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Items: 1 to 50 of 743

1.

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice.

Pang WW, Czechowicz A, Logan AC, Bhardwaj R, Poyser J, Park CY, Weissman IL, Shizuru JA.

Blood. 2019 Feb 11. pii: blood-2018-06-858159. doi: 10.1182/blood-2018-06-858159. [Epub ahead of print]

PMID:
30745302
2.

The Macrophage "Do not Eat Me" Signal, CD47, Is A Clinically Validated Cancer Immunotherapy Target.

Takimoto CH, Chao MP, Gibbs C, McCamish MA, Liu J, Chen JY, Majeti R, Weissman IL.

Ann Oncol. 2019 Jan 24. doi: 10.1093/annonc/mdz006. [Epub ahead of print] No abstract available.

PMID:
30689700
3.

Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo.

Lu R, Czechowicz A, Seita J, Jiang D, Weissman IL.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1447-1456. doi: 10.1073/pnas.1801480116. Epub 2019 Jan 8.

PMID:
30622181
4.

Anti-human CD117 antibody-mediated bone marrow niche clearance in non-human primates and humanized NSG mice.

Kwon HS, Logan AC, Chhabra A, Pang WW, Czechowicz A, Tate K, Le A, Poyser J, Hollis R, Kelly BV, Kohn DB, Weissman IL, Prohaska SS, Shizuru JA.

Blood. 2019 Jan 7. pii: blood-2018-06-853879. doi: 10.1182/blood-2018-06-853879. [Epub ahead of print] No abstract available.

PMID:
30617195
5.

Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis.

Jeong H, Kim S, Hong BJ, Lee CJ, Kim YE, Bok S, Oh JM, Gwak SH, Yoo MY, Lee MS, Chung SJ, Defrêne J, Tessier P, Pelletier M, Jeon H, Roh TY, Kim B, Kim KH, Ju JH, Kim S, Lee YJ, Kim DW, Kim IH, Kim HJ, Park JW, Lee YS, Lee JS, Cheon GJ, Weissman IL, Chung DH, Jeon YK, Ahn GO.

Cancer Res. 2019 Jan 4. pii: canres.2545.2018. doi: 10.1158/0008-5472.CAN-18-2545. [Epub ahead of print]

PMID:
30610087
6.

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.

Hutter G, Theruvath J, Graef CM, Zhang M, Schoen MK, Manz EM, Bennett ML, Olson A, Azad TD, Sinha R, Chan C, Assad Kahn S, Gholamin S, Wilson C, Grant G, He J, Weissman IL, Mitra SS, Cheshier SH.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):997-1006. doi: 10.1073/pnas.1721434116. Epub 2019 Jan 2.

7.

Complex mammalian-like haematopoietic system found in a colonial chordate.

Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.

Nature. 2018 Dec;564(7736):425-429. doi: 10.1038/s41586-018-0783-x. Epub 2018 Dec 5.

PMID:
30518860
8.

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers.

Tsai JM, Sinha R, Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW, McKenna KM, Xing L, Sandholzer M, Sales JH, Shoham M, McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Weissman IL, Rinkevich Y.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaan6735. doi: 10.1126/scitranslmed.aan6735.

PMID:
30487249
9.

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.

Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC.

Nat Genet. 2018 Dec;50(12):1716-1727. doi: 10.1038/s41588-018-0254-1. Epub 2018 Nov 5.

PMID:
30397336
10.

Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.

Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH.

Nat Commun. 2018 Nov 2;9(1):4651. doi: 10.1038/s41467-018-07182-1.

11.

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.

Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, Kline J, Roschewski M, LaCasce A, Collins GP, Tran T, Lynn J, Chen JY, Volkmer JP, Agoram B, Huang J, Majeti R, Weissman IL, Takimoto CH, Chao MP, Smith SM.

N Engl J Med. 2018 Nov 1;379(18):1711-1721. doi: 10.1056/NEJMoa1807315.

PMID:
30380386
12.

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.

Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH.

Nat Commun. 2018 Oct 8;9(1):4121. doi: 10.1038/s41467-018-06564-9. Erratum in: Nat Commun. 2018 Nov 2;9(1):4651.

13.

Identification of the Human Skeletal Stem Cell.

Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT.

Cell. 2018 Sep 20;175(1):43-56.e21. doi: 10.1016/j.cell.2018.07.029.

PMID:
30241615
14.

Screening for genes that regulate the differentiation of human megakaryocytic lineage cells.

Zhu F, Feng M, Sinha R, Seita J, Mori Y, Weissman IL.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9308-E9316. doi: 10.1073/pnas.1805434115. Epub 2018 Aug 27.

PMID:
30150396
15.

Programmed cell removal by calreticulin in tissue homeostasis and cancer.

Feng M, Marjon KD, Zhu F, Weissman-Tsukamoto R, Levett A, Sullivan K, Kao KS, Markovic M, Bump PA, Jackson HM, Choi TS, Chen J, Banuelos AM, Liu J, Gip P, Cheng L, Wang D, Weissman IL.

