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Items: 13


Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.

He H, Singh I, Wek SA, Dey S, Baird TD, Wek RC, Georgiadis MM.

J Biol Chem. 2014 May 23;289(21):15023-34. doi: 10.1074/jbc.M114.560789. Epub 2014 Apr 9.


The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14.


Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p.

Zaborske JM, Narasimhan J, Jiang L, Wek SA, Dittmar KA, Freimoser F, Pan T, Wek RC.

J Biol Chem. 2009 Sep 11;284(37):25254-67. doi: 10.1074/jbc.M109.000877. Epub 2009 Jun 22.


Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG.

J Biol Chem. 2006 Oct 20;281(42):31222-33. Epub 2006 Aug 24.


Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC.

Mol Cell Biol. 2004 Feb;24(3):1365-77.


Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC.

Mol Cell Biol. 2003 Aug;23(16):5651-63.


The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR.

Mol Cell Biol. 2002 Oct;22(19):6681-8.


Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.

Yang R, Wek SA, Wek RC.

Mol Cell Biol. 2000 Apr;20(8):2706-17.


Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.

Greenberg AS, Egan JJ, Wek SA, Moos MC Jr, Londos C, Kimmel AR.

Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12035-9.


Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet.

Egan JJ, Greenberg AS, Chang MK, Wek SA, Moos MC Jr, Londos C.

Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8537-41.


Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.

Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C.

J Biol Chem. 1991 Jun 15;266(17):11341-6.


Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes.

Egan JJ, Saltis J, Wek SA, Simpson IA, Londos C.

Proc Natl Acad Sci U S A. 1990 Feb;87(3):1052-6.

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