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Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.

Hann ZS, Metzger MB, Weissman AM, Lima CD.

Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):552-560. doi: 10.1107/S2053230X19009786. Epub 2019 Aug 2.


The effect of capture and handling stress in Lophius americanus in the scallop dredge fishery.

Weissman AM, Mandelman JW, Rudders DB, Sulikowski JA.

Conserv Physiol. 2018 Oct 26;6(1):coy058. doi: 10.1093/conphys/coy058. eCollection 2018.


Stabilization of p27Kip1/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control.

Whitcomb EA, Tsai YC, Basappa J, Liu K, Le Feuvre AK, Weissman AM, Taylor A.

FASEB J. 2019 Jan;33(1):1235-1247. doi: 10.1096/fj.201800960R. Epub 2018 Aug 16.


The Ubiquitin Ligase (E3) Psh1p Is Required for Proper Segregation of both Centromeric and Two-Micron Plasmids in Saccharomyces cerevisiae.

Metzger MB, Scales JL, Dunklebarger MF, Weissman AM.

G3 (Bethesda). 2017 Nov 6;7(11):3731-3743. doi: 10.1534/g3.117.300227.


Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.

Briggs JW, Ren L, Chakrabarti KR, Tsai YC, Weissman AM, Hansen RJ, Gustafson DL, Khan YA, Dinman JD, Khanna C.

PLoS One. 2017 Sep 19;12(9):e0185089. doi: 10.1371/journal.pone.0185089. eCollection 2017.


An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion.

Cavellini L, Meurisse J, Findinier J, Erpapazoglou Z, Belgareh-Touzé N, Weissman AM, Cohen MM.

Nat Commun. 2017 Jun 13;8:15832. doi: 10.1038/ncomms15832.


Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication.

Tsai YC, Kotiya A, Kiris E, Yang M, Bavari S, Tessarollo L, Oyler GA, Weissman AM.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5158-E5166. doi: 10.1073/pnas.1621076114. Epub 2017 Jun 5.


Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL.

Cell Chem Biol. 2017 Feb 16;24(2):231-242. doi: 10.1016/j.chembiol.2017.01.002. Epub 2017 Feb 2.


Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, Sorscher EJ.

PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.


Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM.

J Biol Chem. 2015 Dec 18;290(51):30225-39. doi: 10.1074/jbc.M115.685867. Epub 2015 Oct 16.


Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.

Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.

PLoS One. 2014 Apr 8;9(4):e92290. doi: 10.1371/journal.pone.0092290. eCollection 2014.


Malfolded protein structure and proteostasis in lung diseases.

Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W.

Am J Respir Crit Care Med. 2014 Jan 1;189(1):96-103. doi: 10.1164/rccm.201306-1164WS.


Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.

Das R, Liang YH, Mariano J, Li J, Huang T, King A, Tarasov SG, Weissman AM, Ji X, Byrd RA.

EMBO J. 2013 Sep 11;32(18):2504-16. doi: 10.1038/emboj.2013.174. Epub 2013 Aug 13.


Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase.

Byrd RA, Weissman AM.

EMBO J. 2013 Jul 31;32(15):2087-9. doi: 10.1038/emboj.2013.158. Epub 2013 Jul 12. Review.


Ubiquitin and drug discovery: challenges and opportunities.

Weissman AM.

Cell Biochem Biophys. 2013 Sep;67(1):1-2. doi: 10.1007/s12013-013-9620-x. No abstract available.


RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

Metzger MB, Pruneda JN, Klevit RE, Weissman AM.

Biochim Biophys Acta. 2014 Jan;1843(1):47-60. doi: 10.1016/j.bbamcr.2013.05.026. Epub 2013 Jun 6. Review.


A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.

Metzger MB, Liang YH, Das R, Mariano J, Li S, Li J, Kostova Z, Byrd RA, Ji X, Weissman AM.

Mol Cell. 2013 May 23;50(4):516-27. doi: 10.1016/j.molcel.2013.04.004. Epub 2013 May 9.


Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains.

Liu S, Chen Y, Li J, Huang T, Tarasov S, King A, Weissman AM, Byrd RA, Das R.

Structure. 2012 Dec 5;20(12):2138-50. doi: 10.1016/j.str.2012.09.020. Epub 2012 Nov 1.


Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.

Mol Biol Cell. 2012 Dec;23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19.


A ubiquitin-binding rhomboid protease aimed at ERADication.

Tsai YC, Weissman AM.

Dev Cell. 2012 Sep 11;23(3):454-6. doi: 10.1016/j.devcel.2012.08.015.


Cullin RING ligases: glommed by glomulin.

Hristova VA, Stringer DK, Weissman AM.

Mol Cell. 2012 Aug 10;47(3):331-2. doi: 10.1016/j.molcel.2012.07.025.


Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.

Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM.

Mol Cell. 2012 Aug 24;47(4):547-57. doi: 10.1016/j.molcel.2012.05.041. Epub 2012 Jun 28.


HECT and RING finger families of E3 ubiquitin ligases at a glance.

Metzger MB, Hristova VA, Weissman AM.

J Cell Sci. 2012 Feb 1;125(Pt 3):531-7. doi: 10.1242/jcs.091777. Review. No abstract available.


Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.

Tsai YC, Weissman AM.

FEBS Lett. 2011 Oct 20;585(20):3166-73. doi: 10.1016/j.febslet.2011.08.031. Epub 2011 Aug 27. Review.


RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis.

Lipkowitz S, Weissman AM.

