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Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis.

Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S.

Cell Rep. 2020 Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.


Secretory Functions of Macrophages in the Human Pancreatic Islet are Regulated by Endogenous Purinergic Signaling.

Weitz JR, Jacques-Silva C, Fahd Qadir MM, Umland O, Pereira E, Qureshi F, Tamayo A, Dominguez-Bendala J, Rodriguez-Diaz R, Almaça J, Caicedo A.

Diabetes. 2020 Apr 3. pii: db190687. doi: 10.2337/db19-0687. [Epub ahead of print]


Linking Light-Dependent Life History Traits with Population Dynamics for Prochlorococcus and Cyanophage.

Demory D, Liu R, Chen Y, Zhao F, Coenen AR, Zeng Q, Weitz JS.

mSystems. 2020 Mar 31;5(2). pii: e00586-19. doi: 10.1128/mSystems.00586-19.


A case study: impact of target surface mesh size and mesh quality on volume-to-surface registration performance in hepatic soft tissue navigation.

Hattab G, Riediger C, Weitz J, Speidel S.

Int J Comput Assist Radiol Surg. 2020 Mar 27. doi: 10.1007/s11548-020-02123-0. [Epub ahead of print]


Impact of concomitant antiplatelet therapy on the efficacy and safety of DOACs for acute venous thromboembolism: systematic review and meta-analysis.

Valeriani E, Porreca E, Weitz JI, Schulman S, Candeloro M, Di Nisio M.

J Thromb Haemost. 2020 Mar 22. doi: 10.1111/jth.14807. [Epub ahead of print]


Mortality Risk Profiles for Sepsis: A Novel Longitudinal and Multivariable Approach.

Liaw PC, Fox-Robichaud AE, Liaw KL, McDonald E, Dwivedi DJ, Zamir NM, Pepler L, Gould TJ, Xu M, Zytaruk N, Medeiros SK, McIntyre L, Tsang J, Dodek PM, Winston BW, Martin C, Fraser DD, Weitz JI, Lellouche F, Cook DJ, Marshall J.

Crit Care Explor. 2019 Aug 1;1(8):e0032. doi: 10.1097/CCE.0000000000000032. eCollection 2019 Aug.


Corrigendum to "Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study" [Thromb. Res. vol. 185, January 2020, pages 13-19].

Mulder FI, van Es N, Kraaijpoel N, Di Nisio M, Carrier M, Duggal A, Gaddh M, Garcia D, Grosso MA, Kakkar AK, Mercuri MF, Middeldorp S, Royle G, Segers A, Shivakumar S, Verhamme P, Wang T, Weitz JI, Zhang G, Büller HR, Raskob G.

Thromb Res. 2020 Mar 6. pii: S0049-3848(20)30069-4. doi: 10.1016/j.thromres.2020.02.022. [Epub ahead of print] No abstract available.


Universal and Efficient Electroporation Protocol for Genetic Engineering of Gastrointestinal Organoids.

Gaebler AM, Hennig A, Buczolich K, Weitz J, Welsch T, Stange DE, Pape K.

J Vis Exp. 2020 Feb 18;(156). doi: 10.3791/60704.


Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia.

Evgrafov OV, Armoskus C, Wrobel BB, Spitsyna VN, Souaiaia T, Herstein JS, Walker CP, Nguyen JD, Camarena A, Weitz JR, Kim JMH, Lopez Duarte E, Wang K, Simpson GM, Sobell JL, Medeiros H, Pato MT, Pato CN, Knowles JA.

Biol Psychiatry. 2020 Jan 22. pii: S0006-3223(20)30010-X. doi: 10.1016/j.biopsych.2020.01.005. [Epub ahead of print]


Therapeutic strategies for thrombosis: new targets and approaches.

Mackman N, Bergmeier W, Stouffer GA, Weitz JI.

Nat Rev Drug Discov. 2020 Mar 4. doi: 10.1038/s41573-020-0061-0. [Epub ahead of print] Review.


Randomized phase 2 trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO-12.

