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Items: 1 to 50 of 899

1.

Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.

Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA.

Cytometry A. 2019 Aug 19. doi: 10.1002/cyto.a.23872. [Epub ahead of print]

PMID:
31423731
2.

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.

Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A.

Cell Rep. 2019 Jun 25;27(13):3972-3987.e6. doi: 10.1016/j.celrep.2019.05.089.

3.

A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.

Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11444-11453. doi: 10.1073/pnas.1702372116. Epub 2019 May 17.

PMID:
31101720
4.

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018 Aug;2(8):578-588. doi: 10.1038/s41551-018-0236-8. Epub 2018 May 21.

PMID:
31015631
5.

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.

Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO.

Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003.

6.

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy.

Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA.

ACS Nano. 2019 Apr 23;13(4):4028-4040. doi: 10.1021/acsnano.8b08177. Epub 2019 Mar 27.

PMID:
30916923
7.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

8.

Bioassay for monitoring the anti-aging effect of cord blood treatment.

Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J.

Theranostics. 2019 Jan 1;9(1):1-10. doi: 10.7150/thno.30422. eCollection 2019.

9.

A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.

Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R.

Bioconjug Chem. 2019 Mar 20;30(3):733-740. doi: 10.1021/acs.bioconjchem.8b00882. Epub 2019 Jan 18.

10.

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Arlauckas SP, Garren SB, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R.

Theranostics. 2018 Nov 12;8(21):5842-5854. doi: 10.7150/thno.26888. eCollection 2018.

11.

A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse.

Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M.

Circ Res. 2018 Nov 9;123(11):1208-1219. doi: 10.1161/CIRCRESAHA.118.313429.

PMID:
30571465
12.

Characterization of single microvesicles in plasma from glioblastoma patients.

Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R.

Neuro Oncol. 2019 May 6;21(5):606-615. doi: 10.1093/neuonc/noy187.

PMID:
30561734
13.

Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning.

Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble B, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R.

Nat Biomed Eng. 2018 Sep;2(9):666-674. doi: 10.1038/s41551-018-0265-3. Epub 2018 Jul 23.

14.

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ.

Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11.

PMID:
30552023
15.

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R.

ACS Nano. 2018 Dec 26;12(12):12814-12826. doi: 10.1021/acsnano.8b07954. Epub 2018 Dec 14.

16.

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA.

ACS Nano. 2018 Dec 26;12(12):12015-12029. doi: 10.1021/acsnano.8b04338. Epub 2018 Dec 11.

17.

Deep transfer learning-based hologram classification for molecular diagnostics.

Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K.

Sci Rep. 2018 Nov 19;8(1):17003. doi: 10.1038/s41598-018-35274-x.

18.

Multichannel digital heteronuclear magnetic resonance biosensor.

Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H.

Biosens Bioelectron. 2019 Feb 1;126:240-248. doi: 10.1016/j.bios.2018.10.052. Epub 2018 Oct 27.

19.

Site occupancy calibration of taxane pharmacology in live cells and tissues.

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14.

20.

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R.

JCI Insight. 2018 Nov 2;3(21). pii: 122961. doi: 10.1172/jci.insight.122961.

21.

Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens.

Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R.

Nat Commun. 2018 Oct 31;9(1):4550. doi: 10.1038/s41467-018-07002-6.

22.

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.

Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10672-E10681. doi: 10.1073/pnas.1810580115. Epub 2018 Oct 22.

23.

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018;2:578-588. Epub 2018 May 21.

24.

Recording the wild lives of immune cells.

Pittet MJ, Garris CS, Arlauckas SP, Weissleder R.

Sci Immunol. 2018 Sep 7;3(27). pii: eaaq0491. doi: 10.1126/sciimmunol.aaq0491. Review.

PMID:
30194240
25.

Unsupervised Medical Image Segmentation Based on the Local Center of Mass.

Aganj I, Harisinghani MG, Weissleder R, Fischl B.

Sci Rep. 2018 Aug 29;8(1):13012. doi: 10.1038/s41598-018-31333-5.

26.

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.

Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M.

Nat Neurosci. 2018 Sep;21(9):1209-1217. doi: 10.1038/s41593-018-0213-2. Epub 2018 Aug 27.

27.

Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings.

Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel JM, Castro CM, Weissleder R, Lee H.

ACS Nano. 2018 Sep 25;12(9):9081-9090. doi: 10.1021/acsnano.8b03029. Epub 2018 Aug 20.

28.

