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AR101 Oral Immunotherapy for Peanut Allergy.

PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW.

N Engl J Med. 2018 Nov 22;379(21):1991-2001. doi: 10.1056/NEJMoa1812856. Epub 2018 Nov 18.


Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics.

Oldstone MBA, Ware BC, Horton LE, Welch MJ, Aiolfi R, Zarpellon A, Ruggeri ZM, Sullivan BM.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7814-E7823. doi: 10.1073/pnas.1804674115. Epub 2018 Jul 30.


An interplay between plasticity and parental phenotype determines impacts of ocean acidification on a reef fish.

Schunter C, Welch MJ, Nilsson GE, Rummer JL, Munday PL, Ravasi T.

Nat Ecol Evol. 2018 Feb;2(2):334-342. doi: 10.1038/s41559-017-0428-8. Epub 2017 Dec 18.


Heritability of behavioural tolerance to high CO2 in a coral reef fish is masked by nonadaptive phenotypic plasticity.

Welch MJ, Munday PL.

Evol Appl. 2017 May 24;10(7):682-693. doi: 10.1111/eva.12483. eCollection 2017 Aug.


Effects of elevated CO2 on predator avoidance behaviour by reef fishes is not altered by experimental test water.

Munday PL, Welch MJ, Allan BJ, Watson SA, McMahon SJ, McCormick MI.

PeerJ. 2016 Oct 6;4:e2501. eCollection 2016.


Altered brain ion gradients following compensation for elevated CO2 are linked to behavioural alterations in a coral reef fish.

Heuer RM, Welch MJ, Rummer JL, Munday PL, Grosell M.

Sci Rep. 2016 Sep 13;6:33216. doi: 10.1038/srep33216.



Singer JR, Nigalye AK, Champion MT, Welch MJ.

Retin Cases Brief Rep. 2018 Winter;12(1):5-9. doi: 10.1097/ICB.0000000000000385.


Pharmacokinetics, pharmacodynamics, and clinical efficacy of albuterol RespiClick(™) dry-powder inhaler in the treatment of asthma.

Welch MJ.

Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):1109-19. doi: 10.1080/17425255.2016.1209485. Epub 2016 Jul 28. Review.


Phase 1 Evaluation of [(64)Cu]DOTA-Patritumab to Assess Dosimetry, Apparent Receptor Occupancy, and Safety in Subjects with Advanced Solid Tumors.

Lockhart AC, Liu Y, Dehdashti F, Laforest R, Picus J, Frye J, Trull L, Belanger S, Desai M, Mahmood S, Mendell J, Welch MJ, Siegel BA.

Mol Imaging Biol. 2016 Jun;18(3):446-53. doi: 10.1007/s11307-015-0912-y.


Privacy and confidentiality in pragmatic clinical trials.

McGraw D, Greene SM, Miner CS, Staman KL, Welch MJ, Rubel A.

Clin Trials. 2015 Oct;12(5):520-9. doi: 10.1177/1740774515597677. Epub 2015 Sep 15.


The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials.

Welch MJ, Lally R, Miller JE, Pittman S, Brodsky L, Caplan AL, Uhlenbrauck G, Louzao DM, Fischer JH, Wilfond B.

Clin Trials. 2015 Oct;12(5):503-10. doi: 10.1177/1740774515597701. Epub 2015 Sep 15.


Bilingual Text Messaging Translation: Translating Text Messages From English Into Spanish for the Text4Walking Program.

Buchholz SW, Sandi G, Ingram D, Welch MJ, Ocampo EV.

JMIR Res Protoc. 2015 May 6;4(2):e51. doi: 10.2196/resprot.3984.


Silicone oil microbubble found in failed full-thickness macular hole closure.

Welch MJ, De Souza SA.

Retin Cases Brief Rep. 2014 Spring;8(2):132-4. doi: 10.1097/ICB.0000000000000023.


Demographic characteristics of U.S. Chinese older adults in the Greater Chicago area: assessing the representativeness of the PINE study.

Simon MA, Chang ES, Rajan KB, Welch MJ, Dong X.

