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Items: 1 to 50 of 312

1.

Autoimmune diabetes mellitus and the leaky gut.

Peters A, Wekerle H.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14788-14790. doi: 10.1073/pnas.1909224116. Epub 2019 Jul 9. No abstract available.

PMID:
31289225
2.

Secondary progressive multiple sclerosis and the gut-brain axis.

Wekerle H.

Brain. 2019 Apr 1;142(4):838-840. doi: 10.1093/brain/awz068. No abstract available.

PMID:
30946474
3.

Avraham Ben-Nun-Pioneer, fighter, friend.

Cohen IR, Wekerle H.

Eur J Immunol. 2019 Apr;49(4):521-522. doi: 10.1002/eji.201970046. No abstract available.

PMID:
30942903
4.

The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.

Enzmann G, Adelfio R, Godel A, Haghayegh Jahromi N, Tietz S, Burgener SS, Deutsch U, Wekerle H, Benarafa C, Engelhardt B.

Int J Mol Sci. 2019 Mar 21;20(6). pii: E1433. doi: 10.3390/ijms20061433.

5.

Brain inflammatory cascade controlled by gut-derived molecules.

Wekerle H.

Nature. 2018 May;557(7707):642-643. doi: 10.1038/d41586-018-05113-0. No abstract available.

PMID:
29805157
6.

Nature, nurture, and microbes: The development of multiple sclerosis.

Wekerle H.

Acta Neurol Scand. 2017 Nov;136 Suppl 201:22-25. doi: 10.1111/ane.12843. Review.

PMID:
29068487
7.

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice.

Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10719-10724. doi: 10.1073/pnas.1711233114. Epub 2017 Sep 11.

8.

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6381-E6389. doi: 10.1073/pnas.1701806114. Epub 2017 Jul 17.

9.

Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers.

Wekerle H.

Trends Immunol. 2017 Jul;38(7):483-497. doi: 10.1016/j.it.2017.03.008. Epub 2017 Jun 7. Review.

PMID:
28601415
10.
11.

B cells in multiple sclerosis.

Wekerle H.

Autoimmunity. 2017 Feb;50(1):57-60. doi: 10.1080/08916934.2017.1281914. Review.

PMID:
28166681
12.

The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria.

Wekerle H.

Rheumatology (Oxford). 2016 Dec;55(suppl 2):ii68-ii75. Review.

PMID:
27856664
13.

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7864-9. doi: 10.1073/pnas.1522730113. Epub 2016 Jun 20.

14.

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.

Hohlfeld R, Dornmair K, Meinl E, Wekerle H.

Lancet Neurol. 2016 Feb;15(2):198-209. doi: 10.1016/S1474-4422(15)00334-8. Epub 2015 Dec 24. Review.

PMID:
26724103
15.

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.

Hohlfeld R, Dornmair K, Meinl E, Wekerle H.

Lancet Neurol. 2016 Mar;15(3):317-31. doi: 10.1016/S1474-4422(15)00313-0. Epub 2015 Dec 24. Review. Erratum in: Lancet Neurol. 2016 Mar;15(3):241.

PMID:
26724102
16.

Nature plus nurture: the triggering of multiple sclerosis.

Wekerle H.

Swiss Med Wkly. 2015 Oct 2;145:w14189. doi: 10.4414/smw.2015.14189. eCollection 2015. Review.

17.

Vaccination and narcolepsy: Immune link found?

Wekerle H.

Sci Transl Med. 2015 Jul 1;7(294):294fs27. doi: 10.1126/scitranslmed.aac7091.

PMID:
26136475
18.

[Multiple sclerosis and microbiota. From genome to metagenome?].

Hohlfeld R, Wekerle H.

Nervenarzt. 2015 Aug;86(8):925-33. doi: 10.1007/s00115-014-4248-7. German.

PMID:
26099498
19.

γ-Secretase directly sheds the survival receptor BCMA from plasma cells.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.

20.

αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features.

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K.

Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107. eCollection 2015 Aug.

21.

The autoimmune concept of multiple sclerosis.

Nicol B, Salou M, Laplaud DA, Wekerle H.

Presse Med. 2015 Apr;44(4 Pt 2):e103-12. doi: 10.1016/j.lpm.2015.02.009. Epub 2015 Mar 23.

PMID:
25813101
22.

Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination.

Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, Meinl E.

Acta Neuropathol Commun. 2014 Dec 11;2:168. doi: 10.1186/s40478-014-0168-9.

23.

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10.

24.

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS.

Koutrolos M, Berer K, Kawakami N, Wekerle H, Krishnamoorthy G.

Acta Neuropathol Commun. 2014 Dec 5;2:163. doi: 10.1186/s40478-014-0163-1.

25.

From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.

Ben-Nun A, Kaushansky N, Kawakami N, Krishnamoorthy G, Berer K, Liblau R, Hohlfeld R, Wekerle H.

J Autoimmun. 2014 Nov;54:33-50. doi: 10.1016/j.jaut.2014.06.004. Epub 2014 Aug 28. Review.

PMID:
25175979
26.

T cell-activation in neuromyelitis optica lesions plays a role in their formation.

Pohl M, Kawakami N, Kitic M, Bauer J, Martins R, Fischer MT, Machado-Santos J, Mader S, Ellwart JW, Misu T, Fujihara K, Wekerle H, Reindl M, Lassmann H, Bradl M.

