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Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.

Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J.

J Biol Chem. 2019 Dec 6;294(49):18674-18684. doi: 10.1074/jbc.RA119.010447. Epub 2019 Oct 28.


Adapting to cell stress from inside and out.

Staschke KA, Wek RC.

Nat Cell Biol. 2019 Jul;21(7):799-800. doi: 10.1038/s41556-019-0354-x. No abstract available.


Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii.

Augusto L, Amin PH, Wek RC, Sullivan WJ Jr.

PLoS Pathog. 2019 Jun 13;15(6):e1007746. doi: 10.1371/journal.ppat.1007746. eCollection 2019 Jun.


Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii.

Holmes MJ, Shah P, Wek RC, Sullivan WJ Jr.

mSphere. 2019 Jun 5;4(3). pii: e00292-19. doi: 10.1128/mSphere.00292-19.


Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation.

Martynowicz J, Augusto L, Wek RC, Boehm SL 2nd, Sullivan WJ Jr.

mBio. 2019 Apr 30;10(2). pii: e00381-19. doi: 10.1128/mBio.00381-19.


Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.

Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E749-E772. doi: 10.1152/ajpendo.00343.2018. Epub 2019 Jan 15.


Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii.

Augusto L, Martynowicz J, Staschke KA, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01442-18. doi: 10.1128/AAC.01442-18. Print 2018 Nov.


Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE.

Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y.


Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.

Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG.

J Biol Chem. 2018 Apr 6;293(14):5005-5015. doi: 10.1074/jbc.RA117.001625. Epub 2018 Feb 15.


Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.

Wek RC.

Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7). pii: a032870. doi: 10.1101/cshperspect.a032870. Review.


Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ Jr.

Cell Host Microbe. 2017 Dec 13;22(6):766-776.e4. doi: 10.1016/j.chom.2017.11.005.


Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.

Collier AE, Spandau DF, Wek RC.

Mol Biol Cell. 2018 Jan 1;29(1):29-41. doi: 10.1091/mbc.E17-06-0362. Epub 2017 Nov 8.


Translational Control in the Latency of Apicomplexan Parasites.

Holmes MJ, Augusto LDS, Zhang M, Wek RC, Sullivan WJ Jr.

Trends Parasitol. 2017 Dec;33(12):947-960. doi: 10.1016/ Epub 2017 Sep 20. Review.


Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.

Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC.

J Biol Chem. 2017 Aug 25;292(34):14050-14065. doi: 10.1074/jbc.M117.799304. Epub 2017 Jul 14.


Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.

Shao Y, Hernandez-Buquer S, Childress P, Stayrook KR, Alvarez MB, Davis H, Plotkin LI, He Y, Condon KW, Burr DB, Warden SJ, Robling AG, Yang FC, Wek RC, Allen MR, Bidwell JP.

Endocrinology. 2017 Sep 1;158(9):2722-2740. doi: 10.1210/en.2017-00355.


Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2.

Collier AE, Wek RC, Spandau DF.

J Invest Dermatol. 2017 Sep;137(9):1924-1934. doi: 10.1016/j.jid.2017.04.029. Epub 2017 May 17.


Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.

Al-Baghdadi RJT, Nikonorova IA, Mirek ET, Wang Y, Park J, Belden WJ, Wek RC, Anthony TG.

Sci Rep. 2017 Apr 28;7(1):1272. doi: 10.1038/s41598-017-01041-7.


Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.

Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG.

J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. Erratum in: J Nutr. 2017 Sep;147(9):1826.


Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.

Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG.

J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27.


ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.

Srivastava RK, Li C, Ahmad A, Abrams O, Gorbatyuk MS, Harrod KS, Wek RC, Afaq F, Athar M.

Arch Biochem Biophys. 2016 Nov 1;609:39-50. doi: 10.1016/ Epub 2016 Sep 13.


Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential.

Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM, Kota J.

Oncotarget. 2016 Nov 1;7(44):71635-71650. doi: 10.18632/oncotarget.11928.


Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response.

Young SK, Wek RC.

J Biol Chem. 2016 Aug 12;291(33):16927-35. doi: 10.1074/jbc.R116.733899. Epub 2016 Jun 29. Review.


Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.

Young SK, Shao Y, Bidwell JP, Wek RC.

J Biol Chem. 2016 Jun 24;291(26):13780-8. doi: 10.1074/jbc.M116.729830. Epub 2016 Apr 29.


Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons.

Young SK, Baird TD, Wek RC.

J Biol Chem. 2016 May 13;291(20):10824-35. doi: 10.1074/jbc.M116.722256. Epub 2016 Mar 21.


