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Reduced bone formation in males and increased bone resorption in females drive bone loss in hemophilia A mice.

Weitzmann MN, Roser-Page S, Vikulina T, Weiss D, Hao L, Baldwin WH, Yu K, Del Mazo Arbona N, McGee-Lawrence ME, Meeks SL, Kempton CL.

Blood Adv. 2019 Feb 12;3(3):288-300. doi: 10.1182/bloodadvances.2018027557.


The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.

Tyagi AM, Yu M, Darby TM, Vaccaro C, Li JY, Owens JA, Hsu E, Adams J, Weitzmann MN, Jones RM, Pacifici R.

Immunity. 2018 Dec 18;49(6):1116-1131.e7. doi: 10.1016/j.immuni.2018.10.013. Epub 2018 Nov 13.


IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production.

Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R.

J Bone Miner Res. 2019 Feb;34(2):349-360. doi: 10.1002/jbmr.3600. Epub 2018 Nov 6.


Neutralization of CD40 ligand costimulation promotes bone formation and accretion of vertebral bone mass in mice.

Roser-Page S, Vikulina T, Yu K, McGee-Lawrence ME, Weitzmann MN.

Rheumatology (Oxford). 2018 Jun 1;57(6):1105-1114. doi: 10.1093/rheumatology/kex525.


CTLA-4Ig (abatacept) balances bone anabolic effects of T cells and Wnt-10b with antianabolic effects of osteoblastic sclerostin.

Roser-Page S, Vikulina T, Weiss D, Habib MM, Beck GR Jr, Pacifici R, Lane TF, Weitzmann MN.

Ann N Y Acad Sci. 2018 Mar;1415(1):21-33. doi: 10.1111/nyas.13643. Epub 2018 Mar 3.


T-cell receptor activator of nuclear factor-κB ligand/osteoprotegerin imbalance is associated with HIV-induced bone loss in patients with higher CD4+ T-cell counts.

Titanji K, Vunnava A, Foster A, Sheth AN, Lennox JL, Knezevic A, Shenvi N, Easley KA, Ofotokun I, Weitzmann MN.

AIDS. 2018 Apr 24;32(7):885-894. doi: 10.1097/QAD.0000000000001764.


GNB3 overexpression causes obesity and metabolic syndrome.

Ozdemir AC, Wynn GM, Vester A, Weitzmann MN, Neigh GN, Srinivasan S, Rudd MK.

PLoS One. 2017 Dec 5;12(12):e0188763. doi: 10.1371/journal.pone.0188763. eCollection 2017.


Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice.

Yu M, D'Amelio P, Tyagi AM, Vaccaro C, Li JY, Hsu E, Buondonno I, Sassi F, Adams J, Weitzmann MN, DiPaolo R, Pacifici R.

EMBO Rep. 2018 Jan;19(1):156-171. doi: 10.15252/embr.201744421. Epub 2017 Nov 20.


Bone and the Immune System.

Weitzmann MN.

Toxicol Pathol. 2017 Oct;45(7):911-924. doi: 10.1177/0192623317735316. Epub 2017 Oct 18. Review.


Homeostatic Expansion of CD4+ T Cells Promotes Cortical and Trabecular Bone Loss, Whereas CD8+ T Cells Induce Trabecular Bone Loss Only.

Weitzmann MN, Vikulina T, Roser-Page S, Yamaguchi M, Ofotokun I.

J Infect Dis. 2017 Nov 27;216(9):1070-1079. doi: 10.1093/infdis/jix444.


Bone Loss in HIV Infection.

Moran CA, Weitzmann MN, Ofotokun I.

Curr Treat Options Infect Dis. 2017 Mar;9(1):52-67. doi: 10.1007/s40506-017-0109-9. Epub 2017 Feb 23.


Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.

Yamaguchi M, Osuka S, Shoji M, Weitzmann MN, Murata T.

Mol Cell Biochem. 2017 Jun;430(1-2):37-46. doi: 10.1007/s11010-017-2952-x. Epub 2017 Feb 8.


Persistence of Vascular Calcification after Reversal of Uremia.

Lomashvili KA, Manning KE, Weitzmann MN, Nelea V, McKee MD, O'Neill WC.

Am J Pathol. 2017 Feb;187(2):332-338. doi: 10.1016/j.ajpath.2016.10.006. Epub 2016 Dec 8.


Bone Loss Among Women Living With HIV.

Weitzmann MN, Ofotokun I, Titanji K, Sharma A, Yin MT.

Curr HIV/AIDS Rep. 2016 Dec;13(6):367-373. Review.


Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.

Yamaguchi M, Osuka S, Weitzmann MN, El-Rayes BF, Shoji M, Murata T.

Int J Oncol. 2016 Oct;49(4):1686-94. doi: 10.3892/ijo.2016.3669. Epub 2016 Aug 23.


Physiological and pathophysiological bone turnover - role of the immune system.

Weitzmann MN, Ofotokun I.