J Aging Health. 2014 Oct;26(7):1100-15. doi: 10.1177/0898264314543472.


Type I interferon is a therapeutic target for virus-induced lethal vascular damage.

Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2.


Timely cholecystectomy for acute gallstone disease: an ongoing challenge in a New Zealand provincial centre.

Welch MJ, Moot AR.

N Z Med J. 2014 Apr 11;127(1392):48-57. Erratum in: N Z Med J. 2014 Jun 6;127(1395):105.


Antisense peptide nucleic acid-functionalized cationic nanocomplex for in vivo mRNA detection.

Shen Y, Shrestha R, Ibricevic A, Gunsten SP, Welch MJ, Wooley KL, Brody SL, Taylor JS, Liu Y.

Interface Focus. 2013 Jun 6;3(3):20120059. doi: 10.1098/rsfs.2012.0059.


Development of a Standard Reference Material for metabolomics research.

Phinney KW, Ballihaut G, Bedner M, Benford BS, Camara JE, Christopher SJ, Davis WC, Dodder NG, Eppe G, Lang BE, Long SE, Lowenthal MS, McGaw EA, Murphy KE, Nelson BC, Prendergast JL, Reiner JL, Rimmer CA, Sander LC, Schantz MM, Sharpless KE, Sniegoski LT, Tai SS, Thomas JB, Vetter TW, Welch MJ, Wise SA, Wood LJ, Guthrie WF, Hagwood CR, Leigh SD, Yen JH, Zhang NF, Chaudhary-Webb M, Chen H, Fazili Z, LaVoie DJ, McCoy LF, Momin SS, Paladugula N, Pendergrast EC, Pfeiffer CM, Powers CD, Rabinowitz D, Rybak ME, Schleicher RL, Toombs BM, Xu M, Zhang M, Castle AL.

Anal Chem. 2013 Dec 17;85(24):11732-8. doi: 10.1021/ac402689t. Epub 2013 Dec 3.


Nucleic Acid-directed Self-assembly of Multifunctional Gold Nanoparticle Imaging Agents.

Zhang Z, Liu Y, Jarreau C, Welch MJ, Taylor JS.

Biomater Sci. 2013 Oct;1(10):1055-1064.


Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus.

Lee AM, Cruite J, Welch MJ, Sullivan B, Oldstone MB.

Virology. 2013 Aug 1;442(2):114-21. doi: 10.1016/j.virol.2013.04.010. Epub 2013 May 16.


PET imaging of chemokine receptors in vascular injury-accelerated atherosclerosis.

Liu Y, Pierce R, Luehmann HP, Sharp TL, Welch MJ.

J Nucl Med. 2013 Jul;54(7):1135-41. doi: 10.2967/jnumed.112.114777. Epub 2013 May 8.


Effects of chelator modifications on (68)Ga-labeled [Tyr (3)]octreotide conjugates.

Lin M, Welch MJ, Lapi SE.

Mol Imaging Biol. 2013 Oct;15(5):606-13. doi: 10.1007/s11307-013-0627-x.


Pelvic magnetic resonance imaging for rectal cancer in a provincial centre: time to follow the standards?

Welch MJ, Meiyappan V, Moot AR.

N Z Med J. 2013 Mar 1;126(1370):119-21. No abstract available.


PEGylation of cationic, shell-crosslinked-knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung.

Ibricevic A, Guntsen SP, Zhang K, Shrestha R, Liu Y, Sun JY, Welch MJ, Wooley KL, Brody SL.

Nanomedicine. 2013 Oct;9(7):912-22. doi: 10.1016/j.nano.2013.02.006. Epub 2013 Feb 27.


A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?

Lapi SE, Welch MJ.

Nucl Med Biol. 2013 Apr;40(3):314-20. doi: 10.1016/j.nucmedbio.2012.12.010. Epub 2013 Jan 26.


Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

Sullivan BM, Welch MJ, Lemke G, Oldstone MB.

