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Items: 1 to 50 of 759

1.

Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.

Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O, Zhao X, Sohn DH, Lepus CM, Sokolove J, Mao R, Cisar CT, Raghu H, Chu CR, Giori NJ, Willingham SB, Prohaska SS, Cheng Z, Weissman IL, Robinson WH.

JCI Insight. 2019 Sep 19;4(18). pii: 128616. doi: 10.1172/jci.insight.128616.

2.

Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation.

Tsai JM, Shoham M, Fernhoff NB, George BM, Marjon KD, McCracken MN, Kao KS, Sinha R, Volkmer AK, Miyanishi M, Seita J, Rinkevich Y, Weissman IL.

Blood Adv. 2019 Sep 24;3(18):2713-2721. doi: 10.1182/bloodadvances.2018024026.

3.

Phagocytosis checkpoints as new targets for cancer immunotherapy.

Feng M, Jiang W, Kim BYS, Zhang CC, Fu YX, Weissman IL.

Nat Rev Cancer. 2019 Oct;19(10):568-586. doi: 10.1038/s41568-019-0183-z. Epub 2019 Aug 28. Review.

PMID:
31462760
4.

The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.

Zhu F, Feng M, Sinha R, Murphy MP, Luo F, Kao KS, Szade K, Seita J, Weissman IL.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18416-18422. doi: 10.1073/pnas.1906251116. Epub 2019 Aug 26.

PMID:
31451629
5.

De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.

Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S.

Nat Biotechnol. 2019 Oct;37(10):1137-1144. doi: 10.1038/s41587-019-0227-7. Epub 2019 Aug 19.

PMID:
31427818
6.

Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.

Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.

Development. 2019 Aug 1;146(15). pii: dev170571. doi: 10.1242/dev.170571. Review.

PMID:
31371526
7.

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.

Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL.

Nature. 2019 Aug;572(7769):392-396. doi: 10.1038/s41586-019-1456-0. Epub 2019 Jul 31.

PMID:
31367043
8.

Single-cell analysis reveals T cell infiltration in old neurogenic niches.

Dulken BW, Buckley MT, Navarro Negredo P, Saligrama N, Cayrol R, Leeman DS, George BM, Boutet SC, Hebestreit K, Pluvinage JV, Wyss-Coray T, Weissman IL, Vogel H, Davis MM, Brunet A.

Nature. 2019 Jul;571(7764):205-210. doi: 10.1038/s41586-019-1362-5. Epub 2019 Jul 3.

PMID:
31270459
9.

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.

Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.

Melanoma Res. 2019 Jun 12. doi: 10.1097/CMR.0000000000000629. [Epub ahead of print]

PMID:
31205227
10.

Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance.

George BM, Kao KS, Kwon HS, Velasco BJ, Poyser J, Chen A, Le AC, Chhabra A, Burnett CE, Cajuste D, Hoover M, Loh KM, Shizuru JA, Weissman IL.

Cell Stem Cell. 2019 Aug 1;25(2):185-192.e3. doi: 10.1016/j.stem.2019.05.018. Epub 2019 Jun 13.

PMID:
31204177
11.

RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance.

Balogh P, Adelman ER, Pluvinage JV, Capaldo BJ, Freeman KC, Singh S, Elagib KE, Nakamura Y, Kurita R, Sashida G, Zunder ER, Li H, Gru AA, Price EA, Schrier SL, Weissman IL, Figueroa ME, Pang WW, Goldfarb AN.

Haematologica. 2019 Jun 6. pii: haematol.2018.208918. doi: 10.3324/haematol.2018.208918. [Epub ahead of print]

12.

CD47-Targeted Near-Infrared Photoimmunotherapy for Human Bladder Cancer.

Kiss B, van den Berg NS, Ertsey R, McKenna K, Mach KE, Zhang CA, Volkmer JP, Weissman IL, Rosenthal EL, Liao JC.

Clin Cancer Res. 2019 Jun 15;25(12):3561-3571. doi: 10.1158/1078-0432.CCR-18-3267. Epub 2019 Mar 19.

