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The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.

Arora H, Wilcox SM, Johnson LA, Munro L, Eyford BA, Pfeifer CG, Welch I, Jefferies WA.

Immunity. 2019 Feb 19;50(2):418-431.e6. doi: 10.1016/j.immuni.2019.01.014. Epub 2019 Feb 12.


Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2-/- mice.

Wang R, Sheps JA, Liu L, Han J, Chen PSK, Lamontagne J, Wilson PD, Welch I, Borchers CH, Ling V.

J Lipid Res. 2019 Jan;60(1):85-97. doi: 10.1194/jlr.M088070. Epub 2018 Nov 11.


An efficient approach for feature construction of high-dimensional microarray data by random projections.

Tariq H, Eldridge E, Welch I.

PLoS One. 2018 Apr 27;13(4):e0196385. doi: 10.1371/journal.pone.0196385. eCollection 2018.


Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.

Saranchova I, Han J, Zaman R, Arora H, Huang H, Fenninger F, Choi KB, Munro L, Pfeifer CG, Welch I, Takei F, Jefferies WA.

Sci Rep. 2018 Feb 13;8(1):2924. doi: 10.1038/s41598-018-20608-6.


Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis.

Fang H, Huang L, Welch I, Norley C, Holdsworth DW, Beier F, Cai D.

Sci Rep. 2018 Feb 12;8(1):2855. doi: 10.1038/s41598-018-21184-5.


An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics.

Asiri YI, Fung T, Schwarz SKW, Asseri KA, Welch ID, Schuppli CA, Barr AM, Wall RA, Puil E, MacLeod BA.

Anesth Analg. 2018 Aug;127(2):548-555. doi: 10.1213/ANE.0000000000002525.


Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.

Szabo PA, Goswami A, Mazzuca DM, Kim K, O'Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM.

J Immunol. 2017 Apr 1;198(7):2805-2818. doi: 10.4049/jimmunol.1601366. Epub 2017 Feb 20.


Patient-Reported Outcomes for Acute Gallstone Pathology.

Parkin E, Stott M, Brockbank J, Galloway S, Welch I, Macdonald A.

World J Surg. 2017 May;41(5):1234-1238. doi: 10.1007/s00268-016-3854-x.


An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.

Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA.

Mol Cell. 2016 Dec 15;64(6):1074-1087. doi: 10.1016/j.molcel.2016.10.021. Epub 2016 Nov 23.


Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.

Thwaites MJ, Cecchini MJ, Passos DT, Welch I, Dick FA.

Mol Cell Biol. 2017 Jan 4;37(2). pii: e00561-16. doi: 10.1128/MCB.00561-16. Print 2017 Jan 15.


Recurrent cubital tunnel syndrome treated with revision neurolysis and amniotic membrane nerve wrapping.

Gaspar MP, Abdelfattah HM, Welch IW, Vosbikian MM, Kane PM, Rekant MS.

J Shoulder Elbow Surg. 2016 Dec;25(12):2057-2065. doi: 10.1016/j.jse.2016.09.013. Epub 2016 Oct 14.


Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.

Saranchova I, Han J, Huang H, Fenninger F, Choi KB, Munro L, Pfeifer C, Welch I, Wyatt AW, Fazli L, Gleave ME, Jefferies WA.

Sci Rep. 2016 Sep 13;6:30555. doi: 10.1038/srep30555.


Context-specific protection of TGFα null mice from osteoarthritis.

Usmani SE, Ulici V, Pest MA, Hill TL, Welch ID, Beier F.

Sci Rep. 2016 Jul 26;6:30434. doi: 10.1038/srep30434.


Quantification of Alloantibody-Mediated Cytotoxicity In Vivo.

Memarnejadian A, Meilleur CE, Mazzuca DM, Welch ID, Haeryfar SM.

Transplantation. 2016 May;100(5):1041-51. doi: 10.1097/TP.0000000000001154.


The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig.

Sarr O, Blake A, Thompson JA, Zhao L, Rabicki K, Walsh JC, Welch I, Regnault TR.

J Physiol. 2016 Mar 15;594(6):1753-72. doi: 10.1113/JP271777. Epub 2016 Feb 17.


Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

Stewart MK, Bechberger JF, Welch I, Naus CC, Laird DW.

Oncotarget. 2015 Nov 10;6(35):37185-99. doi: 10.18632/oncotarget.5953.


Quantification of mouse in vivo whole-body vibration amplitude from motion-blur using x-ray imaging.

Hu Z, Welch I, Yuan X, Pollmann SI, Nikolov HN, Holdsworth DW.

Phys Med Biol. 2015 Aug 21;60(16):6423-39. doi: 10.1088/0031-9155/60/16/6423. Epub 2015 Aug 6.


Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F.

J Mol Med (Berl). 2015 Aug;93(8):845-56. doi: 10.1007/s00109-015-1311-1. Epub 2015 Jul 4.


Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus.

Kaiser JC, Omer S, Sheldon JR, Welch I, Heinrichs DE.

Infect Immun. 2015 Mar;83(3):1019-29. doi: 10.1128/IAI.02542-14. Epub 2014 Dec 29.


PU.1 opposes IL-7-dependent proliferation of developing B cells with involvement of the direct target gene bruton tyrosine kinase.

Christie DA, Xu LS, Turkistany SA, Solomon LA, Li SK, Yim E, Welch I, Bell GI, Hess DA, DeKoter RP.

J Immunol. 2015 Jan 15;194(2):595-605. doi: 10.4049/jimmunol.1401569. Epub 2014 Dec 10.


Magnetic resonance image guided transurethral ultrasound prostate ablation: a preclinical safety and feasibility study with 28-day followup.

Burtnyk M, Hill T, Cadieux-Pitre H, Welch I.

J Urol. 2015 May;193(5):1669-75. doi: 10.1016/j.juro.2014.11.089. Epub 2014 Nov 22.


Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.

Ratneswaran A, LeBlanc EA, Walser E, Welch I, Mort JS, Borradaile N, Beier F.

Arthritis Rheumatol. 2015 Feb;67(2):454-64. doi: 10.1002/art.38915.


Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus.

Arifin AJ, Hannauer M, Welch I, Heinrichs DE.

Microbes Infect. 2014 Nov;16(11):967-72. doi: 10.1016/j.micinf.2014.09.003. Epub 2014 Sep 22.


T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis.

Anantha RV, Mazzuca DM, Xu SX, Porcelli SA, Fraser DD, Martin CM, Welch I, Mele T, Haeryfar SM, McCormick JK.

Clin Exp Immunol. 2014 Nov;178(2):292-309. doi: 10.1111/cei.12404.


Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.

Kasper KJ, Zeppa JJ, Wakabayashi AT, Xu SX, Mazzuca DM, Welch I, Baroja ML, Kotb M, Cairns E, Cleary PP, Haeryfar SM, McCormick JK.

PLoS Pathog. 2014 May 29;10(5):e1004155. doi: 10.1371/journal.ppat.1004155. eCollection 2014 May.


Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.

Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA.

Cancer Discov. 2014 Jul;4(7):840-53. doi: 10.1158/2159-8290.CD-14-0215. Epub 2014 Apr 16.


A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.

Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA.

Mol Cell Biol. 2014 Jun;34(11):2029-45. doi: 10.1128/MCB.01589-13. Epub 2014 Mar 24.


ILK modulates epithelial polarity and matrix formation in hair follicles.

Rudkouskaya A, Welch I, Dagnino L.

Mol Biol Cell. 2014 Mar;25(5):620-32. doi: 10.1091/mbc.E13-08-0499. Epub 2013 Dec 26.


FGFR2, HER2 and cMet in gastric adenocarcinoma: detection, prognostic significance and assessment of downstream pathway activation.

Betts G, Valentine H, Pritchard S, Swindell R, Williams V, Morgan S, Griffiths EA, Welch I, West C, Womack C.

Virchows Arch. 2014 Feb;464(2):145-56. doi: 10.1007/s00428-013-1517-y. Epub 2013 Dec 4.


Is surgery in the elderly for oesophageal cancer justifiable? Results from a single centre.

Mirza A, Pritchard S, Welch I.

ISRN Surg. 2013 Sep 24;2013:609252. doi: 10.1155/2013/609252. eCollection 2013.


Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.

Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffé M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA.

FASEB J. 2013 Sep;27(9):3594-607. doi: 10.1096/fj.13-232280. Epub 2013 May 31.


A pilot study to investigate the role of thymidylate synthase as a marker of prognosis for neoadjuvant chemotherapy in gastric and gastro-oesophageal junction adenocarcinoma.

Mirza A, Brown M, McNulty C, Valentine J, Annesley A, Galloway S, Welch I, West CM, Pritchard S.

Gastroenterol Res Pract. 2013;2013:502153. doi: 10.1155/2013/502153. Epub 2013 Mar 3.


Establishment of a stringent large animal model of insulin-dependent diabetes for islet autotransplantation: combination of pancreatectomy and streptozotocin.

Pepper AR, Welch I, Bruni A, MacGillivary A, Mazzuca DM, White DJ, Wall W.

Pancreas. 2013 Mar;42(2):329-38. doi: 10.1097/MPA.0b013e318264bcdd. Erratum in: Pancreas. 2014 Aug;43(6):977. Pancreas. 2014 Aug;43(6):977.


Intrinsic microvasculature of the sciatic nerve in the rat.

Zamir M, Twynstra J, Vercnocke AJ, Welch I, Jorgensen SM, Ritman EL, Holdsworth DW, Shoemaker JK.

