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Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain.

Yang J, Price MA, Wanshura LEC, He J, Yi M, Welch DR, Li G, Conner S, Sachs J, Turley EA, McCarthy JB.

Melanoma Res. 2019 Aug;29(4):365-375. doi: 10.1097/CMR.0000000000000574.


Defining the Hallmarks of Metastasis.

Welch DR, Hurst DR.

Cancer Res. 2019 Jun 15;79(12):3011-3027. doi: 10.1158/0008-5472.CAN-19-0458. Epub 2019 May 3. Review.


The second genome: Effects of the mitochondrial genome on cancer progression.

Scheid AD, Beadnell TC, Welch DR.

Adv Cancer Res. 2019;142:63-105. doi: 10.1016/bs.acr.2019.01.001. Epub 2019 Feb 27.


The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered.

Pantoja-Uceda D, Neira JL, Contreras LM, Manton CA, Welch DR, Rizzuti B.

Arch Biochem Biophys. 2019 Mar 30;664:95-101. doi: 10.1016/ Epub 2019 Jan 30.


Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models.

Vivian CJ, Hagedorn TM, Jensen RA, Brinker AE, Welch DR.

Cancer Metastasis Rev. 2018 Dec;37(4):633-642. doi: 10.1007/s10555-018-9773-6.


Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer.

Beadnell TC, Scheid AD, Vivian CJ, Welch DR.

Cancer Metastasis Rev. 2018 Dec;37(4):615-632. doi: 10.1007/s10555-018-9772-7. Review.


Zeeman spectroscopy as a method for determining the magnetic field distribution in self-magnetic-pinch diodes (invited).

Patel SG, Johnston MD, Webb TJ, Bennett NL, Welch DR, Gilgenbach RM, Cuneo ME, Kiefer ML, Leckbee JJ, Mazarakis MG, Muron DJ, Renk TJ, Simpson SC, Doron R, Biswas S, Mikitchuk D, Maron Y.

Rev Sci Instrum. 2018 Oct;89(10):10D123. doi: 10.1063/1.5039386.


Mitochondrial genetics - new model uncovering roles in tumorigenicity and metastasis.

Beadnell TC, Welch DR.

Oncoscience. 2018 Apr 29;5(3-4):71-72. doi: 10.18632/oncoscience.407. eCollection 2018 Mar. No abstract available.


Automated quantitative image analysis for ex vivo metastasis assays reveals differing lung composition requirements for metastasis suppression by KISS1.

Young ED, Strom K, Tsue AF, Usset JL, MacPherson S, McGuire JT, Welch DR.

Clin Exp Metastasis. 2018 Feb;35(1-2):77-86. doi: 10.1007/s10585-018-9882-1. Epub 2018 Mar 26.


NGF reprograms metastatic melanoma to a bipotent glial-melanocyte neural crest-like precursor.

Kasemeier-Kulesa JC, Romine MH, Morrison JA, Bailey CM, Welch DR, Kulesa PM.

Biol Open. 2018 Jan 11;7(1). pii: bio030817. doi: 10.1242/bio.030817.


Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver-Dependent Manner.

Brinker AE, Vivian CJ, Koestler DC, Tsue TT, Jensen RA, Welch DR.

Cancer Res. 2017 Dec 15;77(24):6941-6949. doi: 10.1158/0008-5472.CAN-17-2194. Epub 2017 Oct 25.


Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy.

Kaverina N, Borovjagin AV, Kadagidze Z, Baryshnikov A, Baryshnikova M, Malin D, Ghosh D, Shah N, Welch DR, Gabikian P, Karseladze A, Cobbs C, Ulasov IV.

Autophagy. 2017;13(11):1905-1923. doi: 10.1080/15548627.2017.1360466. Epub 2017 Oct 5.


Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.

Vivian CJ, Brinker AE, Graw S, Koestler DC, Legendre C, Gooden GC, Salhia B, Welch DR.

Cancer Res. 2017 Nov 15;77(22):6202-6214. doi: 10.1158/0008-5472.CAN-17-1473. Epub 2017 Jun 29.


The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation.

Manley SJ, Liu W, Welch DR.

J Mol Med (Berl). 2017 Sep;95(9):951-963. doi: 10.1007/s00109-017-1552-2. Epub 2017 Jun 8.


Gd2O3-doped silica @ Au nanoparticles for in vitro imaging cancer biomarkers using surface-enhanced Raman scattering.

Xiao L, Tian X, Harihar S, Li Q, Li L, Welch DR, Zhou A.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 15;181:218-225. doi: 10.1016/j.saa.2017.03.033. Epub 2017 Mar 22.


Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.

Sasaki K, Kurahara H, Young ED, Natsugoe S, Ijichi A, Iwakuma T, Welch DR.

Clin Exp Metastasis. 2017 Apr;34(3-4):229-239. doi: 10.1007/s10585-017-9840-3. Epub 2017 Mar 13.


Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.

Burikhanov R, Hebbar N, Noothi SK, Shukla N, Sledziona J, Araujo N, Kudrimoti M, Wang QJ, Watt DS, Welch DR, Maranchie J, Harada A, Rangnekar VM.

Cell Rep. 2017 Jan 10;18(2):508-519. doi: 10.1016/j.celrep.2016.12.051.


Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.

Kesterson RA, Johnson LW, Lambert LJ, Vivian JL, Welch DR, Ballinger SW.

Bio Protoc. 2016 Oct 20;6(20). pii: e1976.



Welch DR, Fisher PB.

Adv Cancer Res. 2016;132:xi-xiv. doi: 10.1016/S0065-230X(16)30064-1. No abstract available.


Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action.

Welch DR, Manton CA, Hurst DR.

Adv Cancer Res. 2016;132:111-37. doi: 10.1016/bs.acr.2016.05.003. Epub 2016 Jun 17. Review.


Transition from Beam-Target to Thermonuclear Fusion in High-Current Deuterium Z-Pinch Simulations.

Offermann DT, Welch DR, Rose DV, Thoma C, Clark RE, Mostrom CB, Schmidt AE, Link AJ.

Phys Rev Lett. 2016 May 13;116(19):195001. doi: 10.1103/PhysRevLett.116.195001. Epub 2016 May 9.


Tumor Cell Invasion-Not All Barriers Are Created Equal.

Welch DR.

Cancer Res. 2016 Apr 1;76(7):1675-6. doi: 10.1158/0008-5472.CAN-16-0550.


Targeting the untargetable? Nodal expression in TNBC.

Young ED, Welch DR.

Cell Cycle. 2016 Jun 2;15(11):1400. doi: 10.1080/15384101.2016.1166816. Epub 2016 Mar 30. No abstract available.


Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.

Kurahara H, Bohl C, Natsugoe S, Nishizono Y, Harihar S, Sharma R, Iwakuma T, Welch DR.

Int J Cancer. 2016 Aug 1;139(3):628-38. doi: 10.1002/ijc.30110.


Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.

Roesley SN, Suryadinata R, Morrish E, Tan AR, Issa SM, Oakhill JS, Bernard O, Welch DR, Šarčević B.

Cell Cycle. 2016;15(1):137-51. doi: 10.1080/15384101.2015.1121328.


In vitro biophysical, microspectroscopic and cytotoxic evaluation of metastatic and non-metastatic cancer cells in responses to anti-cancer drug.

Li Q, Xiao L, Harihar S, Welch DR, Vargis E, Zhou A.

Anal Methods. 2015 Dec 21;7(24):10162-10169. Epub 2015 Nov 3.


Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and Predictions.

Welch DR.

Cancer Res. 2016 Jan 1;76(1):4-6. doi: 10.1158/0008-5472.CAN-15-3024. Epub 2016 Jan 3.


Essential Components of Cancer Education.

Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ; Cancer Biology Training Consortium.

Cancer Res. 2015 Dec 15;75(24):5202-5. doi: 10.1158/0008-5472.CAN-15-2077. Epub 2015 Dec 1. Review.


Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential.

Feeley KP, Bray AW, Westbrook DG, Johnson LW, Kesterson RA, Ballinger SW, Welch DR.

Cancer Res. 2015 Oct 15;75(20):4429-36. doi: 10.1158/0008-5472.CAN-15-0074.


Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells.

Rangarajan P, Subramaniam D, Paul S, Kwatra D, Palaniyandi K, Islam S, Harihar S, Ramalingam S, Gutheil W, Putty S, Pradhan R, Padhye S, Welch DR, Anant S, Dhar A.

Oncotarget. 2015 Sep 29;6(29):27661-73. doi: 10.18632/oncotarget.4871.


MTBP inhibits migration and metastasis of hepatocellular carcinoma.

Bi Q, Ranjan A, Fan R, Agarwal N, Welch DR, Weinman SA, Ding J, Iwakuma T.

Clin Exp Metastasis. 2015 Apr;32(4):301-11. doi: 10.1007/s10585-015-9706-5. Epub 2015 Mar 11.


Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopy.

