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Items: 1 to 50 of 103


The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.

Green AM, Weitzman MD.

DNA Repair (Amst). 2019 Nov;83:102700. doi: 10.1016/j.dnarep.2019.102700. Epub 2019 Sep 13. Review.


SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.

Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA, Weitzman MD.

Cell Rep. 2019 Jul 9;28(2):434-448.e6. doi: 10.1016/j.celrep.2019.06.027.


Herpes simplex virus replication compartments: From naked release to recombining together.

Kobiler O, Weitzman MD.

PLoS Pathog. 2019 Jun 3;15(6):e1007714. doi: 10.1371/journal.ppat.1007714. eCollection 2019 Jun. No abstract available.


Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses.

Tomer E, Cohen EM, Drayman N, Afriat A, Weitzman MD, Zaritsky A, Kobiler O.

FASEB J. 2019 Aug;33(8):9388-9403. doi: 10.1096/fj.201900032R. Epub 2019 May 20.


Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.

Akhtar LN, Bowen CD, Renner DW, Pandey U, Della Fera AN, Kimberlin DW, Prichard MN, Whitley RJ, Weitzman MD, Szpara ML.

mSphere. 2019 Feb 27;4(1). pii: e00590-18. doi: 10.1128/mSphere.00590-18.


Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays.

Lamarche BJ, Orazio NI, Goben B, Meisenhelder J, You Z, Weitzman MD, Hunter T.

DNA Repair (Amst). 2019 Feb;74:80-90. doi: 10.1016/j.dnarep.2018.12.001. Epub 2018 Dec 10.


Ubiquitination at the interface of tumor viruses and DNA damage responses.

Dybas JM, Herrmann C, Weitzman MD.

Curr Opin Virol. 2018 Oct;32:40-47. doi: 10.1016/j.coviro.2018.08.017. Epub 2018 Sep 24. Review.


Virus DNA Replication and the Host DNA Damage Response.

Weitzman MD, Fradet-Turcotte A.

Annu Rev Virol. 2018 Sep 29;5(1):141-164. doi: 10.1146/annurev-virology-092917-043534. Epub 2018 Jul 11. Review.


Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex.

Pancholi NJ, Weitzman MD.

Virology. 2018 May;518:221-231. doi: 10.1016/j.virol.2018.02.023. Epub 2018 Mar 15.


Identifying Host Factors Associated with DNA Replicated During Virus Infection.

Reyes ED, Kulej K, Pancholi NJ, Akhtar LN, Avgousti DC, Kim ET, Bricker DK, Spruce LA, Koniski SA, Seeholzer SH, Isaacs SN, Garcia BA, Weitzman MD.

Mol Cell Proteomics. 2017 Dec;16(12):2079-2097. doi: 10.1074/mcp.M117.067116. Epub 2017 Oct 2.


Take your PIKK: tumour viruses and DNA damage response pathways.

Pancholi NJ, Price AM, Weitzman MD.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732). pii: 20160269. doi: 10.1098/rstb.2016.0269. Review.


Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome.

Avgousti DC, Della Fera AN, Otter CJ, Herrmann C, Pancholi NJ, Weitzman MD.

J Virol. 2017 Sep 27;91(20). pii: e01089-17. doi: 10.1128/JVI.01089-17. Print 2017 Oct 15.


Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors.

Lutz G, Jurak I, Kim ET, Kim JY, Hackenberg M, Leader A, Stoller ML, Fekete DM, Weitzman MD, Coen DM, Wilson AC.

Viruses. 2017 Aug 7;9(8). pii: E210. doi: 10.3390/v9080210.


Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.

Green AM, Budagyan K, Hayer KE, Reed MA, Savani MR, Wertheim GB, Weitzman MD.

Cancer Res. 2017 Sep 1;77(17):4579-4588. doi: 10.1158/0008-5472.CAN-16-3394. Epub 2017 Jun 27.


Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase.

Joglekar M, Elbazanti WO, Weitzman MD, Lehman HL, van Golen KL.

J Cell Biochem. 2017 May;118(5):1273. doi: 10.1002/jcb.25876. No abstract available.


Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) Infection.