Nat Commun. 2018 Aug 10;9(1):3194. doi: 10.1038/s41467-018-05211-7.

16.

HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.

Kim YE, Lee M, Gu H, Kim J, Jeong S, Yeo S, Lee YJ, Im SH, Sung YC, Kim HJ, Weissman IL, Ahn GO.

Dis Model Mech. 2018 Jul 30;11(7). pii: dmm033241. doi: 10.1242/dmm.033241.

17.

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration.

Tsai JM, Weissman IL, Rinkevich Y.

J Vis Exp. 2018 May 31;(135). doi: 10.3791/57302.

PMID:
29912198
18.

Isolation and functional assessment of mouse skeletal stem cell lineage.

Gulati GS, Murphy MP, Marecic O, Lopez M, Brewer RE, Koepke LS, Manjunath A, Ransom RC, Salhotra A, Weissman IL, Longaker MT, Chan CKF.

Nat Protoc. 2018 Jun;13(6):1294-1309. doi: 10.1038/nprot.2018.041. Epub 2018 May 10.

PMID:
29748647
19.

Computational correction of index switching in multiplexed sequencing libraries.

Larsson AJM, Stanley G, Sinha R, Weissman IL, Sandberg R.

Nat Methods. 2018 Apr 27;15(5):305-307. doi: 10.1038/nmeth.4666. No abstract available.

PMID:
29702636
20.

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells.

Ang LT, Tan AKY, Autio MI, Goh SH, Choo SH, Lee KL, Tan J, Pan B, Lee JJH, Lum JJ, Lim CYY, Yeo IKX, Wong CJY, Liu M, Oh JLL, Chia CPL, Loh CH, Chen A, Chen Q, Weissman IL, Loh KM, Lim B.

Cell Rep. 2018 Feb 20;22(8):2190-2205. doi: 10.1016/j.celrep.2018.01.087.

21.

Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice.

Bok S, Kim YE, Woo Y, Kim S, Kang SJ, Lee Y, Park SK, Weissman IL, Ahn GO.

Oncotarget. 2017 Dec 1;8(67):111508-111521. doi: 10.18632/oncotarget.22851. eCollection 2017 Dec 19.

22.

Improving immune-vascular crosstalk for cancer immunotherapy.

Huang Y, Kim BYS, Chan CK, Hahn SM, Weissman IL, Jiang W.

Nat Rev Immunol. 2018 Mar;18(3):195-203. doi: 10.1038/nri.2017.145. Epub 2018 Jan 15. Review.

23.

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.

Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL.

Nat Immunol. 2018 Jan;19(1):76-84. doi: 10.1038/s41590-017-0004-z. Epub 2017 Nov 27.

24.

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20.

25.

Where Hematopoietic Stem Cells Live: The Bone Marrow Niche.

Szade K, Gulati GS, Chan CKF, Kao KS, Miyanishi M, Marjon KD, Sinha R, George BM, Chen JY, Weissman IL.

Antioxid Redox Signal. 2018 Jul 10;29(2):191-204. doi: 10.1089/ars.2017.7419. Epub 2018 Jan 9.

PMID:
29113449
26.

Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair.

Hu MS, Walmsley GG, Barnes LA, Weiskopf K, Rennert RC, Duscher D, Januszyk M, Maan ZN, Hong WX, Cheung AT, Leavitt T, Marshall CD, Ransom RC, Malhotra S, Moore AL, Rajadas J, Lorenz HP, Weissman IL, Gurtner GC, Longaker MT.

JCI Insight. 2017 Oct 5;2(19). pii: 96260. doi: 10.1172/jci.insight.96260. [Epub ahead of print]

27.

Immune Priming of the Tumor Microenvironment by Radiation.

Jiang W, Chan CK, Weissman IL, Kim BYS, Hahn SM.

Trends Cancer. 2016 Nov;2(11):638-645. doi: 10.1016/j.trecan.2016.09.007. Epub 2016 Oct 15. Review.

PMID:
28741502
28.

Brief Report: External Beam Radiation Therapy for the Treatment of Human Pluripotent Stem Cell-Derived Teratomas.

Lee AS, Tang C, Hong WX, Park S, Bazalova-Carter M, Nelson G, Sanchez-Freire V, Bakerman I, Zhang W, Neofytou E, Connolly AJ, Chan CK, Graves EE, Weissman IL, Nguyen PK, Wu JC.

Stem Cells. 2017 Aug;35(8):1994-2000. doi: 10.1002/stem.2653. Epub 2017 Jul 10.

29.

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.

Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL.

Nature. 2017 May 25;545(7655):495-499. doi: 10.1038/nature22396. Epub 2017 May 17.

30.

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.

Xu J, Ueno H, Xu CY, Chen B, Weissman IL, Xu PX.

Nat Commun. 2017 May 11;8:15046. doi: 10.1038/ncomms15046.