Xiao L, Harihar S, Welch DR, Zhou A.

Anal Chim Acta. 2014 Sep 16;843:73-82. doi: 10.1016/j.aca.2014.06.036. Epub 2014 Jun 21.


Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.

Liu W, Vivian CJ, Brinker AE, Hampton KR, Lianidou E, Welch DR.

Cancer Microenviron. 2014 Dec;7(3):117-31. doi: 10.1007/s12307-014-0148-4. Epub 2014 Jun 18.


Toward a drug development path that targets metastatic progression in osteosarcoma.

Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M.

Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6.


Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer.

Balgkouranidou I, Chimonidou M, Milaki G, Tsarouxa EG, Kakolyris S, Welch DR, Georgoulias V, Lianidou ES.

Br J Cancer. 2014 Apr 15;110(8):2054-62. doi: 10.1038/bjc.2014.104. Epub 2014 Mar 18.


Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas.

Jones J, Wang H, Karanam B, Theodore S, Dean-Colomb W, Welch DR, Grizzle W, Yates C.

Clin Exp Metastasis. 2014 Jun;31(5):497-510. doi: 10.1007/s10585-014-9644-7. Epub 2014 Feb 26.


Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing.

Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR.

PLoS One. 2014 Jan 13;9(1):e84958. doi: 10.1371/journal.pone.0084958. eCollection 2014.


Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, Pounds KM, Denning WL, Diers AR, Landar A, Dhar A, Iwakuma T, Welch DR.

Cancer Res. 2014 Feb 1;74(3):954-63. doi: 10.1158/0008-5472.CAN-13-1183. Epub 2013 Dec 18.


Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.

Bohl CR, Harihar S, Denning WL, Sharma R, Welch DR.

J Mol Med (Berl). 2014 Jan;92(1):13-30. doi: 10.1007/s00109-013-1109-y. Epub 2013 Dec 6. Review.


MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro.

Moon HJ, Finney J, Xu L, Moore D, Welch DR, Mure M.

J Biol Chem. 2013 Oct 18;288(42):30000-8. doi: 10.1074/jbc.C113.502310. Epub 2013 Sep 6.


Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR.

Mol Carcinog. 2014 Dec;53(12):1011-26. doi: 10.1002/mc.22068. Epub 2013 Sep 2.


Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW.

Biochem J. 2013 Oct 15;455(2):157-67. doi: 10.1042/BJ20130029. Erratum in: Biochem J. 2013 Oct 1;455(1):147.


Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

Diers AR, Vayalil PK, Oliva CR, Griguer CE, Darley-Usmar V, Hurst DR, Welch DR, Landar A.

PLoS One. 2013 Jun 28;8(6):e68348. doi: 10.1371/journal.pone.0068348. Print 2013.


Breast cancer metastasis suppressor-1 promoter methylation in primary breast tumors and corresponding circulating tumor cells.

Chimonidou M, Kallergi G, Georgoulias V, Welch DR, Lianidou ES.

Mol Cancer Res. 2013 Oct;11(10):1248-57. doi: 10.1158/1541-7786.MCR-13-0096. Epub 2013 Jun 6.


Unraveling the 'TGF-β paradox' one metastamir at a time.

Welch DR, Hurst DR.

Breast Cancer Res. 2013 Feb 27;15(1):305. doi: 10.1186/bcr3383.


The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.

Hurst DR, Xie Y, Thomas JW, Liu J, Edmonds MD, Stewart MD, Welch DR.

PLoS One. 2013;8(2):e55966. doi: 10.1371/journal.pone.0055966. Epub 2013 Feb 4.


Simulations of magnetic field generation in unmagnetized plasmas via beat-wave current drive.

Welch DR, Genoni TC, Thoma C, Bruner N, Rose DV, Hsu SC.

Phys Rev Lett. 2012 Nov 30;109(22):225002. Epub 2012 Nov 28.


Preface. Metastasis genes.

Welch DR.

Cancer Metastasis Rev. 2012 Dec;31(3-4):417-8. doi: 10.1007/s10555-012-9386-4. No abstract available.


Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.

Winter SF, Lukes L, Walker RC, Welch DR, Hunter KW.

PLoS Genet. 2012 May;8(5):e1002735. doi: 10.1371/journal.pgen.1002735. Epub 2012 May 31.


MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.

Agarwal N, Adhikari AS, Iyer SV, Hekmatdoost K, Welch DR, Iwakuma T.

Oncogene. 2013 Jan 24;32(4):462-70. doi: 10.1038/onc.2012.69. Epub 2012 Feb 27.

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