Kulej K, Avgousti DC, Sidoli S, Herrmann C, Della Fera AN, Kim ET, Garcia BA, Weitzman MD.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S92-S107. doi: 10.1074/mcp.M116.065987. Epub 2017 Feb 8.


An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.

Lou DI, Kim ET, Meyerson NR, Pancholi NJ, Mohni KN, Enard D, Petrov DA, Weller SK, Weitzman MD, Sawyer SL.

Cell Host Microbe. 2016 Aug 10;20(2):178-88. doi: 10.1016/j.chom.2016.07.003.


A core viral protein binds host nucleosomes to sequester immune danger signals.

Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD.

Nature. 2016 Jul 7;535(7610):173-7. Epub 2016 Jun 29.


APOBEC3A damages the cellular genome during DNA replication.

Green AM, Landry S, Budagyan K, Avgousti DC, Shalhout S, Bhagwat AS, Weitzman MD.

Cell Cycle. 2016;15(7):998-1008. doi: 10.1080/15384101.2016.1152426.


Stress Flips a Chromatin Switch to Wake Up Latent Virus.

Avgousti DC, Weitzman MD.

Cell Host Microbe. 2015 Dec 9;18(6):639-41. doi: 10.1016/j.chom.2015.11.011.


Characterization of histone post-translational modifications during virus infection using mass spectrometry-based proteomics.

Kulej K, Avgousti DC, Weitzman MD, Garcia BA.

Methods. 2015 Nov 15;90:8-20. doi: 10.1016/j.ymeth.2015.06.008. Epub 2015 Jun 17.


Caveolin-1 mediates inflammatory breast cancer cell invasion via the Akt1 pathway and RhoC GTPase.

Joglekar M, Elbezanti WO, Weitzman MD, Lehman HL, van Golen KL.

J Cell Biochem. 2015 Jun;116(6):923-33. doi: 10.1002/jcb.25025. Erratum in: J Cell Biochem. 2017 May;118(5):1273.


HSV-1 remodels host telomeres to facilitate viral replication.

Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM.

Cell Rep. 2014 Dec 24;9(6):2263-78. doi: 10.1016/j.celrep.2014.11.019. Epub 2014 Dec 11.


Applying the speed-dating model and other approaches to foster future leaders for the American Society of Gene and Cell Therapy.

Adair JE, Weitzman MD.

Mol Ther. 2014 Aug;22(8):1397-1398. doi: 10.1038/mt.2014.119. No abstract available.


APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition.

Richardson SR, Narvaiza I, Planegger RA, Weitzman MD, Moran JV.

Elife. 2014 Apr 24;3:e02008. doi: 10.7554/eLife.02008.


What's the damage? The impact of pathogens on pathways that maintain host genome integrity.

Weitzman MD, Weitzman JB.

Cell Host Microbe. 2014 Mar 12;15(3):283-94. doi: 10.1016/j.chom.2014.02.010. Review.


Differential L1 regulation in pluripotent stem cells of humans and apes.

Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH.

Nature. 2013 Nov 28;503(7477):525-529. doi: 10.1038/nature12686. Epub 2013 Oct 23.


SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

Kim ET, White TE, Brandariz-Núñez A, Diaz-Griffero F, Weitzman MD.

J Virol. 2013 Dec;87(23):12949-56. doi: 10.1128/JVI.02291-13. Epub 2013 Sep 25.


OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes.

Marsolier J, Pineau S, Medjkane S, Perichon M, Yin Q, Flemington E, Weitzman MD, Weitzman JB.

PLoS Pathog. 2013;9(4):e1003222. doi: 10.1371/journal.ppat.1003222. Epub 2013 Apr 18.


Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.

Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M.

Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23.


Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain.

Chaurushiya MS, Lilley CE, Aslanian A, Meisenhelder J, Scott DC, Landry S, Ticau S, Boutell C, Yates JR 3rd, Schulman BA, Hunter T, Weitzman MD.

Mol Cell. 2012 Apr 13;46(1):79-90. doi: 10.1016/j.molcel.2012.02.004. Epub 2012 Mar 7.


APOBEC3 proteins and genomic stability: the high cost of a good defense.

Narvaiza I, Landry S, Weitzman MD.

Cell Cycle. 2012 Jan 1;11(1):33-8. doi: 10.4161/cc.11.1.18706. Epub 2012 Jan 1.