J Virol. 2013 Apr;87(7):4071-4. doi: 10.1128/JVI.03268-12. Epub 2013 Jan 16.


Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

Oldstone MB, Edelmann KH, McGavern DB, Cruite JT, Welch MJ.

PLoS Pathog. 2012;8(11):e1003044. doi: 10.1371/journal.ppat.1003044. Epub 2012 Nov 29.


Hierarchically assembled theranostic nanostructures for siRNA delivery and imaging applications.

Shrestha R, Elsabahy M, Luehmann H, Samarajeewa S, Florez-Malaver S, Lee NS, Welch MJ, Liu Y, Wooley KL.

J Am Chem Soc. 2012 Oct 24;134(42):17362-5. doi: 10.1021/ja306616n. Epub 2012 Oct 10.


Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.

Li A, Luehmann HP, Sun G, Samarajeewa S, Zou J, Zhang S, Zhang F, Welch MJ, Liu Y, Wooley KL.

ACS Nano. 2012 Oct 23;6(10):8970-82. doi: 10.1021/nn303030t. Epub 2012 Oct 8.


Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6233-6. doi: 10.1016/j.bmcl.2012.08.010. Epub 2012 Aug 9.


Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.

Lin M, Ranganathan D, Mori T, Hagooly A, Rossin R, Welch MJ, Lapi SE.

Appl Radiat Isot. 2012 Oct;70(10):2539-44. doi: 10.1016/j.apradiso.2012.05.009. Epub 2012 Jun 19.


Highly efficient click labeling using 2-[¹⁸F]fluoroethyl azide and synthesis of an ¹⁸FN-hydroxysuccinimide ester as conjugation agent.

Zhou D, Chu W, Dence CS, Mach RH, Welch MJ.

Nucl Med Biol. 2012 Nov;39(8):1175-81. doi: 10.1016/j.nucmedbio.2012.06.002. Epub 2012 Jul 4.


Monoclonal antibody RM2 as a potential ligand for a new immunotracer for prostate cancer imaging.

Hasegawa Y, Oyama N, Nagase K, Fujibayashi Y, Furukawa T, Murayama Y, Arai Y, Saito S, Welch MJ, Yokoyama O.

Nucl Med Biol. 2012 Oct;39(7):944-7. doi: 10.1016/j.nucmedbio.2012.05.008. Epub 2012 Jul 4.


Synthesis and biological evaluation of two agents for imaging estrogen receptor β by positron emission tomography: challenges in PET imaging of a low abundance target.

Lee JH, Peters O, Lehmann L, Dence CS, Sharp TL, Carlson KE, Zhou D, Jeyakumar M, Welch MJ, Katzenellenbogen JA.

Nucl Med Biol. 2012 Nov;39(8):1105-16. doi: 10.1016/j.nucmedbio.2012.05.011. Epub 2012 Jun 30.


Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.

Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB.

Cell Host Microbe. 2012 Jun 14;11(6):643-53. doi: 10.1016/j.chom.2012.04.016.


Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer.

Fowler AM, Chan SR, Sharp TL, Fettig NM, Zhou D, Dence CS, Carlson KE, Jeyakumar M, Katzenellenbogen JA, Schreiber RD, Welch MJ.

J Nucl Med. 2012 Jul;53(7):1119-26. doi: 10.2967/jnumed.112.103465. Epub 2012 Jun 5.


CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.

Welch MJ, Teijaro JR, Lewicki HA, Colonna M, Oldstone MB.

Virology. 2012 Aug 1;429(2):163-70. doi: 10.1016/j.virol.2012.04.006. Epub 2012 May 12.


64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.

Zeng D, Lee NS, Liu Y, Zhou D, Dence CS, Wooley KL, Katzenellenbogen JA, Welch MJ.

ACS Nano. 2012 Jun 26;6(6):5209-19. doi: 10.1021/nn300974s. Epub 2012 May 8.


A semi-automated system for the routine production of copper-64.

Kume M, Carey PC, Gaehle G, Madrid E, Voller T, Margenau W, Welch MJ, Lapi SE.

