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Ultra-fast cycling for multiplexed cellular fluorescence imaging.

Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R.

Angew Chem Int Ed Engl. 2020 Jan 31. doi: 10.1002/anie.201915153. [Epub ahead of print]


Improving nanotherapy delivery and action through image-guided systems pharmacology.

Ng TSC, Garlin MA, Weissleder R, Miller MA.

Theranostics. 2020 Jan 1;10(3):968-997. doi: 10.7150/thno.37215. eCollection 2020. Review.


Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy.

Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R.

Cell Chem Biol. 2020 Jan 16;27(1):94-104.e5. doi: 10.1016/j.chembiol.2019.12.007. Epub 2020 Jan 2.


Point-of-care cervical cancer screening using deep learning-based microholography.

Pathania D, Landeros C, Rohrer L, D'Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM.

Theranostics. 2019 Nov 26;9(26):8438-8447. doi: 10.7150/thno.37187. eCollection 2019.


Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.

Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R.

Theranostics. 2019 Nov 26;9(26):8426-8436. doi: 10.7150/thno.35434. eCollection 2019.


Advances in clinical MRI technology.

Harisinghani MG, O'Shea A, Weissleder R.

Sci Transl Med. 2019 Dec 18;11(523). pii: eaba2591. doi: 10.1126/scitranslmed.aba2591. Review.


Large and small extracellular vesicles released by glioma cells in vitro and in vivo.

Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L.

J Extracell Vesicles. 2019 Nov 27;9(1):1689784. doi: 10.1080/20013078.2019.1689784. eCollection 2020.


Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand.

Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R.

ACS Chem Biol. 2020 Jan 17;15(1):151-157. doi: 10.1021/acschembio.9b00724. Epub 2019 Dec 13.


LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects.

Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ.

Cell Stress. 2019 Oct 14;3(11):348-360. doi: 10.15698/cst2019.11.204.


Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs.

Chin LY, Carroll C, Raigani S, Detelich DM, Tessier SN, Wojtkiewicz GR, Schmidt SP, Weissleder R, Yeh H, Uygun K, Parekkadan B.

PLoS One. 2019 Dec 2;14(12):e0225222. doi: 10.1371/journal.pone.0225222. eCollection 2019.


Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.

Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO.

Sci Rep. 2019 Nov 22;9(1):17387. doi: 10.1038/s41598-019-53554-y.


Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.

Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M.

Immunity. 2019 Nov 19;51(5):899-914.e7. doi: 10.1016/j.immuni.2019.10.010. Epub 2019 Nov 12.


Screening for new macrophage therapeutics.

Rodell CB, Koch PD, Weissleder R.

Theranostics. 2019 Oct 15;9(25):7714-7729. doi: 10.7150/thno.34421. eCollection 2019. Review.


High dynamic range fluorescence imaging.

Vinegoni C, Feruglio PF, Weissleder R.

IEEE J Sel Top Quantum Electron. 2019 Jan-Feb;25(1). pii: 6801507. doi: 10.1109/JSTQE.2018.2881608. Epub 2018 Nov 19.


Compact and Filter-Free Luminescence Biosensor for Mobile in Vitro Diagnoses.

Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H.

ACS Nano. 2019 Oct 22;13(10):11698-11706. doi: 10.1021/acsnano.9b05634. Epub 2019 Sep 6.


Glass Chemistry to Analyze Human Cells under Adverse Conditions.

Marquard AN, Carlson JCT, Weissleder R.

ACS Omega. 2019 Jul 3;4(7):11515-11521. doi: 10.1021/acsomega.9b01036. eCollection 2019 Jul 31.


Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.

Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA.

Cytometry A. 2019 Aug 19. doi: 10.1002/cyto.a.23872. [Epub ahead of print]


Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.

Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A.

Cell Rep. 2019 Jun 25;27(13):3972-3987.e6. doi: 10.1016/j.celrep.2019.05.089.


A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.

Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11444-11453. doi: 10.1073/pnas.1702372116. Epub 2019 May 17.


TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018 Aug;2(8):578-588. doi: 10.1038/s41551-018-0236-8. Epub 2018 May 21.


Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.

Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO.

Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003.


Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy.

Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA.

ACS Nano. 2019 Apr 23;13(4):4028-4040. doi: 10.1021/acsnano.8b08177. Epub 2019 Mar 27.


Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.


Bioassay for monitoring the anti-aging effect of cord blood treatment.

Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J.

