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Items: 1 to 50 of 163

1.

Application of an automated small-scale in vitro transfer model to predict in vivo precipitation inhibition.

Jede C, Wagner C, Kubas H, Weber C, Weigandt M, Koziolek M, Weitschies W.

Int J Pharm. 2019 Jun 30;565:458-471. doi: 10.1016/j.ijpharm.2019.05.028. Epub 2019 May 11.

PMID:
31085255
2.

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Vertzoni M, Augustijns P, Grimm M, Koziolek M, Lemmens G, Parrott N, Pentafragka C, Reppas C, Rubbens J, Van Den Αbeele J, Vanuytsel T, Weitschies W, Wilson CG.

Eur J Pharm Sci. 2019 Jun 15;134:153-175. doi: 10.1016/j.ejps.2019.04.013. Epub 2019 Apr 13.

3.

INFOGEST static in vitro simulation of gastrointestinal food digestion.

Brodkorb A, Egger L, Alminger M, Alvito P, Assunção R, Ballance S, Bohn T, Bourlieu-Lacanal C, Boutrou R, Carrière F, Clemente A, Corredig M, Dupont D, Dufour C, Edwards C, Golding M, Karakaya S, Kirkhus B, Le Feunteun S, Lesmes U, Macierzanka A, Mackie AR, Martins C, Marze S, McClements DJ, Ménard O, Minekus M, Portmann R, Santos CN, Souchon I, Singh RP, Vegarud GE, Wickham MSJ, Weitschies W, Recio I.

Nat Protoc. 2019 Apr;14(4):991-1014. doi: 10.1038/s41596-018-0119-1. Epub 2019 Mar 18.

PMID:
30886367
4.

Combined Application of MRI and the Salivary Tracer Technique to Determine the in Vivo Disintegration Time of Immediate Release Formulation Administered to Healthy, Fasted Subjects.

Sager M, Grimm M, Jedamzik P, Merdivan S, Kromrey ML, Hasan M, Koziolek M, Tzvetkov MV, Weitschies W.

Mol Pharm. 2019 Apr 1;16(4):1782-1786. doi: 10.1021/acs.molpharmaceut.8b01320. Epub 2019 Mar 8.

PMID:
30821987
5.

Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule.

Koziolek M, Grimm M, Bollmann T, Schäfer KJ, Blattner SM, Lotz R, Boeck G, Weitschies W.

Eur J Pharm Biopharm. 2019 Mar;136:221-230. doi: 10.1016/j.ejpb.2019.01.026. Epub 2019 Jan 28.

PMID:
30703546
6.

Characterization of the gastrointestinal transit and disintegration behavior of floating and sinking acid-resistant capsules using a novel MRI labeling technique.

Grimm M, Ball K, Scholz E, Schneider F, Sivert A, Benameur H, Kromrey ML, Kühn JP, Weitschies W.

Eur J Pharm Sci. 2019 Mar 1;129:163-172. doi: 10.1016/j.ejps.2019.01.012. Epub 2019 Jan 10.

PMID:
30639530
7.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration.

Butler J, Hens B, Vertzoni M, Brouwers J, Berben P, Dressman J, Andreas CJ, Schaefer KJ, Mann J, McAllister M, Jamei M, Kostewicz E, Kesisoglou F, Langguth P, Minekus M, Müllertz A, Schilderink R, Koziolek M, Jedamzik P, Weitschies W, Reppas C, Augustijns P.

Eur J Pharm Biopharm. 2019 Mar;136:70-83. doi: 10.1016/j.ejpb.2018.12.010. Epub 2018 Dec 20.

8.

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

Jede C, Wagner C, Kubas H, Weber C, Weigandt M, Koziolek M, Weitschies W.

Int J Pharm. 2019 Feb 10;556:150-158. doi: 10.1016/j.ijpharm.2018.12.013. Epub 2018 Dec 12.

PMID:
30553006
9.

Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.

Wirthgen E, Otten W, Tuchscherer M, Tuchscherer A, Domanska G, Brenmoehl J, Günther J, Ohde D, Weitschies W, Seidlitz A, Scheuch E, Kanitz E.

Int J Mol Sci. 2018 Oct 2;19(10). pii: E3009. doi: 10.3390/ijms19103009.

10.

In-line derivative spectroscopy as a promising application to a small-scale in vitro transfer model in biorelevant supersaturation and precipitation testing.

Jede C, Wagner C, Kubas H, Weber C, Weitschies W.

J Pharm Pharmacol. 2018 Oct;70(10):1315-1323. doi: 10.1111/jphp.12991. Epub 2018 Jul 30.

PMID:
30062721
11.

7.1 T MRI and T2 mapping of the human and porcine vitreous body post mortem.

Stein S, Hadlich S, Langner S, Biesenack A, Zehm N, Kruschke S, Oelze M, Grimm M, Mahnhardt S, Weitschies W, Seidlitz A.

