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Items: 41


Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies.

Murphy JR, Weiss WR, Fryauff D, Dowler M, Savransky T, Stoyanov C, Muratova O, Lambert L, Orr-Gonzalez S, Zeleski KL, Hinderer J, Fay MP, Joshi G, Gwadz RW, Richie TL, Villasante EF, Richardson JH, Duffy PE, Chen J.

Malar J. 2014 Jun 3;13:215. doi: 10.1186/1475-2875-13-215.


Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites.

Weiss WR, Jiang CG.

PLoS One. 2012;7(2):e31247. doi: 10.1371/journal.pone.0031247. Epub 2012 Feb 15.


Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques.

Hamid MM, Remarque EJ, El Hassan IM, Hussain AA, Narum DL, Thomas AW, Kocken CH, Weiss WR, Faber BW.

Malar J. 2011 Feb 8;10:29. doi: 10.1186/1475-2875-10-29.


Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies.

Jiang G, Shi M, Conteh S, Richie N, Banania G, Geneshan H, Valencia A, Singh P, Aguiar J, Limbach K, Kamrud KI, Rayner J, Smith J, Bruder JT, King CR, Tsuboi T, Takeo S, Endo Y, Doolan DL, Richie TL, Weiss WR.

PLoS One. 2009 Aug 10;4(8):e6559. doi: 10.1371/journal.pone.0006559.


Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens.

Weiss WR, Kumar A, Jiang G, Williams J, Bostick A, Conteh S, Fryauff D, Aguiar J, Singh M, O'Hagan DT, Ulmer JB, Richie TL.

PLoS One. 2007 Oct 24;2(10):e1063.


Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization.

Jiang G, Charoenvit Y, Moreno A, Baraceros MF, Banania G, Richie N, Abot S, Ganeshan H, Fallarme V, Patterson NB, Geall A, Weiss WR, Strobert E, Caro-Aquilar I, Lanar DE, Saul A, Martin LB, Gowda K, Morrissette CR, Kaslow DC, Carucci DJ, Galinski MR, Doolan DL.

Malar J. 2007 Oct 9;6:135.


Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.

Wille-Reece U, Flynn BJ, Loré K, Koup RA, Miles AP, Saul A, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.

J Exp Med. 2006 May 15;203(5):1249-58. Epub 2006 Apr 24.


HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.

Wille-Reece U, Flynn BJ, Loré K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15190-4. Epub 2005 Oct 11.


Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genome.

Haddad D, Bilcikova E, Witney AA, Carlton JM, White CE, Blair PL, Chattopadhyay R, Russell J, Abot E, Charoenvit Y, Aguiar JC, Carucci DJ, Weiss WR.

Infect Immun. 2004 Mar;72(3):1594-602.


Utilization of genomic sequence information to develop malaria vaccines.

Doolan DL, Aguiar JC, Weiss WR, Sette A, Felgner PL, Regis DP, Quinones-Casas P, Yates JR 3rd, Blair PL, Richie TL, Hoffman SL, Carucci DJ.

J Exp Biol. 2003 Nov;206(Pt 21):3789-802. Review.


Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers.

Sedegah M, Belmonte M, Epstein JE, Siegrist CA, Weiss WR, Jones TR, Lu M, Carucci DJ, Hoffman SL.

J Immunol. 2003 Sep 15;171(6):3148-53.


Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen.

Rogers WO, Weiss WR, Kumar A, Aguiar JC, Tine JA, Gwadz R, Harre JG, Gowda K, Rathore D, Kumar S, Hoffman SL.

Infect Immun. 2002 Aug;70(8):4329-35.


Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy.

Witney AA, Doolan DL, Anthony RM, Weiss WR, Hoffman SL, Carucci DJ.

Mol Biochem Parasitol. 2001 Dec;118(2):233-45.


Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules.

Villinger F, Bostik P, Mayne A, King CL, Genain CP, Weiss WR, Ansari AA.

Immunogenetics. 2001 May-Jun;53(4):315-28.


Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles.

Haddad D, Ramprakash J, Sedegah M, Charoenvit Y, Baumgartner R, Kumar S, Hoffman SL, Weiss WR.

J Immunol. 2000 Oct 1;165(7):3772-81.


Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques.

Raviprakash K, Porter KR, Kochel TJ, Ewing D, Simmons M, Phillips I, Murphy GS, Weiss WR, Hayes CG.

J Gen Virol. 2000 Jul;81(Pt 7):1659-67.


Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor.

Ishii KJ, Weiss WR, Klinman DM.

Vaccine. 1999 Nov 12;18(7-8):703-10.


Activity and safety of DNA plasmids encoding IL-4 and IFN gamma.

Ishii KJ, Weiss WR, Ichino M, Verthelyi D, Klinman DM.

Gene Ther. 1999 Feb;6(2):237-44.


Factors associated with the development of neonatal tolerance after the administration of a plasmid DNA vaccine.

Ichino M, Mor G, Conover J, Weiss WR, Takeno M, Ishii KJ, Klinman DM.

J Immunol. 1999 Apr 1;162(7):3814-8.


Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

Wang R, Doolan DL, Le TP, Hedstrom RC, Coonan KM, Charoenvit Y, Jones TR, Hobart P, Margalith M, Ng J, Weiss WR, Sedegah M, de Taisne C, Norman JA, Hoffman SL.