Hofheinz R, Fokas E, Allgäuer M, Polat B, Klautke G, Grabenbauer G, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu A, Schmiegel W, Jacobasch L, Weitz J, Folprecht G, Germer C, Grützmann R, Schwarzbach M, Bechstein W, Friede T, Ghadimi M, Rödel C.

Ann Oncol. 2019 Jul;30 Suppl 4:iv129. doi: 10.1093/annonc/mdz154.010. Epub 2019 Dec 4. No abstract available.


Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels.

Seifert AM, Reiche C, Heiduk M, Tannert A, Meinecke AC, Baier S, von Renesse J, Kahlert C, Distler M, Welsch T, Reissfelder C, Aust DE, Miller G, Weitz J, Seifert L.

Oncogene. 2020 Feb 13. doi: 10.1038/s41388-020-1186-7. [Epub ahead of print]


Erratum to "CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids".

Hennig A, Wolf L, Jahnke B, Polster H, Seidlitz T, Werner K, Aust DE, Hampe J, Distler M, Weitz J, Stange DE, Welsch T.

Stem Cells Int. 2019 Sep 18;2019:9209764. doi: 10.1155/2019/9209764. eCollection 2019.


Quantitative Models of Phage-Antibiotic Combination Therapy.

Rodriguez-Gonzalez RA, Leung CY, Chan BK, Turner PE, Weitz JS.

mSystems. 2020 Feb 4;5(1). pii: e00756-19. doi: 10.1128/mSystems.00756-19.


Adjuvant therapy is associated with improved overall survival in patients with pancreatobiliary or mixed subtype ampullary cancer after pancreatoduodenectomy - A multicenter cohort study.

Bolm L, Ohrner K, Nappo G, Rückert F, Zimmermann C, Rau BM, Petrova E, Honselmann KC, Lapshyn H, Bausch D, Weitz J, Sandini M, Keck T, Zerbi A, Distler M, Wellner UF.

Pancreatology. 2020 Jan 21. pii: S1424-3903(20)30027-2. doi: 10.1016/j.pan.2020.01.009. [Epub ahead of print]


Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients with Renal Impairment: Insights from the MAGELLAN and MARINER Trials.

Weitz JI, Raskob GE, Spyropoulos AC, Spiro TE, De Sanctis Y, Xu J, Lu W, Suh E, Argenti D, Yang H, Albanese J, Lipardi C, Barnathan ES.

Thromb Haemost. 2020 Mar;120(3):515-524. doi: 10.1055/s-0039-1701009. Epub 2020 Jan 23.


Prognostic impact of para-aortic lymph node metastases in non-pancreatic periampullary cancer.

Hempel S, Oehme F, Müssle B, Aust DE, Distler M, Saeger HD, Weitz J, Welsch T.

World J Surg Oncol. 2020 Jan 21;18(1):16. doi: 10.1186/s12957-020-1783-5.


Development of a template tool for facilitating fibula osteotomy in reconstruction of mandibular defects by digital analysis of the human mandible.

Nobis CP, Kesting MR, Wolff KD, Frohwitter G, Rau A, Weitz J.

Clin Oral Investig. 2020 Jan 18. doi: 10.1007/s00784-019-03177-4. [Epub ahead of print]


Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease.

Capodanno D, Bhatt DL, Eikelboom JW, Fox KAA, Geisler T, Michael Gibson C, Gonzalez-Juanatey JR, James S, Lopes RD, Mehran R, Montalescot G, Patel M, Steg PG, Storey RF, Vranckx P, Weitz JI, Welsh R, Zeymer U, Angiolillo DJ.

Nat Rev Cardiol. 2020 Apr;17(4):242-257. doi: 10.1038/s41569-019-0314-y. Epub 2020 Jan 17. Review.


Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty: The FOXTROT Randomized Clinical Trial.

Weitz JI, Bauersachs R, Becker B, Berkowitz SD, Freitas MCS, Lassen MR, Metzig C, Raskob GE.

JAMA. 2020 Jan 14;323(2):130-139. doi: 10.1001/jama.2019.20687.


Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.

