Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 107


Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01.

Pinto D, Fenwick C, Caillat C, Silacci C, Guseva S, Dehez F, Chipot C, Barbieri S, Minola A, Jarrossay D, Tomaras GD, Shen X, Riva A, Tarkowski M, Schwartz O, Bruel T, Dufloo J, Seaman MS, Montefiori DC, Lanzavecchia A, Corti D, Pantaleo G, Weissenhorn W.

Cell Host Microbe. 2019 Nov 13;26(5):623-637.e8. doi: 10.1016/j.chom.2019.09.016. Epub 2019 Oct 22.


Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes.

Strokappe NM, Hock M, Rutten L, Mccoy LE, Back JW, Caillat C, Haffke M, Weiss RA, Weissenhorn W, Verrips T.

Antibodies (Basel). 2019 Jun 18;8(2). pii: E38. doi: 10.3390/antib8020038.


Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.

Fenwick C, Loredo-Varela JL, Joo V, Pellaton C, Farina A, Rajah N, Esteves-Leuenberger L, Decaillon T, Suffiotti M, Noto A, Ohmiti K, Gottardo R, Weissenhorn W, Pantaleo G.

J Exp Med. 2019 Jul 1;216(7):1525-1541. doi: 10.1084/jem.20182359. Epub 2019 May 23.


Activation of the ILT7 receptor and plasmacytoid dendritic cell responses are governed by structurally-distinct BST2 determinants.

Bego MG, Miguet N, Laliberté A, Aschman N, Gerard F, Merakos AA, Weissenhorn W, Cohen ÉA.

J Biol Chem. 2019 Jul 5;294(27):10503-10518. doi: 10.1074/jbc.RA119.008481. Epub 2019 May 22.


VPS4 triggers constriction and cleavage of ESCRT-III helical filaments.

Maity S, Caillat C, Miguet N, Sulbaran G, Effantin G, Schoehn G, Roos WH, Weissenhorn W.

Sci Adv. 2019 Apr 10;5(4):eaau7198. doi: 10.1126/sciadv.aau7198. eCollection 2019 Apr.


The role of VPS4 in ESCRT-III polymer remodeling.

Caillat C, Maity S, Miguet N, Roos WH, Weissenhorn W.

Biochem Soc Trans. 2019 Feb 28;47(1):441-448. doi: 10.1042/BST20180026. Epub 2019 Feb 19. Review.


Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector.

Bresk CA, Hofer T, Wilmschen S, Krismer M, Beierfuß A, Effantin G, Weissenhorn W, Hogan MJ, Jordan APO, Gelman RS, Montefiori DC, Liao HX, Schmitz JE, Haynes BF, von Laer D, Kimpel J.

Viruses. 2019 Feb 15;11(2). pii: E159. doi: 10.3390/v11020159.


CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.

Ventimiglia LN, Cuesta-Geijo MA, Martinelli N, Caballe A, Macheboeuf P, Miguet N, Parnham IM, Olmos Y, Carlton JG, Weissenhorn W, Martin-Serrano J.

Dev Cell. 2018 Dec 3;47(5):547-563.e6. doi: 10.1016/j.devcel.2018.11.012.


The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks.

De Franceschi N, Alqabandi M, Miguet N, Caillat C, Mangenot S, Weissenhorn W, Bassereau P.

J Cell Sci. 2018 Aug 3;132(4). pii: jcs217968. doi: 10.1242/jcs.217968.


CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis.

Crespo-Yàñez X, Aguilar-Gurrieri C, Jacomin AC, Journet A, Mortier M, Taillebourg E, Soleilhac E, Weissenhorn W, Fauvarque MO.

PLoS Genet. 2018 Jun 22;14(6):e1007456. doi: 10.1371/journal.pgen.1007456. eCollection 2018 Jun.


Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.

Mikulecky P, Andreeva E, Amara P, Weissenhorn W, Nicolet Y, Macheboeuf P.

FEBS Lett. 2018 Jan;592(2):199-208. doi: 10.1002/1873-3468.12941. Epub 2018 Jan 9.


Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights.

Gray ER, Brookes JC, Caillat C, Turbé V, Webb BLJ, Granger LA, Miller BS, McCoy LE, El Khattabi M, Verrips CT, Weiss RA, Duffy DM, Weissenhorn W, McKendry RA.