J Peripher Nerv Syst. 2012 Dec;17(4):377-84. doi: 10.1111/j.1529-8027.2012.00435.x.


Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.

Wiebe JP, Zhang G, Welch I, Cadieux-Pitre HA.

Breast Cancer Res. 2013 May 11;15(3):R38. doi: 10.1186/bcr3422.


A novel intubation technique for minimally invasive longitudinal studies of rat lungs using hyperpolarized 3He magnetic resonance imaging.

Fox MS, Welch I, Hobson D, Santyr GE.

Lab Anim. 2012 Oct;46(4):311-7. doi: 10.1258/la.2012.011139.


Investigation of the epithelial to mesenchymal transition markers S100A4, vimentin and Snail1 in gastroesophageal junction tumors.

Mirza A, Foster L, Valentine H, Welch I, West CM, Pritchard S.

Dis Esophagus. 2014 Jul;27(5):485-92. doi: 10.1111/j.1442-2050.2012.01435.x. Epub 2012 Oct 19.


Tissue factor expression in the metaplasia-adenoma-carcinoma sequence of gastric cancer in a European population.

Lo L, Valentine H, Harrison J, Hayes S, Welch I, Pritchard S, West C, Ang Y.

Br J Cancer. 2012 Sep 25;107(7):1125-30. doi: 10.1038/bjc.2012.363. Epub 2012 Aug 28.


Ultrasound-guided insertion of intramuscular electrodes into suboccipital muscles in the non-human primate.

Corneil BD, Goonetilleke SC, Peel TR, Green KA, Welch ID.

J Electromyogr Kinesiol. 2012 Aug;22(4):553-9. doi: 10.1016/j.jelekin.2012.02.014. Epub 2012 Mar 22.


CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens.

Hayworth JL, Mazzuca DM, Maleki Vareki S, Welch I, McCormick JK, Haeryfar SM.

Immunol Cell Biol. 2012 Aug;90(7):699-709. doi: 10.1038/icb.2011.90. Epub 2011 Nov 1.


Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.

Walker KM, Rytelewski M, Mazzuca DM, Meilleur SA, Mannik LA, Yue D, Brintnell WC, Welch I, Cairns E, Haeryfar SM.

Immunol Cell Biol. 2012 Jul;90(6):630-9. doi: 10.1038/icb.2011.78. Epub 2011 Sep 13.


Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia.

Sokalski KM, Li SK, Welch I, Cadieux-Pitre HA, Gruca MR, DeKoter RP.

Blood. 2011 Sep 8;118(10):2801-8. doi: 10.1182/blood-2011-02-335539. Epub 2011 Jul 18.


Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.

Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A.

J Invest Dermatol. 2011 Oct;131(10):1996-2003. doi: 10.1038/jid.2011.156. Epub 2011 Jun 9.


Use of imaging biomarkers to assess perfusion and glucose metabolism in the skeletal muscle of dystrophic mice.

Ahmad N, Welch I, Grange R, Hadway J, Dhanvantari S, Hill D, Lee TY, Hoffman LM.

BMC Musculoskelet Disord. 2011 Jun 4;12:127. doi: 10.1186/1471-2474-12-127.


Rodent cardiovascular responses to baroreceptor unloading: effect of plane of anaesthesia.

Usselman CW, Mattar L, Twynstra J, Welch I, Shoemaker JK.

Appl Physiol Nutr Metab. 2011 Jun;36(3):376-81. doi: 10.1139/h11-029. Epub 2011 May 16.


Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning.

Sillah K, Williams LR, Laasch HU, Saleem A, Watkins G, Pritchard SA, Price PM, West CM, Welch IM.

World J Gastrointest Oncol. 2010 Apr 15;2(4):197-204. doi: 10.4251/wjgo.v2.i4.197.


Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro-oesophageal junction cancers.

Brown M, Sillah K, Griffiths EA, Swindell R, West CM, Page RD, Welch IM, Pritchard SA.

Histopathology. 2010 Jun;56(7):893-9. doi: 10.1111/j.1365-2559.2010.03559.x.


Atrophy among mucosa-only versus muscular mucosa superiorly based pharyngeal flaps: a pilot animal study.

Brandt MG, Husein M, Matic DB, Leung AE, Wehrli BM, Welch I, Ho D, Kassam Z, Silver I, Doyle PC.

Plast Reconstr Surg. 2010 Jun;125(6):1679-84. doi: 10.1097/PRS.0b013e3181d4fdff.


Anti-adhesive coating and clearance of device associated uropathogenic Escherichia coli cystitis.

Pechey A, Elwood CN, Wignall GR, Dalsin JL, Lee BP, Vanjecek M, Welch I, Ko R, Razvi H, Cadieux PA.

J Urol. 2009 Oct;182(4):1628-36. doi: 10.1016/j.juro.2009.06.008. Epub 2009 Aug 15.

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