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Items: 1 to 50 of 124

1.

Enabling Biocatalysis by High-Throughput Protein Engineering Using Droplet Microfluidics Coupled to Mass Spectrometry.

Diefenbach XW, Farasat I, Guetschow ED, Welch CJ, Kennedy RT, Sun S, Moore JC.

ACS Omega. 2018 Feb 28;3(2):1498-1508. doi: 10.1021/acsomega.7b01973. Epub 2018 Feb 5.

2.

Optical Chirality Sensing with a Stereodynamic Aluminum Biphenolate Probe.

De Los Santos ZA, Joyce LA, Sherer EC, Welch CJ, Wolf C.

J Org Chem. 2018 Jul 27. doi: 10.1021/acs.joc.8b01301. [Epub ahead of print]

PMID:
30019902
3.

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS.

Lin S, Dikler S, Blincoe WD, Ferguson RD, Sheridan RP, Peng Z, Conway DV, Zawatzky K, Wang H, Cernak T, Davies IW, DiRocco DA, Sheng H, Welch CJ, Dreher SD.

Science. 2018 Aug 10;361(6402). pii: eaar6236. doi: 10.1126/science.aar6236. Epub 2018 May 24.

PMID:
29794218
4.

Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors.

Li Y, Liu Y, Gao H, Helmy R, Wuelfing WP, Welch CJ, Cooks RG.

Chemistry. 2018 May 23;24(29):7349-7353. doi: 10.1002/chem.201801176. Epub 2018 Apr 30.

PMID:
29653016
5.

Modeling and predicting chiral stationary phase enantioselectivity: An efficient random forest classifier using an optimally balanced training dataset and an aggregation strategy.

Piras P, Sheridan R, Sherer EC, Schafer W, Welch CJ, Roussel C.

J Sep Sci. 2018 Mar;41(6):1365-1375. doi: 10.1002/jssc.201701334. Epub 2018 Mar 2.

PMID:
29383846
6.

Characterization of the Submicrometer Hierarchy Levels in the Twist-Bend Nematic Phase with Nanometric Helices via Photopolymerization. Explanation for the Sign Reversal in the Polar Response.

Panov VP, Sreenilayam SP, Panarin YP, Vij JK, Welch CJ, Mehl GH.

Nano Lett. 2017 Dec 13;17(12):7515-7519. doi: 10.1021/acs.nanolett.7b03441. Epub 2017 Nov 27.

PMID:
29136474
7.

Telephone triage could further stress primary care.

Welch CJ.

BMJ. 2017 Oct 30;359:j4902. doi: 10.1136/bmj.j4902. No abstract available.

PMID:
29084712
8.

Are We Approaching a Speed Limit for the Chromatographic Separation of Enantiomers?

Welch CJ.

ACS Cent Sci. 2017 Aug 23;3(8):823-829. doi: 10.1021/acscentsci.7b00250. Epub 2017 Aug 7. Review.

9.

An Asymmetric, Catalytic (4 + 3) Cycloaddition Reaction of Cyclopentenyl Oxyallylic Cations.

Topinka M, Zawatzky K, Barnes CL, Welch CJ, Harmata M.

Org Lett. 2017 Aug 4;19(15):4106-4109. doi: 10.1021/acs.orglett.7b01868. Epub 2017 Jul 25.

PMID:
28741952
10.

Evidence based medicine misses the "art" of helping humans.

Welch CJ.

BMJ. 2017 Jul 18;358:j3426. doi: 10.1136/bmj.j3426. No abstract available.

PMID:
28720585
11.

Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study.

Jia T, Zhang M, McCollom SP, Bellomo A, Montel S, Mao J, Dreher SD, Welch CJ, Regalado EL, Williamson RT, Manor BC, Tomson NC, Walsh PJ.

J Am Chem Soc. 2017 Jun 21;139(24):8337-8345. doi: 10.1021/jacs.7b03623. Epub 2017 Jun 7.

PMID:
28537724
12.

Separation of small interfering RNA stereoisomers using reversed-phase ion-pairing chromatography.

Li L, Leone T, Foley JP, Welch CJ.

J Chromatogr A. 2017 Jun 2;1500:84-88. doi: 10.1016/j.chroma.2017.04.008. Epub 2017 Apr 8.