31.

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ.

Nature. 2017 May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3.

32.

Unifying mechanism for different fibrotic diseases.

Wernig G, Chen SY, Cui L, Van Neste C, Tsai JM, Kambham N, Vogel H, Natkunam Y, Gilliland DG, Nolan G, Weissman IL.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4757-4762. doi: 10.1073/pnas.1621375114. Epub 2017 Apr 19.

33.

Normal and Neoplastic Stem Cells.

McCracken MN, George BM, Kao KS, Marjon KD, Raveh T, Weissman IL.

Cold Spring Harb Symp Quant Biol. 2016;81:1-9. doi: 10.1101/sqb.2016.81.030965. Epub 2017 Apr 17. Review.

34.

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.

Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, Ho P, Gip P, Swigut T, Sherwood RI, Clarke MF, Somlo G, Young RA, Weissman IL.

Nat Commun. 2017 Apr 5;8:14802. doi: 10.1038/ncomms14802.

35.

Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors.

Tsai JM, Koh PW, Stefanska A, Xing L, Walmsley GG, Poux N, Weissman IL, Rinkevich Y.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3654-3659. doi: 10.1073/pnas.1621361114. Epub 2017 Mar 22.

36.

Lessons from immuno-oncology: a new era for cancer nanomedicine?

Jiang W, Yuan H, Chan CK, von Roemeling CA, Yan Z, Weissman IL, Kim BYS.

Nat Rev Drug Discov. 2017 Jun;16(6):369-370. doi: 10.1038/nrd.2017.34. Epub 2017 Mar 17.

PMID:
28303024
37.

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.

Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH.

Sci Transl Med. 2017 Mar 15;9(381). pii: eaaf2968. doi: 10.1126/scitranslmed.aaf2968.

PMID:
28298418
38.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.

39.

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.

Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D.

Nat Commun. 2017 Feb 22;8:14533. doi: 10.1038/ncomms14533.

40.

The Role of Efferocytosis in Atherosclerosis.

Kojima Y, Weissman IL, Leeper NJ.

Circulation. 2017 Jan 31;135(5):476-489. doi: 10.1161/CIRCULATIONAHA.116.025684.

41.

Age-associated changes in human hematopoietic stem cells.

Pang WW, Schrier SL, Weissman IL.

Semin Hematol. 2017 Jan;54(1):39-42. doi: 10.1053/j.seminhematol.2016.10.004. Epub 2016 Oct 20. Review.

PMID:
28088986
42.

Pharmacological rescue of diabetic skeletal stem cell niches.

Tevlin R, Seo EY, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, Rodrigues M, Nguyen A, Januszyk M, Maan Z, Paik K, Yapa KS, Rajadas J, Wan DC, Gurtner GC, Snyder M, Beachy PA, Yang F, Goodman SB, Weissman IL, Chan CK, Longaker MT.

Sci Transl Med. 2017 Jan 11;9(372). pii: eaag2809. doi: 10.1126/scitranslmed.aag2809.

43.

Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy.

Zhu H, Leiss L, Yang N, Rygh CB, Mitra SS, Cheshier SH, Weissman IL, Huang B, Miletic H, Bjerkvig R, Enger PØ, Li X, Wang J.

Oncotarget. 2017 Feb 14;8(7):12145-12157. doi: 10.18632/oncotarget.14553.

44.

An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development.

Koh PW, Sinha R, Barkal AA, Morganti RM, Chen A, Weissman IL, Ang LT, Kundaje A, Loh KM.

Sci Data. 2016 Dec 20;3:160109. doi: 10.1038/sdata.2016.109.

45.

Practical Immuno-PET Radiotracer Design Considerations for Human Immune Checkpoint Imaging.

Mayer AT, Natarajan A, Gordon SR, Maute RL, McCracken MN, Ring AM, Weissman IL, Gambhir SS.

J Nucl Med. 2017 Apr;58(4):538-546. doi: 10.2967/jnumed.116.177659. Epub 2016 Dec 15.

46.

LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage.

Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA.

Cell Rep. 2016 Nov 22;17(9):2286-2298. doi: 10.1016/j.celrep.2016.10.080.

47.

Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.

Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, O'Sullivan MG, Weissman IL, Modiano JF.

Cancer Immunol Res. 2016 Dec;4(12):1072-1087. Epub 2016 Nov 14.

48.

Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.

Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.

Cell Stem Cell. 2016 Nov 3;19(5):587-592. doi: 10.1016/j.stem.2016.10.013.

49.

Myeloid Cell Origins, Differentiation, and Clinical Implications.

Weiskopf K, Schnorr PJ, Pang WW, Chao MP, Chhabra A, Seita J, Feng M, Weissman IL.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.MCHD-0031-2016. Review.

50.

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy.

Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA.

Sci Transl Med. 2016 Aug 10;8(351):351ra105. doi: 10.1126/scitranslmed.aae0501.

PMID:
27510901

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