Eur J Pharm Biopharm. 2018 Oct;131:82-91. doi: 10.1016/j.ejpb.2018.07.021. Epub 2018 Jul 25.

PMID:
30055255
12.

Development of a dual extrusion printing technique for an acid- and thermo-labile drug.

Kempin W, Domsta V, Brecht I, Semmling B, Tillmann S, Weitschies W, Seidlitz A.

Eur J Pharm Sci. 2018 Oct 15;123:191-198. doi: 10.1016/j.ejps.2018.07.041. Epub 2018 Jul 19.

PMID:
30031859
13.

Influence of Postprandial Intragastric Pressures on Drug Release from Gastroretentive Dosage Forms.

Schneider F, Hoppe M, Koziolek M, Weitschies W.

AAPS PharmSciTech. 2018 Oct;19(7):2843-2850. doi: 10.1208/s12249-018-1022-3. Epub 2018 May 29.

PMID:
29845498
14.

Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug.

Kempin W, Domsta V, Grathoff G, Brecht I, Semmling B, Tillmann S, Weitschies W, Seidlitz A.

Pharm Res. 2018 Apr 20;35(6):124. doi: 10.1007/s11095-018-2405-6.

PMID:
29679157
15.

Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study.

Sager M, Jedamzik P, Merdivan S, Grimm M, Schneider F, Kromrey ML, Hasan M, Oswald S, Kühn J, Koziolek M, Weitschies W.

Eur J Pharm Biopharm. 2018 Jun;127:443-452. doi: 10.1016/j.ejpb.2018.03.011. Epub 2018 Mar 27.

PMID:
29602018
16.

Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water.

Grimm M, Koziolek M, Kühn JP, Weitschies W.

Eur J Pharm Biopharm. 2018 Jun;127:309-317. doi: 10.1016/j.ejpb.2018.03.002. Epub 2018 Mar 6.

PMID:
29522898
17.

Influence of the test method on in vitro drug release from intravitreal model implants containing dexamethasone or fluorescein sodium in poly (d,l-lactide-co-glycolide) or polycaprolactone.

Stein S, Auel T, Kempin W, Bogdahn M, Weitschies W, Seidlitz A.

Eur J Pharm Biopharm. 2018 Jun;127:270-278. doi: 10.1016/j.ejpb.2018.02.034. Epub 2018 Feb 25.

PMID:
29490233
18.

Gastroresistant gelatin films prepared by addition of cellulose acetate phthalate.

Maciejewski B, Weitschies W, Schneider F, Sznitowska M.

Pharmazie. 2017 Jun 1;72(6):324-328. doi: 10.1691/ph.2017.6186.

PMID:
29442019
19.

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects.

Grimm M, Koziolek M, Saleh M, Schneider F, Garbacz G, Kühn JP, Weitschies W.

Mol Pharm. 2018 Feb 5;15(2):548-559. doi: 10.1021/acs.molpharmaceut.7b00919. Epub 2018 Jan 18.

PMID:
29298479
20.

Effect of Coadministered Water on the In Vivo Performance of Oral Formulations Containing N-Acetylcysteine: An In Vitro Approach Using the Dynamic Open Flow-Through Test Apparatus.

Sager M, Schneider F, Jedamzik P, Wiedmann M, Schremmer E, Koziolek M, Weitschies W.

Mol Pharm. 2017 Dec 4;14(12):4272-4280. doi: 10.1021/acs.molpharmaceut.7b00763. Epub 2017 Nov 3.

PMID:
29064257
21.

The Global Bioequivalence Harmonization Initiative: Summary report for EUFEPS international conference.

Chen ML, Blume H, Beuerle G, Davit B, Mehta M, Potthast H, Schug B, Tsang YC, Wedemeyer RS, Weitschies W, Welink J.

Eur J Pharm Sci. 2018 Jan 1;111:153-157. doi: 10.1016/j.ejps.2017.09.047. Epub 2017 Sep 28. Review.

PMID:
28964950
22.

In vitro dissolution testing of parenteral aqueous solutions and oily suspensions of paracetamol and prednisolone.

Probst M, Schmidt M, Tietz K, Klein S, Weitschies W, Seidlitz A.

Int J Pharm. 2017 Oct 30;532(1):519-527. doi: 10.1016/j.ijpharm.2017.09.052. Epub 2017 Sep 19.

PMID:
28935252
23.

Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions.

Grimm M, Scholz E, Koziolek M, Kühn JP, Weitschies W.

Mol Pharm. 2017 Dec 4;14(12):4262-4271. doi: 10.1021/acs.molpharmaceut.7b00623. Epub 2017 Oct 5.

PMID:
28930464
24.