Engel C, Ahadova A, Seppälä TT, Aretz S, Bigirwamungu-Bargeman M, Bläker H, Bucksch K, Büttner R, de Vos Tot Nederveen Cappel WT, Endris V, Holinski-Feder E, Holzapfel S, Hüneburg R, Jacobs MAJM, Koornstra JJ, Langers AM, Lepistö A, Morak M, Möslein G, Peltomäki P, Pylvänäinen K, Rahner N, Renkonen-Sinisalo L, Schulmann K, Steinke-Lange V, Stenzinger A, Strassburg CP, van de Meeberg PC, van Kouwen M, van Leerdam M, Vangala DB, Vecht J, Verhulst ML, von Knebel Doeberitz M, Weitz J, Zachariae S, Loeffler M, Mecklin JP, Kloor M, Vasen HF; German HNPCC Consortium, the Dutch Lynch Syndrome Collaborative Group; Finnish Lynch Syndrome Registry.

Gastroenterology. 2020 Apr;158(5):1326-1333. doi: 10.1053/j.gastro.2019.12.032. Epub 2020 Jan 8.


MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling.

Mziaut H, Henniger G, Ganss K, Hempel S, Wolk S, McChord J, Chowdhury K, Ravassard P, Knoch KP, Krautz C, Weitz J, Grützmann R, Pilarsky C, Solimena M, Kersting S.

Mol Metab. 2020 Jan;31:150-162. doi: 10.1016/j.molmet.2019.11.012. Epub 2019 Nov 22.


Novel antithrombotic strategies for treatment of venous thromboembolism.

Weitz JI, Chan NC.

Blood. 2020 Jan 30;135(5):351-359. doi: 10.1182/blood.2019000919.


Rivaroxaban and Dabigatran for Suppression of Mechanical Heart Valve-Induced Thrombin Generation.

Jaffer IH, Fredenburgh JC, Stafford A, Whitlock RP, Weitz JI.

Ann Thorac Surg. 2019 Dec 24. pii: S0003-4975(19)31916-2. doi: 10.1016/j.athoracsur.2019.10.091. [Epub ahead of print]


Drain Amylase or Lipase for the Detection of POPF-Adding Evidence to an Ongoing Discussion.

Müssle B, Oehme F, Schade S, Sommer M, Bogner A, Hempel S, Pochhammer J, Kahlert C, Distler M, Weitz J, Welsch T.

J Clin Med. 2019 Dec 19;9(1). pii: E7. doi: 10.3390/jcm9010007.


Broadening the Categories of Patients Eligible for Extended Venous Thromboembolism Treatment.

Schindewolf M, Weitz JI.

Thromb Haemost. 2020 Jan;120(1):14-26. doi: 10.1055/s-0039-3400302. Epub 2019 Dec 13.


Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900).

Hüttner FJ, Bruckner T, Hackbusch M, Weitz J, Bork U, Kotschenreuther P, Heupel O, Kümmel S, Schlitt HJ, Mattulat M, Pintér L, Seiler CM, Gutt CN, Nottberg HS, Pohl A, Ghanem F, Meyer T, Imdahl A, Neudecker J, Müller VA, Gehrig T, Reineke M, von Frankenberg M, Schumacher G, Hennes R, Mihaljevic AL, Rossion I, Klose C, Kieser M, Büchler MW, Diener MK, Knebel P.

Ann Surg. 2019 Nov 27. doi: 10.1097/SLA.0000000000003705. [Epub ahead of print]


The prognostic role of circulating tumor cells in colorectal cancer.

Nanduri LK, Hissa B, Weitz J, Schölch S, Bork U.

Expert Rev Anticancer Ther. 2019 Dec;19(12):1077-1088. doi: 10.1080/14737140.2019.1699065. Epub 2019 Dec 6. Review.


Lubricant-Infused PET Grafts with Built-In Biofunctional Nanoprobes Attenuate Thrombin Generation and Promote Targeted Binding of Cells.

Badv M, Weitz JI, Didar TF.

Small. 2019 Dec;15(51):e1905562. doi: 10.1002/smll.201905562. Epub 2019 Nov 27.