Nat Rev Endocrinol. 2016 Sep;12(9):518-32. doi: 10.1038/nrendo.2016.91. Epub 2016 Jun 17. Review.


Differential CD4+ cell count increase and CD4+ :  CD8+ ratio normalization with maraviroc compared with tenofovir.

Chan ES, Landay AL, Brown TT, Ribaudo HJ, Mirmonsef P, Ofotokun I, Weitzmann MN, Martinson J, Klingman KL, Eron JJ, Fichtenbaum CJ, Plants J, Taiwo BO.

AIDS. 2016 Aug 24;30(13):2091-7. doi: 10.1097/QAD.0000000000001181.


A Single-dose Zoledronic Acid Infusion Prevents Antiretroviral Therapy-induced Bone Loss in Treatment-naive HIV-infected Patients: A Phase IIb Trial.

Ofotokun I, Titanji K, Lahiri CD, Vunnava A, Foster A, Sanford SE, Sheth AN, Lennox JL, Knezevic A, Ward L, Easley KA, Powers P, Weitzmann MN.

Clin Infect Dis. 2016 Sep 1;63(5):663-671. doi: 10.1093/cid/ciw331. Epub 2016 May 18.


Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics.

Li JY, Chassaing B, Tyagi AM, Vaccaro C, Luo T, Adams J, Darby TM, Weitzmann MN, Mulle JG, Gewirtz AT, Jones RM, Pacifici R.

J Clin Invest. 2016 Jun 1;126(6):2049-63. doi: 10.1172/JCI86062. Epub 2016 Apr 25.


Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.

Jarry CR, Martinez EF, Peruzzo DC, Carregaro V, Sacramento LA, Araújo VC, Weitzmann MN, Napimoga MH.

Mol Med Rep. 2016 May;13(5):4252-8. doi: 10.3892/mmr.2016.5045. Epub 2016 Mar 24.


Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.

Yamaguchi M, Osuka S, Weitzmann MN, El-Rayes BF, Shoji M, Murata T.

Int J Oncol. 2016 May;48(5):1955-64. doi: 10.3892/ijo.2016.3409. Epub 2016 Feb 25.


The protease inhibitors and HIV-associated bone loss.

Moran CA, Weitzmann MN, Ofotokun I.

Curr Opin HIV AIDS. 2016 May;11(3):333-42. doi: 10.1097/COH.0000000000000260. Review.


Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection.

Ofotokun I, Titanji K, Vunnava A, Roser-Page S, Vikulina T, Villinger F, Rogers K, Sheth AN, Lahiri CD, Lennox JL, Weitzmann MN.

AIDS. 2016 Jan 28;30(3):405-14. doi: 10.1097/QAD.0000000000000918.


IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.

Li JY, D'Amelio P, Robinson J, Walker LD, Vaccaro C, Luo T, Tyagi AM, Yu M, Reott M, Sassi F, Buondonno I, Adams J, Weitzmann MN, Isaia GC, Pacifici R.

Cell Metab. 2015 Nov 3;22(5):799-810. doi: 10.1016/j.cmet.2015.09.012. Epub 2015 Oct 8.


Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.

Ofotokun I, Titanji K, Vikulina T, Roser-Page S, Yamaguchi M, Zayzafoon M, Williams IR, Weitzmann MN.

Nat Commun. 2015 Sep 22;6:8282. doi: 10.1038/ncomms9282.


The flavonoid p-hydroxycinnamic acid mediates anticancer effects on MDA-MB-231 human breast cancer cells in vitro: Implications for suppression of bone metastases.

Yamaguchi M, Murata T, Shoji M, Weitzmann MN.

Int J Oncol. 2015 Oct;47(4):1563-71. doi: 10.3892/ijo.2015.3106. Epub 2015 Jul 28.


Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet.

Capers PL, Hyacinth HI, Cue S, Chappa P, Vikulina T, Roser-Page S, Weitzmann MN, Archer DR, Newman GW, Quarshie A, Stiles JK, Hibbert JM.

J Nutr Sci. 2015 Feb 27;4:e6. doi: 10.1017/jns.2014.63. eCollection 2015.


Bioactive silica nanoparticles reverse age-associated bone loss in mice.

Weitzmann MN, Ha SW, Vikulina T, Roser-Page S, Lee JK, Beck GR Jr.

Nanomedicine. 2015 May;11(4):959-967. doi: 10.1016/j.nano.2015.01.013. Epub 2015 Feb 11.


Curcumin analog UBS109 prevents bone marrow osteoblastogenesis and osteoclastogenesis disordered by coculture with breast cancer MDA-MB-231 bone metastatic cells in vitro.

Yamaguchi M, Zhu S, Weitzmann MN, Snyder JP, Shoji M.

Mol Cell Biochem. 2015 Mar;401(1-2):1-10. doi: 10.1007/s11010-014-2286-x. Epub 2014 Nov 22.


Dysregulated B cell expression of RANKL and OPG correlates with loss of bone mineral density in HIV infection.