ACS Infect Dis. 2017 Jul 14;3(7):479-491. doi: 10.1021/acsinfecdis.6b00189. Epub 2017 Jun 26.


Antigp41 membrane proximal external region antibodies and the art of using the membrane for neutralization.

Cerutti N, Loredo-Varela JL, Caillat C, Weissenhorn W.

Curr Opin HIV AIDS. 2017 May;12(3):250-256. doi: 10.1097/COH.0000000000000364. Review.


The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model.

Saletti D, Radzimanowski J, Effantin G, Midtvedt D, Mangenot S, Weissenhorn W, Bassereau P, Bally M.

Sci Rep. 2017 Jan 25;7:40801. doi: 10.1038/srep40801.


Cryo-electron Microscopy Structure of the Native Prototype Foamy Virus Glycoprotein and Virus Architecture.

Effantin G, Estrozi LF, Aschman N, Renesto P, Stanke N, Lindemann D, Schoehn G, Weissenhorn W.

PLoS Pathog. 2016 Jul 11;12(7):e1005721. doi: 10.1371/journal.ppat.1005721. eCollection 2016 Jul.


Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.

Caillat C, Macheboeuf P, Wu Y, McCarthy AA, Boeri-Erba E, Effantin G, Göttlinger HG, Weissenhorn W, Renesto P.

Nat Commun. 2015 Dec 3;6:8781. doi: 10.1038/ncomms9781.


Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.

Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N.

Cell Rep. 2015 Dec 15;13(10):2273-86. doi: 10.1016/j.celrep.2015.11.001. Epub 2015 Nov 25.


Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells.

Bego MG, Côté É, Aschman N, Mercier J, Weissenhorn W, Cohen ÉA.

PLoS Pathog. 2015 Jul 14;11(7):e1005024. doi: 10.1371/journal.ppat.1005024. eCollection 2015 Jul.


Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6.

Bittame A, Effantin G, Pètre G, Ruffiot P, Travier L, Schoehn G, Weissenhorn W, Cesbron-Delauw MF, Gagnon J, Mercier C.

Biochem Biophys Res Commun. 2015 Mar 27;459(1):107-12. doi: 10.1016/j.bbrc.2015.02.078. Epub 2015 Feb 21.


The cooperative function of arginine residues in the Prototype Foamy Virus Gag C-terminus mediates viral and cellular RNA encapsidation.

Hamann MV, Müllers E, Reh J, Stanke N, Effantin G, Weissenhorn W, Lindemann D.

Retrovirology. 2014 Oct 8;11:87. doi: 10.1186/s12977-014-0087-7.


A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1.

Lai RP, Hock M, Radzimanowski J, Tonks P, Hulsik DL, Effantin G, Seilly DJ, Dreja H, Kliche A, Wagner R, Barnett SW, Tumba N, Morris L, LaBranche CC, Montefiori DC, Seaman MS, Heeney JL, Weissenhorn W.

J Biol Chem. 2014 Oct 24;289(43):29912-26. doi: 10.1074/jbc.M114.569566. Epub 2014 Aug 26.


Conformational plasticity of the Ebola virus matrix protein.

Radzimanowski J, Effantin G, Weissenhorn W.

Protein Sci. 2014 Nov;23(11):1519-27. doi: 10.1002/pro.2541. Epub 2014 Sep 4. Review.


A small switch has a large effect on autophagy.

Weissenhorn W, Fauvarque MO.

Structure. 2014 Jan 7;22(1):1-2. doi: 10.1016/j.str.2013.12.006.


Endophilin-A1 BAR domain interaction with arachidonyl CoA.

Petoukhov MV, Weissenhorn W, Svergun DI.

Front Mol Biosci. 2014 Oct 28;1:20. doi: 10.3389/fmolb.2014.00020. eCollection 2014.


How to get out: ssRNA enveloped viruses and membrane fission.

Weissenhorn W, Poudevigne E, Effantin G, Bassereau P.

Curr Opin Virol. 2013 Apr;3(2):159-67. doi: 10.1016/j.coviro.2013.03.011. Epub 2013 Apr 11. Review.


