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Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging.

Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS.

Redox Biol. 2018 Sep;18:191-199. doi: 10.1016/j.redox.2018.06.005. Epub 2018 Jun 19.


Sulindac induces differentiation of glioblastoma stem cells making them more sensitive to oxidative stress.

Allani SK, Weissbach H, Lopez Toledano MA.

Neoplasma. 2018 Mar 14;65(3):376-388. doi: 10.4149/neo_2018_170404N245.


Identification of activators of methionine sulfoxide reductases A and B.

Cudic P, Joshi N, Sagher D, Williams BT, Stawikowski MJ, Weissbach H.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):863-7. doi: 10.1016/j.bbrc.2015.12.077. Epub 2015 Dec 21.


Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.

Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D, Hinton DR, Blanks J, Weissbach H.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16754-9. doi: 10.1073/pnas.1419576111. Epub 2014 Nov 10.


Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage.

Ayyanathan K, Kesaraju S, Dawson-Scully K, Weissbach H.

PLoS One. 2012;7(7):e39949. doi: 10.1371/journal.pone.0039949. Epub 2012 Jul 17.


Protective effects of taurine against oxidative stress in the heart of MsrA knockout mice.

Chen G, Nan C, Tian J, Jean-Charles P, Li Y, Weissbach H, Huang XP.

J Cell Biochem. 2012 Nov;113(11):3559-66. doi: 10.1002/jcb.24233.


Studies on the metabolism and biological activity of the epimers of sulindac.

Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H.

Drug Metab Dispos. 2011 Jun;39(6):1014-21. doi: 10.1124/dmd.110.037663. Epub 2011 Mar 7.


Deficiency of methionine sulfoxide reductase A causes cellular dysfunction and mitochondrial damage in cardiac myocytes under physical and oxidative stresses.

Nan C, Li Y, Jean-Charles PY, Chen G, Kreymerman A, Prentice H, Weissbach H, Huang X.

Biochem Biophys Res Commun. 2010 Nov 26;402(4):608-13. doi: 10.1016/j.bbrc.2010.10.064. Epub 2010 Oct 28.


A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A.

Brunell D, Weissbach H, Hodder P, Brot N.

Assay Drug Dev Technol. 2010 Oct;8(5):615-20. doi: 10.1089/adt.2009.0263. Epub 2010 Jun 1.


Methionine sulfoxide reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress.

Zhang C, Jia P, Jia Y, Weissbach H, Webster KA, Huang X, Lemanski SL, Achary M, Lemanski LF.

J Cell Biochem. 2010 Sep 1;111(1):94-103. doi: 10.1002/jcb.22666.


Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms.

Moench I, Prentice H, Rickaway Z, Weissbach H.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19611-6. doi: 10.1073/pnas.0911046106. Epub 2009 Nov 2.


Sulindac enhances the killing of cancer cells exposed to oxidative stress.

Marchetti M, Resnick L, Gamliel E, Kesaraju S, Weissbach H, Binninger D.

PLoS One. 2009 Jun 5;4(6):e5804. doi: 10.1371/journal.pone.0005804.


Topical sulindac combined with hydrogen peroxide in the treatment of actinic keratoses.

Resnick L, Rabinovitz H, Binninger D, Marchetti M, Weissbach H.

J Drugs Dermatol. 2009 Jan;8(1):29-32.


Origin and evolution of the protein-repairing enzymes methionine sulphoxide reductases.

Zhang XH, Weissbach H.

Biol Rev Camb Philos Soc. 2008 Aug;83(3):249-57. doi: 10.1111/j.1469-185X.2008.00042.x. Review.


The isolation of the vitamin B12 coenzyme and the role of the vitamin in methionine synthesis.

Weissbach H.

J Biol Chem. 2008 Aug 29;283(35):23497-504. doi: 10.1074/jbc.X800006200. Epub 2008 Jun 4. Review. No abstract available.


MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death.

Prentice HM, Moench IA, Rickaway ZT, Dougherty CJ, Webster KA, Weissbach H.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):775-8. Epub 2007 Dec 18.


Studies on the reducing systems for plant and animal thioredoxin-independent methionine sulfoxide reductases B.

Ding D, Sagher D, Laugier E, Rey P, Weissbach H, Zhang XH.

Biochem Biophys Res Commun. 2007 Sep 28;361(3):629-33. Epub 2007 Jul 25.


Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function.

Lin Z, Johnson LC, Weissbach H, Brot N, Lively MO, Lowther WT.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9597-602. Epub 2007 May 29.


Ecdysone induction of MsrA protects against oxidative stress in Drosophila.

Roesijadi G, Rezvankhah S, Binninger DM, Weissbach H.

Biochem Biophys Res Commun. 2007 Mar 9;354(2):511-6. Epub 2007 Jan 9.


Silencing of the methionine sulfoxide reductase A gene results in loss of mitochondrial membrane potential and increased ROS production in human lens cells.

Marchetti MA, Lee W, Cowell TL, Wells TM, Weissbach H, Kantorow M.