Titanji K, Vunnava A, Sheth AN, Delille C, Lennox JL, Sanford SE, Foster A, Knezevic A, Easley KA, Weitzmann MN, Ofotokun I.

PLoS Pathog. 2014 Nov 13;10(10):e1004497. doi: 10.1371/journal.ppat.1004497. eCollection 2014 Oct.


T cell-expressed CD40L potentiates the bone anabolic activity of intermittent PTH treatment.

Robinson JW, Li JY, Walker LD, Tyagi AM, Reott MA, Yu M, Adams J, Weitzmann MN, Pacifici R.

J Bone Miner Res. 2015 Apr;30(4):695-705. doi: 10.1002/jbmr.2394.


T-cells and B-cells in osteoporosis.

Weitzmann MN.

Curr Opin Endocrinol Diabetes Obes. 2014 Dec;21(6):461-7. doi: 10.1097/MED.0000000000000103. Review.


Suppression of NF-κB activation by gentian violet promotes osteoblastogenesis and suppresses osteoclastogenesis.

Yamaguchi M, Vikulina T, Arbiser JL, Weitzmann MN.

Curr Mol Med. 2014;14(6):783-92.


Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.

Lykken JM, DiLillo DJ, Weimer ET, Roser-Page S, Heise MT, Grayson JM, Weitzmann MN, Tedder TF.

J Immunol. 2014 Jul 15;193(2):746-56. doi: 10.4049/jimmunol.1302848. Epub 2014 Jun 13.


Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62.

Ha SW, Weitzmann MN, Beck GR Jr.

ACS Nano. 2014 Jun 24;8(6):5898-910. doi: 10.1021/nn5009879. Epub 2014 May 14.


CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model.

Roser-Page S, Vikulina T, Zayzafoon M, Weitzmann MN.

Arthritis Rheumatol. 2014 Apr;66(4):990-9. doi: 10.1002/art.38319.


Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats.

Lafferty MK, Fantry L, Bryant J, Jones O, Hammoud D, Weitzmann MN, Lewis GK, Garzino-Demo A, Reid W.

Pathog Dis. 2014 Jun;71(1):81-9. doi: 10.1111/2049-632X.12117. Epub 2014 Jan 10.


B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice.

Li Y, Terauchi M, Vikulina T, Roser-Page S, Weitzmann MN.

Open Bone J. 2014;6:8-17.


The sclerostin-independent bone anabolic activity of intermittent PTH treatment is mediated by T-cell-produced Wnt10b.

Li JY, Walker LD, Tyagi AM, Adams J, Weitzmann MN, Pacifici R.

J Bone Miner Res. 2014 Jan;29(1):43-54. doi: 10.1002/jbmr.2044.


Bio-active engineered 50 nm silica nanoparticles with bone anabolic activity: therapeutic index, effective concentration, and cytotoxicity profile in vitro.

Ha SW, Sikorski JA, Weitzmann MN, Beck GR Jr.

Toxicol In Vitro. 2014 Apr;28(3):354-64. doi: 10.1016/j.tiv.2013.12.001. Epub 2013 Dec 12.


The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis.

Weitzmann MN.

Scientifica (Cairo). 2013;2013:125705. doi: 10.1155/2013/125705. Epub 2013 Feb 3. Review.


Bone loss in surgically ovariectomized premenopausal women is associated with T lymphocyte activation and thymic hypertrophy.

Adeel S, Singh K, Vydareny KH, Kumari M, Shah E, Weitzmann MN, Tangpricha V.

J Investig Med. 2013 Dec;61(8):1178-83. doi: 10.2310/JIM.0000000000000016.


Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B.

Li JY, Adams J, Calvi LM, Lane TF, Weitzmann MN, Pacifici R.

Blood. 2013 Oct 3;122(14):2346-57. doi: 10.1182/blood-2013-03-487801. Epub 2013 Aug 16.


Link protein N-terminal peptide binds to bone morphogenetic protein (BMP) type II receptor and drives matrix protein expression in rabbit intervertebral disc cells.

Wang Z, Weitzmann MN, Sangadala S, Hutton WC, Yoon ST.

J Biol Chem. 2013 Sep 27;288(39):28243-53. doi: 10.1074/jbc.M113.451948. Epub 2013 Aug 12.


Do γδ T cells predict osteonecrosis of the jaw?

Weitzmann MN.

J Bone Miner Res. 2013 Apr;28(4):723-7. doi: 10.1002/jbmr.1886. No abstract available.


PTH expands short-term murine hemopoietic stem cells through T cells.

Li JY, Adams J, Calvi LM, Lane TF, DiPaolo R, Weitzmann MN, Pacifici R.

Blood. 2012 Nov 22;120(22):4352-62. doi: 10.1182/blood-2012-06-438531. Epub 2012 Sep 5.


Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture.

Yamaguchi M, Weitzmann MN, Baile CA, Murata T.

Integr Biol (Camb). 2012 Oct;4(10):1215-22.


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