[Current recommendations for surveillance, risk reduction and therapy in Lynch syndrome patients].

Hüneburg R, Aretz S, Büttner R, Daum S, Engel C, Fechner G, Habermann JK, Heling D, Hoffmann K, Holinski-Feder E, Kloor M, von Knebel-Döberitz M, Loeffler M, Möslein G, Perne C, Redler S, Rieß O, Schmiegel W, Seufferlein T, Siebers-Renelt U, Steinke-Lange V, Tecklenburg J, Vangala D, Vilz T, Weitz J, Wiedenmann B, Strassburg CP, Nattermann J.

Z Gastroenterol. 2019 Nov;57(11):1309-1320. doi: 10.1055/a-1008-9827. Epub 2019 Nov 18. German.


Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study.

Mulder FI, van Es N, Kraaijpoel N, Di Nisio M, Carrier M, Duggal A, Gaddh M, Garcia D, Grosso MA, Kakkar AK, Mercuri MF, Middeldorp S, Royle G, Segers A, Shivakumar S, Verhamme P, Wang T, Weitz JI, Zhang G, Büller HR, Raskob G.

Thromb Res. 2020 Jan;185:13-19. doi: 10.1016/j.thromres.2019.11.007. Epub 2019 Nov 9. Erratum in: Thromb Res. 2020 Mar 6;:.


Clinical implications of incidental venous thromboembolism in cancer patients.

Mulder FI, Di Nisio M, Ay C, Carrier M, Bosch FTM, Segers A, Kraaijpoel N, Grosso MA, Zhang G, Verhamme P, Wang TF, Weitz JI, Middeldorp S, Raskob G, Beenen LFM, Büller HR, van Es N.

Eur Respir J. 2020 Feb 6;55(2). pii: 1901697. doi: 10.1183/13993003.01697-2019. Print 2020 Feb.


Functional and Comparative Genomic Analysis of Integrated Prophage-Like Sequences in "Candidatus Liberibacter asiaticus".

Dominguez-Mirazo M, Jin R, Weitz JS.

mSphere. 2019 Nov 13;4(6). pii: e00409-19. doi: 10.1128/mSphere.00409-19.


A Standard Algorithm for Reconstruction of Scalp Defects With Simultaneous Free Flaps in an Interdisciplinary Two-Team Approach.

Weitz J, Spaas C, Wolff KD, Meyer B, Shiban E, Ritschl LM.

Front Oncol. 2019 Oct 25;9:1130. doi: 10.3389/fonc.2019.01130. eCollection 2019.


Rivaroxaban plus aspirin for cardiovascular protection: Rationale for the vascular dose and dual pathway inhibition.

Ramacciotti E, Weitz JI.

Thromb Res. 2019 Dec;184:44-49. doi: 10.1016/j.thromres.2019.09.033. Epub 2019 Oct 23. Review.


Randomized clinical trial of BioFoam® Surgical Matrix to achieve hemostasis after liver resection.

Rahbari NN, Birgin E, Sturm D, Schwanebeck U, Weitz J, Reissfelder C.

HPB (Oxford). 2019 Nov 1. pii: S1365-182X(19)32271-3. doi: 10.1016/j.hpb.2019.10.1529. [Epub ahead of print]


Tumor-Specific Regulatory T Cells from the Bone Marrow Orchestrate Antitumor Immunity in Breast Cancer.

Ge Y, Böhm HH, Rathinasamy A, Xydia M, Hu X, Pincha M, Umansky L, Breyer C, Hillier M, Bonertz A, Sevko A, Domschke C, Schuetz F, Frebel H, Dettling S, Herold-Mende C, Reissfelder C, Weitz J, Umansky V, Beckhove P.

Cancer Immunol Res. 2019 Dec;7(12):1998-2012. doi: 10.1158/2326-6066.CIR-18-0763. Epub 2019 Oct 31.


Are Ticks the Answer to Medical Device-Associated Clotting?

Weitz JI, Chan NC.

J Am Coll Cardiol. 2019 Oct 29;74(17):2190-2192. doi: 10.1016/j.jacc.2019.08.1027. No abstract available.