PMID:
30890547
13.

Wounds Inhibit Tumor Growth In Vivo.

Hu MS, Maan ZN, Leavitt T, Hong WX, Rennert RC, Marshall CD, Borrelli MR, Zhu TN, Esquivel M, Zimmermann A, McArdle A, Chung MT, Foster DS, Jones RE, Gurtner GC, Giaccia AJ, Lorenz HP, Weissman IL, Longaker MT.

Ann Surg. 2019 Feb 27. doi: 10.1097/SLA.0000000000003255. [Epub ahead of print]

PMID:
30829705
14.

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers.

Sikic BI, Lakhani N, Patnaik A, Shah SA, Chandana SR, Rasco D, Colevas AD, O'Rourke T, Narayanan S, Papadopoulos K, Fisher GA, Villalobos V, Prohaska SS, Howard M, Beeram M, Chao MP, Agoram B, Chen JY, Huang J, Axt M, Liu J, Volkmer JP, Majeti R, Weissman IL, Takimoto CH, Supan D, Wakelee HA, Aoki R, Pegram MD, Padda SK.

J Clin Oncol. 2019 Apr 20;37(12):946-953. doi: 10.1200/JCO.18.02018. Epub 2019 Feb 27.

PMID:
30811285
15.

Regenerating the field of cardiovascular cell therapy.

Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL.

Nat Biotechnol. 2019 Mar;37(3):232-237. doi: 10.1038/s41587-019-0042-1. Epub 2019 Feb 18. Review.

PMID:
30778231
16.

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.

Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ.

Nat Commun. 2019 Feb 15;10(1):794. doi: 10.1038/s41467-019-08637-9.

17.

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice.

Pang WW, Czechowicz A, Logan AC, Bhardwaj R, Poyser J, Park CY, Weissman IL, Shizuru JA.

Blood. 2019 May 9;133(19):2069-2078. doi: 10.1182/blood-2018-06-858159. Epub 2019 Feb 11.

PMID:
30745302
18.

The Macrophage 'Do not eat me' signal, CD47, is a clinically validated cancer immunotherapy target.

Takimoto CH, Chao MP, Gibbs C, McCamish MA, Liu J, Chen JY, Majeti R, Weissman IL.

Ann Oncol. 2019 Mar 1;30(3):486-489. doi: 10.1093/annonc/mdz006. No abstract available.

PMID:
30689700
19.

Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo.

Lu R, Czechowicz A, Seita J, Jiang D, Weissman IL.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1447-1456. doi: 10.1073/pnas.1801480116. Epub 2019 Jan 8.

20.

Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice.

Kwon HS, Logan AC, Chhabra A, Pang WW, Czechowicz A, Tate K, Le A, Poyser J, Hollis R, Kelly BV, Kohn DB, Weissman IL, Prohaska SS, Shizuru JA.

Blood. 2019 May 9;133(19):2104-2108. doi: 10.1182/blood-2018-06-853879. Epub 2019 Jan 7. No abstract available.

PMID:
30617195
21.

Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis.

Jeong H, Kim S, Hong BJ, Lee CJ, Kim YE, Bok S, Oh JM, Gwak SH, Yoo MY, Lee MS, Chung SJ, Defrêne J, Tessier P, Pelletier M, Jeon H, Roh TY, Kim B, Kim KH, Ju JH, Kim S, Lee YJ, Kim DW, Kim IH, Kim HJ, Park JW, Lee YS, Lee JS, Cheon GJ, Weissman IL, Chung DH, Jeon YK, Ahn GO.

Cancer Res. 2019 Feb 15;79(4):795-806. doi: 10.1158/0008-5472.CAN-18-2545. Epub 2019 Jan 4.

PMID:
30610087
22.

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.

Hutter G, Theruvath J, Graef CM, Zhang M, Schoen MK, Manz EM, Bennett ML, Olson A, Azad TD, Sinha R, Chan C, Assad Kahn S, Gholamin S, Wilson C, Grant G, He J, Weissman IL, Mitra SS, Cheshier SH.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):997-1006. doi: 10.1073/pnas.1721434116. Epub 2019 Jan 2.