A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

Lutje Hulsik D, Liu YY, Strokappe NM, Battella S, El Khattabi M, McCoy LE, Sabin C, Hinz A, Hock M, Macheboeuf P, Bonvin AM, Langedijk JP, Davis D, Forsman Quigley A, Aasa-Chapman MM, Seaman MS, Ramos A, Poignard P, Favier A, Simorre JP, Weiss RA, Verrips CT, Weissenhorn W, Rutten L.

PLoS Pathog. 2013 Mar;9(3):e1003202. doi: 10.1371/journal.ppat.1003202. Epub 2013 Mar 7.


Cryo-electron microscopy three-dimensional structure of the jumbo phage ΦRSL1 infecting the phytopathogen Ralstonia solanacearum.

Effantin G, Hamasaki R, Kawasaki T, Bacia M, Moriscot C, Weissenhorn W, Yamada T, Schoehn G.

Structure. 2013 Feb 5;21(2):298-305. doi: 10.1016/j.str.2012.12.017.


ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.

Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist WI, Schoehn G, Weissenhorn W.

Cell Microbiol. 2013 Feb;15(2):213-26. doi: 10.1111/cmi.12041. Epub 2012 Nov 6.


Structural basis of tetherin function.

Weissenhorn W, Miguet N, Aschman N, Renesto P, Usami Y, Gottlinger HG.

Curr HIV Res. 2012 Jun;10(4):298-306. Review.


CC2D1A is a regulator of ESCRT-III CHMP4B.

Martinelli N, Hartlieb B, Usami Y, Sabin C, Dordor A, Miguet N, Avilov SV, Ribeiro EA Jr, Göttlinger H, Weissenhorn W.

J Mol Biol. 2012 May 25;419(1-2):75-88. doi: 10.1016/j.jmb.2012.02.044. Epub 2012 Mar 8.


Essential and supporting host cell factors for HIV-1 budding.

Dordor A, Poudevigne E, Göttlinger H, Weissenhorn W.

Future Microbiol. 2011 Oct;6(10):1159-70. doi: 10.2217/fmb.11.100. Review.


Conserved proline-rich region of Ebola virus matrix protein VP40 is essential for plasma membrane targeting and virus-like particle release.

Reynard O, Nemirov K, Page A, Mateo M, Raoul H, Weissenhorn W, Volchkov VE.

J Infect Dis. 2011 Nov;204 Suppl 3:S884-91. doi: 10.1093/infdis/jir359.


Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane.

Bodon G, Chassefeyre R, Pernet-Gallay K, Martinelli N, Effantin G, Hulsik DL, Belly A, Goldberg Y, Chatellard-Causse C, Blot B, Schoehn G, Weissenhorn W, Sadoul R.

J Biol Chem. 2011 Nov 18;286(46):40276-86. doi: 10.1074/jbc.M111.283671. Epub 2011 Sep 16.


Structural basis for ESCRT-III CHMP3 recruitment of AMSH.

Solomons J, Sabin C, Poudevigne E, Usami Y, Hulsik DL, Macheboeuf P, Hartlieb B, Göttlinger H, Weissenhorn W.

Structure. 2011 Aug 10;19(8):1149-59. doi: 10.1016/j.str.2011.05.011.


Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB.

Moriscot C, Gribaldo S, Jault JM, Krupovic M, Arnaud J, Jamin M, Schoehn G, Forterre P, Weissenhorn W, Renesto P.

PLoS One. 2011;6(7):e21921. doi: 10.1371/journal.pone.0021921. Epub 2011 Jul 8.


Essential ingredients for HIV-1 budding.

Weissenhorn W, Göttlinger H.

Cell Host Microbe. 2011 Mar 17;9(3):172-174. doi: 10.1016/j.chom.2011.03.005.


Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.

Sabin C, Corti D, Buzon V, Seaman MS, Lutje Hulsik D, Hinz A, Vanzetta F, Agatic G, Silacci C, Mainetti L, Scarlatti G, Sallusto F, Weiss R, Lanzavecchia A, Weissenhorn W.

PLoS Pathog. 2010 Nov 18;6(11):e1001195. doi: 10.1371/journal.ppat.1001195.


Divergent pathways lead to ESCRT-III-catalyzed membrane fission.

Peel S, Macheboeuf P, Martinelli N, Weissenhorn W.

Trends Biochem Sci. 2011 Apr;36(4):199-210. doi: 10.1016/j.tibs.2010.09.004. Epub 2010 Oct 26. Review.


