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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.

Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P.

Arch Toxicol. 2020 Jan 9. doi: 10.1007/s00204-019-02630-3. [Epub ahead of print]


Serum Adiponectin Levels Do Not Distinguish Primary from Metastatic Liver Tumors.

Feder S, Kandulski A, Schacherer D, Weiss TS, Buechler C.

Anticancer Res. 2020 Jan;40(1):143-151. doi: 10.21873/anticanres.13935.


Augmenter of Liver Regeneration Reduces Ischemia Reperfusion Injury by Less Chemokine Expression, Gr-1 Infiltration and Oxidative Stress.

Weiss TS, Lupke M, Dayoub R, Geissler EK, Schlitt HJ, Melter M, Eggenhofer E.

Cells. 2019 Nov 12;8(11). pii: E1421. doi: 10.3390/cells8111421.


Increased Expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH).

Kaur S, Rawal P, Siddiqui H, Rohilla S, Sharma S, Tripathi DM, Baweja S, Hassan M, Vlaic S, Guthke R, Thomas M, Dayoub R, Bihari C, Sarin SK, Weiss TS.

Cells. 2019 Oct 18;8(10). pii: E1277. doi: 10.3390/cells8101277.


Serum Chemerin Does Not Differentiate Colorectal Liver Metastases from Hepatocellular Carcinoma.

Feder S, Kandulski A, Schacherer D, Weiss TS, Buechler C.

Int J Mol Sci. 2019 Aug 12;20(16). pii: E3919. doi: 10.3390/ijms20163919.


Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma.

Asimakopoulou A, Vucur M, Luedde T, Schneiders S, Kalampoka S, Weiss TS, Weiskirchen R.

Cancers (Basel). 2019 Mar 19;11(3). pii: E385. doi: 10.3390/cancers11030385.


Augmenter of liver regeneration: Essential for growth and beyond.

Ibrahim S, Weiss TS.

Cytokine Growth Factor Rev. 2019 Feb;45:65-80. doi: 10.1016/j.cytogfr.2018.12.003. Epub 2018 Dec 16. Review.


Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism.

Ibrahim S, Dayoub R, Krautbauer S, Liebisch G, Wege AK, Melter M, Weiss TS.

Exp Cell Res. 2019 Jan 1;374(1):189-197. doi: 10.1016/j.yexcr.2018.11.023. Epub 2018 Nov 28.


Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.

Henkel J, Coleman CD, Schraplau A, Jöhrens K, Weiss TS, Jonas W, Schürmann A, Püschel GP.

Sci Rep. 2018 Oct 31;8(1):16127. doi: 10.1038/s41598-018-34633-y.


Bile acids down-regulate the expression of Augmenter of Liver Regeneration (ALR) via SHP/HNF4α1 and independent of Egr-1.

Ibrahim S, Dayoub R, Melter M, Weiss TS.

Exp Mol Pathol. 2018 Dec;105(3):236-242. doi: 10.1016/j.yexmp.2018.09.004. Epub 2018 Sep 20.


β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.

Klag T, Thomas M, Ehmann D, Courth L, Mailänder-Sanchez D, Weiss TS, Dayoub R, Abshagen K, Vollmar B, Thasler WE, Stange EF, Berg CP, Malek NP, Zanger UM, Wehkamp J.

Front Immunol. 2018 Jul 27;9:1735. doi: 10.3389/fimmu.2018.01735. eCollection 2018.


The adaptor protein alpha-syntrophin is reduced in human non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma.

Rein-Fischboeck L, Pohl R, Haberl EM, Weiss TS, Buechler C.

Exp Mol Pathol. 2017 Oct;103(2):204-209. doi: 10.1016/j.yexmp.2017.09.005. Epub 2017 Sep 21.


Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways.

Weiss TS, Lupke M, Ibrahim S, Buechler C, Lorenz J, Ruemmele P, Hofmann U, Melter M, Dayoub R.

PLoS One. 2017 Sep 6;12(9):e0184282. doi: 10.1371/journal.pone.0184282. eCollection 2017.


Diagnostic Value of Systemic Cholesteryl Ester/Free Cholesterol Ratio in Hepatocellular Carcinoma.

Krautbauer S, Weiss TS, Wiest R, Schacherer D, Liebisch G, Buechler C.

Anticancer Res. 2017 Jul;37(7):3527-3535.


Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.

Zimny S, Pohl R, Rein-Fischboeck L, Haberl EM, Krautbauer S, Weiss TS, Buechler C.

Exp Mol Pathol. 2017 Aug;103(1):1-8. doi: 10.1016/j.yexmp.2017.06.001. Epub 2017 Jun 15.


Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis.

Dengler M, Staufer K, Huber H, Stauber R, Bantel H, Weiss KH, Starlinger P, Pock H, Klöters-Plachky P, Gotthardt DN, Rauch P, Lackner C, Stift J, Brostjan C, Gruenberger T, Kumada T, Toyoda H, Tada T, Weiss TS, Trauner M, Mikulits W.

Oncotarget. 2017 Jul 11;8(28):46234-46248. doi: 10.18632/oncotarget.17598.


Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response.

Dayoub R, Buerger L, Ibrahim S, Melter M, Weiss TS.

Exp Mol Pathol. 2017 Jun;102(3):428-433. doi: 10.1016/j.yexmp.2017.05.011. Epub 2017 May 12.


Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O.

Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13.


Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.

Rein-Fischboeck L, Pohl R, Haberl EM, Zimny S, Neumann M, Eisinger K, Weiss TS, Krautbauer S, Buechler C.

Mol Cell Biochem. 2017 Apr;428(1-2):161-170. doi: 10.1007/s11010-016-2926-4. Epub 2017 Jan 7.


Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis.

Pohl R, Haberl EM, Rein-Fischboeck L, Zimny S, Neumann M, Aslanidis C, Schacherer D, Krautbauer S, Eisinger K, Weiss TS, Buechler C.

Eur J Clin Invest. 2017 Jan;47(1):7-18. doi: 10.1111/eci.12695. Epub 2016 Nov 21.


Ceramide and polyunsaturated phospholipids are strongly reduced in human hepatocellular carcinoma.

Krautbauer S, Meier EM, Rein-Fischboeck L, Pohl R, Weiss TS, Sigruener A, Aslanidis C, Liebisch G, Buechler C.

Biochim Biophys Acta. 2016 Nov;1861(11):1767-1774. doi: 10.1016/j.bbalip.2016.08.014. Epub 2016 Aug 26.


Chemokine-Like Receptor 1 mRNA Weakly Correlates with Non-Alcoholic Steatohepatitis Score in Male but Not Female Individuals.

Neumann M, Meier EM, Rein-Fischboeck L, Krautbauer S, Eisinger K, Aslanidis C, Pohl R, Weiss TS, Buechler C.

Int J Mol Sci. 2016 Aug 18;17(8). pii: E1335. doi: 10.3390/ijms17081335.


Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.


Annexin A6 protein is downregulated in human hepatocellular carcinoma.

Meier EM, Rein-Fischboeck L, Pohl R, Wanninger J, Hoy AJ, Grewal T, Eisinger K, Krautbauer S, Liebisch G, Weiss TS, Buechler C.

Mol Cell Biochem. 2016 Jul;418(1-2):81-90. doi: 10.1007/s11010-016-2735-9. Epub 2016 Jun 23.


Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

Matz-Soja M, Rennert C, Schönefeld K, Aleithe S, Boettger J, Schmidt-Heck W, Weiss TS, Hovhannisyan A, Zellmer S, Klöting N, Schulz A, Kratzsch J, Guthke R, Gebhardt R.

Elife. 2016 May 17;5. pii: e13308. doi: 10.7554/eLife.13308.


Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.

Chen S, Feng T, Vujić Spasić M, Altamura S, Breitkopf-Heinlein K, Altenöder J, Weiss TS, Dooley S, Muckenthaler MU.

J Biol Chem. 2016 Jun 17;291(25):13160-74. doi: 10.1074/jbc.M115.691543. Epub 2016 Apr 27.


Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2016 Feb;64(2):525-526. doi: 10.1016/j.jhep.2015.11.003. Epub 2015 Dec 2. No abstract available.


Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease.

Rein-Fischboeck L, Krautbauer S, Eisinger K, Pohl R, Meier EM, Weiss TS, Buechler C.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):377-82. doi: 10.1016/j.bbrc.2015.09.149. Epub 2015 Sep 30.


Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.

Braeuning A, Thomas M, Hofmann U, Vetter S, Zeller E, Petzuch B, Johänning J, Schroth W, Weiss TS, Zanger UM, Schwarz M.

Drug Metab Dispos. 2015 Nov;43(11):1781-7. doi: 10.1124/dmd.115.064667. Epub 2015 Aug 26.


The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes.

Thomas M, Bayha C, Klein K, Müller S, Weiss TS, Schwab M, Zanger UM.

BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x.


Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. Erratum in: J Hepatol. 2016 Feb;64(2):525-6. Erratum in: J Hepatol. 2016 Feb;64(2):525-526.


Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.

Weiß F, Schnabel A, Planatscher H, van den Berg BH, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz O.