23.

Complex mammalian-like haematopoietic system found in a colonial chordate.

Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.

Nature. 2018 Dec;564(7736):425-429. doi: 10.1038/s41586-018-0783-x. Epub 2018 Dec 5.

24.

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers.

Tsai JM, Sinha R, Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW, McKenna KM, Xing L, Sandholzer M, Sales JH, Shoham M, McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Weissman IL, Rinkevich Y.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaan6735. doi: 10.1126/scitranslmed.aan6735.

PMID:
30487249
25.

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.

Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC.

Nat Genet. 2018 Dec;50(12):1716-1727. doi: 10.1038/s41588-018-0254-1. Epub 2018 Nov 5.

26.

Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.

Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH.

Nat Commun. 2018 Nov 2;9(1):4651. doi: 10.1038/s41467-018-07182-1.

27.

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.

Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, Kline J, Roschewski M, LaCasce A, Collins GP, Tran T, Lynn J, Chen JY, Volkmer JP, Agoram B, Huang J, Majeti R, Weissman IL, Takimoto CH, Chao MP, Smith SM.

N Engl J Med. 2018 Nov 1;379(18):1711-1721. doi: 10.1056/NEJMoa1807315.

PMID:
30380386
28.

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.

Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH.

Nat Commun. 2018 Oct 8;9(1):4121. doi: 10.1038/s41467-018-06564-9. Erratum in: Nat Commun. 2018 Nov 2;9(1):4651.

29.

Identification of the Human Skeletal Stem Cell.

Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT.

Cell. 2018 Sep 20;175(1):43-56.e21. doi: 10.1016/j.cell.2018.07.029.

30.

Screening for genes that regulate the differentiation of human megakaryocytic lineage cells.

Zhu F, Feng M, Sinha R, Seita J, Mori Y, Weissman IL.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9308-E9316. doi: 10.1073/pnas.1805434115. Epub 2018 Aug 27.

31.

Programmed cell removal by calreticulin in tissue homeostasis and cancer.

Feng M, Marjon KD, Zhu F, Weissman-Tsukamoto R, Levett A, Sullivan K, Kao KS, Markovic M, Bump PA, Jackson HM, Choi TS, Chen J, Banuelos AM, Liu J, Gip P, Cheng L, Wang D, Weissman IL.

Nat Commun. 2018 Aug 10;9(1):3194. doi: 10.1038/s41467-018-05211-7.

32.

HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.

Kim YE, Lee M, Gu H, Kim J, Jeong S, Yeo S, Lee YJ, Im SH, Sung YC, Kim HJ, Weissman IL, Ahn GO.

Dis Model Mech. 2018 Jul 30;11(7). pii: dmm033241. doi: 10.1242/dmm.033241.

33.

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration.

Tsai JM, Weissman IL, Rinkevich Y.

J Vis Exp. 2018 May 31;(135). doi: 10.3791/57302.

34.

Isolation and functional assessment of mouse skeletal stem cell lineage.

Gulati GS, Murphy MP, Marecic O, Lopez M, Brewer RE, Koepke LS, Manjunath A, Ransom RC, Salhotra A, Weissman IL, Longaker MT, Chan CKF.

Nat Protoc. 2018 Jun;13(6):1294-1309. doi: 10.1038/nprot.2018.041. Epub 2018 May 10.

35.

Computational correction of index switching in multiplexed sequencing libraries.

Larsson AJM, Stanley G, Sinha R, Weissman IL, Sandberg R.

Nat Methods. 2018 Apr 27;15(5):305-307. doi: 10.1038/nmeth.4666. No abstract available.

PMID:
29702636
36.

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells.

Ang LT, Tan AKY, Autio MI, Goh SH, Choo SH, Lee KL, Tan J, Pan B, Lee JJH, Lum JJ, Lim CYY, Yeo IKX, Wong CJY, Liu M, Oh JLL, Chia CPL, Loh CH, Chen A, Chen Q, Weissman IL, Loh KM, Lim B.