Distribution of fluorescein sodium and triamcinolone acetonide in the simulated liquefied and vitrectomized Vitreous Model with simulated eye movements.

Stein S, Bogdahn M, Rosenbaum C, Weitschies W, Seidlitz A.

Eur J Pharm Sci. 2017 Nov 15;109:233-243. doi: 10.1016/j.ejps.2017.08.018. Epub 2017 Aug 18.

PMID:
28823853
25.

A novel mechanical antrum model for the prediction of the gastroretentive potential of dosage forms.

Neumann M, Schneider F, Koziolek M, Garbacz G, Weitschies W.

Int J Pharm. 2017 Sep 15;530(1-2):63-70. doi: 10.1016/j.ijpharm.2017.07.067. Epub 2017 Jul 24.

PMID:
28750896
26.

In vitro simulation of realistic gastric pressure profiles.

Schneider F, Beeck R, Hoppe M, Koziolek M, Weitschies W.

Eur J Pharm Sci. 2017 Sep 30;107:71-77. doi: 10.1016/j.ejps.2017.06.037. Epub 2017 Jun 30.

PMID:
28673756
27.

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools.

Van Den Abeele J, Schilderink R, Schneider F, Mols R, Minekus M, Weitschies W, Brouwers J, Tack J, Augustijns P.

Mol Pharm. 2017 Dec 4;14(12):4220-4232. doi: 10.1021/acs.molpharmaceut.7b00253. Epub 2017 Jul 7.

PMID:
28621952
28.

Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging.

Probst M, Kühn JP, Modeß C, Scheuch E, Seidlitz A, Hosten N, Siegmund W, Weitschies W.

Drug Saf Case Rep. 2017 Dec;4(1):7. doi: 10.1007/s40800-017-0049-9.

29.

Preparation and characterization of gastrointestinal wafer formulations.

Kirsch K, Hanke U, Weitschies W.

Int J Pharm. 2017 Apr 30;522(1-2):165-171. doi: 10.1016/j.ijpharm.2017.02.045. Epub 2017 Mar 3.

PMID:
28263833
30.

Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants.

Kempin W, Franz C, Koster LC, Schneider F, Bogdahn M, Weitschies W, Seidlitz A.

Eur J Pharm Biopharm. 2017 Jun;115:84-93. doi: 10.1016/j.ejpb.2017.02.014. Epub 2017 Feb 20.

PMID:
28232106
31.

An overview of intestinal wafers for oral drug delivery.

Kirsch K, Hanke U, Weitschies W.

Eur J Pharm Biopharm. 2017 May;114:135-144. doi: 10.1016/j.ejpb.2017.01.003. Epub 2017 Jan 19. Review. No abstract available.

PMID:
28111241
32.

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities.

Hens B, Corsetti M, Spiller R, Marciani L, Vanuytsel T, Tack J, Talattof A, Amidon GL, Koziolek M, Weitschies W, Wilson CG, Bennink RJ, Brouwers J, Augustijns P.

Int J Pharm. 2017 Mar 15;519(1-2):79-97. doi: 10.1016/j.ijpharm.2016.11.063. Epub 2016 Nov 30. Review.

PMID:
27915009
33.

Trospium chloride is absorbed from two intestinal "absorption windows" with different permeability in healthy subjects.

Tadken T, Weiss M, Modess C, Wegner D, Roustom T, Neumeister C, Schwantes U, Schulz HU, Weitschies W, Siegmund W.

Int J Pharm. 2016 Dec 30;515(1-2):367-373. doi: 10.1016/j.ijpharm.2016.10.030. Epub 2016 Oct 17.

PMID:
27765726
34.

Track M. Drug Delivery Technology.

Kempin W, Franz C, Weitschies W, Seidlitz A.

Biomed Tech (Berl). 2016 Sep 1;61(s1):125-132. doi: 10.1515/bmt-2016-5011. No abstract available.

PMID:
27682693
35.

Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed state.

Schneider F, Grimm M, Koziolek M, Modeß C, Dokter A, Roustom T, Siegmund W, Weitschies W.

Eur J Pharm Biopharm. 2016 Nov;108:214-219. doi: 10.1016/j.ejpb.2016.09.009. Epub 2016 Sep 14.

PMID:
27639346
36.

Erratum to: Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years.

Kromrey ML, Liedtke KR, Ittermann T, Langner S, Kirsch M, Weitschies W, Kühn JP.

Eur Radiol. 2017 Feb;27(2):778. doi: 10.1007/s00330-016-4472-6. No abstract available.

PMID:
27329521
37.

Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years.

Kromrey ML, Liedtke KR, Ittermann T, Langner S, Kirsch M, Weitschies W, Kühn JP.