Crystal structure of the neutralizing Llama V(HH) D7 and its mode of HIV-1 gp120 interaction.

Hinz A, Lutje Hulsik D, Forsman A, Koh WW, Belrhali H, Gorlani A, de Haard H, Weiss RA, Verrips T, Weissenhorn W.

PLoS One. 2010 May 5;5(5):e10482. doi: 10.1371/journal.pone.0010482.


Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.

Buzon V, Natrajan G, Schibli D, Campelo F, Kozlov MM, Weissenhorn W.

PLoS Pathog. 2010 May 6;6(5):e1000880. doi: 10.1371/journal.ppat.1000880.


Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.

Hinz A, Miguet N, Natrajan G, Usami Y, Yamanaka H, Renesto P, Hartlieb B, McCarthy AA, Simorre JP, Göttlinger H, Weissenhorn W.

Cell Host Microbe. 2010 Apr 22;7(4):314-23. doi: 10.1016/j.chom.2010.03.005.


Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

Corti D, Langedijk JP, Hinz A, Seaman MS, Vanzetta F, Fernandez-Rodriguez BM, Silacci C, Pinna D, Jarrossay D, Balla-Jhagjhoorsingh S, Willems B, Zekveld MJ, Dreja H, O'Sullivan E, Pade C, Orkin C, Jeffs SA, Montefiori DC, Davis D, Weissenhorn W, McKnight A, Heeney JL, Sallusto F, Sattentau QJ, Weiss RA, Lanzavecchia A.

PLoS One. 2010 Jan 20;5(1):e8805. doi: 10.1371/journal.pone.0008805.


RNA induced polymerization of the Borna disease virus nucleoprotein.

Hock M, Kraus I, Schoehn G, Jamin M, Andrei-Selmer C, Garten W, Weissenhorn W.

Virology. 2010 Feb 5;397(1):64-72. doi: 10.1016/j.virol.2009.11.016. Epub 2009 Nov 30.


Computational model of membrane fission catalyzed by ESCRT-III.

Fabrikant G, Lata S, Riches JD, Briggs JA, Weissenhorn W, Kozlov MM.

PLoS Comput Biol. 2009 Nov;5(11):e1000575. doi: 10.1371/journal.pcbi.1000575. Epub 2009 Nov 20.


Characterization of a trimeric MPER containing HIV-1 gp41 antigen.

Hinz A, Schoehn G, Quendler H, Hulsik DL, Stiegler G, Katinger H, Seaman MS, Montefiori D, Weissenhorn W.

Virology. 2009 Aug 1;390(2):221-7. doi: 10.1016/j.virol.2009.05.015. Epub 2009 Jun 18.


A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.

Pires R, Hartlieb B, Signor L, Schoehn G, Lata S, Roessle M, Moriscot C, Popov S, Hinz A, Jamin M, Boyer V, Sadoul R, Forest E, Svergun DI, Göttlinger HG, Weissenhorn W.

Structure. 2009 Jun 10;17(6):843-56. doi: 10.1016/j.str.2009.04.007.


The ESCRT pathway and HIV-1 budding.

Usami Y, Popov S, Popova E, Inoue M, Weissenhorn W, G Göttlinger H.

Biochem Soc Trans. 2009 Feb;37(Pt 1):181-4. doi: 10.1042/BST0370181.


Structure and function of ESCRT-III.

Lata S, Schoehn G, Solomons J, Pires R, Göttlinger HG, Weissenhorn W.

Biochem Soc Trans. 2009 Feb;37(Pt 1):156-60. doi: 10.1042/BST0370156. Review.


Helical structures of ESCRT-III are disassembled by VPS4.

Lata S, Schoehn G, Jain A, Pires R, Piehler J, Gottlinger HG, Weissenhorn W.

Science. 2008 Sep 5;321(5894):1354-7. doi: 10.1126/science.1161070. Epub 2008 Aug 7.


Subviral particle release determinants of prototype foamy virus.

Stange A, Lüftenegger D, Reh J, Weissenhorn W, Lindemann D.

J Virol. 2008 Oct;82(20):9858-69. doi: 10.1128/JVI.00949-08. Epub 2008 Aug 6.

Supplemental Content

Loading ...
Support Center