PMID:
28449879
13.

Overcoming "speed limits" in high throughput chromatographic analysis.

Zawatzky K, Barhate CL, Regalado EL, Mann BF, Marshall N, Moore JC, Welch CJ.

J Chromatogr A. 2017 May 26;1499:211-216. doi: 10.1016/j.chroma.2017.04.002. Epub 2017 Apr 4.

PMID:
28416217
14.

Effects of pressure and frictional heating on protein separation using monolithic columns in reversed-phase chromatography.

Mann BF, Makarov AA, Wang H, Welch CJ.

J Chromatogr A. 2017 Mar 17;1489:58-64. doi: 10.1016/j.chroma.2017.01.071. Epub 2017 Jan 27.

PMID:
28193469
15.

Ultrafast Chiral Chromatography as the Second Dimension in Two-Dimensional Liquid Chromatography Experiments.

Barhate CL, Regalado EL, Contrella ND, Lee J, Jo J, Makarov AA, Armstrong DW, Welch CJ.

Anal Chem. 2017 Mar 21;89(6):3545-3553. doi: 10.1021/acs.analchem.6b04834. Epub 2017 Jan 23.

PMID:
28192943
16.

2D-LC as an on-line desalting tool allowing peptide identification directly from MS unfriendly HPLC methods.

Luo H, Zhong W, Yang J, Zhuang P, Meng F, Caldwell J, Mao B, Welch CJ.

J Pharm Biomed Anal. 2017 Apr 15;137:139-145. doi: 10.1016/j.jpba.2016.11.012. Epub 2016 Nov 10.

PMID:
28113090
17.

Assessment of coulometric array electrochemical detection coupled with HPLC-UV for the absolute quantitation of pharmaceuticals.

Hicks MB, Salituro L, Mangion I, Schafer W, Xiang R, Gong X, Welch CJ.

Analyst. 2017 Jan 26;142(3):525-536. doi: 10.1039/c6an02432g.

PMID:
28098264
18.

Online sensing of palladium in flowing streams.

Bu X, Williams M, Jo J, Koide K, Welch CJ.

Chem Commun (Camb). 2017 Jan 5;53(4):720-723. doi: 10.1039/c6cc08562h.

PMID:
27990538
19.

Unusual reversal of enantioselectivity in the asymmetric autocatalysis of pyrimidyl alkanol triggered by chiral aromatic alkanols and amines.

Matusmoto A, Fujiwara S, Hiyoshi Y, Zawatzky K, Makarov AA, Welch CJ, Soai K.

Org Biomol Chem. 2017 Jan 18;15(3):555-558. doi: 10.1039/c6ob02415g.

PMID:
27942665
20.

Ultrafast chiral separations for high throughput enantiopurity analysis.

Barhate CL, Joyce LA, Makarov AA, Zawatzky K, Bernardoni F, Schafer WA, Armstrong DW, Welch CJ, Regalado EL.

Chem Commun (Camb). 2017 Jan 3;53(3):509-512. doi: 10.1039/c6cc08512a.

PMID:
27872920
21.

Can the analyte-triggered asymmetric autocatalytic Soai reaction serve as a universal analytical tool for measuring enantiopurity and assigning absolute configuration?

Welch CJ, Zawatzky K, Makarov AA, Fujiwara S, Matsumoto A, Soai K.

Org Biomol Chem. 2016 Dec 20;15(1):96-101.

PMID:
27714244
22.

Mining Chromatographic Enantioseparation Data Using Matched Molecular Pair Analysis.

Sheridan RP, Piras P, Sherer EC, Roussel C, Pirkle WH, Welch CJ.

Molecules. 2016 Sep 29;21(10). pii: E1297.

23.

Visualizing small differences using subtractive chromatographic analysis.

Zawatzky K, Reibarkh M, Canfield N, Wang TC, Li S, Du L, Welch CJ.

J Chromatogr A. 2016 Oct 14;1468:245-249. doi: 10.1016/j.chroma.2016.09.025. Epub 2016 Sep 13.

PMID:
27663729
24.

Using chromatogram averaging to improve quantitation of minor impurities.

Zawatzky K, Lin M, Schafer W, Mao B, Trapp O, Welch CJ.