Imaging the Vascular Bone Marrow Niche During Inflammatory Stress.

Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M.

Circ Res. 2018 Aug 3;123(4):415-427. doi: 10.1161/CIRCRESAHA.118.313302.

29.

Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma.

Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS.

PLoS One. 2018 Jul 5;13(7):e0199414. doi: 10.1371/journal.pone.0199414. eCollection 2018.

30.

Developing a Roadmap for Interventional Oncology.

Schoenberg SO, Attenberger UI, Solomon SB, Weissleder R.

Oncologist. 2018 Oct;23(10):1162-1170. doi: 10.1634/theoncologist.2017-0654. Epub 2018 Jun 29. Review.

PMID:
29959284
31.

Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System.

Park J, Im H, Hong S, Castro CM, Weissleder R, Lee H.

ACS Photonics. 2018 Feb 21;5(2):487-494. doi: 10.1021/acsphotonics.7b00992. Epub 2017 Nov 3.

32.

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.

33.

Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis.

Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H.

ACS Nano. 2018 Apr 24;12(4):3378-3384. doi: 10.1021/acsnano.7b08965. Epub 2018 Mar 20.

34.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA.

Sci Adv. 2018 Mar 7;4(3):eaar2766. doi: 10.1126/sciadv.aar2766. eCollection 2018 Mar.

35.

Fluorescence anisotropy imaging in drug discovery.

Vinegoni C, Feruglio PF, Gryczynski I, Mazitschek R, Weissleder R.

Adv Drug Deliv Rev. 2018 Feb 2. pii: S0169-409X(18)30027-9. doi: 10.1016/j.addr.2018.01.019. [Epub ahead of print]

36.

Unraveling Tetrazine-Triggered Bioorthogonal Elimination Enables Chemical Tools for Ultrafast Release and Universal Cleavage.

Carlson JCT, Mikula H, Weissleder R.

J Am Chem Soc. 2018 Mar 14;140(10):3603-3612. doi: 10.1021/jacs.7b11217. Epub 2018 Feb 14.

37.

New Technologies for Analysis of Extracellular Vesicles.

Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H.

Chem Rev. 2018 Feb 28;118(4):1917-1950. doi: 10.1021/acs.chemrev.7b00534. Epub 2018 Jan 31. Review.

38.

Cardiac macrophages promote diastolic dysfunction.

Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M.

J Exp Med. 2018 Feb 5;215(2):423-440. doi: 10.1084/jem.20171274. Epub 2018 Jan 16.

39.

Multiplexed Profiling of Single Extracellular Vesicles.

Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca EA, Breakefield XO, Lee H, Weissleder R.

ACS Nano. 2018 Jan 23;12(1):494-503. doi: 10.1021/acsnano.7b07060. Epub 2018 Jan 4.

40.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

41.

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease.

Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R.

Chem Commun (Camb). 2017 Dec 19;54(1):42-45. doi: 10.1039/c7cc07581b.

42.

Nanomagnetic System for Rapid Diagnosis of Acute Infection.

Park KS, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H.

ACS Nano. 2017 Nov 28;11(11):11425-11432. doi: 10.1021/acsnano.7b06074. Epub 2017 Nov 14.

43.

IRF3 and type I interferons fuel a fatal response to myocardial infarction.

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP Jr, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R.

Nat Med. 2017 Dec;23(12):1481-1487. doi: 10.1038/nm.4428. Epub 2017 Nov 6.

44.

Prediction of Anti-cancer Nanotherapy Efficacy by Imaging.

Miller MA, Arlauckas S, Weissleder R.

Nanotheranostics. 2017 Jul 6;1(3):296-312. doi: 10.7150/ntno.20564. eCollection 2017. Review.

45.

Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.

Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H.

Lab Chip. 2017 Nov 21;17(23):4000-4007. doi: 10.1039/c7lc00934h.

46.

Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection.

Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR.

ACS Nano. 2017 Nov 28;11(11):11041-11046. doi: 10.1021/acsnano.7b05083. Epub 2017 Oct 25.

47.

Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.

Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen PY, Chiocca EA, Lawler SE.

Neuro Oncol. 2018 Jan 22;20(2):225-235. doi: 10.1093/neuonc/nox139.

48.

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK.

J Exp Med. 2017 Nov 6;214(11):3293-3310. doi: 10.1084/jem.20170689. Epub 2017 Oct 4.

49.

PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.

50.

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7776-E7785. doi: 10.1073/pnas.1707381114. Epub 2017 Aug 24.

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