Cell Rep. 2018 Feb 20;22(8):2190-2205. doi: 10.1016/j.celrep.2018.01.087.

37.

Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice.

Bok S, Kim YE, Woo Y, Kim S, Kang SJ, Lee Y, Park SK, Weissman IL, Ahn GO.

Oncotarget. 2017 Dec 1;8(67):111508-111521. doi: 10.18632/oncotarget.22851. eCollection 2017 Dec 19.

38.

Improving immune-vascular crosstalk for cancer immunotherapy.

Huang Y, Kim BYS, Chan CK, Hahn SM, Weissman IL, Jiang W.

Nat Rev Immunol. 2018 Mar;18(3):195-203. doi: 10.1038/nri.2017.145. Epub 2018 Jan 15. Review.

39.

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.

Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL.

Nat Immunol. 2018 Jan;19(1):76-84. doi: 10.1038/s41590-017-0004-z. Epub 2017 Nov 27.

40.

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20.

41.

Where Hematopoietic Stem Cells Live: The Bone Marrow Niche.

Szade K, Gulati GS, Chan CKF, Kao KS, Miyanishi M, Marjon KD, Sinha R, George BM, Chen JY, Weissman IL.

Antioxid Redox Signal. 2018 Jul 10;29(2):191-204. doi: 10.1089/ars.2017.7419. Epub 2018 Jan 9. Review.

42.

Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair.

Hu MS, Walmsley GG, Barnes LA, Weiskopf K, Rennert RC, Duscher D, Januszyk M, Maan ZN, Hong WX, Cheung AT, Leavitt T, Marshall CD, Ransom RC, Malhotra S, Moore AL, Rajadas J, Lorenz HP, Weissman IL, Gurtner GC, Longaker MT.

JCI Insight. 2017 Oct 5;2(19). pii: 96260. doi: 10.1172/jci.insight.96260.

43.

Immune Priming of the Tumor Microenvironment by Radiation.

Jiang W, Chan CK, Weissman IL, Kim BYS, Hahn SM.

Trends Cancer. 2016 Nov;2(11):638-645. doi: 10.1016/j.trecan.2016.09.007. Epub 2016 Oct 15. Review.

PMID:
28741502
44.

Brief Report: External Beam Radiation Therapy for the Treatment of Human Pluripotent Stem Cell-Derived Teratomas.

Lee AS, Tang C, Hong WX, Park S, Bazalova-Carter M, Nelson G, Sanchez-Freire V, Bakerman I, Zhang W, Neofytou E, Connolly AJ, Chan CK, Graves EE, Weissman IL, Nguyen PK, Wu JC.

Stem Cells. 2017 Aug;35(8):1994-2000. doi: 10.1002/stem.2653. Epub 2017 Jul 10.

45.

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.

Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL.

Nature. 2017 May 25;545(7655):495-499. doi: 10.1038/nature22396. Epub 2017 May 17.

46.

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.

Xu J, Ueno H, Xu CY, Chen B, Weissman IL, Xu PX.

Nat Commun. 2017 May 11;8:15046. doi: 10.1038/ncomms15046.

47.

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ.

Nature. 2017 May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3.

48.

Unifying mechanism for different fibrotic diseases.

Wernig G, Chen SY, Cui L, Van Neste C, Tsai JM, Kambham N, Vogel H, Natkunam Y, Gilliland DG, Nolan G, Weissman IL.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4757-4762. doi: 10.1073/pnas.1621375114. Epub 2017 Apr 19.

49.

Normal and Neoplastic Stem Cells.

McCracken MN, George BM, Kao KS, Marjon KD, Raveh T, Weissman IL.

Cold Spring Harb Symp Quant Biol. 2016;81:1-9. doi: 10.1101/sqb.2016.81.030965. Epub 2017 Apr 17. Review.

50.

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.

Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, Ho P, Gip P, Swigut T, Sherwood RI, Clarke MF, Somlo G, Young RA, Weissman IL.

Nat Commun. 2017 Apr 5;8:14802. doi: 10.1038/ncomms14802.

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