The MEGNA Score and Preoperative Anemia are Major Prognostic Factors After Resection in the German Intrahepatic Cholangiocarcinoma Cohort.

Schnitzbauer AA, Eberhard J, Bartsch F, Brunner SM, Ceyhan GO, Walter D, Fries H, Hannes S, Hecker A, Li J, Oldhafer K, Rahbari N, Rauchfuss F, Schlitt HJ, Settmacher U, Stavrou G, Weitz J, Lang H, Bechstein WO, Rückert F.

Ann Surg Oncol. 2020 Apr;27(4):1147-1155. doi: 10.1245/s10434-019-07968-7. Epub 2019 Oct 23.


State of the Art - Rectal Cancer Surgery.

Bogner A, Kirchberg J, Weitz J, Fritzmann J.

Visc Med. 2019 Aug;35(4):252-258. doi: 10.1159/000501133. Epub 2019 Jun 27. Review.


Novel Concepts in the Management of Colorectal Cancer.

Seufferlein T, Weitz J.

Visc Med. 2019 Aug;35(4):245. doi: 10.1159/000501750. Epub 2019 Jul 30. No abstract available.


Dabigatran Reversal With Idarucizumab in Patients Requiring Urgent Surgery: A Subanalysis of the RE-VERSE AD Study.

Levy JH, van Ryn J, Sellke FW, Reilly PA, Elsaesser A, Glund S, Kreuzer J, Weitz JI, Pollack CV Jr.

Ann Surg. 2019 Oct 9. doi: 10.1097/SLA.0000000000003638. [Epub ahead of print]


Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.

Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE.

Gastroenterology. 2019 Dec;157(6):1599-1614.e2. doi: 10.1053/j.gastro.2019.09.026. Epub 2019 Oct 1.


Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment.

Eikelboom JW, van Ryn J, Reilly P, Hylek EM, Elsaesser A, Glund S, Pollack CV, Weitz JI.

J Am Coll Cardiol. 2019 Oct 8;74(14):1760-1768. doi: 10.1016/j.jacc.2019.07.070.


Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis.

Weitz JI, Segers A, Raskob G, Roberts RS, Francis C, Lassen MR, Fuji T, Swaim RM, Lee M, Peters G, DiBattiste PM, Tesfaye F, Strony J.

J Thromb Haemost. 2019 Dec;17(12):2081-2088. doi: 10.1111/jth.14639. Epub 2019 Oct 13.


Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes.

Barovic M, Distler M, Schöniger E, Radisch N, Aust D, Weitz J, Ibberson M, Schulte AM, Solimena M.

Mol Metab. 2019 Sep;27S:S1-S6. doi: 10.1016/j.molmet.2019.06.006. Review.


Interdisciplinary Comparison of Endoscopic Laser-Assisted Diverticulotomy vs. Transcervical Myotomy as a Treatment for Zenker's Diverticulum.

Nitschke P, Kemper M, König P, Zahnert T, Weitz J, Reissfelder C, Distler M.

J Gastrointest Surg. 2019 Sep 3. doi: 10.1007/s11605-019-04381-z. [Epub ahead of print]


The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma.

Zimmermann C, Wolk S, Aust DE, Meier F, Saeger HD, Ehehalt F, Weitz J, Welsch T, Distler M.

Sci Rep. 2019 Sep 3;9(1):12676. doi: 10.1038/s41598-019-49179-w.


AV loop free flap: an interdisciplinary approach for perineal and sacral defect reconstruction after radical oncological exenteration and radiation in a colorectal cancer patient.

Matschke J, Armbruster R, Reeps C, Weitz J, Dragu A.

World J Surg Oncol. 2019 Sep 2;17(1):154. doi: 10.1186/s12957-019-1698-1.


Results of portosystemic shunts during extended pancreatic resections.

Oehme F, Distler M, Müssle B, Kahlert C, Weitz J, Welsch T.

Langenbecks Arch Surg. 2019 Dec;404(8):959-966. doi: 10.1007/s00423-019-01816-8. Epub 2019 Aug 24.


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