 10.1371/journal.pone.0145645. eCollection 2016.


A Video Analysis of Intra- and Interprofessional Leadership Behaviors Within "The Burns Suite": Identifying Key Leadership Models.

Sadideen H, Weldon SM, Saadeddin M, Loon M, Kneebone R.

J Surg Educ. 2016 Jan-Feb;73(1):31-9. doi: 10.1016/j.jsurg.2015.09.011. Epub 2015 Dec 11.


Unsettled teamwork: communication and learning in the operating theatres of an urban hospital.

Bezemer J, Korkiakangas T, Weldon SM, Kress G, Kneebone R.

J Adv Nurs. 2016 Feb;72(2):361-72. doi: 10.1111/jan.12835. Epub 2015 Nov 6.


Classic resectional technique for mitral valve repair: triangular resection via right anterior thoracotomy.

Pocock E, Tsai PI, Markan S, Weldon SA, Rosengart TK.

Ann Cardiothorac Surg. 2015 Sep;4(5):476-7. doi: 10.3978/j.issn.2225-319X.2015.02.03. Review. No abstract available.


GDF11 does not rescue aging-related pathological hypertrophy.

Smith SC, Zhang X, Zhang X, Gross P, Starosta T, Mohsin S, Franti M, Gupta P, Hayes D, Myzithras M, Kahn J, Tanner J, Weldon SM, Khalil A, Guo X, Sabri A, Chen X, MacDonnell S, Houser SR.

Circ Res. 2015 Nov 6;117(11):926-32. doi: 10.1161/CIRCRESAHA.115.307527. Epub 2015 Sep 17.


A secretory leukocyte protease inhibitor variant with improved activity against lung infection.

Camper N, Glasgow AM, Osbourn M, Quinn DJ, Small DM, McLean DT, Lundy FT, Elborn JS, McNally P, Ingram RJ, Weldon S, Taggart CC.

Mucosal Immunol. 2016 May;9(3):669-76. doi: 10.1038/mi.2015.90. Epub 2015 Sep 16.


Sequential Simulation (SqS): an innovative approach to educating GP receptionists about integrated care via a patient journey--a mixed methods approach.

Weldon SM, Ralhan S, Paice E, Kneebone R, Bello F.

BMC Fam Pract. 2015 Aug 27;16:109. doi: 10.1186/s12875-015-0327-5.


The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity.

McGarry N, Greene CM, McElvaney NG, Weldon S, Taggart CC.

J Immunol Res. 2015;2015:507315. doi: 10.1155/2015/507315. Epub 2015 Jul 12.


Music and communication in the operating theatre.

Weldon SM, Korkiakangas T, Bezemer J, Kneebone R.

J Adv Nurs. 2015 Dec;71(12):2763-74. doi: 10.1111/jan.12744. Epub 2015 Aug 4.


The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung.

Twigg MS, Brockbank S, Lowry P, FitzGerald SP, Taggart C, Weldon S.

Mediators Inflamm. 2015;2015:293053. doi: 10.1155/2015/293053. Epub 2015 Jun 21. Review.


A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung.

Glasgow AM, Small DM, Scott A, McLean DT, Camper N, Hamid U, Hegarty S, Parekh D, O'Kane C, Lundy FT, McNally P, Elborn JS, McAuley DF, Weldon S, Taggart CC.

Thorax. 2015 May;70(5):426-32. doi: 10.1136/thoraxjnl-2014-206488. Epub 2015 Mar 13.


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