Adeno-associated virus biology.

Weitzman MD, Linden RM.

Methods Mol Biol. 2011;807:1-23. doi: 10.1007/978-1-61779-370-7_1.


Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.

Vogel R, Seyffert M, Strasser R, de Oliveira AP, Dresch C, Glauser DL, Jolinon N, Salvetti A, Weitzman MD, Ackermann M, Fraefel C.

J Virol. 2012 Jan;86(1):143-55. doi: 10.1128/JVI.05694-11. Epub 2011 Oct 19.


The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.

Lilley CE, Chaurushiya MS, Boutell C, Everett RD, Weitzman MD.

PLoS Pathog. 2011 Jun;7(6):e1002084. doi: 10.1371/journal.ppat.1002084. Epub 2011 Jun 16.


Changing the ubiquitin landscape during viral manipulation of the DNA damage response.

Weitzman MD, Lilley CE, Chaurushiya MS.

FEBS Lett. 2011 Sep 16;585(18):2897-906. doi: 10.1016/j.febslet.2011.04.049. Epub 2011 May 5. Review.


APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.

Landry S, Narvaiza I, Linfesty DC, Weitzman MD.

EMBO Rep. 2011 May;12(5):444-50. doi: 10.1038/embor.2011.46. Epub 2011 Apr 1.


Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation.

Lilley CE, Weitzman MD.

Cell Host Microbe. 2010 Dec 16;8(6):464-6. doi: 10.1016/j.chom.2010.11.010.


Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities.

Bulliard Y, Narvaiza I, Bertero A, Peddi S, Röhrig UF, Ortiz M, Zoete V, Castro-Díaz N, Turelli P, Telenti A, Michielin O, Weitzman MD, Trono D.

J Virol. 2011 Feb;85(4):1765-76. doi: 10.1128/JVI.01651-10. Epub 2010 Dec 1.


The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.

Orazio NI, Naeger CM, Karlseder J, Weitzman MD.

J Virol. 2011 Feb;85(4):1887-92. doi: 10.1128/JVI.02134-10. Epub 2010 Dec 1.


Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.

Adeyemi RO, Landry S, Davis ME, Weitzman MD, Pintel DJ.

PLoS Pathog. 2010 Oct 7;6(10):e1001141. doi: 10.1371/journal.ppat.1001141.


Genomes in conflict: maintaining genome integrity during virus infection.

Weitzman MD, Lilley CE, Chaurushiya MS.

Annu Rev Microbiol. 2010;64:61-81. doi: 10.1146/annurev.micro.112408.134016. Review.


The MRN complex in double-strand break repair and telomere maintenance.

Lamarche BJ, Orazio NI, Weitzman MD.

FEBS Lett. 2010 Sep 10;584(17):3682-95. doi: 10.1016/j.febslet.2010.07.029. Epub 2010 Jul 24. Review.


A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.

Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD.

EMBO J. 2010 Mar 3;29(5):943-55. doi: 10.1038/emboj.2009.400. Epub 2010 Jan 14.


Chromatin at the intersection of viral infection and DNA damage.

Lilley CE, Chaurushiya MS, Weitzman MD.

Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):319-27. doi: 10.1016/j.bbagrm.2009.06.007. Epub 2009 Jul 17. Review.


Viral manipulation of DNA repair and cell cycle checkpoints.

Chaurushiya MS, Weitzman MD.

DNA Repair (Amst). 2009 Sep 2;8(9):1166-76. doi: 10.1016/j.dnarep.2009.04.016. Epub 2009 May 26. Review.


Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.

Narvaiza I, Linfesty DC, Greener BN, Hakata Y, Pintel DJ, Logue E, Landau NR, Weitzman MD.

PLoS Pathog. 2009 May;5(5):e1000439. doi: 10.1371/journal.ppat.1000439. Epub 2009 May 22.


Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.

Schwartz RA, Carson CT, Schuberth C, Weitzman MD.

J Virol. 2009 Jun;83(12):6269-78. doi: 10.1128/JVI.00318-09. Epub 2009 Apr 1.


Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.

Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD.

EMBO J. 2009 Mar 18;28(6):652-62. doi: 10.1038/emboj.2009.15. Epub 2009 Feb 5.

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