Eur Radiol. 2017 Feb;27(2):772-777. doi: 10.1007/s00330-016-4418-z. Epub 2016 May 24. Erratum in: Eur Radiol. 2017 Feb;27(2):778.

PMID:
27221561
38.

Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer.

Mahajan UM, Teller S, Sendler M, Palankar R, van den Brandt C, Schwaiger T, Kühn JP, Ribback S, Glöckl G, Evert M, Weitschies W, Hosten N, Dombrowski F, Delcea M, Weiss FU, Lerch MM, Mayerle J.

Gut. 2016 Nov;65(11):1838-1849. doi: 10.1136/gutjnl-2016-311393. Epub 2016 May 12.

39.

Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers.

Koziolek M, Grimm M, Schneider F, Jedamzik P, Sager M, Kühn JP, Siegmund W, Weitschies W.

Adv Drug Deliv Rev. 2016 Jun 1;101:75-88. doi: 10.1016/j.addr.2016.03.009. Epub 2016 Mar 29. Review.

PMID:
27037063
40.

Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots.

Probst M, Kühn JP, Scheuch E, Seidlitz A, Hadlich S, Evert K, Oswald S, Siegmund W, Weitschies W.

J Control Release. 2016 Apr 10;227:1-12. doi: 10.1016/j.jconrel.2016.02.029. Epub 2016 Feb 17.

PMID:
26899995
41.

Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects.

Kolbow J, Weitschies W, Siegmund W.

J Clin Pharmacol. 2016 Feb;56(2):248-9. doi: 10.1002/jcph.659. No abstract available.

PMID:
26780488
42.

Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model.

Wirthgen E, Kanitz E, Tuchscherer M, Tuchscherer A, Domanska G, Weitschies W, Seidlitz A, Scheuch E, Otten W.

Exp Anim. 2016 May 20;65(2):147-55. doi: 10.1538/expanim.15-0096. Epub 2015 Dec 28.

43.

Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment.

Rauschenberger L, Staar D, Thom K, Scharf C, Venz S, Homuth G, Schlüter R, Brandenburg LO, Ziegler P, Zimmermann U, Weitschies W, Völker U, Lendeckel U, Walther R, Burchardt M, Stope MB.

Prostate. 2016 Mar;76(4):409-24. doi: 10.1002/pros.23132. Epub 2015 Dec 8.

PMID:
26643154
44.

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions.

Hénin E, Bergstrand M, Weitschies W, Karlsson MO.

Pharm Res. 2016 Mar;33(3):751-62. doi: 10.1007/s11095-015-1824-x. Epub 2015 Nov 9.

PMID:
26553354
45.

Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies.

Koziolek M, Schneider F, Grimm M, Modeβ C, Seekamp A, Roustom T, Siegmund W, Weitschies W.

J Control Release. 2015 Dec 28;220(Pt A):71-78. doi: 10.1016/j.jconrel.2015.10.022. Epub 2015 Oct 22.

PMID:
26476174
46.

In vitro evaluation of paclitaxel coatings for delivery via drug-coated balloons.

Kempin W, Kaule S, Reske T, Grabow N, Petersen S, Nagel S, Schmitz KP, Weitschies W, Seidlitz A.

Eur J Pharm Biopharm. 2015 Oct;96:322-8. doi: 10.1016/j.ejpb.2015.08.010. Epub 2015 Aug 28.

PMID:
26318979
47.

Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.

Kolbow J, Modess C, Wegner D, Oswald S, Maritz MA, Rey H, Weitschies W, Siegmund W.

J Clin Pharmacol. 2016 Feb;56(2):239-45. doi: 10.1002/jcph.624. Epub 2015 Oct 20.

PMID:
26313157
48.

Controlling drug delivery from coronary stents: are we aiming for the right targets?

Seidlitz A, Wentzlaff M, Weitschies W.

Ther Deliv. 2015;6(6):705-20. doi: 10.4155/tde.15.25. Review.

PMID:
26149786
49.

In vitro study of sirolimus release from a drug-eluting stent: Comparison of the release profiles obtained using different test setups.

Seidlitz A, Schick W, Reske T, Senz V, Grabow N, Petersen S, Nagel S, Weitschies W.

Eur J Pharm Biopharm. 2015 Jun;93:328-38. doi: 10.1016/j.ejpb.2015.04.016. Epub 2015 May 1.

PMID:
25936852
50.

Characterisation of selected active agents regarding pKa values, solubility concentrations and pH profiles by SiriusT3.

Schönherr D, Wollatz U, Haznar-Garbacz D, Hanke U, Box KJ, Taylor R, Ruiz R, Beato S, Becker D, Weitschies W.

Eur J Pharm Biopharm. 2015 May;92:155-70. doi: 10.1016/j.ejpb.2015.02.028. Epub 2015 Mar 7.

PMID:
25758123

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