Nat Rev Cancer. 2011 Aug 24;11(9):629-43. doi: 10.1038/nrc3120. Review.


The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.

Weissman AM, Shabek N, Ciechanover A.

Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):605-20. doi: 10.1038/nrm3173. Review. Erratum in: Nat Rev Mol Cell Biol. 2011 Oct;12(10):686.


Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion.

Cohen MM, Amiott EA, Day AR, Leboucher GP, Pryce EN, Glickman MH, McCaffery JM, Shaw JM, Weissman AM.

J Cell Sci. 2011 May 1;124(Pt 9):1403-10. doi: 10.1242/jcs.079293.


Ubiquitylation in ERAD: reversing to go forward?

Tsai YC, Weissman AM.

PLoS Biol. 2011 Mar;9(3):e1001038. doi: 10.1371/journal.pbio.1001038. Epub 2011 Mar 29.


Working on a chain: E3s ganging up for ubiquitylation.

Metzger MB, Weissman AM.

Nat Cell Biol. 2010 Dec;12(12):1124-6. doi: 10.1038/ncb1210-1124.


Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system.

Tsai YC, Maditz R, Kuo CL, Fishman PS, Shoemaker CB, Oyler GA, Weissman AM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16554-9. doi: 10.1073/pnas.1008302107. Epub 2010 Sep 7.


Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein.

Ishikura S, Weissman AM, Bonifacino JS.

J Biol Chem. 2010 Jul 30;285(31):23916-24. doi: 10.1074/jbc.M110.127936. Epub 2010 Jun 2.


Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.

Shmueli A, Tsai YC, Yang M, Braun MA, Weissman AM.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):758-62. doi: 10.1016/j.bbrc.2009.10.045. Epub 2009 Oct 14.


A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover.

Amiott EA, Cohen MM, Saint-Georges Y, Weissman AM, Shaw JM.

Mol Biol Cell. 2009 Dec;20(23):5026-35. doi: 10.1091/mbc.E09-07-0622. Epub 2009 Oct 7.


Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.

Das R, Mariano J, Tsai YC, Kalathur RC, Kostova Z, Li J, Tarasov SG, McFeeters RL, Altieri AS, Ji X, Byrd RA, Weissman AM.

Mol Cell. 2009 Jun 26;34(6):674-85. doi: 10.1016/j.molcel.2009.05.010.


A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.

Kostova Z, Mariano J, Scholz S, Koenig C, Weissman AM.

J Cell Sci. 2009 May 1;122(Pt 9):1374-81. doi: 10.1242/jcs.044255. Epub 2009 Apr 14.


Differences in the tumor microenvironment between African-American and European-American breast cancer patients.

Martin DN, Boersma BJ, Yi M, Reimers M, Howe TM, Yfantis HG, Tsai YC, Williams EH, Lee DH, Stephens RM, Weissman AM, Ambs S.

PLoS One. 2009;4(2):e4531. doi: 10.1371/journal.pone.0004531. Epub 2009 Feb 19.


Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer.

Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR.

Ernst Schering Found Symp Proc. 2008;(1):171-90.


Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

Clement JA, Kitagaki J, Yang Y, Saucedo CJ, O'Keefe BR, Weissman AM, McKee TC, McMahon JB.

Bioorg Med Chem. 2008 Dec 1;16(23):10022-8. doi: 10.1016/j.bmc.2008.10.024. Epub 2008 Oct 14.


EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.

Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13433-8. doi: 10.1073/pnas.0806298105. Epub 2008 Aug 29.


Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.

Kitagaki J, Agama KK, Pommier Y, Yang Y, Weissman AM.

Mol Cancer Ther. 2008 Aug;7(8):2445-54. doi: 10.1158/1535-7163.MCT-08-0063.


Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.

Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM.

J Biol Chem. 2008 Aug 8;283(32):22166-76. doi: 10.1074/jbc.M709668200. Epub 2008 Jun 10.


How much REST is enough?

Weissman AM.

Cancer Cell. 2008 May;13(5):381-3. doi: 10.1016/j.ccr.2008.04.011.


Solubilization of lymphocytes.

Weissman AM.

Curr Protoc Immunol. 2003 Nov;Chapter 8:Unit 8.1A. doi: 10.1002/0471142735.im0801as57. Review.


Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion.

Cohen MM, Leboucher GP, Livnat-Levanon N, Glickman MH, Weissman AM.

Mol Biol Cell. 2008 Jun;19(6):2457-64. doi: 10.1091/mbc.E08-02-0227. Epub 2008 Mar 19.


Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.

Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR.

J Biomol Screen. 2008 Mar;13(3):229-37. doi: 10.1177/1087057108315038. Epub 2008 Feb 12.


Studies of the ubiquitin proteasome system.

Lorick KL, Yang Y, Jensen JP, Iwai K, Weissman AM.

Curr Protoc Cell Biol. 2006 Jul;Chapter 15:Unit 15.9. doi: 10.1002/0471143030.cb1509s31.


The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Tsai YC, Mendoza A, Mariano JM, Zhou M, Kostova Z, Chen B, Veenstra T, Hewitt SM, Helman LJ, Khanna C, Weissman AM.

Nat Med. 2007 Dec;13(12):1504-9. Epub 2007 Nov 25.


Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.

Kostova Z, Tsai YC, Weissman AM.

Semin Cell Dev Biol. 2007 Dec;18(6):770-9. Epub 2007 Sep 8. Review.


Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM.

Cancer Res. 2007 Oct 1;67(19):9472-81.

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