Exp Eye Res. 2006 Nov;83(5):1281-6. Epub 2006 Aug 24.


The thioredoxin domain of Neisseria gonorrhoeae PilB can use electrons from DsbD to reduce downstream methionine sulfoxide reductases.

Brot N, Collet JF, Johnson LC, Jönsson TJ, Weissbach H, Lowther WT.

J Biol Chem. 2006 Oct 27;281(43):32668-75. Epub 2006 Aug 22.


Selenocompounds can serve as oxidoreductants with the methionine sulfoxide reductase enzymes.

Sagher D, Brunell D, Brot N, Vallee BL, Weissbach H.

J Biol Chem. 2006 Oct 20;281(42):31184-7. Epub 2006 Aug 17.


Thionein can serve as a reducing agent for the methionine sulfoxide reductases.

Sagher D, Brunell D, Hejtmancik JF, Kantorow M, Brot N, Weissbach H.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8656-61. Epub 2006 May 30.


Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina.

Lee JW, Gordiyenko NV, Marchetti M, Tserentsoodol N, Sagher D, Alam S, Weissbach H, Kantorow M, Rodriguez IR.

Exp Eye Res. 2006 May;82(5):816-27. Epub 2005 Dec 20.


Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells.

Marchetti MA, Pizarro GO, Sagher D, Deamicis C, Brot N, Hejtmancik JF, Weissbach H, Kantorow M.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2107-12.


Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.

Weissbach H, Resnick L, Brot N.

Biochim Biophys Acta. 2005 Jan 17;1703(2):203-12. Epub 2004 Nov 11. Review.


Sidney Udenfriend.

Weissbach H, Witkop B.

Biogr Mem Natl Acad Sci. 2003;83:270-98. No abstract available.


Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation.

Yermolaieva O, Xu R, Schinstock C, Brot N, Weissbach H, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1159-64. Epub 2004 Jan 26.


Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system.

Etienne F, Resnick L, Sagher D, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1005-10.


New membrane-associated and soluble peptide methionine sulfoxide reductases in Escherichia coli.

Spector D, Etienne F, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Mar 7;302(2):284-9.


How I became a biochemist.

Weissbach H.

IUBMB Life. 2002 Oct;54(4):225-8. No abstract available.


A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide.

Etienne F, Spector D, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):378-82.


The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species.

Skaar EP, Tobiason DM, Quick J, Judd RC, Weissbach H, Etienne F, Brot N, Seifert HS.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10108-13. Epub 2002 Jul 2.


The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB.

Lowther WT, Weissbach H, Etienne F, Brot N, Matthews BW.

Nat Struct Biol. 2002 May;9(5):348-52.


High-quality life extension by the enzyme peptide methionine sulfoxide reductase.

Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53. Epub 2002 Feb 26. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184. Chen, M-L [corrected to Chen, Mai-Lei]; Joiner, MA [corrected to Joiner, Mei-Ling A]; Heinemann, Stephen H [corrected to Heinemann, Stefan H].


Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.

Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N.

Arch Biochem Biophys. 2002 Jan 15;397(2):172-8. Review.


Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.

St John G, Brot N, Ruan J, Erdjument-Bromage H, Tempst P, Weissbach H, Nathan C.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9901-6. Epub 2001 Jul 31.


Oxidative regulation of large conductance calcium-activated potassium channels.

Tang XD, Daggett H, Hanner M, Garcia ML, McManus OB, Brot N, Weissbach H, Heinemann SH, Hoshi T.

J Gen Physiol. 2001 Mar;117(3):253-74.


Peptide methionine sulfoxide reductase: biochemistry and physiological role.

Brot N, Weissbach H.

Biopolymers. 2000;55(4):288-96. Review.


Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.

Lowther WT, Brot N, Weissbach H, Matthews BW.

Biochemistry. 2000 Nov 7;39(44):13307-12.


Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.

Lowther WT, Brot N, Weissbach H, Honek JF, Matthews BW.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6463-8.


Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling.

Yermolaieva O, Brot N, Weissbach H, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):448-53.


Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).

Kuschel L, Hansel A, Schönherr R, Weissbach H, Brot N, Hoshi T, Heinemann SH.

FEBS Lett. 1999 Jul 30;456(1):17-21.


Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C.

Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T.

FEBS Lett. 1999 Jan 8;442(1):48-52.


A revisit to bacterial protein synthesis: the search for the role of GTP.

Weissbach H.

Protein Sci. 1998 Feb;7(2):516-21. No abstract available.


Modulation of potassium channel function by methionine oxidation and reduction.

Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9932-7.


Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.

Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7985-90.


ATP hydrolysis is not required for the dissociation of a substance P.BiP complex.

Vidal V, Qiu NH, Redfield B, Carlino A, Brot N, Weissbach H.

Arch Biochem Biophys. 1996 Jun 15;330(2):314-8.


Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.

Moskovitz J, Jenkins NA, Gilbert DJ, Copeland NG, Jursky F, Weissbach H, Brot N.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3205-8.

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