Science. 1998 Oct 16;282(5388):476-80.


A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine.

Weiss WR, Ishii KJ, Hedstrom RC, Sedegah M, Ichino M, Barnhart K, Klinman DM, Hoffman SL.

J Immunol. 1998 Sep 1;161(5):2325-32.


Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids.

Wang R, Doolan DL, Charoenvit Y, Hedstrom RC, Gardner MJ, Hobart P, Tine J, Sedegah M, Fallarme V, Sacci JB Jr, Kaur M, Klinman DM, Hoffman SL, Weiss WR.

Infect Immun. 1998 Sep;66(9):4193-202.


Toward clinical trials of DNA vaccines against malaria.

Hoffman SL, Doolan DL, Sedegah M, Wang R, Scheller LF, Kumar A, Weiss WR, Le TP, Klinman DM, Hobart P, Norman JA, Hedstrom RC.

Immunol Cell Biol. 1997 Aug;75(4):376-81. Review.


Cytotoxic T cell reactivity and HLA-B35 binding of the variant Plasmodium falciparum circumsporozoite protein CD8+ CTL epitope in naturally exposed Kenyan adults.

Udhayakumar V, Ongecha JM, Shi YP, Aidoo M, Orago AS, Oloo AJ, Hawley WA, Nahlen BL, Hoffman SL, Weiss WR, Lal AA.

Eur J Immunol. 1997 Aug;27(8):1952-7.


Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use.

Hoffman SL, Doolan DL, Sedegah M, Aguiar JC, Wang R, Malik A, Gramzinski RA, Weiss WR, Hobart P, Norman JA, Margalith M, Hedstrom RC.

Vaccine. 1997 Jun;15(8):842-5.


The development of a multivalent DNA vaccine for malaria.

Hedstrom RC, Doolan DL, Wang R, Gardner MJ, Kumar A, Sedegah M, Gramzinski RA, Sacci JB Jr, Charoenvit Y, Weiss WR, Margalith M, Norman JA, Hobart P, Hoffman SL.

Springer Semin Immunopathol. 1997;19(2):147-59. Review. No abstract available.


Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay.

Beadle C, Long GW, Weiss WR, McElroy PD, Maret SM, Oloo AJ, Hoffman SL.

Lancet. 1994 Mar 5;343(8897):564-8.


The role of CD4+ T cells in immunity to malaria sporozoites.

Weiss WR, Sedegah M, Berzofsky JA, Hoffman SL.

J Immunol. 1993 Sep 1;151(5):2690-8.


A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.

Weiss WR, Berzofsky JA, Houghten RA, Sedegah M, Hollindale M, Hoffman SL.

J Immunol. 1992 Sep 15;149(6):2103-9.


Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity.

Sedegah M, Chiang CH, Weiss WR, Mellouk S, Cochran MD, Houghten RA, Beaudoin RL, Smith D, Hoffman SL.

Vaccine. 1992;10(9):578-84.


Generation of a cytotoxic T-lymphocyte response using a Salmonella antigen-delivery system.

Flynn JL, Weiss WR, Norris KA, Seifert HS, Kumar S, So M.

Mol Microbiol. 1990 Dec;4(12):2111-8.


Host-parasite interactions and immunity to irradiated sporozoites.

Weiss WR.

Immunol Lett. 1990 Aug;25(1-3):39-42. Review.


Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.

Weiss WR, Mellouk S, Houghten RA, Sedegah M, Kumar S, Good MF, Berzofsky JA, Miller LH, Hoffman SL.

J Exp Med. 1990 Mar 1;171(3):763-73.


Genetic restriction of protective immunity to Plasmodium yoelii sporozoites.

Weiss WR, Good MF, Hollingdale MR, Miller LH, Berzofsky JA.

Bull World Health Organ. 1990;68 Suppl:104-8.


A CTL epitope on the circumsporozoite protein of P. yoelii.

Weiss WR, Houghten RA, Good MF, Berzofsky JA, Miller LH, Hoffman SL.

Bull World Health Organ. 1990;68 Suppl:99-103.


Evidence implicating MHC genes in the immunological nonresponsiveness to the Plasmodium falciparum CS protein.

Good MF, Kumar S, De Groot AS, Weiss WR, Quakyi IA, Dontfraid F, Smith GE, Cochran M, Berzofsky JA, Miller LH.

Bull World Health Organ. 1990;68 Suppl:80-4.


Genetic control of immunity to Plasmodium yoelii sporozoites.

Weiss WR, Good MF, Hollingdale MR, Miller LH, Berzofsky JA.

J Immunol. 1989 Dec 15;143(12):4263-6.


T-cell antigenic sites of the malaria circumsporozoite protein.

Good MF, Kumar S, Weiss WR, Miller LH.

Blood. 1989 Aug 15;74(3):895-900. Review. No abstract available.


CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

Weiss WR, Sedegah M, Beaudoin RL, Miller LH, Good MF.

Proc Natl Acad Sci U S A. 1988 Jan;85(2):573-6.


In vivo testing of subunit vaccines against malaria sporozoites using a rodent system.

Lal AA, de la Cruz VF, Good MF, Weiss WR, Lunde M, Maloy WL, Welsh JA, McCutchan TF.

Proc Natl Acad Sci U S A. 1987 Dec;84(23):8647-51.

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