J Chromatogr A. 2016 Sep 23;1465:205-10. doi: 10.1016/j.chroma.2016.08.047. Epub 2016 Aug 22.

PMID:
27578409
25.

Hydroxypyridyl Imines: Enhancing Chromatographic Separation and Stereochemical Analysis of Chiral Amines via Circular Dichroism.

Joyce LA, Regalado EL, Welch CJ.

J Org Chem. 2016 Sep 16;81(18):8199-205. doi: 10.1021/acs.joc.6b01162. Epub 2016 Sep 1.

PMID:
27529785
26.

Evaluation of C18 monolithic columns for radiochemical purity measurement.

Schenk DJ, Welch CJ, Antonucci V.

J Labelled Comp Radiopharm. 2016 Aug;59(10):391-7. doi: 10.1002/jlcr.3422. Epub 2016 Jul 13.

PMID:
27411721
27.

Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.

Mangion I, Liu Y, Reibarkh M, Williamson RT, Welch CJ.

J Org Chem. 2016 Aug 19;81(16):6937-44. doi: 10.1021/acs.joc.6b00937. Epub 2016 Jun 22.

PMID:
27322370
28.

Toward structure-based predictive tools for the selection of chiral stationary phases for the chromatographic separation of enantiomers.

Sheridan R, Schafer W, Piras P, Zawatzky K, Sherer EC, Roussel C, Welch CJ.

J Chromatogr A. 2016 Oct 7;1467:206-213. doi: 10.1016/j.chroma.2016.05.066. Epub 2016 May 20.

PMID:
27318509
29.

Multiple-injection high-throughput gas chromatography analysis.

Schafer W, Wang H, Welch CJ.

J Sep Sci. 2016 Aug;39(15):2978-85. doi: 10.1002/jssc.201600332. Epub 2016 Jul 22.

PMID:
27292909
30.

Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity.

Yang L, Wenzel T, Williamson RT, Christensen M, Schafer W, Welch CJ.

ACS Cent Sci. 2016 May 25;2(5):332-40. doi: 10.1021/acscentsci.6b00062. Epub 2016 Apr 20.

31.

Are fluorine-rich pharmaceuticals lost by partition into fluorous phases?

Sun S, Zawatzky K, Regalado EL, Mangion IK, Welch CJ.

J Pharm Biomed Anal. 2016 Sep 5;128:106-110. doi: 10.1016/j.jpba.2016.05.025. Epub 2016 May 17.

PMID:
27239759
32.

Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity.

Makarov AA, Helmy R, Joyce L, Reibarkh M, Maust M, Ren S, Mergelsberg I, Welch CJ.

Org Biomol Chem. 2016 May 11;14(19):4448-55. doi: 10.1039/c6ob00550k.

PMID:
27088756
33.

A competitive and reversible deactivation approach to catalysis-based quantitative assays.

Koide K, Tracey MP, Bu X, Jo J, Williams MJ, Welch CJ.

Nat Commun. 2016 Feb 19;7:10691. doi: 10.1038/ncomms10691.

34.

Antenna Biphenols: Development of Extended Wavelength Chiroptical Reporters.

Bentley KW, Joyce LA, Sherer EC, Sheng H, Wolf C, Welch CJ.

J Org Chem. 2016 Feb 5;81(3):1185-91. doi: 10.1021/acs.joc.5b02716. Epub 2016 Jan 26.

PMID:
26756165
35.

MISER chiral supercritical fluid chromatography for high throughput analysis of enantiopurity.

Zawatzky K, Biba M, Regalado EL, Welch CJ.

J Chromatogr A. 2016 Jan 15;1429:374-9. doi: 10.1016/j.chroma.2015.12.057. Epub 2015 Dec 23.

PMID:
26747691
36.

Ultrafast separation of fluorinated and desfluorinated pharmaceuticals using highly efficient and selective chiral selectors bonded to superficially porous particles.

Barhate CL, Breitbach ZS, Pinto EC, Regalado EL, Welch CJ, Armstrong DW.

J Chromatogr A. 2015 Dec 24;1426:241-7. doi: 10.1016/j.chroma.2015.11.056. Epub 2015 Nov 28.