Acta Neuropathol Commun. 2013 Dec 24;1:85. doi: 10.1186/2051-5960-1-85.

27.

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS.

J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9.

28.

Tissue hypoxia in autoimmune brain disease: a Columbian discovery?

Wekerle H.

Ann Neurol. 2013 Dec;74(6):765-7. doi: 10.1002/ana.24054. No abstract available.

PMID:
24242899
29.

Remote control-triggering of brain autoimmune disease in the gut.

Wekerle H, Berer K, Krishnamoorthy G.

Curr Opin Immunol. 2013 Dec;25(6):683-9. doi: 10.1016/j.coi.2013.09.009. Epub 2013 Oct 23. Review.

PMID:
24161654
30.

Multiple sclerosis: An old drug plays a new trick.

Wekerle H, Meinl E.

Nature. 2013 Oct 17;502(7471):314-5. doi: 10.1038/nature12694. Epub 2013 Oct 9. No abstract available.

PMID:
24107991
31.

Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.

Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E.

J Immunol. 2013 Oct 1;191(7):3594-604. doi: 10.4049/jimmunol.1301296. Epub 2013 Sep 6.

32.

Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator.

Mues M, Bartholomäus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G.

Nat Med. 2013 Jun;19(6):778-83. doi: 10.1038/nm.3180. Epub 2013 May 12.

PMID:
23685843
33.

2-photon imaging of phagocyte-mediated T cell activation in the CNS.

Pesic M, Bartholomäus I, Kyratsous NI, Heissmeyer V, Wekerle H, Kawakami N.

J Clin Invest. 2013 Mar;123(3):1192-201. doi: 10.1172/JCI67233. Epub 2013 Feb 1.

34.

Brain microglia: watchdogs with pedigree.

Neumann H, Wekerle H.

Nat Neurosci. 2013 Mar;16(3):253-5. doi: 10.1038/nn.3338. No abstract available.

PMID:
23434975
35.

T cells become licensed in the lung to enter the central nervous system.

Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A.

Nature. 2012 Aug 30;488(7413):675-9. doi: 10.1038/nature11337.

PMID:
22914092
36.

β-Amyloid: enemy or remedy?

Hohlfeld R, Wekerle H.

Sci Transl Med. 2012 Aug 1;4(145):145fs24. doi: 10.1126/scitranslmed.3004586. No abstract available.

PMID:
22855459
37.

Brain autoimmunity: the CD8 question(s).

Wekerle H, Krishnamoorthy G.

Immunity. 2012 Jul 27;37(1):8-10. doi: 10.1016/j.immuni.2012.07.002.

38.

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.

Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K.

Nat Med. 2012 May;18(5):824-8. doi: 10.1038/nm.2720.

PMID:
22484809
39.

Autoimmunity's next top models.

Wekerle H, Flügel A, Fugger L, Schett G, Serreze D.

Nat Med. 2012 Jan 6;18(1):66-70. doi: 10.1038/nm.2635. No abstract available.

PMID:
22227675
40.

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G.

Nature. 2011 Oct 26;479(7374):538-41. doi: 10.1038/nature10554.

PMID:
22031325
41.

Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.

Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E, Derfuss T.

Neurology. 2011 Aug 9;77(6):580-8. doi: 10.1212/WNL.0b013e318228c0b1. Epub 2011 Jul 27.

PMID:
21795651
42.

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.

Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K.

J Neuroimmunol. 2011 Apr;233(1-2):245-8. doi: 10.1016/j.jneuroim.2011.01.010. Epub 2011 Feb 24.

43.

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G.

PLoS One. 2010 Nov 29;5(11):e15531. doi: 10.1371/journal.pone.0015531.

44.

Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity.

Liblau RS, Wekerle H, Tisch RM.

Front Immunol. 2011 Oct 5;2:47. doi: 10.3389/fimmu.2011.00047. eCollection 2011.

45.

B cells in spontaneous autoimmune diseases of the central nervous system.

Berer K, Wekerle H, Krishnamoorthy G.

Mol Immunol. 2011 Jun;48(11):1332-7. doi: 10.1016/j.molimm.2010.10.025. Epub 2010 Dec 13. Review.

PMID:
21146219
46.

Beneficial brain autoimmunity?

Wekerle H, Hohlfeld R.

Brain. 2010 Aug;133(Pt 8):2182-4. doi: 10.1093/brain/awq206. No abstract available.

PMID:
20826427
47.

Fragile privileges: autoimmunity in brain and eye.

Wekerle H, Sun DM.

Acta Pharmacol Sin. 2010 Sep;31(9):1141-8. doi: 10.1038/aps.2010.149. Review.

48.

Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells.

Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E.

Brain Pathol. 2010 Sep;20(5):966-75. doi: 10.1111/j.1750-3639.2010.00399.x. Epub 2010 Mar 25.

PMID:
20456365
49.

Zero tolerance (to acetylcholine receptor) and ways to overcome it.

Wekerle H, Hohlfeld R.

Ann Neurol. 2010 Apr;67(4):422-4. doi: 10.1002/ana.22025. No abstract available.

PMID:
20437576
50.

Molecular oracles for multiple sclerosis therapy.

Wekerle H, Hohlfeld R.

Nat Med. 2010 Apr;16(4):376-7. doi: 10.1038/nm0410-376. No abstract available.

PMID:
20376043

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