Theranostics. 2019 Jan 1;9(1):1-10. doi: 10.7150/thno.30422. eCollection 2019.


A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.

Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R.

Bioconjug Chem. 2019 Mar 20;30(3):733-740. doi: 10.1021/acs.bioconjchem.8b00882. Epub 2019 Jan 18.


Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Arlauckas SP, Garren SB, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R.

Theranostics. 2018 Nov 12;8(21):5842-5854. doi: 10.7150/thno.26888. eCollection 2018.


A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse.

Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M.

Circ Res. 2018 Nov 9;123(11):1208-1219. doi: 10.1161/CIRCRESAHA.118.313429.


Characterization of single microvesicles in plasma from glioblastoma patients.

Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R.

Neuro Oncol. 2019 May 6;21(5):606-615. doi: 10.1093/neuonc/noy187.


Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning.

Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble B, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R.

Nat Biomed Eng. 2018 Sep;2(9):666-674. doi: 10.1038/s41551-018-0265-3. Epub 2018 Jul 23.


Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ.

Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11.


Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R.

ACS Nano. 2018 Dec 26;12(12):12814-12826. doi: 10.1021/acsnano.8b07954. Epub 2018 Dec 14.


Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA.

ACS Nano. 2018 Dec 26;12(12):12015-12029. doi: 10.1021/acsnano.8b04338. Epub 2018 Dec 11.


Deep transfer learning-based hologram classification for molecular diagnostics.

Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K.

Sci Rep. 2018 Nov 19;8(1):17003. doi: 10.1038/s41598-018-35274-x.


Multichannel digital heteronuclear magnetic resonance biosensor.

Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H.

Biosens Bioelectron. 2019 Feb 1;126:240-248. doi: 10.1016/j.bios.2018.10.052. Epub 2018 Oct 27.


Site occupancy calibration of taxane pharmacology in live cells and tissues.

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14.


Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R.

JCI Insight. 2018 Nov 2;3(21). pii: 122961. doi: 10.1172/jci.insight.122961.


Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens.

Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R.

Nat Commun. 2018 Oct 31;9(1):4550. doi: 10.1038/s41467-018-07002-6.


Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.

Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10672-E10681. doi: 10.1073/pnas.1810580115. Epub 2018 Oct 22.


TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018;2:578-588. Epub 2018 May 21.


Recording the wild lives of immune cells.

Pittet MJ, Garris CS, Arlauckas SP, Weissleder R.

Sci Immunol. 2018 Sep 7;3(27). pii: eaaq0491. doi: 10.1126/sciimmunol.aaq0491. Review.


Unsupervised Medical Image Segmentation Based on the Local Center of Mass.

Aganj I, Harisinghani MG, Weissleder R, Fischl B.

Sci Rep. 2018 Aug 29;8(1):13012. doi: 10.1038/s41598-018-31333-5.


Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.

Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M.

Nat Neurosci. 2018 Sep;21(9):1209-1217. doi: 10.1038/s41593-018-0213-2. Epub 2018 Aug 27.


Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings.

Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel JM, Castro CM, Weissleder R, Lee H.

ACS Nano. 2018 Sep 25;12(9):9081-9090. doi: 10.1021/acsnano.8b03029. Epub 2018 Aug 20.


Imaging the Vascular Bone Marrow Niche During Inflammatory Stress.

Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M.

Circ Res. 2018 Aug 3;123(4):415-427. doi: 10.1161/CIRCRESAHA.118.313302.


Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma.

Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS.

PLoS One. 2018 Jul 5;13(7):e0199414. doi: 10.1371/journal.pone.0199414. eCollection 2018.


Developing a Roadmap for Interventional Oncology.

Schoenberg SO, Attenberger UI, Solomon SB, Weissleder R.

Oncologist. 2018 Oct;23(10):1162-1170. doi: 10.1634/theoncologist.2017-0654. Epub 2018 Jun 29. Review.


Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System.

Park J, Im H, Hong S, Castro CM, Weissleder R, Lee H.

ACS Photonics. 2018 Feb 21;5(2):487-494. doi: 10.1021/acsphotonics.7b00992. Epub 2017 Nov 3.


Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.


Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis.

Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H.

ACS Nano. 2018 Apr 24;12(4):3378-3384. doi: 10.1021/acsnano.7b08965. Epub 2018 Mar 20.


Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA.

Sci Adv. 2018 Mar 7;4(3):eaar2766. doi: 10.1126/sciadv.aar2766. eCollection 2018 Mar.

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