General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.

Phillipson-Weiner L, Mirek ET, Wang Y, McAuliffe WG, Wek RC, Anthony TG.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1061-70. doi: 10.1152/ajpgi.00052.2016. Epub 2016 Mar 11.


Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC.

Mol Biol Cell. 2016 May 1;27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9.


Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response.

Young SK, Palam LR, Wu C, Sachs MS, Wek RC.

J Biol Chem. 2016 Mar 18;291(12):6546-58. doi: 10.1074/jbc.M115.705640. Epub 2016 Jan 27.


Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.

Young SK, Willy JA, Wu C, Sachs MS, Wek RC.

J Biol Chem. 2015 Nov 20;290(47):28257-71. doi: 10.1074/jbc.M115.693184. Epub 2015 Oct 7.


Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.

Benmerzouga I, Checkley LA, Ferdig MT, Arrizabalaga G, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2015 Nov;59(11):6939-45. doi: 10.1128/AAC.01683-15. Epub 2015 Aug 24.


Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response.

Collier AE, Wek RC, Spandau DF.

J Invest Dermatol. 2015 Oct;135(10):2502-2511. doi: 10.1038/jid.2015.177. Epub 2015 May 7.


CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis.

Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC.

Mol Biol Cell. 2015 Jun 15;26(12):2190-204. doi: 10.1091/mbc.E15-01-0036. Epub 2015 Apr 22.


GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG.

Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E283-93. doi: 10.1152/ajpendo.00361.2014. Epub 2014 Dec 9.


Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Gao R, Chen S, Kobayashi M, Yu H, Zhang Y, Wan Y, Young SK, Soltis A, Yu M, Vemula S, Fraenkel E, Cantor A, Antipin Y, Xu Y, Yoder MC, Wek RC, Ellis SR, Kapur R, Zhu X, Liu Y.

Stem Cells. 2015 Mar;33(3):925-38. doi: 10.1002/stem.1896.


Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.

He H, Singh I, Wek SA, Dey S, Baird TD, Wek RC, Georgiadis MM.

J Biol Chem. 2014 May 23;289(21):15023-34. doi: 10.1074/jbc.M114.560789. Epub 2014 Apr 9.


Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα.

Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2014 May;25(10):1686-97. doi: 10.1091/mbc.E14-02-0704. Epub 2014 Mar 19.


Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7. doi: 10.1016/j.bbrc.2013.12.021. Epub 2013 Dec 11.


GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii.

Konrad C, Wek RC, Sullivan WJ Jr.

Int J Parasitol. 2014 Feb;44(2):139-46. doi: 10.1016/j.ijpara.2013.08.005. Epub 2013 Oct 12.


General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.

She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG.

J Biol Chem. 2013 Oct 25;288(43):31250-60. doi: 10.1074/jbc.M113.498469. Epub 2013 Sep 9.


The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.

Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3.


CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.

Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC.

Mol Biol Cell. 2013 Aug;24(15):2477-90. doi: 10.1091/mbc.E13-01-0067. Epub 2013 Jun 12.


The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control.

Joyce BR, Tampaki Z, Kim K, Wek RC, Sullivan WJ Jr.

Eukaryot Cell. 2013 Jul;12(7):979-89. doi: 10.1128/EC.00021-13. Epub 2013 May 10.


Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA.

J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23.


Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.

Konrad C, Queener SF, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2013 Apr;57(4):1815-22. doi: 10.1128/AAC.01899-12. Epub 2013 Feb 4.


TXNIP switches tracks toward a terminal UPR.

Anthony TG, Wek RC.

Cell Metab. 2012 Aug 8;16(2):135-7. doi: 10.1016/j.cmet.2012.07.012.


Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E.

Cell Rep. 2012 Jun 28;1(6):676-88. doi: 10.1016/j.celrep.2012.04.010. Epub 2012 May 24.


Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.

Baird TD, Wek RC.

Adv Nutr. 2012 May 1;3(3):307-21. doi: 10.3945/an.112.002113. Review.


Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.

Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC.

J Biol Chem. 2012 Jun 22;287(26):21936-49. doi: 10.1074/jbc.M112.351783. Epub 2012 May 3.


Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.

Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H.

J Biol Chem. 2012 May 18;287(21):17120-9. doi: 10.1074/jbc.M111.311902. Epub 2012 Mar 30.


The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14.


A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites.

Konrad C, Wek RC, Sullivan WJ Jr.

Eukaryot Cell. 2011 Nov;10(11):1403-12. doi: 10.1128/EC.05117-11. Epub 2011 Sep 9.

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