Sci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.


FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells.

Schuster S, Penke M, Gorski T, Gebhardt R, Weiss TS, Kiess W, Garten A.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):334-40. doi: 10.1016/j.bbrc.2015.01.111. Epub 2015 Feb 3.


Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grässer F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM.

Clin Sci (Lond). 2015 Jun;128(11):761-74. doi: 10.1042/CS20140606.


Reduced serum chemerin in patients with more severe liver cirrhosis.

Eisinger K, Krautbauer S, Wiest R, Weiss TS, Buechler C.

Exp Mol Pathol. 2015 Apr;98(2):208-13. doi: 10.1016/j.yexmp.2015.01.010. Epub 2015 Jan 13.


Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.


Adiponectin isoforms differentially affect gene expression and the lipidome of primary human hepatocytes.

Wanninger J, Liebisch G, Eisinger K, Neumeier M, Aslanidis C, Voggenreiter L, Pohl R, Weiss TS, Krautbauer S, Buechler C.

Metabolites. 2014 May 23;4(2):394-407. doi: 10.3390/metabo4020394.


Attenuated and protease-profile modified sendai virus vectors as a new tool for virotherapy of solid tumors.

Zimmermann M, Armeanu-Ebinger S, Bossow S, Lampe J, Smirnow I, Schenk A, Lange S, Weiss TS, Neubert W, Lauer UM, Bitzer M.

PLoS One. 2014 Mar 5;9(3):e90508. doi: 10.1371/journal.pone.0090508. eCollection 2014.


Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma.

Valletta D, Czech B, Spruss T, Ikenberg K, Wild P, Hartmann A, Weiss TS, Oefner PJ, Müller M, Bosserhoff AK, Hellerbrand C.

Carcinogenesis. 2014 Jun;35(6):1407-15. doi: 10.1093/carcin/bgu054. Epub 2014 Mar 3.


Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease.

Krautbauer S, Eisinger K, Lupke M, Wanninger J, Ruemmele P, Hader Y, Weiss TS, Buechler C.

Exp Mol Pathol. 2013 Dec;95(3):330-5. doi: 10.1016/j.yexmp.2013.10.003. Epub 2013 Oct 22.


Human parenchymal and non-parenchymal liver cell isolation, culture and characterization.

Damm G, Pfeiffer E, Burkhardt B, Vermehren J, Nüssler AK, Weiss TS.

Hepatol Int. 2013 Oct;7(4):951-8. doi: 10.1007/s12072-013-9475-7. Epub 2013 Oct 10.


Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells.

Venturelli S, Berger A, Böcker A, Busch C, Weiland T, Noor S, Leischner C, Schleicher S, Mayer M, Weiss TS, Bischoff SC, Lauer UM, Bitzer M.

PLoS One. 2013 Aug 30;8(8):e73097. doi: 10.1371/journal.pone.0073097. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/5b9a8614-1009-40ca-b90b-db817fe445c9.


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.


Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Haider C, Grubinger M, Řezníčková E, Weiss TS, Rotheneder H, Miklos W, Berger W, Jorda R, Zatloukal M, Gucky T, Strnad M, Kryštof V, Mikulits W.

Mol Cancer Ther. 2013 Oct;12(10):1947-57. doi: 10.1158/1535-7163.MCT-13-0263. Epub 2013 Aug 12.


Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver.

Krautbauer S, Wanninger J, Eisinger K, Hader Y, Beck M, Kopp A, Schmid A, Weiss TS, Dorn C, Buechler C.

Exp Mol Pathol. 2013 Oct;95(2):199-205. doi: 10.1016/j.yexmp.2013.07.009. Epub 2013 Jul 29.


Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.

Dayoub R, Vogel A, Schuett J, Lupke M, Spieker SM, Kettern N, Hildt E, Melter M, Weiss TS.

Mol Med. 2013 Aug 28;19:237-44. doi: 10.2119/molmed.2013.00027.


Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus.

Hoffmann J, Boehm C, Himmelsbach K, Donnerhak C, Roettger H, Weiss TS, Ploen D, Hildt E.

J Hepatol. 2013 Nov;59(5):934-41. doi: 10.1016/j.jhep.2013.06.020. Epub 2013 Jun 28.


TIP47 plays a crucial role in the life cycle of hepatitis C virus.

Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, Weiss TS, Baumert TF, Schuster C, Hildt E.

J Hepatol. 2013 Jun;58(6):1081-8. doi: 10.1016/j.jhep.2013.01.022. Epub 2013 Jan 24.


Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM.

Mol Pharmacol. 2013 Mar;83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7.


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