PMID:
26643720
37.

Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry.

Osterberg PM, Niemeier JK, Welch CJ, Hawkins JM, Martinelli JR, Johnson TE, Root TW, Stahl SS.

Org Process Res Dev. 2015 Nov 20;19(11):1537-1543. Epub 2014 Dec 6. Review.

38.

Capture of reactive monophosphine-ligated palladium(0) intermediates by mass spectrometry.

Zheng Q, Liu Y, Chen Q, Hu M, Helmy R, Sherer EC, Welch CJ, Chen H.

J Am Chem Soc. 2015 Nov 11;137(44):14035-8. doi: 10.1021/jacs.5b08905. Epub 2015 Oct 28.

PMID:
26498505
39.

Benzophenone and its analogs bind to human glyoxalase 1.

Mihai DM, Hall S, Deng H, Welch CJ, Kawamura A.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5349-51. doi: 10.1016/j.bmcl.2015.09.036. Epub 2015 Sep 15.

40.

Supercritical fluid chromatography for GMP analysis in support of pharmaceutical development and manufacturing activities.

Hicks MB, Regalado EL, Tan F, Gong X, Welch CJ.

J Pharm Biomed Anal. 2016 Jan 5;117:316-24. doi: 10.1016/j.jpba.2015.09.014. Epub 2015 Sep 15.

PMID:
26412720
41.

Pushing the speed limit in enantioselective supercritical fluid chromatography.

Regalado EL, Welch CJ.

J Sep Sci. 2015 Aug;38(16):2826-32. doi: 10.1002/jssc.201500270. Epub 2015 Jul 17.

PMID:
26075564
42.

Search for improved fluorinated stationary phases for separation of fluorine-containing pharmaceuticals from their desfluoro analogs.

Regalado EL, Makarov AA, McClain R, Przybyciel M, Welch CJ.

J Chromatogr A. 2015 Feb 6;1380:45-54. doi: 10.1016/j.chroma.2014.12.025. Epub 2014 Dec 17.

PMID:
25595532
43.

Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.

Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD.

Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20.

44.

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

Regalado EL, Schariter JA, Welch CJ.

J Chromatogr A. 2014 Oct 10;1363:200-6. doi: 10.1016/j.chroma.2014.08.025. Epub 2014 Aug 14.

PMID:
25160950
45.

Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography.

Biba M, Regalado EL, Wu N, Welch CJ.

J Chromatogr A. 2014 Oct 10;1363:250-6. doi: 10.1016/j.chroma.2014.07.010. Epub 2014 Jul 12.

PMID:
25082525
46.

Estimating optimal time for fast chromatographic separations.

Welch CJ, Regalado EL.

J Sep Sci. 2014 Sep;37(18):2552-8. doi: 10.1002/jssc.201400508. Epub 2014 Aug 8.

PMID:
24995384
47.

Effect of pressure on the chromatographic separation of enantiomers under reversed-phase conditions.

Makarov AA, Regalado EL, Welch CJ, Schafer WA.

J Chromatogr A. 2014 Jul 25;1352:87-92. doi: 10.1016/j.chroma.2014.05.044. Epub 2014 May 28.

PMID:
24928149
48.

Investigation of a new core-shell particle column for ion-pair reversed-phase liquid chromatography analysis of oligonucleotides.

Biba M, Welch CJ, Foley JP.

J Pharm Biomed Anal. 2014 Aug 5;96:54-7. doi: 10.1016/j.jpba.2014.03.029. Epub 2014 Mar 26.

PMID:
24727281
49.

Chromatographic resolution of closely related species: drug metabolites and analogs.

Regalado EL, Helmy R, Green MD, Welch CJ.

J Sep Sci. 2014 May;37(9-10):1094-102. doi: 10.1002/jssc.201400038. Epub 2014 Apr 10.

PMID:
24596023
50.

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.

Regalado EL, Kozlowski MC, Curto JM, Ritter T, Campbell MG, Mazzotti AR, Hamper BC, Spilling CD, Mannino MP, Wan L, Yu JQ, Liu J, Welch CJ.

Org Biomol Chem. 2014 Apr 14;12(14):2161-6. doi: 10.1039/c3ob42195c. Review.

PMID:
24589831

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