Appl Radiat Isot. 2012 Aug;70(8):1803-6. doi: 10.1016/j.apradiso.2012.03.009. Epub 2012 Mar 15.


Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione.

Dehdashti F, Laforest R, Gao F, Aft RL, Dence CS, Zhou D, Shoghi KI, Siegel BA, Katzenellenbogen JA, Welch MJ.

J Nucl Med. 2012 Mar;53(3):363-70. doi: 10.2967/jnumed.111.098319. Epub 2012 Feb 13.


STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas.

Chan SR, Vermi W, Luo J, Lucini L, Rickert C, Fowler AM, Lonardi S, Arthur C, Young LJ, Levy DE, Welch MJ, Cardiff RD, Schreiber RD.

Breast Cancer Res. 2012 Jan 20;14(1):R16.


A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC?

Lapi SE, Welch MJ.

Nucl Med Biol. 2012 Jul;39(5):601-8. doi: 10.1016/j.nucmedbio.2011.11.005. Epub 2012 Jan 20. Review.


Nanoparticles labeled with positron emitting nuclides: advantages, methods, and applications.

Liu Y, Welch MJ.

Bioconjug Chem. 2012 Apr 18;23(4):671-82. doi: 10.1021/bc200264c. Epub 2012 Feb 6. Review.


Targeting angiogenesis using a C-type atrial natriuretic factor-conjugated nanoprobe and PET.

Liu Y, Pressly ED, Abendschein DR, Hawker CJ, Woodard GE, Woodard PK, Welch MJ.

J Nucl Med. 2011 Dec;52(12):1956-63. doi: 10.2967/jnumed.111.089581. Epub 2011 Nov 2.


Preparation and value assignment of standard reference material 968e fat-soluble vitamins, carotenoids, and cholesterol in human serum.

Thomas JB, Duewer DL, Mugenya IO, Phinney KW, Sander LC, Sharpless KE, Sniegoski LT, Tai SS, Welch MJ, Yen JH.

Anal Bioanal Chem. 2012 Jan;402(2):749-62. doi: 10.1007/s00216-011-5447-8. Epub 2011 Oct 21.


Synthesis and evaluation of 18F-labeled PPARγ antagonists.

Lee H, Chen DL, Rothfuss JM, Welch MJ, Gropler RJ, Mach RH.

Nucl Med Biol. 2012 Jan;39(1):77-87. doi: 10.1016/j.nucmedbio.2011.07.002. Epub 2011 Sep 9.


Characterization of 64Cu-DOTA-conatumumab: a PET tracer for in vivo imaging of death receptor 5.

Rossin R, Kohno T, Hagooly A, Sharp T, Gliniak B, Arroll T, Chen Q, Hewig A, Kaplan-Lefko P, Friberg G, Radinsky R, Evelhoch JL, Welch MJ, Hwang DR.

J Nucl Med. 2011 Jun;52(6):942-9. doi: 10.2967/jnumed.110.086157. Epub 2011 May 13.


Luminescence imaging using radionuclides: a potential application in molecular imaging.

Park JC, Il An G, Park SI, Oh J, Kim HJ, Su Ha Y, Wang EK, Min Kim K, Kim JY, Lee J, Welch MJ, Yoo J.

Nucl Med Biol. 2011 Apr;38(3):321-9. doi: 10.1016/j.nucmedbio.2010.09.003. Epub 2010 Oct 27.


Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma.

Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Mori T, Yoshii H, Asai T, Okazawa H, Welch MJ, Fujibayashi Y.

Nucl Med Biol. 2011 Feb;38(2):151-7. doi: 10.1016/j.nucmedbio.2010.08.009. Epub 2010 Oct 27.


Evaluation of multivalent, functional polymeric nanoparticles for imaging applications.

Shokeen M, Pressly ED, Hagooly A, Zheleznyak A, Ramos N, Fiamengo AL, Welch MJ, Hawker CJ, Anderson CJ.

ACS Nano. 2011 Feb 22;5(2):738-47. doi: 10.1021/nn102278w. Epub 2011 Jan 28.

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